-
公开(公告)号：US20080119457A1
公开(公告)日：2008-05-22
申请号：US11844816
申请日：2007-08-24
申请人： Kenneth He Huang , John Mangette , Thomas Barta , Steven E. Hall , James Veal , Philip Hughes
发明人： Kenneth He Huang , John Mangette , Thomas Barta , Steven E. Hall , James Veal , Philip Hughes
IPC分类号： A61K31/55 , A61K31/551 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/501 , C07D413/02 , C07D403/02
CPC分类号： C07D207/02 , C07D209/04 , C07D231/22 , C07D231/38 , C07D231/56 , C07D333/22 , C07D471/04 , C07D487/04 , C07D491/04
摘要： Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R31, and R41 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译： 公开了式I的化合物和药学上可接受的盐，其中A，Q 1，Q 2，Q 3，R 31， SUB＆gt;和R 41'如本文所定义。 式I化合物可用于治疗与细胞增殖相关的疾病和/或病症，例如癌症，炎症，关节炎，血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
-
22.发明授权公开(公告)号：US06649025B2
公开(公告)日：2003-11-18
申请号：US10040264
申请日：2001-12-31
申请人： Russell P. Mills , Rick Behm , Thomas Barta , Laurent Paquot
发明人： Russell P. Mills , Rick Behm , Thomas Barta , Laurent Paquot
IPC分类号： D21F1100
CPC分类号： B31F1/07 , B31F2201/0733 , B31F2201/0764 , B32B29/00 , D21F11/14 , D21F11/145 , D21H27/40 , Y10T156/1023 , Y10T428/24455 , Y10T428/24463 , Y10T428/24479 , Y10T428/24562 , Y10T428/24612 , Y10T428/24826 , Y10T428/24942
摘要： A laminate wiping product is disclosed. The wiping product includes a first outer ply that has a textured surface. For example, the first outer ply can be an uncreped throughdried paper web having a three-dimensional conformation. The second outer ply, on the other hand, can be a smoother and softer web. The plies are laminated together by any suitable process. In one embodiment, the plies are embossed and nested together to form the final product.
摘要翻译： 公开了一种层压制品。 擦拭产品包括具有纹理表面的第一外层。 例如，第一外层可以是具有三维构象的未干燥的经过干燥的纸幅。 另一方面，第二个外层可以是更平滑和更软的网。 通过任何合适的方法将层叠在一起。 在一个实施例中，将层压花并嵌套在一起以形成最终产品。
-
公开(公告)号：US20050075374A1
公开(公告)日：2005-04-07
申请号：US10867391
申请日：2004-06-14
申请人： Louis Bedell , Joseph McDonald , Thomas Barta , Daniel Becker , Shashidhar Rao , John Freskos , Brent Mischke , Daniel Getman , Gary DeCrescenzo , Clara Villamil
发明人： Louis Bedell , Joseph McDonald , Thomas Barta , Daniel Becker , Shashidhar Rao , John Freskos , Brent Mischke , Daniel Getman , Gary DeCrescenzo , Clara Villamil
IPC分类号： C07C311/16 , C07C311/21 , C07C317/22 , C07C317/44 , C07C323/65 , C07D207/14 , C07D207/16 , C07D211/16 , C07D211/18 , C07D211/46 , C07D211/54 , C07D211/62 , C07D213/30 , C07D213/82 , C07D295/15 , C07D295/26 , C07D309/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D211/84 , A61K31/4015 , A61K31/44
CPC分类号： C07D295/26 , C07C311/16 , C07C311/21 , C07C317/22 , C07C317/44 , C07C323/65 , C07D207/14 , C07D207/16 , C07D211/16 , C07D211/18 , C07D211/46 , C07D211/54 , C07D211/62 , C07D213/30 , C07D213/82 , C07D295/15 , C07D309/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12
摘要： A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.
摘要翻译： 公开了包括抑制基质金属蛋白酶活性的磺酰芳族或杂芳族环异羟肟酸化合物，其处理方法包括将具有MMP酶抑制有效量的考虑的磺酰芳族或杂芳族环异羟肟酸化合物施用于具有条件 与病理基质金属蛋白酶活性相关。
-
24.发明申请Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors 失效哌啶基和哌嗪基 - 磺酰基甲基异羟肟酸及其作为蛋白酶抑制剂的用途公开(公告)号：US20050009838A1
公开(公告)日：2005-01-13
申请号：US10618288
申请日：2003-04-25
申请人： Thomas Barta , Daniel Becker , Louis Bedell , Terri Boehm , David Brown , Jeffery Carroll , Yiyuan Chen , Yvette Fobian , John Freskos , Alan Gasiecki , Margaret Grapperhaus , Robert Heintz , Susan Hockerman , Darren Kassab , Ish Khanna , Stephen Kolodziej , Mark Massa , Joseph McDonald , Brent Mischke , Deborah Mischke , Patrick Mullins , Mark Nagy , Monica Norton , Joseph Rico , Michelle Schmidt , Nathan Stehle , John Talley , William Vernier , Clara Villamil , Lijuan Wang , Thomas Wynn
发明人： Thomas Barta , Daniel Becker , Louis Bedell , Terri Boehm , David Brown , Jeffery Carroll , Yiyuan Chen , Yvette Fobian , John Freskos , Alan Gasiecki , Margaret Grapperhaus , Robert Heintz , Susan Hockerman , Darren Kassab , Ish Khanna , Stephen Kolodziej , Mark Massa , Joseph McDonald , Brent Mischke , Deborah Mischke , Patrick Mullins , Mark Nagy , Monica Norton , Joseph Rico , Michelle Schmidt , Nathan Stehle , John Talley , William Vernier , Clara Villamil , Lijuan Wang , Thomas Wynn
IPC分类号： C07D295/22 , A61K31/451 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P1/02 , A61P1/04 , A61P1/14 , A61P1/16 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/08 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P25/00 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P37/02 , A61P39/00 , A61P41/00 , A61P43/00 , C07D211/66 , C07D211/96 , C07D213/74 , C07D309/08 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D411/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/445 , C07D211/26
CPC分类号： C07D213/74 , C07D211/66 , C07D211/96 , C07D309/08 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D411/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to the following formula: (wherein A1, A2, Y, E1, E2, E3, and Rx are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.
摘要翻译： 本发明一般涉及蛋白酶（也称为“蛋白酶”）抑制剂，尤其涉及哌啶基和哌嗪基 - 磺酰基甲基异羟肟酸，其特别是抑制基质金属蛋白酶（也称为“基质金属蛋白酶”或“MMP “）活性和/或蛋白聚糖蛋白聚糖酶活性。 这种异羟肟酸通常在结构上对应于下式：（其中A 1，A 2，Y，E 1，E 2，E 3和R x如 本说明书），并且还包括这些化合物的盐。 本发明还涉及这种异羟肟酸的组合物，用于合成这种异羟肟酸的中间体，制备这种异羟肟酸的方法，以及用于治疗与MMP活性和/或蛋白聚糖蛋白聚糖酶活性相关的病症（特别是病理状态）的方法。
-
公开(公告)号：US20050101641A1
公开(公告)日：2005-05-12
申请号：US10992483
申请日：2004-11-17
申请人： John Freskos , Yvette Fobian , Thomas Barta , Daniel Becker , Louis Bedell , Terri Boehm , Jeffery Carroll , Gary DeCrescenzo , Susan Hockerman , Darren Kassab , Steve Kolodziej , Joseph McDonald , Deborah Mischke , Monica Norton , Joseph Rico , John Talley , Clara Villamil , Lijuan Wang
发明人： John Freskos , Yvette Fobian , Thomas Barta , Daniel Becker , Louis Bedell , Terri Boehm , Jeffery Carroll , Gary DeCrescenzo , Susan Hockerman , Darren Kassab , Steve Kolodziej , Joseph McDonald , Deborah Mischke , Monica Norton , Joseph Rico , John Talley , Clara Villamil , Lijuan Wang
IPC分类号： C07D491/048 , A61K31/35 , A61K31/351 , A61K31/357 , A61K31/381 , A61K31/397 , A61K31/4025 , A61K31/404 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/4355 , A61K31/4433 , A61K31/445 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/53 , A61K31/5377 , A61P1/02 , A61P1/04 , A61P1/16 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P25/00 , A61P25/18 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P37/02 , A61P37/06 , A61P39/00 , A61P43/00 , C07D211/66 , C07D309/08 , C07D309/12 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/04 , A61K31/401
CPC分类号： C07D401/12 , A61K31/351 , A61K31/41 , A61K31/453 , A61K31/454 , C04B35/632 , C07D211/66 , C07D309/08 , C07D309/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/04 , Y02A50/411
摘要： This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.
-
-
-
-
搜索结果
25 条记录 (耗时 0.062 秒)
