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99 条记录 (耗时 0.039 秒)

    Tumor-targeted optical contrast agents
    21.
    发明授权
    Tumor-targeted optical contrast agents 失效
    肿瘤靶向光学造影剂

    公开(公告)号：US07198778B2

    公开(公告)日：2007-04-03

    申请号：US10654033

    申请日：2003-09-03

    申请人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj ,  Muthunadar P. Periasamy

    发明人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj ,  Muthunadar P. Periasamy

    IPC分类号： A61B10/00 ,  A61B8/00

    CPC分类号： A61K49/0032 ,  A61K41/0033 ,  A61K49/0056 ,  C07D209/14 ,  C07D405/06 ,  C07K1/13 ,  C07K14/655

    摘要： Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologs. The compounds may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1300 nm, the exact range being dependent upon the particular dye. The use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluoresence tumor imaging, detection and therapy.

    摘要翻译： 公开了可用于诊断成像和治疗的花青染料生物缀合物。 缀合物包括几种具有多种双和四（羧酸）同系物的花青染料。 化合物可以与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。 与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的递送。 各种染料在350至1300nm的范围内是有用的，精确的范围取决于特定的染料。 使用二甲基亚砜有助于维持化合物的荧光。 本发明化合物可用于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声波荧光肿瘤成像，检测和治疗。

    Quinoline ligands and metal complexes for diagnosis and therapy
    24.
    发明授权
    Quinoline ligands and metal complexes for diagnosis and therapy 失效
    喹啉配体和金属配合物用于诊断和治疗

    公开(公告)号：US06277841B1

    公开(公告)日：2001-08-21

    申请号：US09517252

    申请日：2000-03-02

    申请人： Raghavan Rajagopalan ,  Samuel I. Achilefu ,  Joseph E. Bugaj ,  Richard B. Dorshow

    发明人： Raghavan Rajagopalan ,  Samuel I. Achilefu ,  Joseph E. Bugaj ,  Richard B. Dorshow

    IPC分类号： C07F700

    CPC分类号： C07F13/005 ,  C07D215/26

    摘要： The present invention relates to novel ligands for forming metal complexes that absorb or fluoresce in the visible or near-infrared (NIR) region of the electromagnetic spectrum, new complexes incorporating such ligands, process for preparing such complexes, and methods of imaging or therapy using such agents. More particularly, the present invention specifically pertains to novel metal complexes derived from quinoline based heterocyclic N2O3, N3O3, N3O4, N3O5 and N2OS ligands, and are useful as general imaging, diagnostic, or therapeutic agents employing optical, nuclear medicine, or magnetic resonance procedures.

    摘要翻译： 本发明涉及用于形成在电磁光谱的可见光或近红外（NIR）区域中吸收或发出荧光的金属络合物的新配体，包含这种配体的新配合物，制备这种配体的方法，以及使用 这样的代理。 更具体地说，本发明具体涉及衍生自喹啉类杂环N 2 O 3，N 3 O 3，N 3 O 4，N 3 O 5和N 2 OS配体的新型金属络合物，并且可用作使用光学，核医学或磁共振程序的一般成像，诊断或治疗剂 。

    INTERNAL IMAGE ANTIBODIES FOR OPTICAL IMAGING AND THERAPY
    27.
    发明申请
    INTERNAL IMAGE ANTIBODIES FOR OPTICAL IMAGING AND THERAPY 审中-公开
    用于光学成像和治疗的内部图像抗体

    公开(公告)号：US20090016965A1

    公开(公告)日：2009-01-15

    申请号：US12183692

    申请日：2008-07-31

    申请人： Raghaven Ragajopalan ,  Joseph E. Bugaj ,  Samuel I. Achilefu ,  Richard B. Dorshow

    发明人： Raghaven Ragajopalan ,  Joseph E. Bugaj ,  Samuel I. Achilefu ,  Richard B. Dorshow

    IPC分类号： A61K49/00

    CPC分类号： A61K49/0058 ,  A61K41/0071 ,  A61K49/0032 ,  A61K2039/505 ,  C07K16/4208

    摘要： Methods using internal image antibodies for photodiagnosis and/or phototherapy. The internal image antibodies are conjugated with a photoactive molecule such as a dye or photosensitizer, to target specific regions, such as biological receptors. The photoactive molecules are then activated for diagnosis or therapy. Advantageously, the internal image antibody is specific for a biological receptor, but does not require isolation of the receptor to prepare the antibody, and provides the desired specificity and selectivity for targeted diagnosis or therapy.

    摘要翻译： 使用内部图像抗体进行光诊断和/或光疗的方法。 将内部图像抗体与光活性分子例如染料或光敏剂共轭，以靶向特定区域，例如生物受体。 然后激活光活性分子进行诊断或治疗。 有利地，内部图像抗体对于生物受体是特异性的，但不需要分离受体以制备抗体，并且为靶向诊断或治疗提供期望的特异性和选择性。

    Tissue sealant compositions, vascular closure devices, and uses thereof
    28.
    发明授权
    Tissue sealant compositions, vascular closure devices, and uses thereof 有权
    组织密封剂组合物，血管闭合装置及其用途

    公开(公告)号：US09433700B2

    公开(公告)日：2016-09-06

    申请号：US13266161

    申请日：2010-04-27

    申请人： Bob O. Basore ,  William L. Neumann ,  Richard B. Dorshow ,  Raghavan Rajagopalan

    发明人： Bob O. Basore ,  William L. Neumann ,  Richard B. Dorshow ,  Raghavan Rajagopalan

    IPC分类号： A61L24/10 ,  A61L24/00

    CPC分类号： A61L24/102 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/046 ,  A61L24/106 ,  A61L24/108 ,  A61L2300/418 ,  A61L2300/442 ,  A61L2300/604 ,  A61L2400/04 ,  A61L2430/20 ,  A61L2430/34

    摘要： The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.

    摘要翻译： 本发明提供组织密封剂组合物和脉管系统闭合装置，其可用于光学检测组织密封和/或凝块形成。 本发明的组合物和装置包括当组合物和/或装置结合到组织密封和/或凝块中时经历可观察到的变化的光学染料，例如荧光量子产率的变化和/或视觉颜色的变化，包括 发射和/或吸收波长的变化。 本发明的组织密封剂和血管闭合装置可用于可视化密封和/或血块形成，例如，在外科手术期间或之后，导管移除之后等。本发明还提供用于组织密封的形成和光学检测的方法 或脉管系统穿刺闭合件以及可用于组织密封或脉管系统穿刺闭合件的形成和光学检测的医疗套件。