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    BIREFRINGENT SPECTRAL DEMULTIPLEXER FOR HYPERSPECTRAL IMAGING
    23.
    发明申请
    BIREFRINGENT SPECTRAL DEMULTIPLEXER FOR HYPERSPECTRAL IMAGING 审中-公开

    公开(公告)号：US20190384069A1

    公开(公告)日：2019-12-19

    申请号：US16443519

    申请日：2019-06-17

    Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

    Inventor： Jonathan D. Olson ,  Keith D. Paulsen ,  David W. Roberts

    IPC: G02B27/28 ,  G02B5/20 ,  H04N5/33 ,  H04N5/225

    Abstract: A birefringent spectral demultiplexer for hyperspectral imaging includes N birefringent beamsplitting stages arranged along a light propagation path, to produce 2N mutually divergent output light beams. Each of the output light beams differs from every other one of the output light beams in polarization and/or spectral bandwidth. Each birefringent beamsplitting stage includes a retarder for modifying polarization of each light beam received by the birefringent beamsplitting stage, and a Wollaston prism for splitting each light beam into two orthogonally polarized and divergent light beams. The Wollaston prism has a beamsplitting interface arranged at an oblique angle to the light propagation path. The oblique angle of the beamsplitting interface of each Wollaston prism of the series, except for the first one, is smaller than the oblique angle of the beamsplitting interface of each preceding Wollaston prism. The demultiplexer may be configured to accept input light of any polarization.

    METHOD AND APPARATUS FOR QUANTITATIVE HYPERSPECTRAL FLUORESCENCE AND REFLECTANCE IMAGING FOR SURGICAL GUIDANCE
    25.
    发明申请
    METHOD AND APPARATUS FOR QUANTITATIVE HYPERSPECTRAL FLUORESCENCE AND REFLECTANCE IMAGING FOR SURGICAL GUIDANCE 有权

    公开(公告)号：US20240377627A1

    公开(公告)日：2024-11-14

    申请号：US18783802

    申请日：2024-07-25

    Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

    Inventor： Pablo A. Valdes ,  David W. Roberts ,  Keith D. Paulsen ,  Frederic Leblond

    IPC: G02B21/06 ,  A61B1/06 ,  G02B21/36

    Abstract: A surgical microscope with a fluorescence excitation illuminator receives fluorescence emissions from a target, the surgical microscope having an optical output port. A tunable filter passes a filtered portion of light from the surgical microscope, the filtered light has wavelengths selected by the tunable filter and is provided to a high-resolution, broad-bandwidth electronic camera. The electronic camera converts light from the tunable filter to electrical signals. A processor processes the electrical signals to form an image of the target including estimated fluorophore depth, the image corrected for optical absorption and scattering parameters of the target. The processor also performs deformation modeling of the target to track tumor position changes during surgery. Embodiments track surface changes of the target using stereo cameras to support the deformation modeling, some images may include information from preoperative CT or MRI, and some images may map biomarkers like HbO2 and DexoHb.

    Method and apparatus for quantitative hyperspectral fluorescence and reflectance imaging for surgical guidance
    29.
    发明授权
    Method and apparatus for quantitative hyperspectral fluorescence and reflectance imaging for surgical guidance 有权

    公开(公告)号：US11656448B2

    公开(公告)日：2023-05-23

    申请号：US16443760

    申请日：2019-06-17

    Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

    Inventor： Pablo A. Valdes ,  David W. Roberts ,  Keith D. Paulsen ,  Frederic Leblond

    IPC: G02B21/06 ,  G02B21/36 ,  A61B1/06

    CPC classification number: G02B21/06 ,  A61B1/063 ,  G02B21/36

    Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.

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