公开(公告)号：US20170290780A1

公开(公告)日：2017-10-12

申请号：US15625054

申请日：2017-06-16

申请人： ICURE PHARMACEUTICAL INC.

发明人： Young Kweon Choi ,  Dong Hyun Hong ,  Seong Soo Kim

IPC分类号： A61K9/70 ,  A61K47/30

CPC分类号： A61K9/7084 ,  A61K9/70 ,  A61K31/40 ,  A61K31/445 ,  A61K47/30

摘要： The present invention relates to a transdermal composition for dementia treatment containing donepezil as an active ingredient. The transdermal composition according to the present invention contains highly concentrated donepezil in a hydrophobic matrix, can continuously release the drug for a long time by having excellent long-term adhesion to the skin, and further exhibits consistently effective therapeutic effects over a long period of time by having a significantly improved skin penetration rate in comparison with conventional donepezil patches.

公开(公告)号：US09765213B2

公开(公告)日：2017-09-19

申请号：US13355910

申请日：2012-01-23

申请人： Andrew Leonard Lewis ,  Steven Peter Armes ,  Andrew W. Lloyd ,  Jonathan P. Salvage

发明人： Andrew Leonard Lewis ,  Steven Peter Armes ,  Andrew W. Lloyd ,  Jonathan P. Salvage

IPC分类号： A61K47/30 ,  A61P35/00 ,  C08L53/00 ,  A61K9/107 ,  C08F293/00

CPC分类号： C08L53/00 ,  A61K9/1075 ,  C08F293/005 ,  C08L2666/02

摘要： An aqueous composition comprises an amphiphilic block copolymer, having a hydrophilic block comprising pendant zwitterionic groups and a hydrophobic block, and a biologically active compound associated with the polymer. The polymer is preferably in the form of micelles, and preferably the biological active is a hydrophobic drug. The hydrophilic block is preferably formed from acrylic monomer including phosphorylcholine groups. The hydrophobic group is suitably formed from monomer which has groups which can be ionised at useful pH's, especially tertiary amine groups. Micelles may be formed by dissolving the block copolymer in aqueous solvent at a pH at which the amine groups are protonated then raising the pH to a value at which the amine groups are substantially deprotonated, whereupon micelles spontaneously form. The preformed micelles are then contacted with active, under conditions such that solubilisation of the active occurs. The active may be for tumour treatment.

公开(公告)号：US20170173061A1

公开(公告)日：2017-06-22

申请号：US15381877

申请日：2016-12-16

申请人： University of Georgia Research Foundation, Inc.

发明人： Jamie A. Cooper

IPC分类号： A61K31/7016 ,  A23L33/125 ,  A61K9/70 ,  A61K9/00 ,  A61K47/30 ,  A61K9/08

CPC分类号： A61K31/7016 ,  A23L33/125 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/7007

摘要： Disclosed are compositions, articles, and method for enhancing exercise performance in a subject. The method involves contacting the oral cavity of the subject with a composition comprising a sweet and caloric food product for a period sufficient to cause a cephalic phase response in the subject.

公开(公告)号：US09623094B2

公开(公告)日：2017-04-18

申请号：US13260661

申请日：2010-03-26

申请人： Moti Harel ,  Brian Carpenter

发明人： Moti Harel ,  Brian Carpenter

IPC分类号： A61K39/12 ,  A61K39/02 ,  A61P31/14 ,  A61K47/36 ,  A61K9/14 ,  A61P31/00 ,  A61K47/30 ,  A61K39/00 ,  A61K9/00 ,  A61K39/145

CPC分类号： A61K39/39 ,  A61K9/0043 ,  A61K9/006 ,  A61K9/5015 ,  A61K39/00 ,  A61K39/0208 ,  A61K39/0233 ,  A61K39/0241 ,  A61K39/12 ,  A61K39/145 ,  A61K39/21 ,  A61K2039/522 ,  A61K2039/5254 ,  A61K2039/5258 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/55555 ,  A61K2039/55583 ,  C12N7/00 ,  C12N2720/10011 ,  C12N2720/10023 ,  C12N2720/10034 ,  C12N2740/10011 ,  C12N2740/10034 ,  C12N2760/10034 ,  C12N2760/16011 ,  C12N2760/16022 ,  C12N2760/16034

摘要： The invention relates to a composition and a method for manufacturing semi-dry or dry particles containing a mucoadhesive polymer and a bioactive agent such as, but not limited to, an Immunogenic Substance (e.g., a vaccine), that allows the oral or nasal administration and delivery of the bioactive agent essentially unaltered to mucosal surfaces in the animal, including an aquatic animal.

公开(公告)号：US09549846B2

公开(公告)日：2017-01-24

申请号：US14809827

申请日：2015-07-27

申请人： Transcend Medical, Inc.

发明人： Luke Clauson ,  Thomas A. Silvestrini ,  Tsontcho Ianchulev ,  Steven John

IPC分类号： A61F9/00 ,  A61M27/00 ,  A61K9/00 ,  A61K31/00 ,  A61K47/30 ,  A61F9/007

CPC分类号： A61F9/0017 ,  A61F9/00781 ,  A61K9/0024 ,  A61K9/0048 ,  A61K31/00 ,  A61K47/30 ,  A61M27/002 ,  A61M2210/0606 ,  Y02A50/491

摘要： This disclosure relates generally to methods and devices for use in treating eye conditions with implantable drug delivery devices. One method includes introducing an implant into the suprachoroidal space, wherein the interior volume of the implant is plugged with a drug-release material comprising at least one active agent that elutes through at least one opening in the implant, wherein the drug-release material degrades from the interior volume of the implant over a period time.

摘要翻译： 本公开一般涉及用于用可植入药物递送装置治疗眼睛状况的方法和装置。 一种方法包括将植入物引入脉络膜上空间，其中植入物的内部体积用药物释放材料堵塞，所述药​​物释放材料包含至少一种通过植入物中的至少一个开口洗脱的活性剂，其中药物释放材料降解 从植入物的内部体积在一段时间内。

公开(公告)号：US20160375138A1

公开(公告)日：2016-12-29

申请号：US15189009

申请日：2016-06-22

申请人： The Procter & Gamble Company

发明人： Anju Deepali MASSEY-BROOKER ,  Mauro VACCARO ,  Stefano SCIALLA ,  Claudia CRESTINI ,  Heiko LANGE

IPC分类号： A61K47/30 ,  C11D3/382 ,  C11D17/06 ,  C11D3/00

CPC分类号： A61K47/30 ,  A61K8/72 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/00 ,  C07G1/00 ,  C08H6/00 ,  C08L97/005 ,  C09G1/00 ,  C11D3/0084 ,  C11D3/382 ,  C11D17/06

摘要： The present invention relates to a consumer goods product comprising a consumer goods product ingredient and a functionalised lignin oligomer, wherein the functionalised lignin oligomer: (a) comprises less than 1 wt % sulphur content; (b) has a number average molecular weight (Mn) of from 800 Da to 1,800 Da; and (c) comprises at least one functional group selected from carboxyl, ketone, aldehyde, amino and quaternary ammonium, wherein only one type of functional group selected from the group consisting of list is present at a level of at least 0.8 mmol/g, and wherein if any other functional group selected from the group consisting of list is present, it is present at a level of below 0.8 mmol/g, wherein the lignin oligomer is derived from corn, sugar cane, wheat and any combination thereof, and wherein the consumer goods product is selected from an oral care composition, an antiseptic cream, or a detergent composition.

摘要翻译： 本发明涉及包含消费品产品成分和功能化木质素低聚物的消费品产品，其中所述官能化木质素低聚物：（a）包含小于1重量％的硫含量; （b）数均分子量（Mn）为800Da至1,800Da; 和（c）包含至少一种选自羧基，酮，醛，氨基和季铵的官能团，其中只有一种选自列表的官能团以至少0.8mmol / g的量存在， 并且其中如果存在选自列表中的任何其它官能团，则其存在的水平低于0.8mmol / g，其中所述木质素低聚物衍生自玉米，甘蔗，小麦及其任何组合，并且其中 消费品产品选自口腔护理组合物，防腐霜或洗涤剂组合物。

公开(公告)号：US09526699B2

公开(公告)日：2016-12-27

申请号：US11568851

申请日：2006-11-03

申请人： Soo-Chang Song ,  Sun-Mi Lee ,  Chang-Won Kim ,  Mi-Ran Park

发明人： Soo-Chang Song ,  Sun-Mi Lee ,  Chang-Won Kim ,  Mi-Ran Park

IPC分类号： A61K38/00 ,  C08G79/02 ,  A61K9/00 ,  A61K38/02 ,  A61K39/00 ,  A61K48/00 ,  A61K47/30 ,  A61K38/21 ,  A61K38/26 ,  A61K38/18 ,  A61K38/20 ,  A61K38/28 ,  A61K38/23 ,  A61K38/27 ,  A61K39/395 ,  A61K39/29 ,  A61K31/337 ,  A61K31/704 ,  A61K9/06 ,  A61K9/08 ,  A61K47/34 ,  A61K47/48

CPC分类号： A61K9/06 ,  A61K9/0024 ,  A61K9/08 ,  A61K47/34 ,  A61K47/6903 ,  C08G79/025

摘要： The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.

摘要翻译： 本发明涉及具有官能团的生物可降解和热敏聚（有机膦腈），其制备方法及其用于递送生物活性物质的用途。 根据本发明，聚（有机膦腈）是基于温度变化显示生物降解性，热敏性和溶胶 - 凝胶相变的基于磷酸酯的聚合物，其中当用生物活性物质如药物施用于生物体时，聚（有机膦腈 ）在体温下形成凝胶相以能够控制释放生物活性物质。 此外，聚（有机膦腈）具有通过离子键，共价键或配位共价键与生物活性物质化学结合的官能团，由于其良好的结合性能，能够持续释放生物活性物质。 因此，聚（有机膦腈）可用作生物活性物质的递送材料。

公开(公告)号：US09504771B2

公开(公告)日：2016-11-29

申请号：US13103885

申请日：2011-05-09

申请人： Robert L. Cleek ,  Edward H. Cully ,  Jeffrey B. Duncan ,  Theresa A. Holland ,  Thomas R. McDaniel ,  Christine M. Scotti

发明人： Robert L. Cleek ,  Edward H. Cully ,  Jeffrey B. Duncan ,  Theresa A. Holland ,  Thomas R. McDaniel ,  Christine M. Scotti

IPC分类号： A61N1/05 ,  A61K47/30 ,  A61K47/32 ,  A61K31/56 ,  A61F2/01 ,  A61P29/00 ,  A61K31/573 ,  A61P7/02 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16

CPC分类号： A61L31/10 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/222 ,  A61L2300/608 ,  A61L2420/08 ,  A61N1/056 ,  A61N1/0568

摘要： The present invention relates to materials having therapeutic compositions releasably contained within the materials. The materials are configured to release therapeutic compositions at a desired rate. The present invention also relates to devices incorporating the materials.

公开(公告)号：US09481767B2

公开(公告)日：2016-11-01

申请号：US14624262

申请日：2015-02-17

申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY

发明人： Sung-Chul Yoon ,  Mun-Hwan Choi ,  Mohsin Shah

IPC分类号： C08G81/00 ,  A61K9/16 ,  A61K47/30 ,  C08J3/12 ,  C08G63/664 ,  C08G63/91 ,  A61K9/00 ,  A61K9/48 ,  A61K9/51

CPC分类号： C08G81/00 ,  A61K9/0019 ,  A61K9/4866 ,  A61K9/5146 ,  C08G63/664 ,  C08G63/912

摘要： The present invention relates to poly(4-hydroxybutyrate)-b-monomethoxy(polyethylene glycol) copolymer nanoparticles, a method for preparing the same, and a pharmaceutical composition including the same as an active ingredient for treating brain disorders, in which the P(4HB)-b-mPEG nanoparticles according to the present invention break down slowly in brain cells such that gamma-hydroxybutyric acid (GHB) is released and so can sustainedly release a therapeutic level of concentration of GHB which is used as an agent for treating brain disorders such as epilepsy, and the nanoparticles are in the form of a hydrophobic polymer and so cannot easily be used as a hallucinogenic agent or narcotic agent due to the hydrophobic property whereby said nanoparticles do not dissolve in water or alcohol, and so can be used more safely than existing GHB, and hence, can advantageously be used instead of prior-art GHB therapeutic agents.

摘要翻译： 本发明涉及聚（4-羟基丁酸酯）-b-单甲氧基（聚乙二醇）共聚物纳米粒子，其制备方法，以及包含该组合物作为治疗脑部疾病的活性成分的药物组合物，其中P（ 4HB）-b-mPEG纳米颗粒在脑细胞中缓慢分解，使得γ-羟基丁酸（GHB）释放，因此可以持续释放用作治疗脑的药物的GHB浓度的治疗水平 疾病如癫痫和纳米颗粒是疏水性聚合物的形式，因此由于疏水性而不能容易地用作致幻剂或麻醉剂，由此所述纳米颗粒不溶于水或醇，因此可以使用 比现有GHB更安全，因此可以有利地代替现有技术的GHB治疗剂。

公开(公告)号：US09408908B2

公开(公告)日：2016-08-09

申请号：US13768694

申请日：2013-02-15

申请人： University of Saskatchewan ,  The University of British Columbia ,  Dalhousie University ,  International Vaccine Institute

发明人： Sylvia van den Hurk ,  Volker Gerdts ,  Andrew Potter ,  Lorne Babiuk ,  Robert Hancock ,  Scott Halperin ,  Jennifer Kovacs-Nolan ,  George Mutwiri ,  Song Lee ,  Mi-Na Kweon ,  Jason Kindrachuk ,  Melissa Elliott

IPC分类号： A61K39/39 ,  A61K39/12 ,  A61K47/30 ,  A61K45/06 ,  A61K39/155 ,  C07K7/08 ,  A61K39/02 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K39/099 ,  A61K39/12 ,  A61K39/155 ,  A61K45/06 ,  A61K47/30 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/6093 ,  C07K7/08 ,  C12N2760/18534

摘要： Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.