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    Keyed latch valve for fuel filter
    22.
    发明申请
    Keyed latch valve for fuel filter 审中-公开
    用于燃油滤清器的钥匙锁阀

    公开(公告)号：US20050000876A1

    公开(公告)日：2005-01-06

    申请号：US10824916

    申请日：2004-04-15

    Applicant: Steven Knight

    Inventor： Steven Knight

    IPC: B01D29/15 ,  B01D35/153 ,  B01D36/00 ,  F02M37/22 ,  B01D27/00

    CPC classification number: F02M37/22 ,  B01D29/15 ,  B01D29/21 ,  B01D29/902 ,  B01D29/925 ,  B01D29/96 ,  B01D35/153 ,  B01D35/157 ,  B01D35/1573 ,  B01D35/1576 ,  B01D35/18 ,  B01D35/26 ,  B01D36/003 ,  B01D2201/162 ,  B01D2201/34 ,  B01D2201/4046 ,  B01D2201/4084 ,  F02M37/44

    Abstract: A fuel filter includes mating housing portions defining an interior cavity. A pipe in the housing includes a central flow passage with an opening along the length of the pipe, and an exterior groove. A latch device with discrete fingers closely surrounds the pipe and is engageable with the groove to prevent the latch device (68) from moving axially along the pipe. The latch device has an annular sleeve, radially-outwardly spaced from the fingers. A moveable valve device surrounds the pipe and has a valve sleeve normally covering the opening in the pipe. An annular base on the sleeve includes radially projecting tabs defining a plurality of slots. A filter element is removeably located in the housing and has an end cap with a valve actuating portion. The valve actuating portion includes a cylindrical portion and an annular base projecting radially inward from the cylindrical portion. The valve actuating portion includes a plurality of thin, flat keys spaced around the annular base and projecting radially inward from the cylindrical portion and axially outward from the base. The keys have first portions which project through the slots in the valve device and engage the sleeve of the latch device to unlock the latch device from the pipe, and second portions which engage the base of the valve device and move the valve device to uncover the opening in the pipe, when the filter element is inserted into the housing.

    Abstract translation: 燃料过滤器包括限定内腔的配合壳体部分。 壳体中的管道包括具有沿着管的长度的开口的中心流动通道和外部凹槽。 具有分离的指状物的闩锁装置紧密地围绕管并且可与槽接合，以防止闩锁装置（68）沿管道轴向移动。 闩锁装置具有从手指径向向外间隔开的环形套筒。 可移动阀装置围绕管并且具有通常覆盖管道中的开口的阀套筒。 套筒上的环形基座包括限定多个槽的径向突出的突片。 过滤器元件可移除地位于壳体中并且具有带有阀致动部分的端盖。 阀致动部分包括圆柱形部分和从圆柱形部分径向向内突出的环形基部。 阀致动部分包括多个薄的扁平键，其围绕环形基座间隔开并从圆柱形部分径向向内突出并且从基部轴向向外突出。 钥匙具有突出通过阀装置中的狭槽的第一部分并且与闩锁装置的套筒接合以将锁定装置从管道解锁，并且第二部分接合阀装置的底部并且移动阀装置以揭开 当过滤元件插入壳体时，在管道中打开。

    Novel Biphenyl Compounds And Their Use
    23.
    发明申请
    Novel Biphenyl Compounds And Their Use 审中-公开
    新型联苯化合物及其用途

    公开(公告)号：US20070265345A1

    公开(公告)日：2007-11-15

    申请号：US11632331

    申请日：2005-07-27

    Applicant: Amita Chaudhari ,  Dashyant Dhanak ,  Steven Knight ,  David Morgans ,  Cynthia Parrish

    Inventor： Amita Chaudhari ,  Dashyant Dhanak ,  Steven Knight ,  David Morgans ,  Cynthia Parrish

    IPC: A61K31/17 ,  A61K31/165 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  A61P9/00 ,  C07C233/00 ,  C07C273/18 ,  C07C275/00

    CPC classification number: C07C275/28 ,  C07C233/15 ,  C07C233/43 ,  C07C259/06 ,  C07C275/30 ,  C07C275/40 ,  C07C275/42 ,  C07C275/64 ,  C07C317/24 ,  C07C317/42 ,  C07C323/44 ,  C07C335/16 ,  C07D209/02 ,  C07D307/79 ,  C07D317/66 ,  C07D319/18

    Abstract: The invention is directed to certain biphenyl compounds. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and Y are as defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are KSP inhibitors, particularly human KSP inhibitors, and can be useful for the treatment for a variety of diseases and conditions, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders, fungal disorders, and inflammation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting KSP and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. In an additional aspect, the invention provides methods of screening for compounds that will bind to a KSP kinesin, for example compounds that will displace or compete with the binding of the compounds of the invention. The methods comprise combining a labeled compound of the invention, a KSP kinesin, and at least one candidate agent and determining the binding of the candidate bioactive agent to the KSP kinesin. In a further aspect, the invention provides methods of screening for modulators of KSP kinesin activity. The methods comprise combining a compound of the invention, a KSP kinesin, and at least one candidate agent and determining the effect of the candidate bioactive agent on the KSP kinesin activity.

    Abstract translation: 本发明涉及某些联苯化合物。 具体地说，本发明涉及式Ⅰ化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和Y如下所定义，及其药学上可接受的盐。 本发明的化合物是KSP抑制剂，特别是人KSP抑制剂，并且可用于治疗各种疾病和病症，例如癌症，增生，再狭窄，心脏肥大，免疫疾病，真菌病症和炎症。 因此，本发明进一步涉及包含本发明化合物的药物组合物。 本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物抑制KSP和治疗与其相关的病症的方法。 在另一方面，本发明提供筛选将结合KSP驱动蛋白的化合物的方法，例如将取代或与本发明化合物结合竞争的化合物。 所述方法包括组合本发明的标记化合物，KSP驱动蛋白和至少一种候选试剂，并确定候选生物活性剂与KSP驱动蛋白的结合。 另一方面，本发明提供筛选KSP驱动蛋白活性调节剂的方法。 所述方法包括组合本发明的化合物，KSP驱动蛋白和至少一种候选试剂，并确定候选生物活性剂对KSP驱动蛋白活性的影响。

    Vehicle cabin heating system with wax motor three-way valve
    29.
    发明申请
    Vehicle cabin heating system with wax motor three-way valve 审中-公开
    车用加热系统带蜡马达三通阀

    公开(公告)号：US20050224031A1

    公开(公告)日：2005-10-13

    申请号：US11105185

    申请日：2005-04-13

    Applicant: Steven Knight ,  Martin Maxwell

    Inventor： Steven Knight ,  Martin Maxwell

    IPC: F02N19/02 ,  F16K27/02 ,  F16K31/02 ,  F02N17/02

    CPC classification number: F16K31/025 ,  F16K27/0263

    Abstract: The present invention provides a wax motor actuated valve assembly for controlling the flow of coolant to a heater core or cores until the coolant reaches a predetermined operating temperature. The wax motor actuated valve has particular application to vehicle cabin heating systems comprising front and rear heat exchangers (cores) over which air can pass for heating front and rear portions of the cabin, respectively. Initially, flow to the rear heat exchanger is shut off until the temperature of the coolant reaches a predetermined elevated temperature, whereby initial coolant flow is directed to the front heat exchanger for more rapid heating of the forward portion of the vehicle cabin. After the predetermined elevated temperature has been reached, the wax motor valve assembly is actuated to supply coolant to the rear heat exchanger for heating the rear portion of the vehicle cabin.

    Abstract translation: 本发明提供了一种蜡马达致动阀组件，用于控制冷却剂到加热器芯或芯的流动，直到冷却剂达到预定的工作温度。 蜡马达致动阀特别适用于包括前后热交换器（内芯）的车厢加热系统，空气可分别通过该热交换器（核心）加热舱室前部和后部。 首先，流向后部热交换器的流量直到冷却剂的温度达到预定的升高温度为止，由此初始冷却剂流动被引导到前部热交换器，以便更快速地加热车辆舱前部。 在达到预定的升高温度之后，致动蜡马达阀组件以向后部热交换器供应冷却剂，以加热车厢的后部。

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