中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

29 records (took 0.022 seconds)

    Methods And Systems For Analyzing Biological Samples
    21.
    发明申请
    Methods And Systems For Analyzing Biological Samples 有权
    用于分析生物样品的方法和系统

    公开(公告)号：US20090048785A1

    公开(公告)日：2009-02-19

    申请号：US12087543

    申请日：2007-01-09

    Applicant: Nir Katzir ,  Tsafrir Kolatt ,  Irit Bar-Am

    Inventor： Nir Katzir ,  Tsafrir Kolatt ,  Irit Bar-Am

    IPC: G06F19/00 ,  G01N33/48

    CPC classification number: C12Q1/6841 ,  G06K9/00134

    Abstract: Methods, computer readable storage media and systems which can be used for analyzing labeled biological samples, identifying chromosomal aberrations, identifying genetically abnormal cells and/or computationally scanning the samples using randomly or randomized scanning methods are provided. Specifically, the present invention can be used to analyze FISH-stained samples and automatically identify chromosomal aberrations associated with abnormal intensity ratio of stained occurrences in the sample.

    Abstract translation: 提供了可用于分析标记的生物样品，识别染色体畸变，识别遗传异常细胞和/或使用随机或随机扫描方法计算扫描样品的方法，计算机可读存储介质和系统。 具体地，本发明可用于分析FISH染色的样品，并自动识别与样品中染色事件的异常强度比相关的染色体畸变。

    Optical detection method for improved sensitivity
    22.
    发明申请
    Optical detection method for improved sensitivity 有权
    灵敏度提高的光学检测方法

    公开(公告)号：US20020176084A1

    公开(公告)日：2002-11-28

    申请号：US09824684

    申请日：2001-04-04

    Applicant: Applied Spectral Imaging Ltd.

    Inventor： Yuval Garini

    IPC: G01N021/55

    CPC classification number: G06K19/06046 ,  G06K7/10801

    Abstract: A light reflecting article is disclosed. The light reflecting article comprises a sample carrying article layered with a light reflecting layer. The light reflecting layer serves for allowing an optical collection and detection system to collect both luminescent light emitted from a sample positioned on the light reflecting article in a direction of the optical collection and detection system, as well as luminescent light emitted from the sample in a direction away from the optical collection and detection system and reflected in the direction of the optical collection and detection system via the light reflecting layer, thereby increasing a sensitivity of luminescent light detection.

    Abstract translation: 公开了一种光反射制品。 光反射制品包括层叠有光反射层的样品携带物品。 光反射层用于允许光学收集和检测系统从光学收集和检测系统的方向收集从位于光反射物品上的样品发射的发光，以及从样品中发出的发光 方向远离光学采集和检测系统，并通过光反射层在光学采集和检测系统的方向上反射，从而增加了发光光检测的灵敏度。

    Method of and composite for fluorescent in situ hybridization
    23.
    发明授权
    Method of and composite for fluorescent in situ hybridization 失效
    原位荧光杂交法及复合方法

    公开(公告)号：US5871932A

    公开(公告)日：1999-02-16

    申请号：US25131

    申请日：1998-02-17

    Applicant: Irit Bar-Am ,  Yuval Garini ,  Dario Cabib

    Inventor： Irit Bar-Am ,  Yuval Garini ,  Dario Cabib

    IPC: C12Q1/68 ,  C07H21/04

    CPC classification number: C12Q1/6841

    Abstract: A fluorescent in situ hybridization method including the steps of (a) obtaining a chromosome spread of a species; (b) preparing a hybridization composite containing a plurality of chromosomal paints each of the plurality of chromosomal paints being labeled with a different fluorophore-or-combination-of-fluorohores, such that an averaged specific activity of highly repetitive sequences in the hybridization composite substantially equals an averaged specific activity of unique sequences in the hybridization composite; (c) denaturing the hybridization composite and subjecting the hybridization composite to conditions for allowing at least a part of the highly repetitive sequences in the hybridization composite to reanneal while at least a part of the unique sequences in the hybridization composite remaining single stranded; (d) contacting under hybridization conditions the hybridization composite with the chromosome spread; (e) washing away excess of the hybridization composite; and (d) analyzing and presenting images of the now hybridized chromosome spread.

    Abstract translation: 一种荧光原位杂交方法，包括以下步骤：（a）获得物种的染色体扩散; （b）制备含有多个染色体涂料的杂化复合物，所述多个染色体涂料中的每一个都用不同的荧光团或组合的荧光体标记，使得杂交复合物中高度重复序列的平均比活性基本上 等于杂交复合物中独特序列的平均比活性; （c）使杂交复合物变性并对杂交复合物进行条件以允许杂交复合物中的至少一部分高度重复序列进行再冷凝，同时杂交复合物中至少一部分独特序列保持单链; （d）在杂交条件下使杂交复合物与染色体扩散接触; （e）洗去杂交组合物的过量; 和（d）分析和呈现现在杂交的染色体扩增的图像。

    Method and system for spectral imaging
    24.
    发明授权
    Method and system for spectral imaging 有权

    公开(公告)号：US09915565B2

    公开(公告)日：2018-03-13

    申请号：US14438641

    申请日：2013-10-24

    Applicant: Applied Spectral Imaging Ltd.

    Inventor： Nir Katzir

    IPC: G01J3/45 ,  G01J3/453 ,  G02B27/14 ,  G01J3/28 ,  G01J3/02

    CPC classification number: G01J3/4532 ,  G01J3/0237 ,  G01J3/0297 ,  G01J3/2823 ,  G01J3/45 ,  G02B27/144

    Abstract: A method of calibrating a spectral imaging system is disclosed. The spectral imaging system comprises an interferometer having a beam splitter and at least a first reflector and a second reflector. The method comprises: obtaining data pertaining to an interference pattern model, operating the spectral imaging system to provide an interference pattern of a received light beam, and varying a relative orientation between at least two of: the beam splitter, the first reflector and the second reflector, until the interference pattern of the input light beam substantially matches the interference pattern model.

    Method of and system for multiplexed analysis by spectral imaging
    25.
    发明申请
    Method of and system for multiplexed analysis by spectral imaging 审中-公开
    通过光谱成像进行多重分析的方法和系统

    公开(公告)号：US20030215791A1

    公开(公告)日：2003-11-20

    申请号：US10277916

    申请日：2002-10-23

    Applicant: Applied Spectral Imaging Ltd.

    Inventor： Yuval Garini ,  Nir Katzir ,  Irit Bar-Am ,  Uri Milman ,  Eli Horn ,  Yacov Malinovich ,  Terry Hammill ,  Vladimir Cherepakhin

    IPC: C12Q001/70 ,  C12Q001/68 ,  G01N033/53 ,  G01N033/554 ,  G01N033/569 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50

    CPC classification number: B82Y5/00 ,  B82Y10/00 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/54373

    Abstract: A method of detecting the presence, absence and/or level of a plurality of analytes-of-interest in a sample, the method comprisES: (a) providing a plurality of objects, each of the plurality of objects having a predetermined, measurable and different imagery characteristic, and further having a predetermined and specific affinity to one analyte of the plurality of analytes-of-interest, each the imagery characteristic corresponding to one the predetermined specific affinity, hence each the imagery characteristic corresponds to one analyte of the plurality of analytes-of interest; (b) providing at least one affinity moiety having a predetermined and specific affinity or predetermined and specific affinities to the plurality of analytes-of-interest, each the affinity moiety having a predetermined, measurable response to light; (c) combining the objects, the at least one affinity moiety and the sample under conditions for affinity binding; and (d) simultaneously determining, for each object of the plurality of objects an imagery characteristic, and for at least a portion of the at least one affinity moiety a response to light, thereby detecting the presence, absence and/or level of the plurality of analytes-of-interest in the sample.

    Abstract translation: 一种检测样本中多个感兴趣分析物的存在，不存在和/或等级的方法，所述方法包括：（a）提供多个对象，所述多个对象中的每一个具有预定的，可测量的和 不同的图像特征，并且还对多个感兴趣分析物中的一个分析物具有预定和特异性的亲和力，每个图像特征对应于一个预定的特异亲和力，因此每个图像特征对应于多个 分析物 - 兴趣; （b）提供至少一个亲和部分，其具有对多个感兴趣分析物的预定和特异性亲和力或预定和特异性亲和力，每个亲和部分具有对光的预定的可测量响应; （c）在用于亲和结合的条件下将所述目标，所述至少一个亲和部分和所述样品组合; 以及（d）对于所述多个对象的每个对象同时确定图像特征，以及对所述至少一个亲和部分的至少一部分对光的响应，从而检测所述多个对象的存在，不存在和/或等级 的样品中感兴趣的分析物。

    Spectral imaging using illumination of preselected spectral content
    26.
    发明授权
    Spectral imaging using illumination of preselected spectral content 失效
    使用预选光谱含量照明的光谱成像

    公开(公告)号：US6142629A

    公开(公告)日：2000-11-07

    申请号：US143964

    申请日：1998-08-30

    Applicant: Michael E. Adel ,  Dario Cabib ,  David Wine

    Inventor： Michael E. Adel ,  Dario Cabib ,  David Wine

    IPC: G02B6/00 ,  A61B1/06 ,  A61B3/12 ,  A61B3/14 ,  G01J3/10 ,  G01J3/12 ,  G01J3/28 ,  G02B6/04

    CPC classification number: A61B3/10 ,  G01J3/10 ,  G01J3/2823 ,  G01J2003/1282

    Abstract: A device and method for spectral imaging of an object. A plurality of sets of narrow-band light sources such as LEDs are provided. Each set emits illumination radiation in a different narrow spectral band. Each set is activated sequentially to illuminate the object. Light reflected from the object or transmitted by the object is focused on a detector array to image the object. Narrower illumination bands are provided by dispersing the emitted light using a dispersive optical element such as a diffraction grating. Alternatively; selected sets or subsets are activated simultaneously with duty cycles that emulate a preselected spectral distribution. For imaging ocular fundus tissue, the illumination light is shaped into an annular beam by an appropriately shaped waveguide.

    Abstract translation: 用于对象的光谱成像的装置和方法。 提供多组窄带光源如LED。 每组发射不同窄光谱带的照射辐射。 每个组被依次激活以照亮对象。 从物体反射或由物体传输的光聚焦在检测器阵列上以对物体进行成像。 通过使用诸如衍射光栅的分散光学元件分散发射的光来提供较窄的照明带。 或者; 所选择的集合或子集与模拟预选频谱分布的占空比同时激活。 为了对眼底组织进行成像，照明光通过适当形状的波导成形为环形光束。

    Spectral bio-imaging methods for biological research, medical diagnostics and therapy
    29.
    发明授权
    Spectral bio-imaging methods for biological research, medical diagnostics and therapy 失效
    用于生物研究，医学诊断和治疗的光谱生物成像方法

    公开(公告)号：US5784162A

    公开(公告)日：1998-07-21

    申请号：US571047

    申请日：1995-12-12

    Applicant: Dario Cabib ,  Robert A. Buckwald ,  Zvi Malik ,  Yuval Garini ,  Nir Katzir ,  Dirk G. Soeknsen

    Inventor： Dario Cabib ,  Robert A. Buckwald ,  Zvi Malik ,  Yuval Garini ,  Nir Katzir ,  Dirk G. Soeknsen

    IPC: G01B11/00 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  A61B10/00 ,  C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/443 ,  G01J3/45 ,  G01J3/453 ,  G01N21/27 ,  G01N21/64 ,  G01N33/48 ,  G01N33/483 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G02B21/36 ,  G06K9/00 ,  G06K9/76 ,  G01B9/02

    CPC classification number: G01N21/6458 ,  C12Q1/6841 ,  C12Q1/6883 ,  G01J3/12 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/4406 ,  G01J3/453 ,  G01N21/6428 ,  G01N21/6486 ,  G01N33/5005 ,  G01N33/56966 ,  G01N33/582 ,  G06K9/00127 ,  G06K9/76 ,  G01J2003/2866 ,  G01J3/02 ,  G01N2021/6417 ,  G01N2021/6423

    Abstract: According to the present invention there are provided spectral imaging methods for biological research, medical diagnostics and therapy comprising the steps of (a) preparing a sample to be spectrally imaged; (b) viewing the sample through an optical device, the optical device being optically connected to an imaging spectrometer, the optical device and the imaging spectrometer obtaining a spectrum of each pixel of the sample by: (i) collecting incident light simultaneously from all pixels of the sample using collimating optics; (ii) passing the incident collimated light through an interferometer system having a number of elements, to form an exiting light beam; (iii) passing the exiting light beam through a focusing optical system which focuses the exiting light beam on a detector having a two-dimensional array of detector elements, so that at each instant each of the detector elements is the image of one pixel of the sample, so that the real image of the sample is stationary on the plane of the detector array, and so that each of the detector elements produces a signal which is a particular linear combination of light intensity emitted by the pixel at different wavelengths, wherein the linear combination is a function of the instantaneous optical path difference; (iv) rotating one or more of the elements of the interferometer system, so that the optical path difference between the two coherent beams generated by the interferometer system is scanned simultaneously for all the pixels of the sample; and (v) recording signals of each of the detector elements as function of time using a recording device to form a first spectral cube of data; and (c) interpreting the first spectral cube of data using a mathematical algorithm.

    Abstract translation: 根据本发明，提供了用于生物学研究，医学诊断和治疗的光谱成像方法，其包括以下步骤：（a）制备待成像的样品; （b）通过光学装置观察样品，光学装置光学连接到成像光谱仪，光学装置和成像光谱仪通过以下步骤获得样品的每个像素的光谱：（i）从所有像素同时收集入射光 的样品使用准直光学; （ii）使入射的准直光通过具有多个元件的干涉仪系统，以形成出射的光束; （iii）使出射的光束通过聚焦光学系统，该聚焦光学系统将出射的光束聚焦在具有检测器元件的二维阵列的检测器上，使得在每个瞬间，每个检测器元件是 样本，使得样本的真实图像在检测器阵列的平面上是静止的，并且使得每个检测器元件产生信号，其是由不同波长的像素发射的光强度的特定线性组合，其中 线性组合是瞬时光程差的函数; （iv）旋转干涉仪系统的一个或多个元件，使得由干涉仪系统产生的两个相干光束之间的光程差同时扫描样品的所有像素; 以及（v）使用记录装置记录每个检测器元件的信号作为时间的函数，以形成数据的第一光谱立方体; 和（c）使用数学算法解释数据的第一个频谱立方体。

Patent Agency Ranking