公开(公告)号：US10206945B2

公开(公告)日：2019-02-19

申请号：US14263387

申请日：2014-04-28

申请人： BioInteractions Ltd.

发明人： Simon Onis ,  Fanny Burrows ,  Krishan Kapoor ,  Alan Rhodes ,  Ajay Luthra

IPC分类号： A61K31/728 ,  A61K47/32 ,  A61K31/131 ,  A61K9/00 ,  A61K31/727 ,  A61K31/14 ,  A61L27/16 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L29/04 ,  A61L29/08 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  A61L33/00 ,  A61L33/06

摘要： Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.

公开(公告)号：US20180326118A1

公开(公告)日：2018-11-15

申请号：US16042945

申请日：2018-07-23

申请人： Carmeda AB

发明人： Stefan Oscarson ,  Martina Lahmann ,  Karin Leontein ,  Robert Vestberg

IPC分类号： A61L27/34 ,  A61L33/08 ,  A61L33/06 ,  A61L33/00 ,  A61L27/54

CPC分类号： A61L27/34 ,  A61L27/54 ,  A61L33/0029 ,  A61L33/0035 ,  A61L33/0076 ,  A61L33/068 ,  A61L33/08 ,  A61L2300/236 ,  A61L2300/42 ,  A61L2300/608 ,  A61L2400/04

摘要： There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.

公开(公告)号：US09956324B2

公开(公告)日：2018-05-01

申请号：US15244506

申请日：2016-08-23

申请人： TERUMO KABUSHIKI KAISHA

发明人： Takao Anzai ,  Kaori Nishida

IPC分类号： A61L31/00 ,  A61L33/06 ,  A61L27/34 ,  A61L31/10 ,  C08F222/28 ,  C09D133/14 ,  C08F220/28

CPC分类号： A61L33/068 ,  A61L27/34 ,  A61L31/10 ,  A61L33/0041 ,  A61L2300/42 ,  A61L2420/00 ,  C08F220/28 ,  C08F2220/281 ,  C08L33/08 ,  C08L33/10 ,  C08L33/26 ,  C09D133/14 ,  C08F2220/606

摘要： The disclosure relates to a medical material including a copolymer having a repeating unit (A) represented by the following formula (1): wherein R11 is a hydrogen atom or a methyl group, Z is an oxygen atom or —NH—, R12 is a C1-6 alkylene group, R13 and R14 are each independently a C1-4 alkyl group, and R15 is a C1-6 alkylene group, and a repeating unit (B) represented by the following formula (2): wherein R21 is a hydrogen atom or a methyl group, R22 is a C1-6 alkylene group, and R23 is a C1-4 alkyl group. The repeating unit (A) is contained in a proportion of 0.6 to 7 mol % based on all the structural units of the copolymer. The disclosure makes it possible to provide a medical material and a medical device, which exhibit excellent antithrombogenicity even when used under severe conditions prone to thrombus formation.

公开(公告)号：US09895470B2

公开(公告)日：2018-02-20

申请号：US12632686

申请日：2009-12-07

申请人： Jun Li ,  Trevor Squier ,  Zheng Zhang ,  Chad Huval ,  William Shannan O'Shaughnessy ,  Michael Hencke ,  Michael Bouchard ,  Christopher R. Loose

发明人： Jun Li ,  Trevor Squier ,  Zheng Zhang ,  Chad Huval ,  William Shannan O'Shaughnessy ,  Michael Hencke ,  Michael Bouchard ,  Christopher R. Loose

IPC分类号： A61L33/06 ,  A61L27/34 ,  A61L27/50 ,  A61L29/08 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  C07H23/00 ,  C09D5/16 ,  C09D151/00 ,  C09D151/06 ,  C09D151/08 ,  C08L75/04 ,  C08L25/08

CPC分类号： A61L33/06 ,  A61L27/14 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  C08F4/40 ,  C08F265/04 ,  C08F283/00 ,  C08F283/006 ,  C08F291/18 ,  C08L25/08 ,  C08L75/04 ,  C09D5/1637 ,  C09D5/1693 ,  C09D151/003 ,  C09D151/06 ,  C09D151/08 ,  C09D151/085 ,  C08F220/38 ,  C08F220/56 ,  C08L2666/02

摘要： Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.

公开(公告)号：US09895468B2

公开(公告)日：2018-02-20

申请号：US15449752

申请日：2017-03-03

申请人： BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA ,  NORTHWESTERN UNIVERSITY

发明人： Ton That Hai ,  John-Bruce Devault Green ,  Timothy Michael Fulghum ,  Phillip Byron Messersmith ,  Tadas Stanislovas Sileika

IPC分类号： A61L29/16 ,  A61L29/08 ,  A61L33/06 ,  A61L33/04 ,  A61L33/00 ,  A61L29/06

CPC分类号： A61L33/0017 ,  A61L27/54 ,  A61L29/06 ,  A61L29/085 ,  A61L29/16 ,  A61L31/048 ,  A61L31/06 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/0094 ,  A61L33/04 ,  A61L33/068 ,  A61L33/08 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02

摘要： The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

公开(公告)号：US20180028726A1

公开(公告)日：2018-02-01

申请号：US15551781

申请日：2016-03-08

申请人： NATIONAL UNIVERSITY CORPORATION YAMAGATA UNIVERSITY ,  OTSUKA CHEMICAL CO., LTD.

发明人： Masaru TANAKA ,  Hiroyuki ISHITOBI

IPC分类号： A61L33/06 ,  A61L31/16 ,  C08F293/00 ,  A61L31/10

CPC分类号： A61L33/064 ,  A61L29/00 ,  A61L31/00 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/42 ,  A61P7/02 ,  C08F293/005 ,  C08F297/00

摘要： The present invention addresses the problem of providing a block copolymer that has excellent adhesion to a base material and that can impart excellent antithrombogenicity to the base material surface, and providing a medical device comprising the block copolymer. The block copolymer according to the present invention comprises an A block and a B block. The A block is capable of containing intermediate water. The B block is more hydrophobic than the A block. The medical device according to the present invention is obtained by coating a medical device with an antithrombotic coating agent containing the block copolymer.

公开(公告)号：US20170368237A1

公开(公告)日：2017-12-28

申请号：US15684007

申请日：2017-08-23

申请人： W. L. Gore & Associates, Inc.

发明人： Karin Leontein ,  Per Antoni ,  Daniel Nyström ,  Paul Begovac ,  Krzysztof Pietrzak

IPC分类号： A61L33/00 ,  A61L27/34 ,  A61L31/10 ,  A61L33/08 ,  A61L33/06 ,  C08G81/00 ,  A61L29/08

摘要： There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.

公开(公告)号：US20170224884A1

公开(公告)日：2017-08-10

申请号：US15484193

申请日：2017-04-11

申请人： Medtronic ATS Medical, Inc.

发明人： Brian Pederson

IPC分类号： A61L33/00 ,  A61L33/06 ,  A61L33/12

CPC分类号： A61L33/0041 ,  A61L33/0094 ,  A61L33/062 ,  A61L33/126 ,  A61L33/128 ,  A61L2300/42 ,  A61N1/05 ,  A61N1/375 ,  Y10T428/31768

摘要： A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.

公开(公告)号：US09694117B2

公开(公告)日：2017-07-04

申请号：US14627351

申请日：2015-02-20

申请人： TERUMO KABUSHIKI KAISHA

发明人： Takao Anzai

IPC分类号： A61L33/06

CPC分类号： A61L33/064

摘要： A medical material that is excellent in antithrombogenicity even under a severe use condition in which thrombi are easily formed, is provided. The medical material contains a water-insoluble copolymer including a repeating unit (A) (which is derived from acryloylmorpholine, for example) and a repeating unit (B) (which is derived from methoxyethyl acrylate, for example), in which the water-insoluble copolymer has 5 mole % to 20 mole % of the repeating unit (A) with respect to all constituent units of the copolymer.

公开(公告)号：US20170173219A1

公开(公告)日：2017-06-22

申请号：US15388820

申请日：2016-12-22

申请人： Access Vascular, Inc.

发明人： James F. Biggins ,  Michael Bassett ,  Daniel Donahue

IPC分类号： A61L29/04 ,  A61L29/18 ,  A61L29/02 ,  C08J9/00 ,  A61L33/06 ,  A61L33/00 ,  C08J9/28 ,  A61L29/14 ,  A61L29/16

CPC分类号： A61L29/041 ,  A61L17/10 ,  A61L27/16 ,  A61L27/56 ,  A61L29/02 ,  A61L29/049 ,  A61L29/146 ,  A61L29/16 ,  A61L29/18 ,  A61L33/007 ,  A61L33/064 ,  A61L2300/42 ,  A61L2400/12 ,  A61M25/005 ,  B29C48/00 ,  B29C48/05 ,  B29C48/78 ,  B29C48/865 ,  B29C67/0029 ,  B29K2105/04 ,  B29L2031/753 ,  C08J9/0061 ,  C08J9/0066 ,  C08J9/28 ,  C08J2201/03 ,  C08J2201/0546 ,  C08J2205/042 ,  C08J2205/044 ,  C08J2207/10 ,  C08J2329/04 ,  C08J2433/02 ,  D01F1/08 ,  D01F6/14 ,  D01F6/50 ,  C08L29/04

摘要： High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces.