公开(公告)号：US20080152507A1

公开(公告)日：2008-06-26

申请号：US11614364

申请日：2006-12-21

申请人： Sebastian Bohm

发明人： Sebastian Bohm

IPC分类号： F04B49/06

CPC分类号： F04B17/00 ,  A61M5/14244 ,  A61M5/14526 ,  A61M5/14566 ,  A61M5/172 ,  A61M2005/14513 ,  A61M2205/3317 ,  A61M2205/3389 ,  F04B9/107 ,  F04B2201/0201

摘要： Various methods and devices are provided for an electrokinetic infusion pump. In one embodiment of the invention, the infusion pump includes an infusion pump module, which can be configured to dispense an insulin containing infusion liquid, and an electrokinetic engine. The infusion pump module includes a capacitive displacement position sensor configured for sensing a dispensing state of the infusion pump module. The infusion pump module can include an infusion module housing and the electrokinetic engine can include a moveable partition. The capacitive displacement sensor includes a first capacitive plate disposed on the moveable partition and a second capacitive plate disposed on the infusion module housing. The capacitive displacement sensor is configured for measuring capacitance between the first capacitive plate and the second capacitive plate and can send a feedback signal to a closed loop controller that is indicative of the capacitance between the first and second capacitive plates.

摘要翻译： 为电动输液泵提供了各种方法和装置。 在本发明的一个实施例中，输注泵包括输注泵模块，其可以被配置为分配含胰岛素的输注液体和电动发动机。 输注泵模块包括被配置为感测输注泵模块的分配状态的电容式位移位置传感器。 输注泵模块可以包括输注模块壳体，并且电动发动机可以包括可移动分隔件。 电容式位移传感器包括设置在可移动隔板上的第一电容板和设置在输液模块壳体上的第二电容板。 电容位移传感器被配置用于测量第一电容板和第二电容板之间的电容，并且可以向闭环控制器发送指示第一和第二电容板之间的电容的反馈信号。

公开(公告)号：US07156117B2

公开(公告)日：2007-01-02

申请号：US11095374

申请日：2005-03-30

申请人： Sebastian Bohm

发明人： Sebastian Bohm

IPC分类号： F17D1/18 ,  F15C1/04

CPC分类号： G05D7/0694 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2400/0442 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0688 ,  Y10T137/0396 ,  Y10T137/2076 ,  Y10T137/2082 ,  Y10T137/2196 ,  Y10T137/2224

摘要： The present invention is directed to methods of controlling the flow of fluids through a microfluidic circuit and, more particularly, to methods of controlling the movement of fluid through a microfluidic circuit using one or more triggerable passive valves. In one embodiment of a method of controlling the flow of fluids through a microfluidic circuit according to the present invention, the microfluidic circuit includes a triggerable valve in series with a passive valve. In a further embodiment of a method of controlling the flow of fluids through a microfluidic circuit according to the present invention, the microfluidic circuit includes first and second triggerable valves in parallel.

摘要翻译： 本发明涉及控制通过微流体回路的流体流动的方法，更具体地，涉及通过使用一个或多个可触发的被动阀来控制流体通过微流体回路的运动的方法。 在根据本发明的通过微流体回路控制流体流动的方法的一个实施例中，微流体回路包括与被动阀串联的可触发阀。 在根据本发明的通过微流体回路控制流体流动的方法的另一实施例中，微流体回路包括并联的第一和第二可触发阀。

公开(公告)号：US20050217743A1

公开(公告)日：2005-10-06

申请号：US11096036

申请日：2005-03-30

申请人： Sebastian Bohm

发明人： Sebastian Bohm

IPC分类号： G05D7/06

CPC分类号： G05D7/0694 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150946 ,  F16K99/00 ,  Y10T137/2196 ,  Y10T137/2224

摘要： The present invention is directed to valves for use in controlling the flow of fluid and, more particularly, to a triggerable passive valve for use in controlling the flow of fluid. In one embodiment, a fluid delivery channel is connected to a flow restrictor and a passive valve positioned in the fluid delivery channel downstream from the flow restrictor. The first passive valve prevents fluid from moving through the channel when the pressure exerted by the fluid on the first passive valve is below the burst pressure. A pneumatic actuator actuates the valve by forcing fluid through the passive valve.

摘要翻译： 本发明涉及用于控制流体流动的阀门，更具体地，涉及用于控制流体流动的可触发的被动阀。 在一个实施例中，流体输送通道连接到限流器和被定位在流体输送通道中的被动阀，其位于流量限制器的下游。 当第一被动阀上的流体施加的压力低于爆破压力时，第一被动阀防止流体流过通道。 气动执行器通过迫使流体通过被动阀来致动阀。

公开(公告)号：US06463312B1

公开(公告)日：2002-10-08

申请号：US09601873

申请日：2000-09-12

申请人： Piet Bergveld ,  Sebastian Bohm ,  Wouter Olthuis

发明人： Piet Bergveld ,  Sebastian Bohm ,  Wouter Olthuis

IPC分类号： A61B505

CPC分类号： A61B5/14528

摘要： Microdialysis device (10), comprising at least a probe (1) provided with an inlet (2) and an outlet (3) for bringing a perfusion fluid into contact with a bodily fluid in a part of a living organism and causing constituents from this fluid to be taken up by this perfusion fluid, whereby the perfusion fluid is enriched to dialysate, wherein the outlet (3) is integrally received in a silicon chip (5) and debouches in a first fluid channel (6) formed in this silicon chip (5) and wherein further at least one analysis means, for instance an ISFET (17, 18), for analysing constituents of the bodily fluid taken up by the perfusion fluid is integrally received in the silicon chip (5) in a manner such that dialysate flowing from the outlet (3) comes into contact with said analysis means in the first fluid channel (6), and wherein the silicon chip (5) is further optionally provided with pumping means (50) or dosing means.

摘要翻译： 微透析装置（10）包括至少一个设置有入口（2）和出口（3）的探针（1），用于使灌注流体与生物体的一部分中的体液接触并引起来自该生物体的成分 流体被该灌注流体吸收，从而使灌注流体富集成透析液，其中出口（3）整体地容纳在硅芯片（5）中，并且在形成于该硅芯片中的第一流体通道（6）中脱模 （5），并且其中另外至少一个分析装置，例如用于分析由灌注流体吸收的体液的成分的ISFET（17,18）以这样的方式被一体地接收在硅芯片（5）中： 从出口（3）流出的透析液与第一流体通道（6）中的分析装置接触，并且其中硅芯片（5）还可选地设置有泵送装置（50）或给料装置。

公开(公告)号：US20220095968A1

公开(公告)日：2022-03-31

申请号：US17545711

申请日：2021-12-08

申请人： Liang Wang ,  Shwetha Edla ,  Ghazaleh R. Esmaili ,  Hossein Mohammadiarani ,  Sebastian Bohm ,  Rui Ma ,  Minglian Shi ,  Anna Harley-Trochimczyk

发明人： Liang Wang ,  Shwetha Edla ,  Ghazaleh R. Esmaili ,  Hossein Mohammadiarani ,  Sebastian Bohm ,  Rui Ma ,  Minglian Shi ,  Anna Harley-Trochimczyk

IPC分类号： A61B5/145 ,  A61B5/01 ,  A61B5/1468

摘要： Various examples are directed to systems and methods for generating an estimated analyte value. An analyte sensor system may access a first sensor signal from an in vivo analyte sensor and a first temperature signal from the ex vivo temperature sensor. The analyte sensor system may generate a first analyte sensor temperature based at least in part on the first temperature signal and generate a first estimated analyte value based at least in part on the first sensor signal and the first temperature-compensated sensitivity.

公开(公告)号：US09131885B2

公开(公告)日：2015-09-15

申请号：US12829318

申请日：2010-07-01

申请人： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

发明人： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC分类号： A61B5/05 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  B05C3/10

CPC分类号： A61B5/1473 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2560/0223 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/125 ,  B05C3/10

摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

摘要翻译： 提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。 例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。 传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成，绝缘层810将导电层820与细长主体分隔开;膜层沉积在 通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。

公开(公告)号：US07665303B2

公开(公告)日：2010-02-23

申请号：US11095636

申请日：2005-03-30

申请人： Sebastian Bohm ,  Alan W. McNeilage

发明人： Sebastian Bohm ,  Alan W. McNeilage

IPC分类号： F01K1/00

CPC分类号： B01L3/502784 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2200/143 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0442 ,  B01L2400/0487 ,  B01L2400/0694 ,  G01N27/3271 ,  G01N35/1095

摘要： The invention described is a method of segregating a bolus of fluid using a pneumatic actuator in a fluid handling circuit. The described invention further includes a method of segregating a bolus of fluid using a pneumatic actuator in a fluid handling circuit wherein the method includes the step of injecting an air pocket into the fluid stream to create the bolus. In addition, the described invention includes a method of measuring the analyte concentration in a bolus of fluid using a pneumatic actuator in a fluid handling circuit. The described invention further includes a method of measuring the analyte concentration in a bolus of fluid using a pneumatic actuator in a fluid handling circuit wherein the method includes the step of injecting an air pocket into the fluid stream to create the bolus.

摘要翻译： 本发明描述了一种在流体处理电路中使用气动致动器分离流体的方法。 所描述的发明还包括在流体处理电路中使用气动致动器分离流体的方法，其中所述方法包括将空气袋注入流体流以产生推注的步骤。 此外，所描述的发明包括使用流体处理电路中的气动致动器测量流体中的分析物浓度的方法。 所描述的发明还包括使用流体处理电路中的气动致动器来测量流体中的分析物浓度的方法，其中所述方法包括将空气袋注入流体流中以产生推注的步骤。

公开(公告)号：US07654127B2

公开(公告)日：2010-02-02

申请号：US11614211

申请日：2006-12-21

申请人： Peter Krulevitch ,  Mingqi Zhao ,  Sebastian Bohm ,  Deon Anex ,  Michael Gearhart

发明人： Peter Krulevitch ,  Mingqi Zhao ,  Sebastian Bohm ,  Deon Anex ,  Michael Gearhart

IPC分类号： G01F25/00 ,  G01N19/00

CPC分类号： A61M5/14526 ,  A61M5/14244 ,  A61M5/14566 ,  A61M5/16831 ,  A61M2005/14513 ,  A61M2205/3317

摘要： The present application is directed to systems and methods associated with infusion pumps, which can optionally utilize an electrokinetic driving mechanism. Infusion pumps, including electrokinetically-driven pumps, are discussed, along with schemes for controlling their operation. As well, systems and methods of detecting malfunctions in infusion pumps are discussed. Any number of malfunctions can be detected including the presence of occlusions and/or leaks. In some instances, a measurement associated with some aspect of electrokinetic phenomena (e.g., an electrode measurement such as voltage or current) is compared with one or more sample values, the comparison allowing an indication of pump malfunction to be determined. A variety of such measurements and comparison techniques are discussed in the present disclosure.

摘要翻译： 本申请涉及与输注泵相关联的系统和方法，其可以可选地使用电动驱动机构。 讨论了输液泵，包括电动泵，以及控制其操作的方案。 此外，还讨论了检测输液泵故障的系统和方法。 可以检测到任何数量的故障，包括堵塞和/或泄漏的存在。 在一些情况下，将与动电现象的一些方面（例如电极测量例如电压或电流）相关联的测量与一个或多个样本值进行比较，该比较允许确定泵故障的指示。 在本公开中讨论了各种这样的测量和比较技术。

公开(公告)号：US20090139577A1

公开(公告)日：2009-06-04

申请号：US12363850

申请日：2009-02-02

申请人： Sebastian Bohm

发明人： Sebastian Bohm

IPC分类号： F17D1/00

CPC分类号： F04B19/24 ,  F04B43/06 ,  F04B53/10 ,  F04B53/1077 ,  Y10T137/0379

摘要： The present invention is directed to methods for controlling the flow of fluid and, more particularly, to a method of using triggerable passive valves to control the flow of fluid. In one embodiment of the present invention a method of using triggerable passive valves to control the flow of fluid is described wherein fluid is moved through a passive valve by providing pneumatic pressure between the passive valve and a flow restrictor, the pneumatic pressure exerted causing the pressure exerted by the fluid on the passive valve to exceed the burst pressure of the passive valve.

摘要翻译： 本发明涉及用于控制流体流动的方法，更具体地，涉及一种使用可触发的被动阀来控制流体流动的方法。 在本发明的一个实施例中，描述了使用可触发的被动阀来控制流体流动的方法，其中通过在被动阀和限流器之间提供气动压力将流体移动通过被动阀，引起压力的气压 由被动阀上的流体施加以超过被动阀的爆破压力。

公开(公告)号：US20070062250A1

公开(公告)日：2007-03-22

申请号：US11532691

申请日：2006-09-18

申请人： Peter Krulevitch ,  Sebastian Bohm ,  Mingqi Zhao ,  Deon Anex

发明人： Peter Krulevitch ,  Sebastian Bohm ,  Mingqi Zhao ,  Deon Anex

IPC分类号： G01F25/00

CPC分类号： A61M5/14244 ,  A61M5/14248 ,  A61M5/1452 ,  A61M5/16831 ,  A61M5/172 ,  A61M2005/14513 ,  A61M2205/3317 ,  A61M2205/3389

摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.

摘要翻译： 讨论了检测输液泵中的闭塞和流体损失状况（例如断开和/或泄漏）的系统和方法。 例如，电动输液泵可能在流体流动路径中产生阻塞，这可能破坏从泵分散的流体的控制。 同样，输液器断开也可能导致流体损失，这可能是破坏性的。 对于控制输液泵的系统，例如闭环控制器，这种中断可能是麻烦的。 因此，本文所述的系统和方法可用于在输注泵操作期间检测这种闭塞和流体损失状况。 例如，位置传感器可用于监测来自输注泵的流体流动，其中测量值与预期值进行比较以检测堵塞或流体损失状况。 还描述了用于利用位置传感器的其它算法。