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公开(公告)号：US20210319994A1
公开(公告)日：2021-10-14
申请号：US17225514
申请日：2021-04-08
Applicant: Waters Technologies Corporation
Inventor： Joseph A. Jarrell , Martin Gilar
IPC: H01J49/02 , G01N27/623 , H01J49/40 , H01J49/16 , H01J49/00
Abstract: An ion detector comprises a surface configured to receive one or more ions and a detector configured to detect one or more ions by detecting electromagnetic radiation scattered by one or more ions at the surface.
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公开(公告)号：US10192725B2
公开(公告)日：2019-01-29
申请号：US15102910
申请日：2014-12-22
Applicant: Waters Technologies Corporation
Inventor： Joseph A. Jarrell
Abstract: An interface for a mass spectrometer system is provided. The interface can include an inner ceramic tube fabricated from a first ceramic material and an outer tube fabricated from a second ceramic material surrounding the inner ceramic tube. The inner ceramic tube can have high electrical resistivity and high thermal conductivity and the intermediate ceramic tube can have an electrical resistivity that is at least an order of magnitude higher than the electrical resistivity of the first ceramic material and a thermal conductivity that is at least an order of magnitude higher than the thermal conductivity of the first ceramic material.
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公开(公告)号：US10183238B2
公开(公告)日：2019-01-22
申请号：US14383241
申请日：2013-03-05
Applicant: Waters Technologies Corporation
Inventor： Michael R. Jackson , James E. Usowicz , Lucas O. Tiziani , Joseph A. Jarrell , Douglas P. Wittmer
IPC: B01D15/08 , B01D15/14 , B01D15/40 , F04B15/08 , G01N1/40 , G01N30/10 , G01N30/38 , G01N30/72 , G01N30/74 , G01N30/88 , H01J49/04 , G01N30/02 , F04B53/10 , G01N30/24
Abstract: A method includes passing a mobile phase fluid flow comprising liquefied CO2 through a separation column; then introducing a makeup fluid flow into the mobile phase fluid flow to form a mixed fluid flow; and then splitting the mixed fluid flow.
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公开(公告)号：US08834796B2
公开(公告)日：2014-09-16
申请号：US13857552
申请日：2013-04-05
Applicant: Waters Technologies Corporation
Inventor： Joseph A. Jarrell
IPC: G01N21/00 , G01N15/10 , G01N15/14 , G01N30/00 , G01N15/06 , G01N30/74 , G01N35/00 , G01N33/48 , G01N30/84
CPC classification number: G01N15/1429 , G01N15/065 , G01N30/00 , G01N30/74 , G01N2030/8447 , Y10T436/11 , Y10T436/115831 , Y10T436/117497
Abstract: A chromatographic optical detection system includes an optical detector disposed to receive light scattered from a stream of particles and configured to convert the received light to an electrical signal; a signal-processing unit in signal communication with the optical detector to receive the electrical signal, and configured to convert the electrical signal to digital pulses and count the digital pulses to output a first signal corresponding to a number of particles detected in a time interval, and configured to integrate and digitize the electrical signal to output a second signal corresponding to the number of particles detected in the time interval; and a data station in signal communication with the signal-processing unit, and configured to select the first signal, if the number of particles detected in the time interval is less than a threshold criterion, and to select the second signal if the number of particles detected in the time interval exceeds the threshold criterion. The threshold criterion is associated with a saturation condition.
Abstract translation: 色谱光学检测系统包括光学检测器，其被设置为接收从颗粒流散射的光并且被配置为将接收到的光转换成电信号; 信号处理单元，与所述光检测器进行信号通信以接收所述电信号，并且被配置为将所述电信号转换为数字脉冲并对所述数字脉冲进行计数，以输出对应于在时间间隔中检测到的多个颗粒的第一信号， 并且被配置为对电信号进行积分和数字化，以输出对应于在时间间隔中检测到的粒子数量的第二信号; 以及与所述信号处理单元进行信号通信的数据站，并且被配置为如果在所述时间间隔中检测到的粒子的数量小于阈值准则，则选择所述第一信号，并且如果所述粒子的数量选择所述第二信号 在时间间隔内检测超过阈值标准。 阈值准则与饱和条件相关联。
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公开(公告)号：US20130269424A1
公开(公告)日：2013-10-17
申请号：US13857552
申请日：2013-04-05
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： Joseph A. Jarrell
CPC classification number: G01N15/1429 , G01N15/065 , G01N30/00 , G01N30/74 , G01N2030/8447 , Y10T436/11 , Y10T436/115831 , Y10T436/117497
Abstract: A chromatographic optical detection system includes an optical detector disposed to receive light scattered from a stream of particles and configured to convert the received light to an electrical signal; a signal-processing unit in signal communication with the optical detector to receive the electrical signal, and configured to convert the electrical signal to digital pulses and count the digital pulses to output a first signal corresponding to a number of particles detected in a time interval, and configured to integrate and digitize the electrical signal to output a second signal corresponding to the number of particles detected in the time interval; and a data station in signal communication with the signal-processing unit, and configured to select the first signal, if the number of particles detected in the time interval is less than a threshold criterion, and to select the second signal if the number of particles detected in the time interval exceeds the threshold criterion. The threshold criterion is associated with a saturation condition.
Abstract translation: 色谱光学检测系统包括光学检测器，其被设置为接收从颗粒流散射的光并且被配置为将接收到的光转换成电信号; 信号处理单元，与所述光检测器进行信号通信以接收所述电信号，并且被配置为将所述电信号转换为数字脉冲并对所述数字脉冲进行计数，以输出对应于在时间间隔中检测到的多个颗粒的第一信号， 并且被配置为对电信号进行积分和数字化，以输出对应于在时间间隔中检测到的粒子数量的第二信号; 以及与所述信号处理单元进行信号通信的数据站，并且被配置为如果在所述时间间隔中检测到的粒子的数量小于阈值准则，则选择所述第一信号，并且如果所述粒子的数量选择所述第二信号 在时间间隔内检测超过阈值标准。 阈值准则与饱和条件相关联。
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Patent Agency Ranking
公开(公告)号：US20230187193A1
公开(公告)日：2023-06-15
申请号：US18066067
申请日：2022-12-14
Applicant: Waters Technologies Corporation
Inventor： Joseph A. Jarrell , Patrick Brophy , Alistair J. Schofield
CPC classification number: H01J49/027 , H01J49/0031
Abstract: An image charge detection assembly for a mass spectrometer comprising an image charge detector that is housed within an electrically conductive shielding enclosure, and a preamplifier, wherein at least an input stage of the preamplifier, which is electrically connected to the detector, is housed with the detector within the enclosure.
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公开(公告)号：US10753916B2
公开(公告)日：2020-08-25
申请号：US15872842
申请日：2018-01-16
Applicant: Waters Technologies Corporation
Inventor： Moon Chul Jung , Jonathan L. Belanger , Xiangjin Song , Abhijit Tarafder , Joseph A. Jarrell , Wade P. Leveille
Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. The leak detection system includes a sealable compartment disposed to surround at least one component of a chromatography system. The detector is in communication, e.g., fluid communication, with an interior of the sealable compartment and configured to detect the leak by various mean including the presence of liquid or the presence of vapor, or both within the sealable compartment.
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公开(公告)号：US10438689B2
公开(公告)日：2019-10-08
申请号：US15901353
申请日：2018-02-21
Applicant: Waters Technologies Corporation
Inventor： Joseph A. Jarrell
Abstract: A method and apparatus for analyzing a response of a cellular entity to a component of interest are described. The cellular entity may be a cell or an organoid. The method includes processing a heterogeneous population of cellular entities that are combined with the component of interest. An entity flow containing the cellular entities is generated. A morphological image of a portion of the entity flow having a cellular entity is acquired and the cellular entity is identified as belonging to an entity class. The entity flow is provided to a mass spectrometer system that performs an analysis of the cellular entity. The mass spectrometer analysis of the cellular entity can be correlated with the identified entity class. Alternatively, portions of the entity flow are deposited as samples on a sample plate and the mass spectrometer analysis is performed offline, for example, using an ionization process with each sample.
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公开(公告)号：US10371673B2
公开(公告)日：2019-08-06
申请号：US15909264
申请日：2018-03-01
Applicant: Waters Technologies Corporation
Inventor： Michael O. Fogwill , Joseph A. Jarrell , Joseph D. Michienzi , Thomas S. McDonald
Abstract: The present disclosure relates to methodologies, systems and apparatus for controlling pressure in a CO2-based chromatography system. A first CO2 pump operates in constant flow mode and delivers CO2 to a chromatography column, and liquid modifier is introduced to the chromatography column according to a gradient. A second CO2 pump is disposed downstream of the column and operates in constant pressure mode to introduce CO2 into a flow stream at an output of the column. Liquid modifier is also introduced into the flow stream at the output of the column according to a reverse gradient compared to the gradient entering the chromatography column.
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公开(公告)号：US20180253526A1
公开(公告)日：2018-09-06
申请号：US15901353
申请日：2018-02-21
Applicant: Waters Technologies Corporation
Inventor： Joseph A. Jarrell
CPC classification number: G16B20/00 , G01N15/1459 , G01N15/1463 , G01N15/1475 , G01N33/5008 , G01N33/5088 , G01N33/6848 , G06K9/00147 , G06K9/6217 , G16B40/00
Abstract: A method and apparatus for analyzing a response of a cellular entity to a component of interest are described. The cellular entity may be a cell or an organoid. The method includes processing a heterogeneous population of cellular entities that are combined with the component of interest. An entity flow containing the cellular entities is generated. A morphological image of a portion of the entity flow having a cellular entity is acquired and the cellular entity is identified as belonging to an entity class. The entity flow is provided to a mass spectrometer system that performs an analysis of the cellular entity. The mass spectrometer analysis of the cellular entity can be correlated with the identified entity class. Alternatively, portions of the entity flow are deposited as samples on a sample plate and the mass spectrometer analysis is performed offline, for example, using an ionization process with each sample.
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