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公开(公告)号：US20140256736A1
公开(公告)日：2014-09-11
申请号：US14355549
申请日：2012-10-30
Applicant: XENON PHARMACEUTICALS INC.
Inventor： Shifeng Liu , Thilo Focken , Navjot Chahal , Zaihui Zhang , Renata Marcella Oballa , Julia Fonarev
IPC: C07D487/04 , C07D417/12 , C07D471/04
CPC classification number: C07D487/04 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00
Abstract: This invention is directed to biaryl ether sulfonamides, or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
Abstract translation: 本发明涉及用于治疗和/或预防钠通道介导的疾病或病症如疼痛的联芳基醚磺酰胺或其药学上可接受的盐，溶剂合物或前药。
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公开(公告)号：US20130317001A1
公开(公告)日：2013-11-28
申请号：US13899526
申请日：2013-05-21
Applicant: XENON PHARMACEUTICALS INC. , GENENTECH, INC.
Inventor： Jean-Christophe Andrez , Sultan Chowdhury , Shannon Marie Decker , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Jun Li , Daniel F. Ortwine , Brian Safina , Tao Sheng , Shaoyi Sun , Daniel P. Sutherlin , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D403/12 , C07D213/64 , C07D205/04 , C07D311/58 , C07D295/26 , C07D233/84 , C07D257/04 , C07C311/51 , C07C307/06 , C07D213/82 , C07D265/30
CPC classification number: C07D491/107 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/44 , A61K31/5375 , C07B2200/05 , C07C307/06 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/18 , C07C2602/20 , C07C2602/42 , C07C2602/44 , C07C2602/50 , C07C2603/66 , C07C2603/68 , C07C2603/74 , C07D205/04 , C07D207/46 , C07D207/48 , C07D209/52 , C07D211/22 , C07D211/96 , C07D213/64 , C07D213/82 , C07D233/84 , C07D257/04 , C07D265/30 , C07D295/192 , C07D295/26 , C07D307/12 , C07D307/18 , C07D309/08 , C07D311/58 , C07D311/70 , C07D311/72 , C07D403/12 , C07D405/12 , C07D413/12 , C07D451/02 , C07D471/08
Abstract: The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20240101531A1
公开(公告)日：2024-03-28
申请号：US18330100
申请日：2023-06-06
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Paul Scott Charifson , Christoph Martin Dehnhardt , Julien A. Delbrouck , Thilo Focken , Wei Gong , Shawn Johnstone , Xiangyu Li , Jia Yi Mo , Juliette Sabbatani , Hong Wang , Steven Sigmund Wesolowski , Alla Yurevna Zenova , Wei Zhang
IPC: C07D401/12 , C07D401/14 , C07D405/14 , C07D495/04 , C07D513/04 , C07D471/04 , C07D491/048 , C07D491/107 , C07D498/04 , C07D413/14 , C07D487/04 , C07D417/14 , C07D409/14 , C07B59/00 , A61P25/08
CPC classification number: C07D401/12 , C07D401/14 , C07D405/14 , C07D495/04 , C07D513/04 , C07D471/04 , C07D491/048 , C07D491/107 , C07D498/04 , C07D413/14 , C07D487/04 , C07D417/14 , C07D409/14 , C07B59/002 , A61P25/08 , C07B2200/05
Abstract: The present disclosure is directed to compounds of Formula (1):
wherein m, n, Y, R1, R2, R3, R4 and R5 are each as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of Formula (I), as described herein, which are useful as voltage-gated potassium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.-
公开(公告)号：US20210171537A1
公开(公告)日：2021-06-10
申请号：US16805895
申请日：2020-03-02
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , David Earl Bogucki , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Shannon Marie Decker , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , Qi Jia , James Philip Johnson, JR. , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D491/107 , C07D493/10 , C07D237/20 , C07D213/76 , C07D239/69 , C07D261/16 , C07D263/50 , C07D275/03 , C07D277/52 , C07D285/08 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D487/10 , C07D417/14 , C07D451/06
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
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公开(公告)号：US20190382398A1
公开(公告)日：2019-12-19
申请号：US16440459
申请日：2019-06-13
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Kristen Nicole Burford , Thilo Focken , Verner Alexander Lofstrand , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D417/12 , C07D277/52 , C07D413/12 , A61P25/08
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
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Patent Agency Ranking
公开(公告)号：US10125098B2
公开(公告)日：2018-11-13
申请号：US15988956
申请日：2018-05-24
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D207/16 , C07D277/06 , C07D413/14 , C07D413/12 , C07D401/10 , C07D401/12 , C07C235/54 , C07D405/10 , C07D403/14 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10071957B2
公开(公告)日：2018-09-11
申请号：US14413218
申请日：2013-07-05
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Christoph Martin Dehnhardt , Sultan Chowdhury , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Brian Safina , Daniel P. Sutherlin
IPC: C07D205/04 , C07D209/08 , C07D213/63 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/20 , C07D217/02 , C07D231/56 , C07D277/24 , C07D277/34 , C07D277/62 , C07D305/08 , C07D401/12 , C07D405/12 , C07D413/12 , C07C307/06
CPC classification number: C07C307/06 , A61K31/44 , A61K31/4439 , A61K31/444 , C07C2601/04 , C07D205/04 , C07D209/08 , C07D213/63 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/20 , C07D217/02 , C07D231/56 , C07D277/24 , C07D277/34 , C07D277/62 , C07D305/08 , C07D401/12 , C07D405/12 , C07D413/12
Abstract: The invention provides novel compounds having the general formula (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, ring D, R1, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10005724B2
公开(公告)日：2018-06-26
申请号：US15321335
申请日：2015-07-07
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07C235/54 , C07D207/16 , C07D405/10 , C07D401/12 , C07D471/08 , C07D403/14 , C07D401/10 , C07D413/12 , C07D413/14 , C07D277/06
CPC classification number: C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20180162868A1
公开(公告)日：2018-06-14
申请号：US15600612
申请日：2017-05-19
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , David Earl Bogucki , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Shannon Marie Decker , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , Qi Jia , James Philip Johnson, JR. , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D491/107 , C07D277/52 , C07D417/12 , C07D213/76 , C07D285/08 , C07D401/12 , C07D403/12 , C07D275/03 , C07D239/69 , C07D261/16 , C07D413/12 , C07D263/50 , C07D487/10
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
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公开(公告)号：US08952169B2
公开(公告)日：2015-02-10
申请号：US13899526
申请日：2013-05-21
Applicant: Genentech, Inc. , Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , Sultan Chowdhury , Shannon Marie Decker , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Jun Li , Daniel F. Ortwine , Brian Safina , Tao Sheng , Shaoyi Sun , Daniel P. Sutherlin , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07C311/51 , C07D403/12 , C07D213/82 , C07D213/64 , C07D205/04 , C07D311/58 , A61K31/445 , A61K31/44 , A61K31/18 , C07D265/30 , C07D233/84 , C07D257/04 , C07C307/06 , C07D295/26 , C07D207/48 , C07D311/70 , C07D413/12 , C07D451/02 , C07D307/12 , C07D309/08 , C07D311/72 , C07D405/12 , C07D491/107 , C07D211/22 , C07D295/192 , C07D211/96 , C07D307/18
CPC classification number: C07D491/107 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/44 , A61K31/5375 , C07B2200/05 , C07C307/06 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/18 , C07C2602/20 , C07C2602/42 , C07C2602/44 , C07C2602/50 , C07C2603/66 , C07C2603/68 , C07C2603/74 , C07D205/04 , C07D207/46 , C07D207/48 , C07D209/52 , C07D211/22 , C07D211/96 , C07D213/64 , C07D213/82 , C07D233/84 , C07D257/04 , C07D265/30 , C07D295/192 , C07D295/26 , C07D307/12 , C07D307/18 , C07D309/08 , C07D311/58 , C07D311/70 , C07D311/72 , C07D403/12 , C07D405/12 , C07D413/12 , C07D451/02 , C07D471/08
Abstract: The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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