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公开(公告)号：US20120259146A1
公开(公告)日：2012-10-11
申请号：US13441468
申请日：2012-04-06
Applicant: Patrick R. Gruber , Matthew W. Peters , Josefa M. Griffith , Yassin Al Obaidi , Leo E. Manzer , Joshua D. Taylor , David E. Henton
Inventor： Patrick R. Gruber , Matthew W. Peters , Josefa M. Griffith , Yassin Al Obaidi , Leo E. Manzer , Joshua D. Taylor , David E. Henton
CPC classification number: C10L1/08 , C07C1/24 , C07C2/08 , C07C2/76 , C07C5/03 , C07C9/14 , C07C9/15 , C07C51/265 , C10G3/00 , C10G50/00 , C10G69/126 , C10G2300/1011 , C10G2300/42 , C10G2400/02 , C10G2400/04 , C10G2400/08 , C10G2400/30 , C10L1/04 , C10L1/06 , C10L2200/043 , C10L2200/0469 , C10L2270/04 , C10L2290/26 , C10L2290/543 , C12P5/00 , C12P7/04 , C12P7/06 , C12P7/16 , Y02E50/10 , Y02E50/13 , Y02E50/17 , Y02P30/20 , Y02T50/678 , C07C11/02 , C07C15/00 , C07C63/26 , C07C11/09
Abstract: The present invention is directed to renewable compositions derived from fermentation of biomass, and integrated methods of preparing such compositions.
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公开(公告)号：US08193402B2
公开(公告)日：2012-06-05
申请号：US12327723
申请日：2008-12-03
Applicant: Patrick R. Gruber , Matthew W. Peters , Josefa M. Griffith , Yassin Al Obaidi , Leo E. Manzer , Joshua D. Taylor , David E. Henton
Inventor： Patrick R. Gruber , Matthew W. Peters , Josefa M. Griffith , Yassin Al Obaidi , Leo E. Manzer , Joshua D. Taylor , David E. Henton
CPC classification number: C10L1/04 , C10G3/00 , C10G50/00 , C10G69/126 , C10G2300/1011 , C10G2400/08 , C10G2400/22 , C10G2400/30 , C10L1/06 , C10L1/08 , Y02E50/13 , Y02P30/20
Abstract: The present invention is directed to renewable compositions derived from fermentation of biomass, and integrated methods of preparing such compositions.
Abstract translation: 本发明涉及来自生物质发酵的可再生组合物，以及制备这种组合物的综合方法。
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公开(公告)号：US20120064590A1
公开(公告)日：2012-03-15
申请号：US13302775
申请日：2011-11-22
Applicant: William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins
Inventor： William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins
IPC: C12P7/16
CPC classification number: C12M43/00 , C07C29/80 , C07C29/86 , C12C11/11 , C12M45/20 , C12P7/04 , C12P7/16 , Y02E50/10 , Y02E50/17 , Y10T29/49826 , C07C31/12
Abstract: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.
Abstract translation: 本发明涉及从稀释的水溶液如发酵液中回收C3-C6醇的方法。 这样的方法提供了用于发酵的改进的体积生产率并允许酒精回收。 由于通过同时发酵和回收过程增加了醇产物的有效浓度，所以这种方法还允许在用过的发酵液的生产和干燥中减少能量消耗，这增加了每一批发酵液干燥产生和回收的醇的量。 因此，本发明允许以低资本生产和回收C3-C6醇，降低运行成本。
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24.发明授权Method for synthesizing peptides with saccharide linked enzyme polymer conjugates 失效用糖连接的酶聚合物共轭物合成肽的方法
公开(公告)号：US5639633A
公开(公告)日：1997-06-17
申请号：US466403
申请日：1995-06-06
Applicant: Matthew R. Callstrom , Mark D. Bednarski , Patrick R. Gruber
Inventor： Matthew R. Callstrom , Mark D. Bednarski , Patrick R. Gruber
IPC: A61K47/48 , C07H5/06 , C07H13/04 , C07H15/12 , C07K16/12 , C07K16/44 , C08F8/30 , C08F8/34 , C12N11/06 , C12N11/08 , G01N33/545 , G01N33/58 , C12P21/06 , C12N9/00 , C12N9/96
CPC classification number: C07H5/06 , A61K47/48176 , A61K47/4843 , A61K47/48692 , C07H13/04 , C07H15/12 , C07K16/1292 , C07K16/44 , C08F8/30 , C08F8/34 , C12N11/06 , C12N11/08 , G01N33/545 , G01N33/581 , Y10S530/816
Abstract: A method is disclosed for synthesizing peptides using water soluble enzyme polymer conjugates. The method comprises catalyzing the peptide synthesis with enzyme which has been covalently bonded to a polymer through at least three linkers which linkers have three or more hydroxyl groups. The enzyme is conjugated at lysines or arginines.
Abstract translation: 公开了使用水溶性酶聚合物共轭物合成肽的方法。 该方法包括用已经通过至少三个连接体具有三个或更多个羟基的接头共价键合到聚合物上的酶催化肽合成。 酶在赖氨酸或精氨酸缀合。
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公开(公告)号：US5525706A
公开(公告)日：1996-06-11
申请号：US328550
申请日：1994-10-25
Applicant: Patrick R. Gruber , Jeffrey J. Kolstad , Christopher M. Ryan , Eric S. Hall , Robin S. Eichen Conn
Inventor： Patrick R. Gruber , Jeffrey J. Kolstad , Christopher M. Ryan , Eric S. Hall , Robin S. Eichen Conn
IPC: A61L15/26 , A61L31/06 , C08G63/08 , C08G63/90 , C08J5/18 , C08K5/1575 , C08L67/00 , C08L67/04 , C09D167/04 , D01F6/62 , D01F6/84 , D01F6/92 , D03D15/00 , D04H1/42 , D21H19/28 , D21H19/62
CPC classification number: C08J5/18 , A61L15/26 , A61L31/06 , C08G63/08 , C08G63/90 , C08L67/04 , C09D167/04 , D01F6/625 , D04H1/435 , D04H1/4382 , D21H19/28 , D21H19/62 , C08G2230/00 , C08J2367/04 , Y10T428/31786 , Y10T428/31808 , Y10T442/60 , Y10T442/622 , Y10T442/637 , Y10T442/642 , Y10T442/68
Abstract: A nonwoven fabric comprised of a lactide polymer. The lactide polymer comprises a plurality of poly(lactide) polymer chains, residual lactide in concentration of less than about 2 percent and water in concentration of less than about 2000 parts-per-million. A process for manufacturing a nonwoven fabric with the lactide polymer composition is also disclosed.
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Patent Agency Ranking
公开(公告)号：US5359026A
公开(公告)日：1994-10-25
申请号：US100550
申请日：1993-07-30
Applicant: Patrick R. Gruber
Inventor： Patrick R. Gruber
IPC: A61F13/15 , A61F13/49 , A61F13/551 , B29C45/00 , B29C49/00 , B29C51/00 , B29K67/00 , C08F290/00 , C08F299/04 , C08G18/42 , C08G59/40 , C08G63/08 , C08G63/78 , C08G63/91 , C08J3/24 , C08J5/18 , C08L67/04 , D04H1/42 , D21H19/24
CPC classification number: C08G63/08 , Y10T428/31786 , Y10T428/3179 , Y10T442/60
Abstract: A copolymerized poly(lactide) polymer. A lactide is copolymerized with an epoxidized fat, oil, or mixture thereof thereby resulting in poly(lactide) copolymers having improved processing properties over prior poly(lactide)s.
Abstract translation: 共聚聚（丙交酯）聚合物。 丙交酯与环氧化的脂肪，油或其混合物共聚，由此得到具有优于现有聚（丙交酯）的加工性能的聚（丙交酯）共聚物。
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27.发明授权Continuous process for manufacture of lactide polymers with purification by distillation 失效通过蒸馏纯化生产丙交酯聚合物的连续方法
公开(公告)号：US5357035A
公开(公告)日：1994-10-18
申请号：US122145
申请日：1993-09-16
Applicant: Patrick R. Gruber , Eric S. Hall , Jeffrey J. Kolstad , Matthew L. Iwen , Richard D. Benson , Ronald L. Borchardt
Inventor： Patrick R. Gruber , Eric S. Hall , Jeffrey J. Kolstad , Matthew L. Iwen , Richard D. Benson , Ronald L. Borchardt
IPC: C08G63/06 , C08G63/08 , C07D319/12
Abstract: A process for the continuous production of polylactide polymers from lactic acid which incorporates removal of water or a solvent carrier to concentrate the lactic acid feed followed by polymerization to a low-molecular-weight prepolymer. This prepolymer is fed to a reactor in which a catalyst is added to facilitate generation of lactide, the depolymerization product of polylactic acid. The lactide generated is continuously fed to a distillation system as a liquid or vapor wherein water and other impurities are removed. The resultant purified liquid lactide is fed directly to a polymerization process.
Abstract translation: 一种从乳酸连续生产聚丙交酯聚合物的方法，其中除去水或溶剂载体，以将乳酸进料浓缩，然后聚合成低分子量预聚物。 将该预聚物加入反应器中，在该反应器中加入催化剂以促进产生丙交酯，即聚乳酸的解聚产物。 生成的丙交酯以其中除去水和其它杂质的液体或蒸气连续供入蒸馏系统。 将所得纯化液体丙交酯直接进料至聚合过程。
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公开(公告)号：US5274073A
公开(公告)日：1993-12-28
申请号：US935059
申请日：1992-08-24
Applicant: Patrick R. Gruber , Eric S. Hall , Jeffrey J. Kolstad , Matthew L. Iwen , Richard D. Benson , Ronald L. Borchardt
Inventor： Patrick R. Gruber , Eric S. Hall , Jeffrey J. Kolstad , Matthew L. Iwen , Richard D. Benson , Ronald L. Borchardt
IPC: C08G63/06 , C08G63/08 , C07D319/12
Abstract: A process for the continuous conversion of crude lactic acid to a substantially purified lactide or polylactide including the steps of polymerizing the lactic acid to form a prepolymer with subsequent depolymerization to form a crude lactide in the presence of a catalyst. The crude lactide is purified in an improved distillation system in which at least three fractions are formed with the substantially purified lactide removed as an intermediate boiling sidedraw stream. The substantially purified lactide may then be polymerized.
Abstract translation: 一种将粗乳酸连续转化成基本上纯化的丙交酯或聚丙交酯的方法，包括聚合乳酸以形成预聚物的步骤，随后在催化剂存在下解聚形成粗丙交酯。 粗丙交酯在改进的蒸馏系统中纯化，其中至少三个级分形成，基本上纯化的丙交酯作为中间沸腾的侧面流除去。 然后将基本上纯化的丙交酯聚合。
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公开(公告)号：US08546627B2
公开(公告)日：2013-10-01
申请号：US13441468
申请日：2012-04-06
Applicant: Patrick R. Gruber , Matthew W. Peters , Josefa M. Griffith , Yassin Al Obaidi , Leo E. Manzer , Joshua D. Taylor , David E. Henton
Inventor： Patrick R. Gruber , Matthew W. Peters , Josefa M. Griffith , Yassin Al Obaidi , Leo E. Manzer , Joshua D. Taylor , David E. Henton
CPC classification number: C10L1/08 , C07C1/24 , C07C2/08 , C07C2/76 , C07C5/03 , C07C9/14 , C07C9/15 , C07C51/265 , C10G3/00 , C10G50/00 , C10G69/126 , C10G2300/1011 , C10G2300/42 , C10G2400/02 , C10G2400/04 , C10G2400/08 , C10G2400/30 , C10L1/04 , C10L1/06 , C10L2200/043 , C10L2200/0469 , C10L2270/04 , C10L2290/26 , C10L2290/543 , C12P5/00 , C12P7/04 , C12P7/06 , C12P7/16 , Y02E50/10 , Y02E50/13 , Y02E50/17 , Y02P30/20 , Y02T50/678 , C07C11/02 , C07C15/00 , C07C63/26 , C07C11/09
Abstract: The present invention is directed to renewable compositions derived from fermentation of biomass, and integrated methods of preparing such compositions.
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公开(公告)号：US20130183730A9
公开(公告)日：2013-07-18
申请号：US13302775
申请日：2011-11-22
Applicant: William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins , Peter Meinhold , Reid M. Renny Feldman , Uvini Gunawardena , Jun Urano
Inventor： William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins , Peter Meinhold , Reid M. Renny Feldman , Uvini Gunawardena , Jun Urano
IPC: C12P7/16
CPC classification number: C12M43/00 , C07C29/80 , C07C29/86 , C12C11/11 , C12M45/20 , C12P7/04 , C12P7/16 , Y02E50/10 , Y02E50/17 , Y10T29/49826 , C07C31/12
Abstract: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.
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