公开(公告)号：US20160045606A1

公开(公告)日：2016-02-18

申请号：US14829186

申请日：2015-08-18

Applicant: Northwestern University

Inventor： Kevin Baler ,  Igal G. Szleifer ,  Guillermo A. Ameer

IPC: A61K47/42 ,  A61K47/48

CPC classification number: A61K47/42 ,  A61K9/0024 ,  A61K9/1658 ,  A61L15/32 ,  A61L24/0031 ,  A61L24/108 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/085 ,  A61L29/145 ,  A61L29/16 ,  A61L31/10 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/252

Abstract: Provided herein are partially-denatured protein (e.g., albumin) hydrogels and methods of manufacture (e.g., pH induction) and use (e.g., drug delivery) thereof.

Abstract translation: 本文提供了部分变性的蛋白质（例如白蛋白）水凝胶和制造方法（例如，pH诱导）和其使用（例如药物递送）。

公开(公告)号：US20240009357A1

公开(公告)日：2024-01-11

申请号：US18162417

申请日：2023-01-31

Applicant: Northwestern University

Inventor： Jian Yang ,  Evan C. Baker ,  Henry O. T. Ware ,  Fan Zhou ,  Cheng Sun ,  Guillermo A. Ameer ,  Robert Van Lith

IPC: A61L31/06 ,  C08J3/24 ,  B33Y80/00 ,  B29C64/135 ,  B29C41/22 ,  B29C41/00 ,  B33Y30/00 ,  B33Y70/00 ,  B29C64/20 ,  A61L31/16 ,  A61L31/18 ,  C09D167/06

CPC classification number: A61L31/06 ,  C08J3/24 ,  B33Y80/00 ,  B29C64/135 ,  B29C41/22 ,  B29C41/00 ,  B33Y30/00 ,  B33Y70/00 ,  B29C64/20 ,  A61L31/16 ,  A61L31/18 ,  C09D167/06 ,  C08J2367/06 ,  B29K2995/0056 ,  B29L2031/7534

Abstract: Provided herein are methods, compositions, devices, and systems for the 3D printing of biomedical implants. In particular, methods and systems are provided for 3D printing of biomedical devices (e.g., endovascular stents) using photo-curable biomaterial inks (e.g., or methacrylated poly(diol citrate)).

公开(公告)号：US20230293775A1

公开(公告)日：2023-09-21

申请号：US18158746

申请日：2023-01-24

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Simona Morochnik

IPC: A61L27/52 ,  A61K9/00 ,  A61K9/06 ,  A61K31/661 ,  A61K33/06 ,  A61K38/06 ,  A61L27/54 ,  A61K39/385

CPC classification number: A61L27/52 ,  A61K9/0019 ,  A61K9/06 ,  A61K31/661 ,  A61K33/06 ,  A61K38/06 ,  A61L27/54 ,  A61K39/385 ,  A61L2400/06 ,  A61L2430/02 ,  A61K2039/6093

Abstract: Provided herein are injectable, thermoresponsive hydrogels that are liquid at room temperature, provide a carrier material, and gel at body temperature to allow for controlled release. In particular, PPCN-based hydrogels are provided with therapeutic agents (e.g., drugs, ions, etc.) incorporated within or appended thereto, and methods of preparation and use thereof, for example, for the promotion of bone formation/repair and/or the treatment of bone diseases.

公开(公告)号：US11529417B2

公开(公告)日：2022-12-20

申请号：US15931262

申请日：2020-05-13

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Michele Jen ,  Jian Yang

IPC: A01N63/00 ,  A61K47/32 ,  A61K48/00 ,  A61K9/00 ,  A61P17/02 ,  A61K38/50 ,  A61K47/10 ,  A61K47/34 ,  A61L15/24 ,  A61L15/44 ,  A61L15/60 ,  A61L15/62 ,  A61L15/64

Abstract: Compositions and methods are provided for improved wound healing. In particular, provided herein are compositions and methods for the direct delivery of Sirtuin-1 (Sirt1) or vectors encoding Sirt1 to the wounds (e.g., of diabetic patients).

公开(公告)号：US20210106697A1

公开(公告)日：2021-04-15

申请号：US17071653

申请日：2020-10-15

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Evan A. Scott ,  Guillermo A. Ameer ,  Jacqueline A. Burke ,  Helena Freire Haddad

IPC: A61K49/00 ,  A01K67/027

Abstract: The present invention provides methods of making an in vivo animal model for detecting anti-poly(ethylene glycol) (PEG) antibodies. The methods of the disclosure comprises administering subcutaneously to an animal model a composition comprising antibodies against poly(ethylene glycol) chains with a molecular weight of at least 550 Da to maintain an anti-PEG antibody level within the animal model. The in vivo animal model can be used for testing and screening drugs and other compositions for adverse reactions, bioavailability, and immunogenicity prior to administration to a human subject.

公开(公告)号：US10653782B2

公开(公告)日：2020-05-19

申请号：US15529288

申请日：2015-11-25

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Michele Jen

IPC: A01N63/00 ,  A61K47/32 ,  A61K48/00 ,  A61K9/00 ,  A61P17/02 ,  A61K38/50 ,  A61K47/10 ,  A61K47/34 ,  A61L15/24 ,  A61L15/44 ,  A61L15/60 ,  A61L15/62 ,  A61L15/64

Abstract: Compositions and methods are provided for improved wound healing. In particular, provided herein are compositions and methods for the direct delivery of Sirtuin-1 (Sirt1) or vectors encoding Sirt1 to the wounds (e.g., of diabetic patients). In some embodiments, provided herein are therapeutic devices comprising: (a) a vector encoding Sirtuin-1 (Sirt 1); and (b) a hydrogel carrier. In some embodiments, the vector comprises a viral vector comprising a polynucleotide sequence encoding Sirt 1. In some embodiments, the vector comprises a non-viral vector comprising a polynucleotide sequence encoding Sirt1.

公开(公告)号：US10463745B2

公开(公告)日：2019-11-05

申请号：US15573166

申请日：2016-05-12

Applicant: Northwestern University

Inventor： Yunxiao Zhu ,  Zdravka Cankova ,  Milan Mrksich ,  Guillermo A. Ameer

IPC: A61K47/58 ,  A61K38/39 ,  A61L26/00 ,  A61K47/59

Abstract: Provided herein are materials for the promotion of tissue regeneration, and methods of promoting tissue regeneration and wound healing therewith. In particular, materials displaying laminin-derived peptide sequences that facilitate cell migration into the material, and methods of use thereof, are provided.

公开(公告)号：US20190282735A1

公开(公告)日：2019-09-19

申请号：US16349186

申请日：2017-11-14

Applicant: Northwestern University

Inventor： Guillermo A. Ameer

IPC: A61L27/46 ,  A61L27/16

Abstract: Provided herein are thermoresponsive polymer materials and methods of preparation and use thereof. In particular, materials are provided that cure upon exposure to physiologic conditions (e.g., human body temperature) and find use in, for example, orthopedic surgery, bone tissue engineering, and the repair of bone injuries and defects.

公开(公告)号：US20180085492A1

公开(公告)日：2018-03-29

申请号：US15720403

申请日：2017-09-29

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Xunrong Luo ,  Xiaomin Zhang ,  Yunxiao Zhu

IPC: A61L27/38 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/34

CPC classification number: A61L27/3804 ,  A61L27/16 ,  A61L27/18 ,  A61L27/34 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/64 ,  C08L71/02 ,  C08L33/26

Abstract: Provided herein are thermoresponsive citrate-based hydrogels and methods of use thereof for cell delivery. In particular, pancreatic islet cells entrapped within poly(polyethyleneglycol citrate-co-N isopropylacrylamide) (PPCN) hydrogels are provided herein, as well as methods of use thereof for extra-hepatic islet transplantation.

公开(公告)号：US09707281B2

公开(公告)日：2017-07-18

申请号：US14326904

申请日：2014-07-09

Applicant: Northwestern University

Inventor： Melina R. Kibbe ,  Guillermo A. Ameer ,  Vinit N. Varu

IPC: A61K38/48 ,  A61K38/49 ,  A61K38/54 ,  A61M37/00 ,  A61B17/22 ,  A61K31/724 ,  A61K45/06 ,  A61M25/10 ,  A61K9/00

CPC classification number: A61K38/4886 ,  A61B17/2202 ,  A61K9/0019 ,  A61K31/724 ,  A61K38/49 ,  A61K38/54 ,  A61K45/06 ,  A61M25/1011 ,  A61M37/0092 ,  C12Y304/21068 ,  C12Y304/24003 ,  C12Y304/24024 ,  C12Y304/24035 ,  A61K2300/00

Abstract: Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases for digesting plaques and optionally may include or utilize additional agents such as cyclodextrins, chelating agents, and tissue plasminogen activator.