公开(公告)号：US11234624B2

公开(公告)日：2022-02-01

申请号：US16185700

申请日：2018-11-09

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah

IPC: A61B5/1495 ,  G01N27/416 ,  A61B5/00 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  A61B5/1459 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/0537 ,  G01N33/66 ,  A61M5/172 ,  G01N27/02 ,  A61B5/0538 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20210077718A1

公开(公告)日：2021-03-18

申请号：US16569417

申请日：2019-09-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Steven C. Jacks ,  Peter Ajemba ,  Akhil Srinivasan ,  Jacob E. Pananen ,  Sarkis Aroyan ,  Pablo Vazquez ,  Tri T. Dang ,  Ashley N. Sullivan ,  Raghavendhar Gautham

IPC: A61M5/172 ,  A61B5/145 ,  A61M5/142 ,  A61B5/1495

Abstract: Medical devices, systems and methods are provided. One method involves obtaining fabrication process measurement data for a plurality of instances of a sensing element, obtaining reference output measurement data from the plurality of instances in response to a reference stimulus, determining a predictive model for a measurement output of the sensing element as a function of fabrication process measurement variables based on the relationship between the fabrication process measurement data and the reference output measurement data, generating a simulated output measurement distribution across a range of the fabrication process measurement variables using the predictive model, identifying performance thresholds for the measurement output based on the simulated output measurement distribution, obtaining output measurement data from the instance of the sensing element in response to the reference stimulus, and verifying the output measurement data satisfies the performance threshold prior to calibrating a subsequent instance of the sensing element.

公开(公告)号：US10905365B2

公开(公告)日：2021-02-02

申请号：US16171746

申请日：2018-10-26

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Rajiv Shah

IPC: A61B5/1495 ,  A61B5/00 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/053 ,  A61B5/1486 ,  G01N33/66 ,  G01N33/49 ,  G01N27/416 ,  A61M5/158 ,  A61M5/142 ,  A61B5/1459 ,  A61M5/172 ,  G01N27/02 ,  G01N33/96

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20200237268A1

公开(公告)日：2020-07-30

申请号：US16853461

申请日：2020-04-20

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: A61B5/1495 ,  G01N27/416 ,  A61B5/00 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  A61B5/1459 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/053 ,  G01N33/66 ,  A61M5/172 ,  G01N27/02 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20190223771A1

公开(公告)日：2019-07-25

申请号：US15878313

申请日：2018-01-23

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jia Yao ,  Daniel E. Pesantez ,  Anuradha Biswas Bhatia ,  Akhil Srinivasan ,  Guangping Zhang ,  Andrea Varsavsky ,  Raghavendhar Gautham

IPC: A61B5/1486 ,  A61L31/04 ,  A61L31/14 ,  C12Q1/00 ,  C12Q1/54 ,  C12Q1/26 ,  A61B5/145

Abstract: Embodiments of the invention provide optimized polymeric surfaces adapted for use with implantable medical devices as well as methods for making and using such polymeric surfaces. These polymer surfaces have a constellation of features that function to inhibit or avoid an inflammatory immune response generated by implantable medical devices. Typical embodiments of the invention include an implantable glucose sensor used in the management of diabetes having a polymer surface with the disclosed constellation of features.

公开(公告)号：US10342468B2

公开(公告)日：2019-07-09

申请号：US15818341

申请日：2017-11-20

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: G01N27/02 ,  A61B5/1495 ,  G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/00 ,  A61B5/053 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  A61M5/172 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US10335076B2

公开(公告)日：2019-07-02

申请号：US15818111

申请日：2017-11-20

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: G01N27/02 ,  A61B5/1495 ,  G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/00 ,  A61B5/053 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  A61M5/172 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US10251588B2

公开(公告)日：2019-04-09

申请号：US14686653

申请日：2015-04-14

Applicant: Medtronic Minimed, Inc.

Inventor： Bradley Liang ,  Kenneth W. Cooper ,  Raghavendhar Gautham ,  Rajiv Shah

IPC: A61B5/00 ,  A61B5/145 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1486 ,  A61B5/1495

Abstract: Disclosed are methods, apparatuses, etc. for glucose sensor signal reliability analysis.

公开(公告)号：US20180074012A1

公开(公告)日：2018-03-15

申请号：US15818341

申请日：2017-11-20

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486 ,  G01N33/66 ,  G01N27/02 ,  A61M5/172 ,  A61M5/158 ,  A61B5/00 ,  A61B5/1495 ,  A61M5/142 ,  A61B5/053

CPC classification number: A61B5/1495 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20170055892A1

公开(公告)日：2017-03-02

申请号：US15272225

申请日：2016-09-21

Applicant: Medtronic MiniMed, Inc.

Inventor： Megan E. Little ,  Katherine T. Wolfe ,  Raghavendhar Gautham ,  Bradley Chi Liang ,  Rajiv Shah

IPC: A61B5/145 ,  G01N27/327 ,  A61B5/1486 ,  C12Q1/00

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B2562/125 ,  A61B2562/166 ,  A61B2562/222 ,  C12Q1/001 ,  C12Q1/006 ,  G01N27/3272 ,  Y10T29/49204

Abstract: The invention disclosed herein includes sensors having three dimensional configurations that allow expansive “360°” sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

Abstract translation: 本文公开的本发明包括具有三维结构的传感器，其在这些传感器被布置的环境中允许宽广的“360°”感测（即感测来自多个方向的分析物）。 本发明的实施例提供了分析物传感器，其具有适于产生电极元件的优化配置的可折叠基底以及用于制造和使用这种传感器的方法。 本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。