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299 条记录 (耗时 0.023 秒)

    Preparation of alpha-cyanobenzyl esters
    26.
    发明授权
    Preparation of alpha-cyanobenzyl esters 失效
    α-氰基苄基酯的制备

    公开(公告)号：US4849536A

    公开(公告)日：1989-07-18

    申请号：US150953

    申请日：1988-02-01

    申请人： John M. Gruber

    发明人： John M. Gruber

    IPC分类号： C07C255/32

    CPC分类号： C07C253/00

    摘要： A process for the preparation of .alpha.-cyanobenzyl esters of cyclopropane carboxylic acids and substituted alkanoic acids by treating a carboxylic acid and a benzaldehyde with a metal cyanide, followed by treatment with a sulfonyl halide.

    摘要翻译： 通过用金属氰化物处理羧酸和苯甲醛，然后用磺酰卤处理，制备环丙烷羧酸和取代链烷酸的α-氰基苄酯的方法。

    Pharmaceutical phenylacetonitrile derivatives
    30.
    发明授权
    Pharmaceutical phenylacetonitrile derivatives 失效
    药用苯乙腈衍生物

    公开(公告)号：US4612313A

    公开(公告)日：1986-09-16

    申请号：US774354

    申请日：1985-09-10

    申请人： Herbert Leinert ,  Wolfgang Kampe ,  Klaus Strein ,  Bernd Muller-Beckmann ,  Wolfgang Bartsch

    发明人： Herbert Leinert ,  Wolfgang Kampe ,  Klaus Strein ,  Bernd Muller-Beckmann ,  Wolfgang Bartsch

    IPC分类号： A61K31/21 ,  A61K31/275 ,  A61K31/445 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07C67/00 ,  C07C253/00 ,  C07C255/24 ,  C07C255/32 ,  C07C255/42 ,  C07C255/43 ,  C07C255/53 ,  C07C255/58 ,  C07C255/59 ,  C07D207/08 ,  C07D211/22 ,  C07D241/04 ,  C07D295/16 ,  C07D295/18 ,  A61K31/495 ,  C07C121/80

    CPC分类号： C07C255/00 ,  C07D211/22

    摘要： The present invention provides phenylacetonitrile derivatives of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which can be the same or different, are hydrogen or haolgen atoms or alkyl, alkoxy, nitro, amino or acylamino radicals and two adjacent substituents can together also form a methylenedioxy or ethylenedioxy radical, A is a radical of the general formula: ##STR2## in which R.sub.6 is a straight-chained, cyclic or branched, saturated or unsaturated alkyl radical containing 2 to 12 carbon atoms, R.sub.7 is a hydrogen atom or a straight-chained or branched, saturated alkyl radical containing up to 6 carbon atoms, m and n, which can be the same or different, are 2 or 3, p is 1 or 2 and X is a straight-chained, cyclic or branched alkyl radical containing 2 to 10 carbon atoms which is optionally substituted by an amino group or is a grouping of the general formula: ##STR3## wherein Y and Z, which can be the same or different, are straight-chained or branched alkyl radicals containing up to 8 carbon atoms or cycloalkyl, alkylcycloalkyl or cycloalkylalkyl radicals, in which these radicals are optionally interrupted by an oxygen or sulphur atom, and one of the groups Z in general formula II can also be a hydrogen atom or both Z groups are joined to form a ring containing 4 to 6 carbon atoms which is optionally interrupted by a further nitrogen atom which can be substituted by alkyl or alkanoyl, the --O--NO.sub.2 groups being substituents of Y as well as of Z; as well as the salts thereof with physiologically acceptable acids.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.

    摘要翻译： 本发明提供以下通式的苯乙腈衍生物：其中R 1，R 2，R 3，R 4和R 5可以相同或不同，为氢或卤素原子或烷基，烷氧基，硝基，氨基或 酰基氨基和两个相邻的取代基可以一起形成亚甲二氧基或亚乙二氧基，A是下列通式的基团：其中R 6是含有2至12个直链的直链，环状或支链的饱和或不饱和烷基 碳原子，R7是氢原子或含有至多6个碳原子的直链或支链饱和烷基，m和n可相同或不同，为2或3，p为1或2，X为 是含有2至10个碳原子的直链，环状或支链烷基，其任选被氨基取代，或者是通式如下的基团：其中Y和Z可以相同或不同， 是直链或支链烷基基团 引入多达8个碳原子或环烷基，烷基环烷基或环烷基烷基，其中这些基团任选地被氧或硫原子中断，通式II中的基团Z之一也可以是氢原子或两个Z基团连接 形成含有4至6个碳原子的环，其任选被可被烷基或烷酰基取代的另外的氮原子中断，-O-NO 2基团是Y和Z的取代基; 以及其与生理上可接受的酸的盐。 本发明还提供了制备这些化合物的方法和含有它们的药物组合物。