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公开(公告)号：US12041381B2
公开(公告)日：2024-07-16
申请号：US17602438
申请日：2020-04-08
Inventor： Zachary Balcar , Ayetullah Baha Biten , Sara Ahmed , Samer Dessouky , Jerome Helffrich
IPC: G08G1/04 , G01J5/00 , G01J5/48 , G01S11/12 , G06V10/764 , G06V10/82 , G06V20/54 , G08G1/01 , G08G1/015 , G08G1/052 , H04N5/33 , G06T7/246
CPC classification number: H04N5/33 , G01J5/0022 , G01J5/485 , G01S11/12 , G06V10/764 , G06V10/82 , G06V20/54 , G08G1/0116 , G08G1/015 , G08G1/04 , G08G1/052 , G06T7/246 , G06T2207/10048 , G06T2207/20084 , G06T2207/30236
Abstract: The present disclosure relates to systems and methods for passive infrared sensing and detection of vehicular traffic. Vehicle parameters are detected using thermal detection states of pixels of an infrared array sensor. The vehicle parameters can include a velocity of a vehicle. A vehicle record that includes the vehicle parameters can be provided, for example, by a computing device in connection with the infrared array sensor.
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292.发明公开公开(公告)号：US20240223000A1
公开(公告)日：2024-07-04
申请号：US18409972
申请日：2024-01-11
Applicant: National Technology & Engineering Solutions of Sandia, LLC , The Board of Regents of the University of Texas System , Wayne State University
Inventor： Jason E. Heath , Gungor Didem Beskardes , Wallace McAliley , Chester J. Weiss , Mohsen Ahmadian-Tehrani , David T. Chapman , Leela Arava
IPC: H02J7/02 , E21B43/267 , E21B47/06 , E21B47/07 , E21B47/13 , E21B49/00 , E21B49/08 , G01D21/02 , H02J50/00 , H02J50/80
CPC classification number: H02J7/02 , E21B43/267 , E21B47/06 , E21B47/07 , E21B47/13 , E21B49/00 , E21B49/0875 , G01D21/02 , H02J50/001 , H02J50/80 , E21B2200/20
Abstract: Autonomous wireless sensors in subsurface environments can be charged while present in the subsurface environment to allow the sensors to measure and wirelessly transmit measurements. The sensors rely upon a contrast agent to provide a power flow path to the sensors.
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公开(公告)号：US20240216515A1
公开(公告)日：2024-07-04
申请号：US18283406
申请日：2022-03-21
Inventor： Michael Torres , Daniel J. Siegwart , Jackson Eby , Rumpa Bhattacherjee , Brandon Wustman , Vladimir Kharitonov , Qiang Cheng , Tuo Wei
IPC: A61K47/54 , A61K47/14 , A61K47/24 , A61K47/28 , C12N15/113
CPC classification number: A61K47/543 , A61K47/14 , A61K47/24 , A61K47/28 , A61K47/545 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/531
Abstract: Described herein are compositions, kits, and methods for potent delivery to a ceil of a subject. The cell can be of a particular cell type, such as a basal cell. In some cases, the cell can be a lung cell of a particular cell type. Also described herein are pharmaceutical compositions comprising a therapeutic or prophylactic agent assembled with a lipid composition. Tire lipid composition can comprise an ionizable cationic lipid, and a selective organ targeting lipid. The lipid composition can further comprise a phospholipid. Further described herein are high-potency intravenous dosage forms of a therapeutic or prophylactic agent formulated with a lipid composition.
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公开(公告)号：US12024486B2
公开(公告)日：2024-07-02
申请号：US18335974
申请日：2023-06-15
Inventor： Daniel J. Siegwart , Kejin Zhou
IPC: A61K9/51 , A61K31/7105 , A61K31/7125 , A61K47/20 , A61K47/22 , A61K47/59 , A61K47/60 , A61K47/69 , A61K48/00 , C07C321/14 , C07C323/52 , C07D295/15
CPC classification number: C07C321/14 , A61K9/513 , A61K9/5146 , A61K31/7105 , A61K31/7125 , A61K47/20 , A61K47/22 , A61K47/59 , A61K47/60 , A61K47/6931 , A61K48/0041 , C07C323/52 , C07D295/15
Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.
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295.发明公开公开(公告)号：US20240207442A1
公开(公告)日：2024-06-27
申请号：US18556614
申请日：2022-04-22
Inventor： Daniel J. SIEGWART , Lukas FARBIAK
CPC classification number: A61K48/0041 , A61K9/5123 , A61K48/005 , C12N9/22 , C12N15/102 , C12N15/11 , C12N15/88 , C12N15/907 , C12N2310/20
Abstract: In some aspects, the present disclosure provides compositions comprising one or more of each of the following nucleic acids: (1) a mRNA; (2) a sgRNA; and (3) a DNA; and a lipid nanoparticle comprising at least one ionizable lipid; wherein the each of the nucleic acids are encapsulated within the lipid nanoparticle, and pharmaceutical compositions thereof. The present disclosure also provides methods employing said compositions and/or pharmaceutical compositions, such as methods of repairing genes, methods of performing homology directed repair on the genome, and methods of treating diseases or disorders.
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Patent Agency Ranking
公开(公告)号：USD1031044S1
公开(公告)日：2024-06-11
申请号：US29830187
申请日：2022-03-10
Designer： Xiaosong Meng
Abstract: FIG. 1 is a perspective view of a endorectal coil holder, showing my new design;
FIG. 2 is a right side elevational view thereof;
FIG. 3 is a left side elevational view thereof;
FIG. 4 is a rear elevational view thereof;
FIG. 5 is a front elevational view thereof;
FIG. 6 is a top plan view thereof;
FIG. 7 is a bottom plan view thereof; and,
FIG. 8 a perspective, environmental view thereof.
The broken lines shown in the Figures are environment only and show portions of the endorectal coil holder that form no part of the claimed design. The broken lines immediately adjacent the shaded areas represent the bounds of the claimed design while all other broken lines are directed to environment and are for illustrative purposes only; the broken lines form no part of the claimed design.
The shade lines in the Figures show contour and do not claim surface ornamentation or treatment.-
公开(公告)号：US11999778B2
公开(公告)日：2024-06-04
申请号：US16301187
申请日：2017-05-12
Inventor： Nancy Monson
IPC: C07K16/18 , A61P25/28 , C12N15/113
CPC classification number: C07K16/18 , A61P25/28 , C12N15/113 , C07K2317/21 , C07K2317/56 , C12N2310/11 , C12N2310/14
Abstract: The present disclosure in various aspects provides methods for making pharmaceutical compositions for treating neurodegenerative diseases (e.g., demyelinating diseases), such as but not limited to multiple sclerosis, neuromyelitis optica, and transverse myelitis. The pharmaceutical compositions impact specific antibody-mediated processes involved in the biology of neurodegenerative disease. In certain aspects, the disclosure provides pharmaceutical compositions for treating neurodegenerative disease, which are based on inhibiting the action of pathologic antibodies, or alternatively providing antibodies to stimulate neuroprotection or repair processes.
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公开(公告)号：US11992319B2
公开(公告)日：2024-05-28
申请号：US16664329
申请日：2019-10-25
Inventor： Paul Yoonsu Choi , Bong Kyun Kim , Bernardo Garza
CPC classification number: A61B5/24 , A61B5/6877 , A61F2/72 , A61N1/0551 , H01B17/60 , A61B2562/0209 , A61B2562/028 , A61B2562/12
Abstract: Neural interfaces with the peripheral nervous system have been developed to provide a direct communication pathway between peripheral nerves and prosthetic limbs. Described herein is a method of making a microchannel integrated neural interface device comprising a plurality of hollow cylindrical electrodes in a PDMS scaffold, which can control the reinnervated muscles and interpret neurological signals. The acquired bioelectrical signals can be used for the interpretation of mind and create a neural map.
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公开(公告)号：US20240150719A1
公开(公告)日：2024-05-09
申请号：US18547408
申请日：2022-02-21
Inventor： Brijesh S. GILL , Charles S. COX, Jr.
CPC classification number: C12N5/0662 , C12M23/48 , C12M27/10 , C12M35/04 , C12M35/06 , C12N5/0075 , C12N13/00 , C12N2527/00
Abstract: Apparatus and methods for culturing cells in a cell culture medium including magnetic beads in a fluid. A variable magnetic field can be applied to the magnetic beads to create shear forces on cells on the surface of the beads. In certain embodiments, a rotational force can also be applied to the magnetic beads and the magnetic force can counteract the rotational force.
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公开(公告)号：US20240141330A1
公开(公告)日：2024-05-02
申请号：US18409612
申请日：2024-01-10
Inventor： Ralf KITTLER , John D. MINNA , Paul M. YENERALL
CPC classification number: C12N15/1082 , G01N33/5011
Abstract: Disclosures herein are directed to methods and compositions for the detection of and screening for mutations that convey phenotypic properties in a protein such as, for example, drug-resistance. Embodiments of the present disclosure include lentiviral-based compositions for enhanced mutagenesis and screening of genes encoding proteins of interest that confer drug resistance according to methods disclosed herein.
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