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    Affinity adsorbents for Factor VIII and von Willebrand's Factor
    21.
    发明授权
    Affinity adsorbents for Factor VIII and von Willebrand's Factor 有权
    因子VIII和维亚布兰德因子的亲和吸附剂

    公开(公告)号：US07960182B2

    公开(公告)日：2011-06-14

    申请号：US11913508

    申请日：2006-05-09

    Applicant: Jason Richard Betley ,  Baldev Singh Baines

    Inventor： Jason Richard Betley ,  Baldev Singh Baines

    IPC: G01N30/00

    CPC classification number: B01J20/286 ,  B01J20/289 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3244 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J2220/54 ,  B01J2220/58 ,  C07D251/48 ,  C07D251/50 ,  C07D251/70 ,  C07D403/12 ,  C07K14/755 ,  G01N33/86 ,  G01N2333/755 ,  Y10T436/25375 ,  Y10T436/255

    Abstract: For the separation, removal, isolation, purification, characterization, identification or quantification of Factor VIII, von Willebrand's Factor or a protein that is a analogue of either, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C—Cl or C—CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Y is O, S or NR2; Z is O, S or N—R3; R2 and R3 are each H, C1-6 alkyl, C1-6 hydroxyalkyl, benzyl or &bgr;-phenylethyl; B and W are each an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is —CHCOOH—(CH2)3-4—NH2; and R7 is a group bearing a positive charge at neutral pH.

    Abstract translation: 为了分离，去除，分离，纯化，表征，鉴定或定量因子VIII，血管性血友病因子或与之类似的蛋白质，使用亲和吸附剂，其为一个X为 N，另一个是N，C-Cl或C-CN; A是支持基质，任选地通过间隔基与三嗪环连接; Y是O，S或NR2; Z是O，S或N-R 3; R 2和R 3各自为H，C 1-6烷基，C 1-6羟基烷基，苄基或叔丁基苯乙基; B和W各自为含有1至10个碳原子的任选取代的烃键; D是H，OH或伯氨基，仲氨基，叔氨基，季铵，咪唑，胍基或脒基; 或B-D为-CHCOOH-（CH2）3-4-NH2; 而R7是在中性pH下带正电荷的基团。

    Process for the purification of antibodies
    23.
    发明授权
    Process for the purification of antibodies 有权
    抗体纯化方法

    公开(公告)号：US07750129B2

    公开(公告)日：2010-07-06

    申请号：US10589717

    申请日：2005-02-25

    Applicant: Bo-Lennart Johansson ,  Hans J. Johansson ,  Anna Grönberg ,  Jean-Luc Maloisel ,  Nicolas Thevenin

    Inventor： Bo-Lennart Johansson ,  Hans J. Johansson ,  Anna Grönberg ,  Jean-Luc Maloisel ,  Nicolas Thevenin

    IPC: C07K1/18 ,  C07K1/22

    CPC classification number: B01J20/3253 ,  B01D15/3847 ,  B01J20/3242 ,  B01J20/3246 ,  B01J20/3255 ,  B01J20/3285

    Abstract: The present invention relates to a process for the purification of antibodies from one or more impurities in a liquid, which process comprises contacting said liquid with a first chromatography resin comprised of a support to which multi-modal ligands have been immobilised to adsorb the antibodies to the resin, wherein each multi-modal ligand comprises at least one cation-exchanging group and at least one aromatic or heteroaromatic ring system; adding an eluent to release the antibodies from the resin; and contacting the eluate so obtained with a second chromatography resin. In one embodiment, the ring-forming atoms of the aromatic or heteroaromatic entity are selected from the group consisting of C, S and O, and the cation exchanging group is a weak cation exchanger.

    Abstract translation: 本发明涉及一种从液体中的一种或多种杂质纯化抗体的方法，该方法包括使所述液体与包含多元配体的载体的第一层析树脂接触以将抗体吸附到 所述树脂，其中每个多模式配体包含至少一个阳离子交换基团和至少一个芳族或杂芳族环系统; 添加洗脱液以从树脂中释放抗体; 并将如此获得的洗脱液与第二层析树脂接触。 在一个实施方案中，芳族或杂芳族实体的成环原子选自C，S和O，阳离子交换基团是弱阳离子交换剂。

    Optical Isomer separating filler
    26.
    发明申请
    Optical Isomer separating filler 有权
    光学异构体分离填料

    公开(公告)号：US20100041878A1

    公开(公告)日：2010-02-18

    申请号：US12449274

    申请日：2008-02-22

    Applicant: Atsushi Ohnishi ,  Yutaka Isobe

    Inventor： Atsushi Ohnishi ,  Yutaka Isobe

    IPC: C08B1/00 ,  C08B31/00

    CPC classification number: C07B57/00 ,  B01J20/286 ,  B01J20/29 ,  B01J20/3242 ,  B01J20/3253 ,  B01J20/328

    Abstract: Disclosed is an optical isomer separating filler having separating ability/separating characteristics different from those of conventional optical isomer separating fillers, which is capable of separating an optical isomer which cannot be separated by conventional fillers. Specifically disclosed is an optical isomer separating filler wherein a polysaccharide derivative is chemically bonded onto a support. This optical isomer separating filler is characterized in that the halogen content in the filler is 3.0 to 5.0%.

    Abstract translation: 公开了具有与常规光学异构体分离填料不同的分离能力/分离特性的光学异构体分离填料，其能够分离通过常规填料不能分离的旋光异构体。 具体公开了一种光学异构体分离填料，其中多糖衍生物化学键合到载体上。 该光学异构体分离填料的特征在于填料中的卤素含量为3.0-5.0％。

    Coated polydivinylbenzene beads
    30.
    发明授权
    Coated polydivinylbenzene beads 有权
    涂布聚二乙烯基苯珠

    公开(公告)号：US07553911B2

    公开(公告)日：2009-06-30

    申请号：US12080269

    申请日：2008-04-01

    Applicant: Howard C. Jordi ,  Qiding Mi

    Inventor： Howard C. Jordi ,  Qiding Mi

    IPC: C08F8/18

    CPC classification number: B01J20/265 ,  B01D15/34 ,  B01J20/28004 ,  B01J20/28033 ,  B01J20/28097 ,  B01J20/286 ,  B01J20/321 ,  B01J20/3253 ,  B01J2220/54 ,  B01J2220/58 ,  C08F8/10 ,  C08F8/22 ,  C08F8/32 ,  C08J9/40 ,  C08F112/36

    Abstract: The present invention provides novel, polymeric supports, methods of making, and methods of using the supports, that have a fluorinated, amidated surface. The supports include polymeric microbeads, thin layers or membranes, plates, monoliths and the like. The supports are useful as packing materials for normal phase, reverse phase, and size exclusion chromatography, and provide high speed separation of analytes with excellent resolution. The fluorinated, amidated surface may include a composition comprising a plurality of repeating units, for example, having the following structure:

    Abstract translation: 本发明提供具有氟化的酰胺化表面的新颖的聚合物载体，制备方法和使用载体的方法。 载体包括聚合物微珠，薄层或膜，板，整料等。 该载体可用作正相，反相和尺寸排阻层析的包装材料，并且以优异的分辨率提供分析物的高速分离。 氟化的酰胺化表面可以包括包含多个重复单元的组合物，例如具有以下结构：

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