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    Quinazoline derivatives for the treatment of cancer
    4.
    发明授权
    Quinazoline derivatives for the treatment of cancer 有权
    喹唑啉衍生物用于治疗癌症

    公开(公告)号：US07678803B2

    公开(公告)日：2010-03-16

    申请号：US11844584

    申请日：2007-08-24

    申请人： Kenneth He Huang ,  James Veal ,  Thomas Barta ,  Emilie D. Smith ,  Wei Ma ,  Andy Ommen

    发明人： Kenneth He Huang ,  James Veal ,  Thomas Barta ,  Emilie D. Smith ,  Wei Ma ,  Andy Ommen

    IPC分类号： A61K31/517

    CPC分类号： C07D403/04 ,  C07D401/04 ,  C07D401/14 ,  C07D471/04

    摘要： The current invention is directed toward compounds and pharmaceutically acceptable salts of Formula I wherein Q1 is CR1, Q2 is N, Q4 and Q5 are each CR1, Q3 is CR2, X1 is N or CRc, Y is CRc, X2 and X3 are each C(R5)(R6), R7 is O. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer The current invention is also directed toward pharmaceutical compositions comprising compounds of the invention.

    摘要翻译： 本发明涉及其中Q1是CR1，Q2是N，Q4和Q5各自是CR1，Q3是CR2，X1是N或CRc，Y是CRc，X2和X3各自为C的化合物和药学上可接受的盐 （R 5）（R 6），R 7为O.式I的化合物可用于治疗与细胞增殖相关的疾病和/或病症，例如癌症。本发明还涉及包含本发明化合物的药物组合物。

    2, 8-disubstituted Naphthyridine Derivatives
    6.
    发明申请
    2, 8-disubstituted Naphthyridine Derivatives 审中-公开
    2,8-二取代的萘啶衍生物

    公开(公告)号：US20080032991A1

    公开(公告)日：2008-02-07

    申请号：US11872471

    申请日：2007-10-15

    申请人： Gunnar Hanson ,  Roy Ware ,  Thomas Barta ,  He Huang

    发明人： Gunnar Hanson ,  Roy Ware ,  Thomas Barta ,  He Huang

    IPC分类号： A61K31/4375 ,  A61K31/4545 ,  A61K31/496 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  C07D471/04

    CPC分类号： C07D471/04 ,  C07D405/14

    摘要： Disclosed are compounds of formula A: and pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, R3, R21, A1, A2, X, and Z are as defined herein. Compounds of formula A are useful in the treatment of diseases and/or conditions related to cell differentiation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

    摘要翻译： 公开了式A的化合物及其药学上可接受的盐，其中R 1，R 2，R 2，R 3， R 21，A 1，A 2，X和Z如本文所定义。 式A的化合物可用于治疗与细胞分化相关的疾病和/或病症，例如癌症，炎症，关节炎，血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。

    Cyclohexylamino Benzene, Pyridine, and Pyridazine Derivatives
    10.
    发明申请
    Cyclohexylamino Benzene, Pyridine, and Pyridazine Derivatives 审中-公开
    环己基氨基苯，吡啶和哒嗪衍生物

    公开(公告)号：US20070207984A1

    公开(公告)日：2007-09-06

    申请号：US11678975

    申请日：2007-02-26

    申请人： Kenneth Huang ,  Jeron Eaves ,  James Veal ,  Steven Hall ,  Thomas Barta ,  Gunnar Hanson

    发明人： Kenneth Huang ,  Jeron Eaves ,  James Veal ,  Steven Hall ,  Thomas Barta ,  Gunnar Hanson

    IPC分类号： A61K31/675 ,  C07D231/56 ,  C07D209/02 ,  A61K31/405

    CPC分类号： C07D209/08 ,  C07D231/56

    摘要： Disclosed are compounds and pharmaceutically acceptable salts of Formula (I), wherein Q1, Q2, RN, R1, R2, R5, R6, R7, R8, X1, X2, X4, and Y are as defined herein. Compounds of Formula (I) are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

    摘要翻译： 公开了式（I）的化合物和药学上可接受的盐，其中Q 1，Q 2，R N，R 1， R 2，R 5，R 6，R 7，R 8， X 1，X 2，X 4和Y如本文所定义。 式（I）的化合物可用于治疗与细胞增殖有关的疾病和/或病症，例如癌症，炎症，关节炎，血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。