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    ALDEHYDE-FUNCTIONALIZED POLYSACCHARIDES
    22.
    发明申请
    ALDEHYDE-FUNCTIONALIZED POLYSACCHARIDES 有权
    二氢功能多糖

    公开(公告)号：US20120142787A1

    公开(公告)日：2012-06-07

    申请号：US12973967

    申请日：2010-12-21

    申请人： Helen S. M. LU ,  STEVEN W. SHUEY

    发明人： Helen S. M. LU ,  STEVEN W. SHUEY

    IPC分类号： A61K47/36 ,  A61K47/38 ,  C07K14/62 ,  C07H7/02 ,  C07H3/00

    CPC分类号： C08B15/02 ,  C08B31/18 ,  C08B37/00 ,  C08B37/0018 ,  C08B37/0021 ,  C08B37/0054 ,  C08B37/0072 ,  C08L1/04 ,  C08L3/10 ,  C08L5/00 ,  C08L5/02 ,  C08L5/08 ,  C08L5/12

    摘要： Novel aldehyde-functionalized polysaccharide compositions containing pendant dialdehyde groups are described that are more stable in aqueous solution than oxidized polysaccharides. The aldehyde-functionalized polysaccharides may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.

    摘要翻译： 描述了含有侧链二醛基团的新型醛官能化多糖组合物，其在水溶液中比氧化多糖更稳定。 醛官能化多糖可以与各种含胺聚合物反应以形成可用于医学应用的水凝胶组织粘合剂和密封剂，例如伤口闭合，补充或替换缝合或缝合在内部外科手术如肠吻合和血管吻合中 ，组织修复，防止流体如血液，胆汁，胃肠道液体和脑脊液的渗漏，眼科手术，药物递送和预防手术后粘连。

    NEW POLYSACCHARIDE-BASED MATERIALS
    23.
    发明申请
    NEW POLYSACCHARIDE-BASED MATERIALS 审中-公开
    新型多糖基材料

    公开(公告)号：US20120122997A1

    公开(公告)日：2012-05-17

    申请号：US13381007

    申请日：2010-06-29

    申请人： Andrew P. Abbott ,  Andrew Ballantyne

    发明人： Andrew P. Abbott ,  Andrew Ballantyne

    IPC分类号： C08L3/00 ,  C09K3/18 ,  A23L1/058 ,  H01B1/12 ,  A23L1/27 ,  C08L1/00 ,  A61K47/36

    CPC分类号： C08L3/02 ,  C08K5/19 ,  C08K5/21 ,  C08K5/50 ,  C08L1/02 ,  C08L3/12 ,  C08L5/00 ,  C08L5/12 ,  C08L2666/26

    摘要： There is provided a plastic or gel material comprising a mixture of: (a) a compound of formula (I) or a mixture of two or more compounds of formula (I), (R−)n(Xn−) (I) or a hydrate thereof, wherein n, R+ and Xn− have meanings given in the description; (b) one or more uncharged organic compounds, each of which compounds comprises at least one oxygen atom and at least one hydrogen atom that is capable of forming a hydrogen bond with Xn−; and (c) one or more polysaccharides, wherein each polysaccharide is a polymer of pyranose monomers, at least 30% of which monomers are in the α-anomeric conformation. There is also provided articles formed from such materials, uses of such materials and processes for forming such materials.

    摘要翻译： 提供了一种塑料或凝胶材料，其包含以下混合物：（a）式（I）化合物或两种或更多种式（I），（R-）n（Xn-）（I）或 其水合物，其中n，R +和Xn-具有在说明书中给出的含义; （b）一种或多种不带电荷的有机化合物，其中的每一种化合物包含至少一个氧原子和至少一个能够与Xn-形成氢键的氢原子; 和（c）一种或多种多糖，其中每个多糖是吡喃糖单体的聚合物，其中至少30％的单体是α-端基异构体构型。 还提供由这种材料形成的制品，这种材料的使用和用于形成这种材料的方法。

    Bacterial cellulose-containing formulations
    26.
    发明授权
    Bacterial cellulose-containing formulations 有权
    含细菌纤维素的配方

    公开(公告)号：US08053216B2

    公开(公告)日：2011-11-08

    申请号：US11135077

    申请日：2005-05-23

    申请人： Zhi-Fa Yang ,  Neil A. Morrison ,  Todd A. Talashek ,  David F. Brinkmann ,  Don DiMasi ,  You Lung Chen

    发明人： Zhi-Fa Yang ,  Neil A. Morrison ,  Todd A. Talashek ,  David F. Brinkmann ,  Don DiMasi ,  You Lung Chen

    IPC分类号： C12P19/04

    CPC分类号： C08L1/286 ,  C08L1/02 ,  C08L5/06 ,  C08L5/12 ,  D21H11/00

    摘要： A new method to produce formulations of bacterial cellulose that exhibit improved viscosity-modifying properties particularly with low energy applied to effectuate viscosity changes therewith is provided. Such a method includes the novel co-precipitation with a water soluble co-agent that permits precipitation in the presence of excess alcohol to form an insoluble fiber that can than be utilized as a thickener or suspension aid without the need to introduce high energy mixing. Such bacterial cellulose properties have been available in the past but only through highly labor and energy intensive processes. Such an inventive method as now proposed thus provides a bacterial cellulose-containing formulation that exhibits not only properties that are as effective as those for previous bacterial celluloses, but, in some ways, improvements to such previous types. Certain end-use compositions and applications including these novel bacterial cellulose-containing formulations are also encompassed within this invention.

    摘要翻译： 提供了一种产生细菌纤维素制剂的新方法，其具有改善的粘度改性特性，特别是在施加低能量以实现其粘度变化的情况下。 这种方法包括与水溶性助剂的新型共沉淀，其允许在过量醇存在下沉淀以形成不能用作增稠剂或悬浮助剂而不需要引入高能量混合的不溶性纤维。 过去这种细菌纤维素的性质已经可以获得，但只能通过高度劳动和能量密集的方法。 因此，现在提出的这样一种本发明的方法提供了一种含细菌纤维素的制剂，其不仅具有与先前的细菌纤维素相同的效果，而且在某些方面表现出对这些以前类型的改进。 某些最终用途的组合物和应用包括这些新的含细菌纤维素的制剂也包括在本发明内。

    Biodegradable polymer composition
    27.
    发明授权
    Biodegradable polymer composition 失效
    可生物降解的聚合物组成

    公开(公告)号：US08026301B2

    公开(公告)日：2011-09-27

    申请号：US12299360

    申请日：2007-04-26

    申请人： Supreethi Sumanam

    发明人： Supreethi Sumanam

    IPC分类号： C08G18/38 ,  C08L1/00 ,  C08J3/20 ,  C08J3/22 ,  C12N1/00 ,  C12N1/12

    CPC分类号： C08L23/10 ,  C08K3/24 ,  C08K3/28 ,  C08K3/36 ,  C08K5/0033 ,  C08L1/00 ,  C08L1/02 ,  C08L5/12 ,  C08L23/02 ,  C08L23/04 ,  C08L23/06 ,  C08L25/06 ,  C08L27/06 ,  C08L89/00 ,  C08L2023/42 ,  C08L2205/035 ,  C08L2310/00 ,  C08L2666/02 ,  C08L2666/26

    摘要： The invention disclosed in this application relates to a novel biodegradable additive polymer composition useful for the preparation of biodegradable plastic products which comprises of a mixture of (i) a polymer selected from Polyethylene, polypropylene, poly styrene, poly vinyl chloride or a mixture thereof (ii) Cellulose (iii) Amides (iv) nutrients selected from Blue green algae and/or Yeast and (v) Water. This composition can be mixed with a virgin polymer to get a master polymer. The master batch composition may be mixed with a virgin polymer, which is useful for preparing products which are biodegradable.

    摘要翻译： 本申请中公开的发明涉及可用于制备可生物降解塑料制品的新型生物可降解添加剂聚合物组合物，其包含（i）选自聚乙烯，聚丙烯，聚苯乙烯，聚氯乙烯或其混合物的聚合物的混合物 ii）纤维素（iii）酰胺（iv）选自蓝绿藻和/或酵母和（v）水的营养物质。 该组合物可与原始聚合物混合以得到主聚合物。 母料组合物可与原始聚合物混合，其可用于制备可生物降解的产物。

    POLYMER MIXTURES OF ANIONIC AND CATIONIC POLYSACCHARIDES AND USE THEREOF
    28.
    发明申请
    POLYMER MIXTURES OF ANIONIC AND CATIONIC POLYSACCHARIDES AND USE THEREOF 有权
    阴离子和阳离子聚合物的聚合物混合物及其用途

    公开(公告)号：US20090197832A1

    公开(公告)日：2009-08-06

    申请号：US12301552

    申请日：2007-05-21

    申请人： Sergio Paoletti ,  Ivan Donati ,  Eleonora Marsich

    发明人： Sergio Paoletti ,  Ivan Donati ,  Eleonora Marsich

    IPC分类号： A61K31/722 ,  A61P29/00

    CPC分类号： A61L27/20 ,  A61L27/52 ,  C08L1/286 ,  C08L5/00 ,  C08L5/04 ,  C08L5/06 ,  C08L5/08 ,  C08L5/10 ,  C08L5/12 ,  C08L2666/26

    摘要： Described in the present application are compositions comprising mixtures of polyanionic polysaccharides and polycationic polysaccharides consisting of oligosaccharide derivatives of chitosan. In the compositions of the invention said mixtures have proven to be soluble in aqueous environments, despite ionic complexes forming between the acid polysaccharides and chitosan derivatives. Said compositions have also demonstrated significant rheological behaviour with an unexpected increase in viscosity and viscoelasticity, although the polysaccharides used have relatively low average molecular weights. The said solubility and rheological behaviour renders the compositions of the invention particularly advantageous from the biomedical application viewpoint, in particular for viscosupplementation and particularly in the field of articular pathologies and of ophthalmic surgery.

    摘要翻译： 在本申请中描述的是包含聚阴离子多糖和由壳聚糖的寡糖衍生物组成的聚阳离子多糖的混合物的组合物。 在本发明的组合物中，尽管在酸性多糖和壳聚糖衍生物之间形成了离子络合物，但所述混合物已证明可溶于水性环境。 尽管使用的多糖具有相对较低的平均分子量，但所述组合物也已经显示出显着的流变行为，其粘度和粘弹性的意外增加。 所述溶解度和流变行为使得本发明的组合物特别适用于生物医学应用的观点，特别是用于粘性补充，特别是在关节病理学和眼科手术领域。