公开(公告)号：US20220265600A1

公开(公告)日：2022-08-25

申请号：US17618884

申请日：2020-06-12

Applicant: The Trustees of Princeton University ,  Cheers Health Inc.

Inventor： Brooks POWELL ,  Robert K. PRUD'HOMME ,  Nicholas CAGGIANO ,  Chang TIAN

IPC: A61K31/352 ,  A61K47/12 ,  A61K47/14 ,  A61K47/44 ,  A61K9/48 ,  A61K47/18 ,  A61K47/24

Abstract: Formulations including dihydromyricetin (DHM) and a fatty acid salt or a fatty acid.

公开(公告)号：US20180228736A1

公开(公告)日：2018-08-16

申请号：US15751689

申请日：2016-08-08

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： Nikolas T. WEISSMUELLER ,  Robert K. PRUD'HOMME

IPC: A61K9/51 ,  B82Y5/00

CPC classification number: A61K9/5169 ,  B82Y5/00 ,  C08L89/00 ,  C09D189/00

Abstract: In one aspect, methods of preparing composite nanoparticle compositions are described herein. For example, in some embodiments, a method comprises providing a zein solution stream, an organic fluid stream including at least one additive and at least one buffer fluid stream. The zein solution stream, organic fluid stream and buffer fluid stream are delivered to a chamber for mixing at one or more rates sufficient to flash precipitate composite nanoparticles including the additive encapsulated by a shell comprising the zein.

公开(公告)号：US20170042823A1

公开(公告)日：2017-02-16

申请号：US15237219

申请日：2016-08-15

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： Robert K. PRUD'HOMME ,  Hoang D. Lu

IPC: A61K9/50 ,  A61K33/38 ,  A61K31/05 ,  A61K9/51 ,  A61K31/20 ,  A61K31/496 ,  A61K38/12 ,  A61K9/10

CPC classification number: A61K31/05 ,  A61K9/5123 ,  A61K9/5146 ,  A61K31/045 ,  A61K31/496 ,  A61K33/38 ,  A61K38/12 ,  A61K2300/00

Abstract: Microbial infections have become increasingly difficult to treat due to the emergence of drug resistant microbes. Adjunctive therapies can be used to better treat resistant microbes, where multiple drugs are concurrently used to overcome resistant mechanisms and to synergistically treat infections. The practice of adjunctive therapies is limited by the ability to precisely control the pharmacokinetic profiles of the multiple actives. Composite particle-based approaches to enable and enhance adjunctive antimicrobial infections by simultaneous encapsulation and delivery of all components are described herein.

Abstract translation: 微生物感染由于耐药微生物的出现而变得越来越难以治疗。 辅助治疗可用于更好地治疗耐药性微生物，其中多种药物同时用于克服抗性机制并协同治疗感染。 辅助治疗的实践受到精确控制多种活性物质的药代动力学特征的能力的限制。 本文描述了通过同时包封和递送所有组分来实现和增强辅助性抗微生物感染的基于复合粒子的方法。

公开(公告)号：US20170042818A1

公开(公告)日：2017-02-16

申请号：US15243234

申请日：2016-08-22

Applicant: The Trustees of Princeton University ,  Rutgers, The State University of New Jersey

Inventor： Robert K. PRUD'HOMME ,  Patrick J. SINKO ,  Howard A. STONE ,  Nathalie M. PINKERTON ,  Lei SHI ,  Jiandi WAN ,  Sherif IBRAHIM ,  Dayuan GAO

IPC: A61K9/16 ,  A61K31/4745

CPC classification number: A61K9/1641 ,  A61K9/0019 ,  A61K9/1635 ,  A61K9/1647 ,  A61K31/437 ,  A61K31/4745

Abstract: The American Cancer Society estimated that in 2009, 1,479,350 new cancer cases would be diagnosed in the United States of which 219,440 would be lung and bronchus related. The standard treatments for NSCLC include surgery, chemotherapy, radiation, laser and photodynamic therapy, all with various success rates depending on the stage of the cancer. National Cancer Institute assesses, however, that results of standard treatment are generally poor with only a 15 percent 5-year survival rate for combined cancer stages. Challenges facing the current chemotherapy drugs include excessive toxicity to healthy tissues and limited ability to prevent metastases. A dual drug delivery system described herein selectively targets the lung to deliver anti-cancer drugs and inhibit the formation of metastases.

Abstract translation: 美国癌症协会估计，在2009年，美国将诊断出1,479,350例新的癌症病例，其中219,440例与肺和支气管有关。 NSCLC的标准治疗方法包括手术，化学疗法，放射线，激光和光动力疗法，均取决于癌症的各个阶段。 然而，国家癌症研究所评估标准治疗结果普遍较差，联合癌症阶段的5年生存率只有15％。 目前化疗药物面临的挑战包括对健康组织的过度毒性和预防转移的能力有限。 本文描述的双重药物递送系统选择性地靶向肺以递送抗癌药物并抑制转移的形成。

公开(公告)号：US20170037234A1

公开(公告)日：2017-02-09

申请号：US15121715

申请日：2015-02-25

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： Robert K. PRUD'HOMME ,  Rodney D. PRIESTLEY ,  Rui LIU ,  Chris SOSA

IPC: C08L25/06 ,  A61K47/32 ,  B01J31/26 ,  C08L47/00 ,  B01J31/06 ,  B01J31/28 ,  A61K9/16 ,  A01N25/10

CPC classification number: C08L25/06 ,  A01N25/10 ,  A61K9/107 ,  A61K9/122 ,  A61K9/16 ,  A61K47/32 ,  A61K47/34 ,  B01J23/42 ,  B01J23/50 ,  B01J23/52 ,  B01J23/75 ,  B01J31/06 ,  B01J31/26 ,  B01J31/28 ,  B01J35/0013 ,  B01J35/008 ,  B01J37/038 ,  B01J37/16 ,  B01J2231/641 ,  C07C209/36 ,  C08L9/00 ,  C08L47/00

Abstract: Polymer nanoparticles, including Janus nanoparticles, and methods of making them are described.

Abstract translation: 描述了包括Janus纳米颗粒的聚合物纳米颗粒及其制备方法。

公开(公告)号：US20160340495A1

公开(公告)日：2016-11-24

申请号：US15225946

申请日：2016-08-02

Applicant: The Trustees of Princeton University

Inventor： Shuyang PAN ,  Ilhan A. AKSAY ,  Robert K. PRUD'HOMME

IPC: C08K9/00 ,  C08G77/38 ,  C08G77/08 ,  C08J3/205

CPC classification number: C08K9/00 ,  B82Y30/00 ,  C08G77/08 ,  C08G77/16 ,  C08G77/18 ,  C08G77/20 ,  C08G77/38 ,  C08J3/2053 ,  C08J2383/07 ,  C08L83/04

Abstract: A nanocomposite composition having a silicone elastomer matrix having therein a filler loading of greater than 0.05 wt %, based on total nanocomposite weight, wherein the filler is functional graphene sheets (FGS) having a surface area of from 300 m2/g to 2630 m2/g; and a method for producing the nanocomposite and uses thereof.

Abstract translation: 一种纳米复合材料组合物，其具有基于总纳米复合材料重量而具有大于0.05重量％的填料负载量的硅氧烷弹性体基体，其中所述填料是表面积为300m 2 / g至2630m 2 / m 2的功能性石墨烯片（FGS） G; 以及该纳米复合材料的制造方法及其用途。

公开(公告)号：US20150173188A1

公开(公告)日：2015-06-18

申请号：US14515019

申请日：2014-10-15

Applicant: The Trustees of Princeton University

Inventor： Robert K. PRUD'HOMME ,  Ilhan A. Aksay

IPC: H05K1/09 ,  H05K3/10 ,  H05K3/00

CPC classification number: H05K1/095 ,  B82Y30/00 ,  B82Y40/00 ,  C01B31/0423 ,  C01B31/043 ,  C01B31/0476 ,  C01B32/192 ,  C01B32/225 ,  C01B32/23 ,  C01B2204/32 ,  H01G4/206 ,  H05K3/0091 ,  H05K3/10 ,  H05K2201/0323 ,  Y02E60/324 ,  Y02E60/325 ,  Y02E60/328 ,  Y10T428/13 ,  Y10T428/1341 ,  Y10T428/1379 ,  Y10T428/2982

Abstract: A conductive circuit containing a polymer composite, which contains at least one polymer and a modified graphite oxide material, containing thermally exfoliated graphite oxide having a surface area of from about 300 m2/g to 2600 m2/g, and a method of making the same.

Abstract translation: 包含含有至少一种聚合物和改性氧化石墨材料的聚合物复合材料的导电电路，其含有表面积为约300m 2 / g至2600m 2 / g的热剥离石墨氧化物及其制备方法 。

公开(公告)号：US20130336915A1

公开(公告)日：2013-12-19

申请号：US13905015

申请日：2013-05-29

Applicant: The Trustees of Princeton University ,  CELATOR PHARMACEUTICALS INC.

Inventor： Lawrence D. MAYER ,  Robert K. PRUD'HOMME ,  Christine J. ALLEN ,  Walid S. SAAD

IPC: A61K47/48

CPC classification number: A61K47/6931 ,  A61K8/85 ,  A61K9/5153 ,  A61K45/06 ,  A61K47/22 ,  A61K47/54 ,  A61K47/543 ,  A61K47/545 ,  A61K47/55 ,  A61K47/551 ,  A61K47/552 ,  A61K47/58 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6935 ,  A61K2800/57 ,  A61Q17/04 ,  B82Y5/00

Abstract: Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo environments.

Abstract translation: 通过两亲性共聚物稳定并且包含至少一个与疏水部分结合的活性物质的颗粒构建物在体外和体内环境中均提供活性物质的持续释放。