公开(公告)号：US20190358171A1

公开(公告)日：2019-11-28

申请号：US16515906

申请日：2019-07-18

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Weiwei Gao ,  Ronnie H. Fang ,  Che-Ming Jack Hu

IPC: A61K9/51 ,  A61K31/545 ,  A61K31/49 ,  A61K31/43 ,  A61K31/427 ,  A61K39/02 ,  A61K9/50 ,  A61K45/06

Abstract: Nanoparticles are provided comprising an inner core comprising a non-cellular material, and an outer surface comprising a bacterial membrane, e.g., a bacterial membrane derived from a bacteria outer membrane vesicle. Also provided are compositions, e.g., medicament delivery systems and pharmaceutical compositions, comprising the present nanoparticles. Also provided are uses of the present nanoparticles, pharmaceutical compositions and medicament delivery systems for treating and/or preventing a disease or condition, e.g., bacterial infection, in a subject.

公开(公告)号：US10383830B2

公开(公告)日：2019-08-20

申请号：US15558636

申请日：2016-03-18

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Weiwei Gao ,  Ronnie H. Fang ,  Che-Ming Jack Hu

IPC: A61K39/00 ,  A61K9/51 ,  A61K45/06 ,  A61K31/427 ,  A61K31/43 ,  A61K31/49 ,  A61K31/545 ,  A61K9/50 ,  A61K39/02 ,  B82Y5/00

Abstract: Nanoparticles are provided comprising an inner core comprising a non-cellular material, and an outer surface comprising a bacterial membrane, e.g., a bacterial membrane derived from a bacteria outer membrane vesicle. Also provided are compositions, e.g., medicament delivery systems and pharmaceutical compositions, comprising the present nanoparticles. Also provided are uses of the present nanoparticles, pharmaceutical compositions and medicament delivery systems for treating and/or preventing a disease or condition, e.g., bacterial infection, in a subject.

公开(公告)号：US20190070314A1

公开(公告)日：2019-03-07

申请号：US15939104

申请日：2018-03-28

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Berta Esteban-Fernández de Ávila ,  Yi Chen ,  Chava Angell ,  Fernando Soto Alvarez ,  Liangfang Zhang ,  Malthe Hansen-Bruhn

IPC: A61K48/00 ,  A61M31/00 ,  A61M37/00 ,  A61K41/00 ,  C12N15/113 ,  C12N9/22 ,  C12N15/11 ,  C12N9/64 ,  A61K38/48

Abstract: Methods, systems, and devices are disclosed for intracellular payload delivery by nanomotor structures. In some aspects, a nanomotor for intracellular payload delivery includes an asymmetric body having a concave cavity at one end of the nanowire body; a functionalization layer on an outer surface of the nanowire body; and a payload substance coupled to the nanomotor by the functionalization layer in a biologically active conformation, wherein the payload substance is attached to a portion of the functionalization layer or at least partially encapsulated within the functionalization layer, in which the nanomotor is operable to propel in a biological medium and into an intracellular region of a living cell to initiate an interaction of the biologically active payload substance with an intracellular constituent of the living cell.

公开(公告)号：US12285472B2

公开(公告)日：2025-04-29

申请号：US15505148

申请日：2015-08-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Jonathan Copp ,  Ronnie H. Fang ,  Brian T. Luk

IPC: A61K39/00 ,  A61K9/00 ,  A61K9/51 ,  A61K35/12 ,  A61K39/385 ,  A61K45/06 ,  A61K47/34

Abstract: The invention provides a composition, and method of use thereof, comprising self-antigen displaying nanoparticles to target auto-reactive immune components for treating and/or preventing the autoimmune diseases associated therewith. The nanoparticles can also be loaded with cytotoxic drugs for targeted cell killing or with immune-tolerizing compounds to normalize the immune regulation.

公开(公告)号：US20250049716A1

公开(公告)日：2025-02-13

申请号：US18814247

申请日：2024-08-23

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming (Jack) Hu ,  Ronnie Hongbo Fang ,  Jonathan Copp

IPC: A61K9/14 ,  A61K39/00 ,  A61K39/085 ,  A61K39/39 ,  A61K45/06

Abstract: Provided are nanoparticles and methods of using and making thereof. The inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. Medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. Further provided are immunogenic compositions comprising the inventive nanoparticles, and methods of using the inventive immunogenic compositions for eliciting an immune response, and for treating or preventing diseases or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. Vaccines comprising the immunogenic composition comprising the nanoparticles are also provided.

公开(公告)号：US20220151948A1

公开(公告)日：2022-05-19

申请号：US17590684

申请日：2022-02-01

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Kuei-Chun Wang ,  Shu Chien

IPC: A61K9/51 ,  A61K47/69 ,  A61P7/04 ,  A61P9/00 ,  A61P35/00 ,  A61K31/337

Abstract: The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.

公开(公告)号：US11241394B2

公开(公告)日：2022-02-08

申请号：US15737566

申请日：2016-06-07

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Kuei-Chun Wang ,  Shu Chien

IPC: A61K9/51 ,  A61K47/69 ,  A61P7/04 ,  A61P9/00 ,  A61P35/00 ,  A61K31/337 ,  B82Y5/00 ,  B82Y30/00

Abstract: The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.

公开(公告)号：US11224577B2

公开(公告)日：2022-01-18

申请号：US15737594

申请日：2016-06-07

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Soracha Kun Thamphiwatana

IPC: A61K9/51 ,  A61K31/337 ,  A61K31/7042 ,  A61K47/69 ,  A61P31/04 ,  A61K9/50 ,  A61K45/06 ,  B82Y5/00

Abstract: The present invention relates to prevention and/or treatment of infection by a platelet-targeting microbe in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating (and/or related uses) infection by a platelet-targeting microbe in a subject, using, inter alia, an effective amount of a nanoparticle comprising a) an inner core comprising a non-cellular material, b) an outer surface comprising a cellular membrane derived from a platelet; and optionally c) an agent for preventing said infection, treating said infection, diagnosing said infection, prognosing said infection and/or monitoring prevention or treatment of said infection. Exemplary platelet-targeting infections include infections by a bacterium, a virus, a fungus and/or a parasite.

公开(公告)号：US20200268892A1

公开(公告)日：2020-08-27

申请号：US16067950

申请日：2017-01-05

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Weiwei Gao

IPC: A61K47/34 ,  C12N5/071 ,  A61K9/00 ,  A61K35/39

Abstract: The present invention relates to viral or cellular membrane coated nanostructures. Nanostructure networks, nanoscaffolds and articles of manufacture comprising the nanostructure, and uses thereof, are also provided. The present invention also relates to methods for anchoring, attaching and/or growing a target cell. Target cells, constituent(s) of the target cells, target substances made by the target cells or culture medium of the target cells prepared by the present methods, and uses thereof, are also provided.

公开(公告)号：US20180169027A1

公开(公告)日：2018-06-21

申请号：US15737594

申请日：2016-06-07

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Soracha Kun Thamphiwatana

IPC: A61K9/51 ,  A61K31/337 ,  A61K47/69 ,  A61K31/7042 ,  A61K9/50 ,  A61K45/06 ,  A61P31/04

CPC classification number: A61K9/51 ,  A61K9/5068 ,  A61K9/5084 ,  A61K9/5094 ,  A61K31/337 ,  A61K31/7042 ,  A61K45/06 ,  A61K47/6901 ,  A61K2300/00 ,  A61P31/04 ,  B82Y5/00

Abstract: The present invention relates to prevention and/or treatment of infection by a platelet-targeting microbe in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating (and/or related uses) infection by a platelet-targeting microbe in a subject, using, inter alia, an effective amount of a nanoparticle comprising a) an inner core comprising a non-cellular material, b) an outer surface comprising a cellular membrane derived from a platelet; and optionally c) an agent for preventing said infection, treating said infection, diagnosing said infection, prognosing said infection and/or monitoring prevention or treatment of said infection. Exemplary platelet-targeting infections include infections by a bacterium, a virus, a fungus and/or a parasite.