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317 条记录 (耗时 0.172 秒)

    ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO B LYMPHOCYTE STIMULATOR PROTEIN
    21.
    发明申请
    ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO B LYMPHOCYTE STIMULATOR PROTEIN 审中-公开
    免疫组织化学染色体B淋巴细胞刺激蛋白的抗体

    公开(公告)号：US20120121606A1

    公开(公告)日：2012-05-17

    申请号：US13356314

    申请日：2012-01-23

    申请人： Steven M. Ruben ,  Steven C. Barash ,  Gil H. Choi ,  Tristan Vaughan ,  David Hilbert

    发明人： Steven M. Ruben ,  Steven C. Barash ,  Gil H. Choi ,  Tristan Vaughan ,  David Hilbert

    IPC分类号： A61K39/395 ,  C12N9/96 ,  C12N15/13 ,  A61P25/00 ,  G01N33/566 ,  A61P37/06 ,  A61P29/00 ,  C07K16/24 ,  C12N5/10

    CPC分类号： C07K14/70575 ,  A61K47/6849 ,  A61K49/0004 ,  A61K2039/505 ,  C07K14/52 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/564

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.

    摘要翻译： 本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。 本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达或B淋巴细胞刺激因子不适当功能相关的疾病或病症的方法和组合物，其包含免疫特异性结合B淋巴细胞刺激物的抗体或其片段或变体或相关分子。 本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体 或免疫特异性结合B淋巴细胞刺激物的相关分子。

    Antibodies to HNFIP24 polypeptides
    23.
    发明授权
    Antibodies to HNFIP24 polypeptides 失效
    HNFIP24多肽的抗体

    公开(公告)号：US08106165B2

    公开(公告)日：2012-01-31

    申请号：US11745580

    申请日：2007-05-08

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng

    IPC分类号： C07K16/26 ,  C07K16/00 ,  C12N5/12

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K14/47 ,  G01N33/566 ,  G01N2800/00

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

    Human G-Protein Chemokine Receptor (CCR5) HDGNR10
    24.
    发明申请
    Human G-Protein Chemokine Receptor (CCR5) HDGNR10 审中-公开
    人类G蛋白趋化因子受体（CCR5）HDGNR10

    公开(公告)号：US20110081360A1

    公开(公告)日：2011-04-07

    申请号：US12943722

    申请日：2010-11-10

    申请人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K16/00 ,  A61P37/04 ,  A61P9/00 ,  A61P17/06 ,  A61P17/00 ,  A61P11/00

    CPC分类号： C07K14/7158 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/24 ,  C07K16/2866 ,  C07K2319/00 ,  C12N2799/026

    摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.

    摘要翻译： 本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。 还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

    HEMCM42 nucleic acids
    25.
    发明授权
    HEMCM42 nucleic acids 有权
    HEMCM42核酸

    公开(公告)号：US07906634B2

    公开(公告)日：2011-03-15

    申请号：US12324825

    申请日：2008-11-26

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Gregory A. Endress

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Gregory A. Endress

    IPC分类号： C07H21/04

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K16/00

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

    Antibodies to HWHGU54 polypeptides
    26.
    发明授权
    Antibodies to HWHGU54 polypeptides 有权
    HWHGU54多肽的抗体

    公开(公告)号：US07838636B1

    公开(公告)日：2010-11-23

    申请号：US11760578

    申请日：2007-06-08

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Ying-Fei Wei

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Ying-Fei Wei

    IPC分类号： C07K16/40 ,  C12P21/08 ,  C12P21/06 ,  C12N15/09

    CPC分类号： C07K14/47

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

    Antibodies that specifically bind to neurokinin B
    29.
    发明授权
    Antibodies that specifically bind to neurokinin B 失效
    特异性结合神经激肽B的抗体

    公开(公告)号：US07514079B2

    公开(公告)日：2009-04-07

    申请号：US10981692

    申请日：2004-11-05

    申请人： Craig A. Rosen ,  Steven M. Ruben

    发明人： Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： A61K39/395 ,  G01N33/53 ,  C07K16/26

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S424/80 ,  Y10S424/804 ,  Y10S424/806 ,  Y10S424/809 ,  Y10S435/975

    摘要： The present invention relates to antibodies and related molecules that specifically bind to neurokinin B. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including pre-eclampsia, hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain. The invention also relates to nucleic acid molecules encoding anti-neurokinin B antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially pre-eclampsia, as well as hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to neurokinin B.

    摘要翻译： 本发明涉及与神经激肽B特异性结合的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症以及免疫系统疾病和病症，包括先兆子痫，高血压，炎症，哮喘， 胃肠道疾病，焦虑症，抑郁症，成瘾症或疼痛。 本发明还涉及编码抗神经激肽B抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是先兆子痫以及高血压，炎症，哮喘，胃肠道疾病，焦虑，抑郁，成瘾或疼痛的方法和组合物，其包括 向动物，优选人施用有效量的一种或多种特异性结合神经激肽B的抗体或其片段或变体或相关分子。