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公开(公告)号：US20120107891A1
公开(公告)日：2012-05-03
申请号：US13344464
申请日：2012-01-05
Applicant: William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins
Inventor： William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins
IPC: C12P7/16
CPC classification number: C12M43/00 , C07C29/80 , C07C29/86 , C12C11/11 , C12M45/20 , C12P7/04 , C12P7/16 , Y02E50/10 , Y02E50/17 , Y10T29/49826 , C07C31/12
Abstract: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.
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公开(公告)号：US20120107890A1
公开(公告)日：2012-05-03
申请号：US13344460
申请日：2012-01-05
Applicant: William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins
Inventor： William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins
IPC: C12P7/16
CPC classification number: C12M43/00 , C07C29/80 , C07C29/86 , C12C11/11 , C12M45/20 , C12P7/04 , C12P7/16 , Y02E50/10 , Y02E50/17 , Y10T29/49826 , C07C31/12
Abstract: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.
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3.发明申请METHODS FOR THE ECONOMICAL PRODUCTION OF BIOFUEL PRECURSOR THAT IS ALSO A BIOFUEL FROM BIOMASS 审中-公开经济生产生物燃料前体的方法也是生物质的生物燃料公开(公告)号：US20090215137A1
公开(公告)日：2009-08-27
申请号：US12263442
申请日：2008-10-31
Applicant: Andrew C. Hawkins , David A. Glassner , Thomas Buelter , James Wade , Peter Meinhold , Matthew W. Peters , Patrick R. Gruber , William A. Evanko , Aristos A. Aristidou
Inventor： Andrew C. Hawkins , David A. Glassner , Thomas Buelter , James Wade , Peter Meinhold , Matthew W. Peters , Patrick R. Gruber , William A. Evanko , Aristos A. Aristidou
CPC classification number: C12P7/16 , C07K14/245 , C10G1/04 , C10G2300/1014 , C10G2300/4025 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C12N9/0006 , C12N9/0036 , C12N9/2414 , C12N9/2417 , C12N9/2428 , C12N9/2434 , C12P7/04 , C12P7/24 , C12P7/62 , C12Y106/01002 , C12Y302/01001 , C12Y302/01003 , Y02E50/10 , Y02E50/16 , Y02P30/20
Abstract: Methods for producing a biofuel precursor are provided. Also provided are biocatalysts that convert a feedstock to a biofuel precursor.
Abstract translation: 提供生产生物燃料前体的方法。 还提供了将原料转化为生物燃料前体的生物催化剂。
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公开(公告)号：US06320077B1
公开(公告)日：2001-11-20
申请号：US09132720
申请日：1998-08-12
Applicant: Aharon M. Eyal , John N. Starr , Rod Fisher , Betty Hazan , Riki Canari , David R. Witzke , Patrick R. Gruber , Jeffrey J. Kolstad
Inventor： Aharon M. Eyal , John N. Starr , Rod Fisher , Betty Hazan , Riki Canari , David R. Witzke , Patrick R. Gruber , Jeffrey J. Kolstad
IPC: C07C5908
Abstract: The techniques for processing lactic acid/lactate salt mixtures are provided. Preferred mixtures for processing are obtained from fermentation broths, preferably from fermentation processes conducted at a pH of 4.8 or lower. The techniques generally concern the provision of separated lactic acid and lactate streams, from the mixtures. Preferred techniques of separation and processing of each of the streams are provided.
Abstract translation: 提供了乳酸/乳酸盐混合物的加工技术。 优选的用于加工的混合物从发酵液中获得，优选在pH4.8或更低的条件下进行发酵。 这些技术通常涉及从混合物中提供分离的乳酸和乳酸盐流。 提供了每种流的分离和处理的优选技术。
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5.发明授权Compostable multilayer structures, methods for manufacture, and articles prepared therefrom 失效可堆肥多层结构，制造方法和由其制备的制品
公开(公告)号：US5849374A
公开(公告)日：1998-12-15
申请号：US535706
申请日：1995-09-28
Applicant: Patrick R. Gruber , Jeffrey John Kolstad , James Lunt , Christopher M. Ryan , Ali Zakareya El-Afandi , James Nangeroni , Nancy Uzelac Buehler , Mark Hartmann , Jed Richard Randall , Andrea Lee Brosch
Inventor： Patrick R. Gruber , Jeffrey John Kolstad , James Lunt , Christopher M. Ryan , Ali Zakareya El-Afandi , James Nangeroni , Nancy Uzelac Buehler , Mark Hartmann , Jed Richard Randall , Andrea Lee Brosch
CPC classification number: B32B27/08 , B32B27/22 , B32B27/306 , B32B27/32 , B32B27/36 , B32B2250/24 , B32B2250/244 , B32B2307/7163 , B32B2367/00 , Y10T428/1303 , Y10T428/1307 , Y10T428/1352 , Y10T428/1379 , Y10T428/1383 , Y10T428/24942 , Y10T428/254 , Y10T428/265 , Y10T428/269 , Y10T428/31786 , Y10T428/3179
Abstract: A compostable multilayer structure in the form of a film, sheet, laminate, and the like, which comprises a core layer having a first surface and a second surface, a first blocking reducing layer covering the first surface of the core layer, and a second blocking reducing layer covering the second surface of the core layer. The core layer contains a lactic acid residue-containing polymer and has a glass transition temperature (T.sub.g) below about 20.degree. C. The first and second blocking reducing layers include a polymer composition of a hydrolyzable polymer and have a T.sub.g above about 50.degree. C. The multilayer structure can be used for preparing bags and wrappers.
Abstract translation: 包括具有第一表面和第二表面的芯层，覆盖芯层的第一表面的第一阻挡降低层的第一和第二封装层的形式的可堆叠多层结构体， 覆盖芯层的第二表面的阻挡降低层。 核心层含有含乳酸残基的聚合物，玻璃化转变温度（Tg）低于约20℃。第一和第二封闭还原层包括可水解聚合物的聚合物组合物，其Tg高于约50℃ 该多层结构可用于制备袋和包装纸。
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Patent Agency Ranking6.发明授权Method for stabilizing proteins with saccharide linked protein polymer conjugates 失效用糖连接的蛋白质聚合物缀合物稳定蛋白质的方法
公开(公告)号：US5736625A
公开(公告)日：1998-04-07
申请号：US468970
申请日：1995-06-06
Applicant: Matthew R. Callstrom , Mark D. Bednarski , Patrick R. Gruber
Inventor： Matthew R. Callstrom , Mark D. Bednarski , Patrick R. Gruber
IPC: A61K47/48 , C07H5/06 , C07H13/04 , C07H15/12 , C07K16/12 , C07K16/44 , C08F8/30 , C08F8/34 , C12N11/06 , C12N11/08 , G01N33/545 , G01N33/58 , C07K1/00 , C12N1/06 , C12N9/96 , G01N33/536
CPC classification number: C07H5/06 , A61K47/48176 , A61K47/4843 , A61K47/48692 , C07H13/04 , C07H15/12 , C07K16/1292 , C07K16/44 , C08F8/30 , C08F8/34 , C12N11/06 , C12N11/08 , G01N33/545 , G01N33/581 , Y10S530/816
Abstract: A method is disclosed for preparing water soluble protein polymer conjugates which stabilize the protein so as to retain functional properties in a hostile environment. The method comprises covalently bonding the polymer to the protein through at least three linkers which linkers have three or more hydroxyl groups. The protein is conjugated at lysines or arginines.
Abstract translation: 公开了一种制备稳定蛋白质以在敌对环境中保持功能性质的水溶性蛋白质聚合物共轭物的方法。 该方法包括通过至少三个连接体具有三个或更多个羟基共价键将聚合物与蛋白质结合。 蛋白质在赖氨酸或精氨酸缀合。
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7.发明授权Enzyme linked immunoassay with stabilized polymer saccharide enzyme conjugates 失效酶连接免疫测定与稳定的聚合物糖酶缀合物
公开(公告)号：US5691154A
公开(公告)日：1997-11-25
申请号：US469662
申请日：1995-06-06
Applicant: Matthew R. Callstrom , Mark D. Bednarski , Patrick R. Gruber
Inventor： Matthew R. Callstrom , Mark D. Bednarski , Patrick R. Gruber
IPC: A61K47/48 , C07H5/06 , C07H13/04 , C07H15/12 , C07K16/12 , C07K16/44 , C08F8/30 , C08F8/34 , C12N11/06 , C12N11/08 , G01N33/545 , G01N33/58 , G01N33/53 , C12N9/00 , C12N9/96
CPC classification number: C07H5/06 , A61K47/48176 , A61K47/4843 , A61K47/48692 , C07H13/04 , C07H15/12 , C07K16/1292 , C07K16/44 , C08F8/30 , C08F8/34 , C12N11/06 , C12N11/08 , G01N33/545 , G01N33/581 , Y10S530/816
Abstract: An improvement in enzyme linked immunoassays is disclosed wherein the enzyme is in the form of a water soluble polymer saccharide conjugate which is stable in hostile environments. The conjugate comprises the enzyme which is linked to the polymer at multiple points through saccharide linker groups.
Abstract translation: 公开了酶联免疫测定法的改进，其中酶是在恶劣环境中稳定的水溶性聚合物糖共轭物的形式。 缀合物包含通过糖连接基团在多个点与聚合物连接的酶。
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8.发明授权Continuous process for the manufacture of a purified lactide from esters of lactic acid 失效用于从乳酸的酯制造纯化的丙交酯的连续方法
公开(公告)号：US5247059A
公开(公告)日：1993-09-21
申请号：US935566
申请日：1992-08-24
Applicant: Patrick R. Gruber , Eric S. Hall , Jeffrey J. Kolstad , Matthew L. Iwen , Richard D. Benson , Ronald L. Borchardt
Inventor： Patrick R. Gruber , Eric S. Hall , Jeffrey J. Kolstad , Matthew L. Iwen , Richard D. Benson , Ronald L. Borchardt
Abstract: A process for the continuous production of substantially purified lactide and lactide polymers from an ester of lactic acid including the steps of forming crude lactide in the presence of a catalyst means to form a condensation reaction by-product and polylactic acid and depolymerizing the polylactic acid molecules followed by subsequent purification of the crude lactide in a distillation system. A purified lactide is then polymerized.
Abstract translation: 一种从乳酸酯连续制备基本上纯化的丙交酯和丙交酯聚合物的方法，包括在催化剂存在下形成粗丙交酯的步骤，以形成缩合反应副产物和聚乳酸，并解聚聚乳酸分子 随后在蒸馏系统中随后纯化粗丙交酯。 然后将纯化的丙交酯聚合。
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公开(公告)号：US20130261323A1
公开(公告)日：2013-10-03
申请号：US13902119
申请日：2013-05-24
Applicant: Matthew W. Peters , Joshua D. Taylor , David E. Henton , Leo E. Manzer , Patrick R. Gruber , Josefa M. Griffith , Yassin Al Obaidi
Inventor： Matthew W. Peters , Joshua D. Taylor , David E. Henton , Leo E. Manzer , Patrick R. Gruber , Josefa M. Griffith , Yassin Al Obaidi
IPC: C07C1/24 , C07D301/19 , C07C45/53 , C07C37/50 , C07C45/28 , C07C51/16 , C07C67/08 , C07C67/00 , C07C407/00 , C07C37/20
CPC classification number: C07C1/24 , C07C9/16 , C07C11/02 , C07C11/167 , C07C15/02 , C07C15/04 , C07C15/08 , C07C37/20 , C07C37/50 , C07C45/28 , C07C45/53 , C07C51/16 , C07C67/00 , C07C67/08 , C07C407/00 , C07D301/19 , C10G3/00 , C10G29/205 , C10G50/00 , C10G69/12 , Y02P20/52 , Y02P30/20 , C07C11/04 , C07C11/08
Abstract: Isobutene, isoprene, and butadiene are obtained from mixtures of C4 and/or C5 olefins by dehydrogenation. The C4 and/or C5 olefins can be obtained by dehydration of C4 and C5 alcohols, for example, renewable C4 and C5 alcohols prepared from biomass by thermochemical or fermentation processes. Isoprene or butadiene can be polymerized to form polymers such as polyisoprene, polybutadiene, synthetic rubbers such as butyl rubber, etc. in addition, butadiene can be converted to monomers such as methyl methacrylate, adipic acid, adiponitrile, 1,4-butadiene, etc. which can then be polymerized to form nylons, polyesters, polymethylmethacrylate etc.
Abstract translation: 异丁烯，异戊二烯和丁二烯通过脱氢从C4和/或C5烯烃的混合物中获得。 C4和/或C5烯烃可以通过C4和C5醇的脱水获得，例如通过热化学或发酵方法由生物质制备的可再生的C4和C5醇。 异戊二烯或丁二烯可以聚合形成聚合物，如聚异戊二烯，聚丁二烯，合成橡胶如丁基橡胶等。此外，丁二烯可以转化成单体如甲基丙烯酸甲酯，己二酸，己二腈，1,4-丁二烯等 然后将其聚合形成尼龙，聚酯，聚甲基丙烯酸甲酯等
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公开(公告)号：US08304588B2
公开(公告)日：2012-11-06
申请号：US13344464
申请日：2012-01-05
Applicant: William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins
Inventor： William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins
IPC: C07C29/76
CPC classification number: C12M43/00 , C07C29/80 , C07C29/86 , C12C11/11 , C12M45/20 , C12P7/04 , C12P7/16 , Y02E50/10 , Y02E50/17 , Y10T29/49826 , C07C31/12
Abstract: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.
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