公开(公告)号：US11998330B2

公开(公告)日：2024-06-04

申请号：US17162885

申请日：2021-01-29

Applicant: Medtronic MiniMed, Inc.

Inventor： Ashwin K. Rao ,  Qingling Yang ,  Ellis Garai ,  Daniel E. Pesantez

IPC: A61B5/1486 ,  A61B5/145 ,  A61B5/00

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/7246 ,  A61B2562/125

Abstract: Embodiments of the invention provide amperometric analyte sensors having optimized elements such as interference rejection membranes, and associated architectures, as well as methods for making and using such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.

公开(公告)号：US11904146B2

公开(公告)日：2024-02-20

申请号：US17342449

申请日：2021-06-08

Applicant: Medtronic MiniMed, Inc.

Inventor： Ellis Garai ,  Ashwin K. Rao

IPC: A61M5/315

CPC classification number: A61M5/31568 ,  A61M2205/18 ,  A61M2205/3306 ,  A61M2205/52

Abstract: A medicine delivery and tracking system includes a medicine injection pen and a delivery port. The pen includes a needle through which medicine is dispensed and an electronic unit configured to at least one of log dispensing of medicine from the pen, control dispensing of medicine from the pen, or communicate regarding dispensing of medicine from the pen. Alternatively, the electronic unit may be part of a separate computing device. The delivery port is configured for attachment to a user and to receive the needle of the pen such that medicine dispensed from the pen is dispensed into the delivery port and through the delivery port to the user. The delivery port includes a detector mechanism configured to detect a presence of the pen and, in response thereto, to communicate a signal to the electronic unit for use in the at least one of logging, controlling, or communicating.

公开(公告)号：US11718865B2

公开(公告)日：2023-08-08

申请号：US16523882

申请日：2019-07-26

Applicant: Medtronic MiniMed, Inc.

Inventor： Daniel E. Pesantez ,  Ashwin K. Rao ,  Ellis Garai ,  Rui Kong ,  Michael E. Miller

IPC: A61B5/145 ,  C12Q1/00 ,  A61B5/1486 ,  G01N27/327

CPC classification number: C12Q1/006 ,  A61B5/14532 ,  A61B5/14865 ,  G01N27/3271 ,  A61B2562/04 ,  A61B2562/12

Abstract: Embodiments of the invention provide multilayer analyte sensors having elements and/or architectures that function to improve oxygen delivery to sensor enzymes in manner that enhances sensor function, as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

公开(公告)号：US11266332B2

公开(公告)日：2022-03-08

申请号：US16552780

申请日：2019-08-27

Applicant: Medtronic MiniMed, Inc.

Inventor： Ting Huang ,  Ashwin K. Rao ,  Rajiv Shah ,  Qingling Yang

IPC: A61B5/145 ,  A61B5/1477 ,  C25D5/18 ,  A61B5/1486 ,  C12Q1/00 ,  C25D5/00 ,  C25D3/50

Abstract: The invention disclosed herein includes amperometric glucose sensors having electrodes formed from processes that electrodeposit platinum black in a manner that produces relatively smooth three dimensional metal architectures, ones that contribute to sensor reliability and stability. Embodiments of the invention provide analyte sensors having such uniform electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

公开(公告)号：US20210003564A1

公开(公告)日：2021-01-07

申请号：US17025999

申请日：2020-09-18

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ashwin K. Rao ,  Rebecca K. Gottlieb ,  Quyen Ong

IPC: G01N33/52 ,  C12N9/04 ,  G01N1/14

Abstract: Devices, patch sensors, and methods for detecting a ketone body are disclosed. An exemplary device includes a collection apparatus for collecting a sample amount of interstitial fluid and a ketone body indicator having an initial negative state and having a positive state when at least a threshold value of the ketone body is collected in the sample amount.

公开(公告)号：US20170315077A1

公开(公告)日：2017-11-02

申请号：US15141446

申请日：2016-04-28

Applicant: Medtronic MiniMed, Inc.

Inventor： Ashwin K. Rao ,  Daniel E. Pesantez

IPC: G01N27/327 ,  G01N27/30 ,  C12Q1/00

CPC classification number: G01N27/3272 ,  A61B5/14532 ,  A61B5/14865 ,  A61B2562/125 ,  C12Q1/002 ,  C12Q1/003 ,  C12Q1/006 ,  G01N27/307

Abstract: Embodiments of the invention provide an in-situ polymerization technique for creating a glucose sensor chemistry stack. An analyte sensor comprises a crosslinked polymer matrix in contact with an electrode. The crosslinked polymer matrix is formed by exposing ultraviolet (UV) light to a polymer matrix mixture comprising a plurality of hydroxyethyl methacrylate (HEMA) monomers, one or more di-acrylate crosslinkers, one or more UV photoinitiators, and an oxidoreductase. The oxidoreductase is covalently linked to the crosslinked polymer matrix. In typical embodiments, the oxidoreductase is a glucose oxidase-acrylate bioconjugate. In one or more embodiments, the analyte sensor apparatus further comprises a glucose limiting membrane positioned over the crosslinked polymer matrix. The glucose limiting membrane is formed by exposing ultraviolet (UV) light to a glucose limiting membrane mixture comprising a plurality of hydroxyethyl methacrylate (HEMA) monomers, one or more di-acrylate crosslinkers, one or more UV photoinitiators, ethylene glycol, and water.

公开(公告)号：US20240298941A1

公开(公告)日：2024-09-12

申请号：US18666596

申请日：2024-05-16

Applicant: Medtronic MiniMed, Inc.

Inventor： Ashwin K. Rao ,  Qingling Yang ,  Ellis Garai ,  Daniel E. Pesantez

IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/7246 ,  A61B2562/125

Abstract: Embodiments of the invention provide amperometric analyte sensors having optimized elements such as interference rejection membranes, and associated architectures, as well as methods for making and using such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.

公开(公告)号：US11986288B2

公开(公告)日：2024-05-21

申请号：US15912473

申请日：2018-03-05

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ashwin K. Rao ,  Rebecca K. Gottlieb ,  Quyen Ong

IPC: A61B5/145 ,  A61B5/1477 ,  A61B5/1486 ,  G01N33/52 ,  G01N33/66 ,  A61B5/00 ,  C07K14/62 ,  C12Q1/00

CPC classification number: A61B5/14532 ,  A61B5/14517 ,  A61B5/1486 ,  G01N33/526 ,  G01N33/66 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1477 ,  A61B5/6833 ,  C07K14/62 ,  C12Q1/006

Abstract: Described here are patches and methods for measuring glucose in sweat (and tears and the like). In general, the patches comprise an adhesive layer adapted to bond to skin of an individual, a substrate layer disposed over the adhesive layer and comprising a glucose sensing complex including a chromogen that changes color in the presence of certain concentrations of glucose, and a cover. In typical embodiments, the substrate layer has elements formed to direct and accumulate sweat that migrates from the skin of the individual to the glucose sensing complex. Methods of using the invention can comprise cleaning the skin surface, collecting sweat in a patch comprising this microfluidic constellation of elements, and observing concentrations of glucose collected in the sweat, for example either visually, or by using a smartphone or other computer processing device.

公开(公告)号：US11793930B2

公开(公告)日：2023-10-24

申请号：US16893141

申请日：2020-06-04

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Chia-Hung Chiu ,  Rebecca K. Gottlieb ,  Ellis Garai ,  Akhil Srinivasan ,  Andrea Varsavsky ,  Adam S. Trock ,  Ashwin K. Rao ,  Hsifu Wang ,  Daniel E. Pesantez ,  Isabella Ella Miya ,  Xinrui Zhang ,  Guruguhan Meenakshisundaram

IPC: A61M5/142 ,  A61M39/10 ,  A61M5/172 ,  A61M5/162 ,  A61M5/168 ,  A61M37/00

CPC classification number: A61M5/14248 ,  A61M5/162 ,  A61M5/16831 ,  A61M5/1723 ,  A61M37/0015 ,  A61M39/10 ,  A61M2005/14252 ,  A61M2037/0023 ,  A61M2205/50 ,  A61M2205/8206 ,  A61M2205/8243 ,  A61M2230/201

Abstract: A fluid infusion system includes a housing configured to be adhesively coupled to an anatomy of a user, and a tube configured to extend from the housing for insertion into the anatomy of the user. The tube includes a plurality of conduits defined within the tube. The plurality of conduits include a fluid delivery conduit configured to facilitate a fluidic connection between a fluid source and the anatomy of the user, and one or more conduits configured to accommodate a plurality of electrodes for determining a physiological characteristic of the user.

公开(公告)号：US20200060586A1

公开(公告)日：2020-02-27

申请号：US16552780

申请日：2019-08-27

Applicant: Medtronic MiniMed, Inc.

Inventor： Ting Huang ,  Ashwin K. Rao ,  Rajiv Shah ,  Qingling Yang

IPC: A61B5/145 ,  C12Q1/00 ,  A61B5/1486 ,  C25D5/18 ,  A61B5/1477

Abstract: The invention disclosed herein includes amperometric glucose sensors having electrodes formed from processes that electrodeposit platinum black in a manner that produces relatively smooth three dimensional metal architectures, ones that contribute to sensor reliability and stability. Embodiments of the invention provide analyte sensors having such uniform electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.