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    System and method for calculating focus variation for a digital microscope
    22.
    发明授权
    System and method for calculating focus variation for a digital microscope 有权

    公开(公告)号：US11100637B2

    公开(公告)日：2021-08-24

    申请号：US16592335

    申请日：2019-10-03

    Applicant: S.D. Sight Diagnostics Ltd.

    Inventor： Noam Yorav-Raphael ,  Uri Wolfovitz ,  Joseph Joel Pollak

    IPC: G06K9/00 ,  G06T7/00 ,  G02B21/24 ,  G06T7/90

    Abstract: Apparatus and methods are described for use with a digital microscope unit that includes a digital microscope. A biological cell sample disposed within a sample carrier, is received into the digital microscope unit. For at least one imaging field of the biological cell sample, it is determined that, within the imaging field, there is a variation in the focal depth of the biological sample with respect to the microscope. At least one image of the imaging field is captured. A characteristic of the biological sample is determined by analyzing the captured image of the imaging field, the analyzing including, in response to determining that there is a variation in the focal depth of the biological sample with respect to the microscope, accounting for the variation in the focal depth of the biological sample with respect to the microscope. Other applications are also described.

    METHODS AND SYSTEMS FOR DETECTING ENTITIES IN A BIOLOGICAL SAMPLE
    23.
    发明申请
    METHODS AND SYSTEMS FOR DETECTING ENTITIES IN A BIOLOGICAL SAMPLE 审中-公开

    公开(公告)号：US20200181680A1

    公开(公告)日：2020-06-11

    申请号：US16705941

    申请日：2019-12-06

    Applicant: S.D. Sight Diagnostics Ltd.

    Inventor： Joseph Joel Pollak ,  Daniel Levner ,  Yonatan Bilu ,  Arnon Houri Yafin ,  Noam Yorav-Raphael ,  Yuval Greenfield

    IPC: C12Q1/68 ,  G01N1/30

    Abstract: Apparatus and methods for use with a blood sample are described. The blood sample is stained with Hoechst stain and Acridine Orange stain. A plurality of images of the blood sample are acquired. An object is identified as being a white blood cell candidate. A first stained area, which is stained by the Hoechst stain and which is disposed within the white blood cell candidate, is identified. A second stained area, which is stained by the Acridine Orange stain and which is disposed within the white blood cell candidate, is identified. A white blood cell is detected by determining that structural features of the stained areas satisfy predetermined criteria associated with a white blood cell. Other applications are also described.

    METHOD AND SYSTEM FOR IMAGING A CELL SAMPLE
    24.
    发明申请
    METHOD AND SYSTEM FOR IMAGING A CELL SAMPLE 审中-公开

    公开(公告)号：US20190130567A1

    公开(公告)日：2019-05-02

    申请号：US16232124

    申请日：2018-12-26

    Applicant: S.D. SIGHT DIAGNOSTICS LTD.

    Inventor： Yuval Greenfield ,  Yonatan Bilu ,  Joseph Joel Pollak ,  Noam Yorav-Raphael

    IPC: G06T7/00 ,  G06T7/507 ,  G02B21/24 ,  G02B7/38 ,  G02B21/36 ,  G02B21/16

    Abstract: Apparatus and methods are described for use with a cell sample. For each of one or more imaging fields of the cell sample, a depth scan of the cell sample is performed using a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the sample using the microscope, at least partially in response to detecting that the depth level corresponds to a drop in image contrast relative to image contrast at other depth levels. Based upon the depth level identified as being the optimum focal plane for each of the one or more imaging fields of the cell sample, a scanning depth interval over which to perform a depth scan of the cell sample at a further imaging field is defined. Other applications are also described.

    Method, kit and system for imaging a blood sample
    25.
    发明授权
    Method, kit and system for imaging a blood sample 有权
    用于血液样本成像的方法，试剂盒和系统

    公开(公告)号：US09329129B2

    公开(公告)日：2016-05-03

    申请号：US14440864

    申请日：2014-06-30

    Applicant: S.D. SIGHT DIAGNOSTICS LTD.

    Inventor： Joseph Joel Pollak ,  Arnon Houri Yafin ,  Seth J. Salpeter

    IPC: G01N21/64 ,  G02B21/36 ,  G01N33/49 ,  G01N1/28 ,  G01N1/38 ,  G01N15/14 ,  G01N15/00

    CPC classification number: C12Q1/04 ,  G01N1/2813 ,  G01N1/38 ,  G01N15/1463 ,  G01N15/1475 ,  G01N21/6428 ,  G01N21/6486 ,  G01N33/49 ,  G01N2015/0065 ,  G01N2021/6439 ,  G02B21/361

    Abstract: Provided is a method for imaging a blood sample and a kit and system for executing the method. The method includes introducing a cell suspension including red blood cells onto a base surface of a carrier having a vertical height (H) being greater than or equal to a vertical depth (h) of the cell suspension when on the base carrier, the cell suspension including a cell concentration (C) being determined by a defined function; allowing the cells in the cell suspension to settle on the base surface of the carrier to form a monolayer of cells thereon; and acquiring at least one microscope image of at least a portion of the monolayer of cells; wherein the at least one microscope image is obtained by a microscope set to Depth Of Field that is not more than 20% of the vertical height of the cell suspension settled on the base surface.

    Abstract translation: 提供了一种用于对血液样本进行成像的方法以及用于执行该方法的套件和系统。 该方法包括在载体的基底表面上引入包含红细胞的细胞悬浮液，所述载体的垂直高度（H）大于或等于细胞悬液的垂直深度（h） 包括由定义的功能确定的细胞浓度（C）; 允许细胞悬浮液中的细胞沉淀在载体的基底表面上以在其上形成单层细胞; 以及获取细胞单层的至少一部分的至少一个显微镜图像; 其中所述至少一个显微镜图像是通过设置在深度不到所述细胞悬液沉降在所述基面上的垂直高度的20％的显微镜得到的。

    Sample carrier for microscopy and optical density measurements
    26.
    发明授权
    Sample carrier for microscopy and optical density measurements 有权

    公开(公告)号：US12196940B2

    公开(公告)日：2025-01-14

    申请号：US18397324

    申请日：2023-12-27

    Applicant: S.D. SIGHT DIAGNOSTICS LTD

    Inventor： Noam Yorav-Raphael ,  Joseph Joel Pollak ,  Sarah Levy Schreier ,  Yochay Shlomo Eshel

    IPC: G02B21/00 ,  G01N21/64 ,  G02B21/36

    Abstract: Apparatus and methods are described for determining a property of a bodily sample using a microscope and optical-density-measurement apparatus, the apparatus including a sample carrier that includes a plurality of microscopy sample chambers configured to receive a first portion of the sample and to facilitate imaging of the first portion of the sample by the microscope, each of the microscopy sample chambers having an upper and a lower surface, and having respective heights between the upper and lower surfaces that are different from each other. The sample carrier includes at least one optical-density-measurement chamber configured to receive a second portion of the sample, and to facilitate optical density measurements being performed optical-density-measurement apparatus upon the second portion of the sample. Other applications are also described.

    Methods and systems for detecting entities in a biological sample
    30.
    发明授权
    Methods and systems for detecting entities in a biological sample 有权

    公开(公告)号：US11584950B2

    公开(公告)日：2023-02-21

    申请号：US16705941

    申请日：2019-12-06

    Applicant: S.D. Sight Diagnostics Ltd.

    Inventor： Joseph Joel Pollak ,  Daniel Levner ,  Yonatan Bilu ,  Arnon Houri Yafin ,  Noam Yorav-Raphael ,  Yuval Greenfield

    IPC: C12Q1/68 ,  G01N1/30

    Abstract: Apparatus and methods for use with a blood sample are described. The blood sample is stained with Hoechst stain and Acridine Orange stain. A plurality of images of the blood sample are acquired. An object is identified as being a white blood cell candidate. A first stained area, which is stained by the Hoechst stain and which is disposed within the white blood cell candidate, is identified. A second stained area, which is stained by the Acridine Orange stain and which is disposed within the white blood cell candidate, is identified. A white blood cell is detected by determining that structural features of the stained areas satisfy predetermined criteria associated with a white blood cell. Other applications are also described.

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