公开(公告)号：US20230181807A1

公开(公告)日：2023-06-15

申请号：US18109547

申请日：2023-02-14

申请人： FENWAL, INC.

发明人： Amit J. Patel ,  Samantha M. Planas ,  Walter T. Watts ,  Kyungyoon Min ,  Daniel R. Boggs

IPC分类号： A61M1/34 ,  A61M1/36 ,  G01N33/48 ,  A61M1/38 ,  G16H10/60

CPC分类号： A61M1/3496 ,  A61M1/3672 ,  G01N33/48 ,  A61M1/3616 ,  A61M1/3643 ,  A61M1/38 ,  A61M1/382 ,  A61M1/385 ,  G16H10/60 ,  A61M2202/0415 ,  A61M2205/3379 ,  A61M2230/207 ,  A61M2205/3393 ,  A61M2205/502 ,  A61M2205/505

摘要： A method of collecting plasma includes receiving donor parameters at a controller of a plasma collection device electronically from a donor management system. The method includes storing a target volume for raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for raw plasma based on the total donor blood volume. The method includes setting the target volume for raw plasma and controlling the plasma collection device to operate draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and a second blood component comprising red blood cells and to return the second blood component to the donor. The controller operates the draw and return phases until a volume of raw plasma in the collection container equals the target volume of raw plasma.

公开(公告)号：US20160296688A1

公开(公告)日：2016-10-13

申请号：US15184492

申请日：2016-06-16

申请人： Fenwal, Inc.

发明人： Daniel R. Boggs ,  Kyungyoon Min ,  Lan T. Nguyen ,  John T. Foley ,  Brian C. Case

IPC分类号： A61M1/34 ,  A61M1/38 ,  A61M1/36

CPC分类号： A61M1/3455 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3458 ,  A61M1/3496 ,  A61M1/3672 ,  A61M1/38 ,  A61M1/385 ,  A61M2205/3334 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/207 ,  G06F19/00

摘要： Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.

摘要翻译： 公开了用于进行治疗性红细胞交换程序的系统和方法。 一方面，一种系统包括用于使来自患者的全血流动的第一流动路径。 分离器与第一流路连通，用于从血浆中分离至少红细胞。 第二和第三流动路径与分离器连通，用于分离从分离器流出分离的血浆和红细胞。 流量控制器与流动路径相关联，以控制流动路径之间的流体连通。 控制器被配置为基于操作者输入的数据执行完成过程完成时实现剩余的患者细胞的目标部分，目标血细胞比容和目标患者流体体积变化的过程。

公开(公告)号：US20050131334A1

公开(公告)日：2005-06-16

申请号：US11044887

申请日：2005-01-26

申请人： Robert Langley ,  Larry Dumont

发明人： Robert Langley ,  Larry Dumont

IPC分类号： A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  A61M37/00

CPC分类号： A61M1/385 ,  A61M1/02 ,  A61M1/30 ,  A61M1/303 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2205/50 ,  Y10T436/101666 ,  Y10T436/115831 ,  Y10T436/25 ,  Y10T436/25375

摘要： A method and apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield for the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield for the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield my be associated therewith, thereby providing a blood component product.

摘要翻译： 用于生产血液成分产品的方法和装置。 在一个实施例中，从全血源收集多个预定类型的血液成分。 使用至少两种在线产量测定技术来确定收获的血液成分的产量。 一种是预定的产量预测技术，第二种是预定的产量监测技术，每种都是相对于预定的离线产量确定技术单独校准的。 预定的产量预测和监测技术各自提供收获的血液成分的产量，然后利用每个产量来提供确定的产量。 因此，当收集的血液成分被包装时，确定的产量与之相关联，从而提供血液成分产品。

公开(公告)号：US20040199098A1

公开(公告)日：2004-10-07

申请号：US10827951

申请日：2004-04-20

申请人： Baxter International Inc.

发明人： Jennifer A. Pierce ,  Timothy J. Patno ,  Robert Cairone ,  John T. Foley

IPC分类号： A61M037/00

CPC分类号： A61M1/3693 ,  A61M1/02 ,  A61M1/0209 ,  A61M1/0222 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3633 ,  A61M1/3696 ,  A61M1/385 ,  A61M2202/0427 ,  A61M2202/0429 ,  A61M2205/33 ,  A61M2205/3393 ,  A61M2205/60 ,  A61M2230/207 ,  A61M2202/0014 ,  A61M2202/0021

摘要： Blood processing systems and methods convey blood drawn from a donor through a blood processing circuit to separate the blood into at least one targeted blood component for collection. The systems and methods derive an estimated effect of the procedure upon the donor. The estimated effect can be expressed in terms of a net blood fluid volume loss, or as a hematocrit of the donor after completion of the desired blood collection procedure. The systems and methods present the estimated effect to an operator for viewing, reading, or offloading.

公开(公告)号：US06319471B1

公开(公告)日：2001-11-20

申请号：US07912973

申请日：1992-07-10

申请人： Robert Warner Langley ,  Larry Joe Dumont

发明人： Robert Warner Langley ,  Larry Joe Dumont

IPC分类号： G01N102

CPC分类号： A61M1/385 ,  A61M1/02 ,  A61M1/30 ,  A61M1/303 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2205/50 ,  Y10T436/101666 ,  Y10T436/115831 ,  Y10T436/25 ,  Y10T436/25375

摘要： An apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield of the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield of the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield may be associated therewith, thereby providing a blood component product.

摘要翻译： 血液成分制品的制造装置。 在一个实施例中，从全血源收集多个预定类型的血液成分。 使用至少两种在线产量测定技术来确定收获的血液成分的产量。 一种是预定的产量预测技术，第二种是预定的产量监测技术，每种都是相对于预定的离线产量确定技术单独校准的。 预定的产量预测和监测技术各自提供收获的血液成分的产量，然后利用每一种产生提供确定的产量。 因此，当收集的血液成分被包装时，所确定的产量可能与之相关，从而提供血液成分产品。

公开(公告)号：US5970423A

公开(公告)日：1999-10-19

申请号：US928329

申请日：1997-09-12

申请人： Robert W. Langley ,  John J. Keller ,  Steven Gage Urdahl

发明人： Robert W. Langley ,  John J. Keller ,  Steven Gage Urdahl

IPC分类号： A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  A61M1/38 ,  G05B13/00 ,  G06F19/00

CPC分类号： A61M1/30 ,  A61M1/02 ,  A61M1/303 ,  A61M1/307 ,  A61M1/3603 ,  A61M1/3609 ,  A61M1/3672 ,  A61M1/3696 ,  A61M1/38 ,  A61M1/385 ,  A61M1/387 ,  A61M1/3643 ,  A61M1/3693 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2205/12 ,  A61M2205/50

摘要： A blood component collection system with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.

摘要翻译： 具有优化能力的血液成分收集系统。 在一个实施例中，过程参数是根据输入/配置的预定血液成分产量导出的，并且其基于至少一个过程参数的最大化。 此后，使用这些导出的过程控制参数来执行血液成分收集过程。 在另一个实施例中，从至少一个其它过程控制参数的最大值的输入总程序时间导出过程参数，以便在该固定时间内使血液成分产量最大化。 此后，用这些导出的参数进行血液成分收集过程。

公开(公告)号：US5759413A

公开(公告)日：1998-06-02

申请号：US480601

申请日：1995-06-07

申请人： Richard I. Brown

发明人： Richard I. Brown

IPC分类号： A61M1/14 ,  A61M1/02 ,  A61M1/36 ,  B01D17/12 ,  G01N15/05

CPC分类号： A61M1/385 ,  A61M1/02 ,  A61M1/3693 ,  A61M1/0209 ,  A61M1/3672 ,  A61M2202/0415 ,  A61M2202/0427

摘要： Systems and methods take into account that the spleen normally holds a number of platelets in reserve out of circulation. During blood processing, the spleen releases these platelets into the donor's circulatory system, making them available for collection. The systems and methods estimate the number of platelets N.sub.SPLEEN held in reserve by the spleen in a human body. The systems and methods derives a splenic mobilization function (Spleen), which can be expressed as a function of a precount of platelets Plt.sub.PRE. The systems and methods estimate N.sub.SPLEEN where: N.sub.SPLEEN =(Spleen-1).times.Plt.sub.PRE .times.DonVol where DonVol is blood volume in the body. The systems and methods can also estimate the total number of platelets N.sub.PLT in a human body, taking the Spleen function into account, where: N.sub.PLT =Plt.sub.PRE .times.Spleen.times.DonVol

摘要翻译： 系统和方法考虑到脾脏通常保留一定数量的血小板保留在循环中。 在血液处理过程中，脾脏将这些血小板释放到供体的循环系统中，使其可用于收集。 系统和方法估计在人体内由脾脏保留的血小板NSPLEEN的数量。 系统和方法得出脾脏动员功能（脾脏），可以表达为血小板PltPRE计数的函数。 系统和方法估计NSPLEEN其中：NSPLEEN =（Spleen-1）xPltPRExDonVolwhere DonVol是体内血量。 系统和方法还可以估计人体血小板NPLT的总数，考虑脾功能，其中：NPLT = PltPRExSpleenxDonVol

公开(公告)号：US5676841A

公开(公告)日：1997-10-14

申请号：US472439

申请日：1995-06-07

申请人： Richard I. Brown

发明人： Richard I. Brown

IPC分类号： A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D17/038 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B7/08 ,  B04B13/00 ,  B01D17/12

CPC分类号： A61M1/02 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/385 ,  B01D17/0217 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/262 ,  B01D21/34 ,  B04B13/00 ,  B04B5/0442 ,  B04B7/08 ,  A61M2202/0427 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  B01D2221/10

摘要： Blood collection systems and methods minimize citrate toxicity in donors. The systems and methods convey whole blood at a prescribed rate Q.sub.b into a separation device for separation into red blood cells and a plasma constituent. The systems and methods add anticoagulant including citrate to the whole blood. The systems and methods control Qb (in ml/min or equivalent) based upon a citrate equivalent blood flow rate EqQB.sub.CIR, where: ##EQU1## where: CIR is a selected nominal a-symptomatic citrate infusion rate (in mg/kg/min or equivalent), AC is a selected anticoagulant ratio, Wgt is the donor's weight (in kg or equivalent), and CitrateConc is the citrate concentration in the anticoagulant (in mg/ml or equivalent).

摘要翻译： 血液收集系统和方法使捐献者的柠檬酸盐毒性最小化。 系统和方法以规定的速率将全血全部输送到用于分离成红细胞和血浆成分的分离装置中。 系统和方法将全部血液中含有柠檬酸的抗凝剂。 系统和方法基于柠檬酸盐当量血流速度EqQBCIR来控制Qb（ml / min或等同物），其中：其中：CIR是选定的标称有症状的柠檬酸盐输注速率（mg / kg / min或 等效），AC是选择的抗凝血比例，Wgt是供体的体重（以kg或等同物计），CitrateConc为抗凝血剂中的柠檬酸盐浓度（mg / ml或等同物）。

公开(公告)号：US20130267884A1

公开(公告)日：2013-10-10

申请号：US13840113

申请日：2013-03-15

申请人： FENWAL, INC.

发明人： Daniel R. Boggs ,  Kyungyoon Min ,  Lan T. Nguyen ,  John T. Foley ,  Brian Case

IPC分类号： A61M1/38

CPC分类号： A61M1/3455 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3458 ,  A61M1/3496 ,  A61M1/3672 ,  A61M1/38 ,  A61M1/385 ,  A61M2205/3334 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/207 ,  G06F19/00

摘要： Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.

摘要翻译： 公开了用于进行治疗性红细胞交换程序的系统和方法。 一方面，一种系统包括用于使来自患者的全血流动的第一流动路径。 分离器与第一流路连通，用于从血浆中分离至少红细胞。 第二和第三流动路径与分离器连通，用于分离从分离器流出分离的血浆和红细胞。 流量控制器与流动路径相关联，以控制流动路径之间的流体连通。 控制器被配置为基于操作者输入的数据执行完成过程完成时实现剩余的患者细胞的目标部分，目标血细胞比容和目标患者流体体积变化的过程。

公开(公告)号：US06869411B2

公开(公告)日：2005-03-22

申请号：US10699358

申请日：2003-10-30

申请人： Robert Warner Langley ,  Larry Joe Dumont

发明人： Robert Warner Langley ,  Larry Joe Dumont

IPC分类号： A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  A61M37/00 ,  C02F1/44 ,  G01N1/02

CPC分类号： A61M1/385 ,  A61M1/02 ,  A61M1/30 ,  A61M1/303 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2205/50 ,  Y10T436/101666 ,  Y10T436/115831 ,  Y10T436/25 ,  Y10T436/25375

摘要： A method and apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield for the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield for the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield my be associated therewith, thereby providing a blood component product.