公开(公告)号：US10046290B2

公开(公告)日：2018-08-14

申请号：US15203420

申请日：2016-07-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dong Ju Moon ,  Gi Hoon Hong ,  Jae Suk Lee ,  Jae Sun Jung ,  Eun Hyeok Yang ,  Sung Soo Lim ,  Young Su Noh ,  Ji In Park

IPC: B01J8/06 ,  F28D7/10 ,  B01J8/22

Abstract: The present disclosure relates to a shell-and-multi-triple concentric-tube reactor and a shell-and-multi-triple concentric-tube heat exchanger, and to a shell-and-multi-triple concentric-tube reactor and a shell-and-multi-triple concentric-tube heat exchanger which provide a new type of reactor and heat exchanger, thereby maximizing catalyst performance and improving performance of the reactor by optimizing heat exchange efficiency and a heat flow, uniformly distributing a reactant, and increasing a flow rate of the reactant, and accordingly making the reactor and the heat exchanger compact.

公开(公告)号：US10035795B1

公开(公告)日：2018-07-31

申请号：US15480839

申请日：2017-04-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun Joo Roh ,  Bo Ra Mi Jeon ,  Chang Joon Lee ,  Jin Pyo Hong ,  Joo Yeon Jeong ,  Sang Soo Kang

IPC: C07D417/06 ,  C07D279/28

CPC classification number: C07D417/06 ,  C07D279/28

Abstract: The present invention provides a phenothiazine derivative or a pharmaceutically acceptable salt thereof, a method of preparing a compound selected therefrom and a pharmaceutical composition containing the compound as an active ingredient. The phenothiazine derivative according to the present invention has an effect of inhibiting calmodulin (CaM; calcium-modulated protein) and thus helps cell death by maintaining the intracellular level of calcium in lung cancer cells at high concentration. Accordingly, the phenothiazine derivative according to the present invention can be usefully used to prevent or treat malignant tumors such as lung cancer.

公开(公告)号：US10030496B2

公开(公告)日：2018-07-24

申请号：US14439224

申请日：2013-08-01

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hong Gon Kim ,  Min Jae Ko ,  Ju Hee Kim ,  Young Sang Cho ,  Jae Ik Kim ,  Kang-Bong Lee ,  In-Hwan Oh

IPC: E21B43/295 ,  C01B3/06 ,  E21B43/16

Abstract: The present disclosure relates to a method for producing a synthesis gas using a solid acid, more particularly to a method for producing a synthesis gas using a solid acid capable of remarkably decreasing production of environmental pollutants such as carbon dioxide, which includes producing hydrogen by reacting a solid acid with water and producing a synthesis gas by reacting the produced hydrogen with a carbon compound.

公开(公告)号：US20180202970A1

公开(公告)日：2018-07-19

申请号：US15861998

申请日：2018-01-04

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： So Young LEE ,  Hyoung-Juhn Kim ,  Young Seung Na ,  Jin Young Kim ,  Sung Jong Yoo ,  Jong Hyun Jang ,  Jonghee Han ,  Suk Woo Nam

IPC: G01N27/62 ,  G01R27/26 ,  G01K13/00

Abstract: An ionic conductivity measurement device of an electrolytic membrane includes a humidification chamber configured to accommodate an ion-conductive electrolytic membrane and having concave grooves respectively formed at both sides thereof which face the electrolytic membrane to form a measurement space for measuring ionic conductivity of the electrolytic membrane; a plurality of channels formed at a bottom surface of each of the concave grooves; a gas distribution unit detachably coupled to each of the concave grooves with the electrolytic membrane being interposed therebetween; and a plurality of electrodes provided in contact with one side of the electrolytic membrane and supported by the gas distribution unit, the plurality of electrodes being disposed side by side to measure an impedance of the electrolytic membrane.

公开(公告)号：US10020536B2

公开(公告)日：2018-07-10

申请号：US15404708

申请日：2017-01-12

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyoung Chul Kim ,  Sung Jun Choi ,  Jeong Hun Kim ,  Wo Dum Jung ,  Hun Gi Jung ,  Ji Won Son ,  Jong Ho Lee ,  Byung Kook Kim ,  Hae Weon Lee

IPC: H01M10/052 ,  H01M10/0562

CPC classification number: H01M10/0562 ,  C01B17/20 ,  C01B17/22 ,  H01M2300/0068

Abstract: A method for preparing a sulfide-based solid electrolyte which is stable upon exposure to the air is provided. Specifically, a stabilization layer is formed on the surface of a sulfide-based solid electrolyte particle through treatment with a reactive gas.The sulfide-based solid electrolyte with superior air stability can be obtained because oxidation or reduction reactions with water, etc. in the air occur on the stabilization layer rather than on the sulfide-based solid electrolyte particle.

公开(公告)号：US10014216B2

公开(公告)日：2018-07-03

申请号：US14854221

申请日：2015-09-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sanghyeon Kim ,  Daemyeong Geum ,  Min Su Park ,  Won Jun Choi

IPC: H01L21/02 ,  H01L21/20 ,  H01L21/36 ,  H01L21/78 ,  H01L21/683 ,  H01L21/18 ,  H01L31/0304 ,  H01L29/267 ,  H01L29/66 ,  H01L29/861 ,  H01L29/20

CPC classification number: H01L21/78 ,  H01L21/185 ,  H01L21/6835 ,  H01L29/267 ,  H01L29/66219 ,  H01L29/861 ,  H01L31/0304 ,  H01L31/184 ,  H01L31/1892 ,  Y02E10/544 ,  Y02P70/521

Abstract: Disclosed is a method for manufacturing a semiconductor device, which includes providing a template having a first substrate and a patterned first III-V group compound layer located on the first substrate, forming a sacrificial layer on the patterned first III-V group compound layer by epitaxial growth, forming a second III-V group compound layer on the sacrificial layer by epitaxial growth, bonding a second substrate made of silicon onto the second III-V group compound layer, and separating the second III-V group compound layer and the second substrate from the template by removing the sacrificial layer.

公开(公告)号：US20180179331A1

公开(公告)日：2018-06-28

申请号：US15717212

申请日：2017-09-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun KIM ,  Young Mee JUNG ,  Seung Hyuk IM

IPC: C08G63/08

CPC classification number: C08G63/08 ,  G01N25/4866

Abstract: Disclosed is a method for preparing a poly(L-lactic acid) composite. According to the method, PLLA can be processed without losing its physical properties during thermal processing and can be effectively used to manufacture a final product with improved thermal properties. In addition, the monomer is not thermally decomposed during high-temperature polymerization. Therefore, the poly(L-lactic acid) composite can be prevented from browning. Also disclosed is a poly(L-lactic acid) composite prepared by the method.

公开(公告)号：US10004776B2

公开(公告)日：2018-06-26

申请号：US15201819

申请日：2016-07-05

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Kwantae Kim ,  Pilju Choi ,  Buyng Su Hwang ,  Young Seok Kim

IPC: A61K36/00 ,  A61K36/258 ,  A61K9/00

CPC classification number: A61K36/258 ,  A61K9/00 ,  A61K2236/00

Abstract: Provided are a pharmaceutical composition for preventing or treating skin cancer and a method of preventing or treating skin cancer in a subject by using the pharmaceutical composition, wherein the pharmaceutical composition includes a Panax spp. plant extract as an active ingredient.

公开(公告)号：US10004453B2

公开(公告)日：2018-06-26

申请号：US15250469

申请日：2016-08-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Il-Joo Cho ,  Eui Sung Yoon ,  Hyogeun Shin ,  Uikyu Chae ,  Hyunjoo Jenny Lee

IPC: A61M5/32 ,  A61B5/00 ,  A61B5/04 ,  A61M5/158 ,  A61M39/10

CPC classification number: A61B5/4848 ,  A61B5/04001 ,  A61B5/6848 ,  A61B2562/028 ,  A61M5/158 ,  A61M39/105 ,  A61M2210/0693

Abstract: A neural probe structure has a probe having a microfluidic channel. The probe is inserted into an inside of a subject. A body to which the probe is fixed has a fluid entrance communicating with the microfluidic channel. A cover element is fixed to the body to cover the fluid entrance. The cover element has a connecting opening to which an external conduit is connected, and a fluid delivery channel extending such that the connecting opening and the fluid entrance are in fluid communication. A fluid fed from the external conduit flows along the fluid delivery channel, goes into the fluid entrance, and is delivered to the subject through the microfluidic channel.

公开(公告)号：US20180169270A1

公开(公告)日：2018-06-21

申请号：US15845347

申请日：2017-12-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dae Ro AHN ,  Jong Seong HA ,  Jong Bum LEE

IPC: A61K48/00 ,  C12N15/113 ,  C12N15/11

CPC classification number: A61K48/0058 ,  A61K9/0019 ,  A61K9/141 ,  A61K48/0025 ,  B82Y5/00 ,  C12N15/111 ,  C12N15/113 ,  C12N15/88 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/20 ,  C12N2310/3519 ,  C12N2320/32

Abstract: Provided are a self-assembled polyribonucleotide-protein complex including a polyribonucleotide including a plurality of first repeating units having a single guide RNA (sgRNA) region and a small interfering RNA (siRNA) region; and one or more nuclease proteins binding to the sgRNA region, and use thereof.