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21.发明授权Automated process for detecting the presence of a target nucleic acid in a sample 无效用于检测样品中靶核酸的存在的自动化过程公开(公告)号：US07482143B2
公开(公告)日：2009-01-27
申请号：US11169112
申请日：2005-06-29
申请人： Kelly G. Ammann , Ralph E. Burns , Ernest V. Hansberry , Glenn A. Horner , Cheryl A. Jakub , John E. Kling , Donald J. Nieglos , Robert E. Schneider , Robert J. Smith
发明人： Kelly G. Ammann , Ralph E. Burns , Ernest V. Hansberry , Glenn A. Horner , Cheryl A. Jakub , John E. Kling , Donald J. Nieglos , Robert E. Schneider , Robert J. Smith
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automated process for detecting the presence of a target nucleic acid in a sample. The process is performed in a stand-alone unit and includes separating the target nucleic acid from other material present in the sample, engaging a robotic pipettor to combine the separated target nucleic acid and reagents for performing an amplification reaction, and performing an amplification reaction. A product of the amplification reaction is detected as an indication of the presence of the target nucleic acid in the sample.
摘要翻译： 用于检测样品中靶核酸的存在的自动化过程。 该方法在独立单元中进行，包括将目标核酸与样品中存在的其他物质分离，与机器人移液器接合以组合分离的靶核酸和进行扩增反应的试剂，并进行扩增反应。 检测扩增反应的产物作为样品中靶核酸的存在的指示。
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公开(公告)号：US20080147074A1
公开(公告)日：2008-06-19
申请号：US11888802
申请日：2007-08-02
IPC分类号： A61B17/58
CPC分类号： A61B17/15 , A61B17/152 , A61B17/1615 , A61B17/1655 , A61B17/1675 , A61B17/1732 , A61B17/1764 , A61B17/68 , A61B17/8052 , A61B17/809 , A61B17/8095 , A61B2017/1602 , A61B2090/034 , A61F2002/30736
摘要： A method for performing a high tibial, dome osteotomy to adjust the lateral and/or angular disposition of the tibial plateau relative to the lower portion of the tibia, the method comprising: forming an arcuate osteotomy cut in the tibia to subdivide it into upper and lower portions; manipulating the upper and lower portions to adjust their lateral and/or angular dispositions relative to one another; forming a pair of keyholes along the osteotomy cut; forming a keyhole slot to connect the two keyholes; forming a fixation hole in the tibia for each keyhole; providing an implant comprising a pair of keys connected by a bridge, each key comprising a bore for receiving a fixation screw therein; inserting the implant so that the keys are disposed in the keyholes, and so that the bores of the keys are aligned with the fixation holes; and inserting fixation screws through the bores of the keys and into the fixation holes of the keyholes so as to stabilize the upper and lower portions of the tibia.
摘要翻译： 一种用于执行高胫骨，圆顶截骨术来调节胫骨平台相对于胫骨的下部的侧向和/或角度布置的方法，所述方法包括：在胫骨中切割切割成弧形的截骨以将其细分成上部和 下部 操纵上部和下部以相对于彼此调整其横向和/或角度布置; 沿截骨形成一对钥匙孔; 形成一个锁孔，连接两个钥匙孔; 在每个锁孔的胫骨中形成固定孔; 提供植入物，其包括通过桥连接的一对键，每个键包括用于在其中接收固定螺钉的孔; 插入植入物，使得钥匙布置在钥匙孔中，并且使得钥匙的孔与固定孔对齐; 并将固定螺钉穿过键的孔并插入键槽的固定孔中，以稳定胫骨的上部和下部。
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23.发明授权公开(公告)号：US07033820B2
公开(公告)日：2006-04-25
申请号：US09973862
申请日：2001-10-11
申请人： Kelly G. Ammann , Ralph E. Burns , Ernest V. Hansberry , Glenn A. Horner , Cheryl A. Jakub , John E. Kling , Donald J. Nieglos , Robert E. Schneider , Robert J. Smith
发明人： Kelly G. Ammann , Ralph E. Burns , Ernest V. Hansberry , Glenn A. Horner , Cheryl A. Jakub , John E. Kling , Donald J. Nieglos , Robert E. Schneider , Robert J. Smith
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming in analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.
摘要翻译： 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备标本样品，在规定温度下培养规定时间的样品，在分析物分离过程中进行预处理，以及确定目标分析物的存在。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。 在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。
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公开(公告)号：US06517783B2
公开(公告)日：2003-02-11
申请号：US09802648
申请日：2001-03-09
IPC分类号： B01L300
CPC分类号： B01L9/06 , B01L9/543 , G01N33/5304 , G01N35/026 , G01N2035/00277 , G01N2035/103 , G01N2035/1086 , Y10T436/113332
摘要： A reaction receptacle apparatus includes one or more individual receptacles for containing chemical or biological substances. The one or more receptacles are arranged to be engaged by tubular elements of a substance transfer device for transferring substances into or out of the individual receptacles. Multiple receptacles are coupled to one another by a connecting rib structure that defines straight shoulders along opposite sides of the reaction receptacle apparatus, and the shoulders support the apparatus within reaction receptacle apparatus carrying structures. A contact-limiting element holding structure for holding contact-limiting elements, such as protective tips for tubular elements, is associated with each individual receptacle and holds a contact-limiting element in an operative orientation so as to be operatively engageable by the tubular element of the substance transfer device. A receptacle apparatus manipulating structure permits the reaction receptacle apparatus to be moved from one location to another by a robotic manipulating device, and an information panel presents a surface on which human and/or machine readable information may be placed.
摘要翻译： 反应容器设备包括用于容纳化学或生物物质的一个或多个单独的容器。 一个或多个容器被布置成与用于将物质输送到单个容器中的物质转移装置的管状元件接合。 多个插座通过连接肋结构彼此联接，该连接肋结构沿着反应容器装置的相对侧限定了直的肩部，并且肩部将装置支撑在承载结构的反应容器装置内。 用于保持接触限制元件（例如管状元件的保护尖端）的接触限制元件保持结构与每个单独的接头相关联，并且将接触限制元件保持在可操作的方向上，以便可操作地通过管状元件的管状元件 物质转移装置。 容器设备操纵结构允许反应容器设备通过机器人操纵装置从一个位置移动到另一个位置，并且信息面板呈现可以放置人和/或机器可读信息的表面。
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公开(公告)号：US08709814B2
公开(公告)日：2014-04-29
申请号：US13448026
申请日：2012-04-16
IPC分类号： G01N35/00
CPC分类号： B01L7/5255 , B01L7/52 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , G01N35/0098 , G01N35/0099 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： In a computer-controlled, automated method, a nucleic acid amplification procedure is performed within a prescribed incubation temperature range within an instrument that comprises at least one thermal element situated at a first location of the instrument and an amplification incubator situated at a second, spaced-apart location of the instrument. A receptacle and its contents are exposed to the thermal element for a predetermined period of time at the first location, such that the temperature of the contents of the receptacle is adjusted to approximate the incubation temperature. The receptacle is then moved from the first location and into the amplification incubator, and, in the amplification incubator, a nucleic acid contained in the contents of the receptacle is subjected to the nucleic acid amplification procedure.
摘要翻译： 在计算机控制的自动化方法中，核酸扩增程序在仪器内规定的培养温度范围内进行，仪器包含位于仪器第一位置的至少一个热元件，放大培养箱位于第二间隔 - 放置仪器的位置。 容器及其内容物在第一位置暴露于热元件预定的时间段，使得容器的内容物的温度被调节以接近培养温度。 然后将容器从第一位置移动到放大培养箱中，并且在扩增培养箱中，将包含在容器内容物中的核酸进行核酸扩增程序。
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公开(公告)号：US08221682B2
公开(公告)日：2012-07-17
申请号：US13232459
申请日：2011-09-14
IPC分类号： C12M1/38
CPC分类号： B01L7/5255 , B01L7/52 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , G01N35/0098 , G01N35/0099 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated analyzer for performing multiple diagnostic assays includes multiple modules in which aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a sample, pre-heating the sample, incubating the sample, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. A receptacle transporting system moves reaction receptacles from one station to the next. A method for performing an assay includes an automated process for isolating and amplifying a target analyte. The process is performed by moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for pre-heating and incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the analyte after the separation step and before incubation.
摘要翻译： 用于执行多个诊断测定的自动化分析仪包括多个模块，其中对反应容器中包含的流体样品进行测定的方面。 分析仪包括用于自动准备样品，预加热样品，孵育样品，进行分析物分离程序和确定目标分析物的存在的站。 插座运输系统将反应容器从一个站移动到另一个站。 用于进行测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程是通过在站之间移动包含固体支持材料和流体样品的多个反应容器中的每一个进行的，以预热和温育反应容器的内容物，并将与固体支持物结合的目标分析物与流体分离 样品。 在分离步骤之后和孵育前将扩增试剂加入到分析物中。
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27.发明授权公开(公告)号：US08192992B2
公开(公告)日：2012-06-05
申请号：US11924001
申请日：2007-10-25
IPC分类号： G01N35/00
CPC分类号： B01L7/5255 , B01L7/52 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , G01N35/0098 , G01N35/0099 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.
摘要翻译： 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备标本样品的台站，在规定温度下培养样品规定的时间，进行分析物分离程序，并确定目标分析物的存在。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。 在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。
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28.发明授权公开(公告)号：US08137406B2
公开(公告)日：2012-03-20
申请号：US11904453
申请日：2007-09-27
IPC分类号： A61B17/80
CPC分类号： A61B17/151 , A61B17/1615 , A61B17/1675 , A61B17/68 , A61B17/8095 , A61B2090/034 , A61F2002/30736
摘要： An osteotomy plate for maintaining the spacing of a wedge-like opening in bone, the osteotomy plate comprising: a body having a front side and a back side; a protrusion extending out of the back side of the body for disposition in the wedge-like opening; and a plurality of mounting holes for receiving fixation screws therein, the mounting holes being formed in the body such that when the protrusion is disposed in the wedge-like opening, the mounting holes direct the fixation screws into bone on either side of the wedge-like opening.
摘要翻译： 截骨板，用于保持骨中的楔形开口的间隔，所述截骨板包括：具有前侧和后侧的主体; 从所述主体的后侧延伸的突出部，用于设置在所述楔形开口中; 以及多个用于在其中接收固定螺钉的安装孔，所述安装孔形成在所述主体中，使得当所述突起设置在所述楔形开口中时，所述安装孔将所述固定螺钉引导到所述楔形开口的任一侧上的骨中， 像打开
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29.发明申请METHOD AND APPARATUS FOR PERFORMING AN OPEN WEDGE, HIGH TIBIAL OSTEOTOMY 有权用于执行开放式楔形结构的方法和装置，高强度铁素体公开(公告)号：US20110251617A1
公开(公告)日：2011-10-13
申请号：US13047501
申请日：2011-03-14
IPC分类号： A61B17/56
CPC分类号： A61B17/15 , A61B17/02 , A61B17/152 , A61B17/1615 , A61B17/1675 , A61B17/1732 , A61B17/1764 , A61B17/68 , A61B17/8095 , A61B17/88 , A61B2017/1602 , A61B2090/034 , A61B2090/067 , A61F2002/30736
摘要： Apparatus for performing an open wedge, high tibial osteotomy, the apparatus comprising a wedge-shaped implant for disposition in a wedge-shaped opening created in the tibia, wherein the wedge-shaped implant comprises at least one key for disposition in at least one corresponding keyhole formed in the tibia adjacent to the wedge-shaped opening created in the tibia, wherein each of the at least one keys comprises an interior bore for receiving a fixation screw, at least one fixation screw for disposition in the interior bore of the at least one key, and further wherein the apparatus is configured so that when the at least one fixation screw is received in the interior bore, the at least one fixation screw terminates within the bore.
摘要翻译： 用于执行开放楔形，高胫骨截骨术的装置，所述装置包括楔形植入物，用于设置在胫骨中形成的楔形开口，其中所述楔形植入物包括至少一个键，用于至少一个对应的 形成在与胫骨中形成的楔形开口相邻的胫骨中的锁孔，其中至少一个键中的每一个包括用于接收固定螺钉的内孔，至少一个固定螺钉，用于配置在至少 一个键，并且其中所述装置被配置成使得当所述至少一个固定螺钉被容纳在所述内孔中时，所述至少一个固定螺钉终止于所述孔内。
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公开(公告)号：US20090068074A1
公开(公告)日：2009-03-12
申请号：US11869300
申请日：2007-10-09
IPC分类号： B01J19/00
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.
摘要翻译： 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备标本样品，在规定温度下规定时间孵育样品，进行分析物分离程序，以及确定目标分析物的存在的站。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。 在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。
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