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公开(公告)号:US06548273B1
公开(公告)日:2003-04-15
申请号:US09617823
申请日:2000-07-17
申请人: Pan Fong Chan , David J. Holmes , Michael A. Lonetto , Christopher M. Traini , Magdalena Zalacain
发明人: Pan Fong Chan , David J. Holmes , Michael A. Lonetto , Christopher M. Traini , Magdalena Zalacain
IPC分类号: C12P2106
CPC分类号: C07K14/3156 , A61K38/00 , A61K39/00 , G01N33/56944
摘要: The invention provides lacR polypeptides and polynucleotides encoding lacR polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lacR polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了lacR多肽和编码lacR多肽的多核苷酸以及通过重组技术产生这种多肽的方法。 还提供了利用lacR多肽筛选抗菌化合物的方法。
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公开(公告)号:US07202071B2
公开(公告)日:2007-04-10
申请号:US10437581
申请日:2003-05-14
申请人: Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
发明人: Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
摘要: The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号:US06251631B1
公开(公告)日:2001-06-26
申请号:US09250677
申请日:1999-02-16
申请人: Sanjoy Biswas , Martin Karl Russel Burnham , Alison Francis Chalker , Karen Anne Ingraham , Christopher Michael Traini , Patrick Vernon Warren , Magdalena Zalacain
发明人: Sanjoy Biswas , Martin Karl Russel Burnham , Alison Francis Chalker , Karen Anne Ingraham , Christopher Michael Traini , Patrick Vernon Warren , Magdalena Zalacain
IPC分类号: C07K14315
CPC分类号: C07K14/3156 , A61K38/00 , A61K39/00 , C12N9/00
摘要: The invention provides nadE polypeptides and polynucleotides encoding nadE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nadE polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了nadE多肽和编码nadE多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用nadE多肽筛选抗菌化合物的方法。
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公开(公告)号:US06268177B1
公开(公告)日:2001-07-31
申请号:US09285576
申请日:1999-04-02
申请人: Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
发明人: Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号: C12N1500
CPC分类号: C12N9/1077
摘要: The invention provides ndp polypeptides and polynucleotides encoding ndp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ndp polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了ndp多肽和编码ndp多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ndp多肽筛选抗菌化合物的方法。
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公开(公告)号:US6165992A
公开(公告)日:2000-12-26
申请号:US81689
申请日:1998-05-20
IPC分类号: G01N33/53 , A61K38/00 , A61K39/395 , A61K48/00 , A61P31/04 , C07K14/315 , C07K16/40 , C12N9/12 , C12N15/00 , C12N15/09 , C12N15/31 , C12Q1/02 , C12R1/46 , G01N33/50 , C07H21/00 , C12N15/62 , C12N15/63
CPC分类号: C12N9/1223 , A61K38/00 , A61K48/00 , G01N33/5005 , G01N2800/52
摘要: The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供组氨酸激酶多肽和编码组氨酸激酶多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。
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公开(公告)号:US6165991A
公开(公告)日:2000-12-26
申请号:US80963
申请日:1998-05-19
IPC分类号: A61K38/00 , A61K39/00 , A61K48/00 , C12N9/12 , C12N15/31 , C12N15/54 , G01N33/569 , C07H21/00 , C12N15/63
CPC分类号: G01N33/56944 , A61K38/00 , A61K39/00 , A61K48/00 , C12N9/1205 , C12N9/1223 , G01N2800/52
摘要: The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase Polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase Polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供组氨酸激酶多肽和编码组氨酸激酶多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。
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公开(公告)号:US6140061A
公开(公告)日:2000-10-31
申请号:US94103
申请日:1998-06-09
IPC分类号: G01N33/53 , A61K31/70 , A61K38/00 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P11/00 , A61P31/04 , C07K14/315 , C07K16/12 , C12N15/00 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , C12R1/46 , G01N33/566 , G01N33/68 , A61K38/16 , C07K1/00 , C12Q1/00
CPC分类号: C07K14/3156 , G01N33/68 , A61K38/00 , A61K39/00 , G01N2333/315 , G01N2800/52
摘要: The invention provides response regulator polypeptides and polynucleotides encoding response regulator polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing response regulator polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了响应调节剂多肽和编码响应调节多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用响应调节剂多肽筛选抗菌化合物的方法。
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公开(公告)号:US20060115831A1
公开(公告)日:2006-06-01
申请号:US11200907
申请日:2005-08-10
申请人: Sanjoy Biswas , James Brown , Martin Burnham , Alisori Chalker , David Holmes , Karen Ingraham , Thomas Mathie , Richard Warren , Magdalena Zalacain
发明人: Sanjoy Biswas , James Brown , Martin Burnham , Alisori Chalker , David Holmes , Karen Ingraham , Thomas Mathie , Richard Warren , Magdalena Zalacain
IPC分类号: C12Q1/68 , C07H21/04 , C07K14/315
CPC分类号: C12N9/1205 , C07K14/3156 , C12Q1/6883 , G01N33/68 , Y02A50/396
摘要: The invention provides map polypeptides and polynucleotides encoding map polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing map polypeptides to screen for antibacterial compounds.
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公开(公告)号:US06261817B1
公开(公告)日:2001-07-17
申请号:US09197063
申请日:1998-11-20
申请人: Sanjoy Biswas , James Raymond Brown , Lisa Kathleen Shilling , Richard Lloyd Warren , Magdalena Zalacain
发明人: Sanjoy Biswas , James Raymond Brown , Lisa Kathleen Shilling , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号: C12P2106
CPC分类号: C12N9/93 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K14/3156 , G01N33/56944 , G01N33/573 , G01N33/9446 , Y10S435/822
摘要: The invention provides guaA polypeptides and polynucleotides encoding guaA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing guaA polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了guaA多肽和编码guaA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用guaA多肽筛选抗菌化合物的方法。
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公开(公告)号:US6100069A
公开(公告)日:2000-08-08
申请号:US196857
申请日:1998-11-20
申请人: Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Katz , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong
发明人: Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Katz , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong
IPC分类号: C12N15/09 , A61K38/00 , A61K39/00 , C07K14/315 , C12N1/21 , C12N5/02 , C12N9/90 , C12N15/61 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号: C07K14/3156 , C12N9/90 , C12Y502/01008 , A61K38/00 , A61K39/00
摘要: The invention provides tig polypeptides and polynucleotides encoding tig polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tig polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了tig多肽和编码tig多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用tig多肽筛选抗菌化合物的方法。
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