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    Ellipsometry System For Measuring Molecular Binding, Adsorption And Desorption
    312.
    发明申请
    Ellipsometry System For Measuring Molecular Binding, Adsorption And Desorption 审中-公开
    用于测量分子结合，吸附和解吸的椭偏仪系统

    公开(公告)号：US20170074781A1

    公开(公告)日：2017-03-16

    申请号：US15311063

    申请日：2015-05-28

    Applicant: Agency for Science, Technology and Research

    Inventor： Nikolai Yakovlev ,  Laura Sutarlie ,  Dave Siak-wei Ow ,  Tandiono Tandiono

    IPC: G01N21/21 ,  G01N21/05

    CPC classification number: G01N21/211 ,  G01N21/05

    Abstract: According to one aspect of the invention, there is provided an ellipsometry system for measuring any one or more of molecular binding, adsorption and desorption on a substrate, the system comprising: a) a cuvette comprising i) a body within which a cavity is formed and an opening on the body, wherein the cavity extends into the opening through which the substrate is immersed; ii) a window formed on each of two oppositely located walls of the body, wherein the windows are aligned to allow light to enter through one of the two windows to reflect off the portion of the substrate immersed in the cavity and exit through the other of the two windows; iii) a channel arrangement enclosed within the body of the cuvette and comprising two non-contiguous portions, wherein one of the two non-contiguous portions guides fluid into the cavity and the other non-contiguous portion guides fluid out of the cavity; b) a polarized light source disposed to provide the light that enters into one of the two windows on the body of the cuvette; and c) a detection stage disposed to receive the light that exits through the other of the two windows on the body of the cuvette, wherein the detection stage is configured to measure polarization rotation of the received light, the polarization rotation caused by any one or more of molecular binding, adsorption and desorption occurring on the substrate surface. The detection stage preferably contains a polarisation modulator, which is configured to measure polarization rotation of the received light.

    Abstract translation: 根据本发明的一个方面，提供一种用于测量衬底上的分子结合，吸附和解吸中的任何一种或多种的椭偏仪系统，所述系统包括：a）比色皿，其包括i）形成空腔的体 以及在所述主体上的开口，其中所述空腔延伸到所述基底浸入所述开口中; ii）形成在所述主体的两个相对定位的壁中的每一个上的窗口，其中所述窗口对齐以允许光进入所述两个窗口中的一个窗口，以反射浸没在所述空腔中的所述基板的所述部分并且通过 两个窗户 iii）封闭在所述反应杯体内的通道布置并且包括两个非连续部分，其中所述两个非连续部分中的一个引导流体进入所述空腔，而另一非连续部分将流体引导出所述空腔; b）偏振光源，设置成提供进入比色杯身体的两个窗口之一的光; 以及c）检测台，被设置为接收通过所述比色皿主体上的两个窗口中的另一个窗口的光，其中所述检测台被配置为测量所接收的光的偏振旋转，由任何一个或 更多的分子结合，在衬底表面上发生吸附和解吸。 检测级优选地包含偏振调制器，其被配置为测量接收的光的偏振旋转。

    AN ELECTRIC METER, AN ELECTRIC METER SYSTEM AND A METHOD OF PROVIDING BRANCH-LEVEL READINGS FOR A POWER DISTRIBUTION NETWORK
    315.
    发明申请
    AN ELECTRIC METER, AN ELECTRIC METER SYSTEM AND A METHOD OF PROVIDING BRANCH-LEVEL READINGS FOR A POWER DISTRIBUTION NETWORK 审中-公开
    一种电表，一种电表系统和一种为分布式网络提供分支级读数的方法

    公开(公告)号：US20170045561A1

    公开(公告)日：2017-02-16

    申请号：US15307162

    申请日：2015-04-30

    Applicant: ILLINOIS AT SINGAPORE PTE LTD ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Binbin Chen ,  Sreejaya Viswanathan

    IPC: G01R22/10 ,  G01R15/20 ,  G01R19/25

    CPC classification number: G01R22/10 ,  G01R15/205 ,  G01R19/2513

    Abstract: According to various embodiments, there is provided an electric meter including a sensor circuit configured to provide a plurality of instantaneous magnetic field measurements; a processing circuit configured to generate a time-series of magnetic field vectors, each magnetic field vector of the time-series of magnetic field vectors including the plurality of instantaneous magnetic field measurements; and a total current determination circuit configured to determine a total current, wherein the total current is a sum of currents of each branch of a plurality of branches of a power distribution network; wherein the processing circuit is further configured to compute a de-mixing matrix based on the determined total current and the time-series of magnetic field vectors, and further configured to linear transform each magnetic field vector using the de-mixing matrix to determine a current of each branch.

    Abstract translation: 根据各种实施例，提供了一种电表，其包括被配置为提供多个瞬时磁场测量的传感器电路; 处理电路，被配置为产生时间序列的磁场矢量，所述磁场矢量的时间序列的每个磁场矢量包括多个瞬时磁场测量; 以及总电流确定电路，被配置为确定总电流，其中所述总电流是配电网的多个分支中的每个分支的电流之和; 其中所述处理电路还被配置为基于所确定的总电流和所述磁场矢量的时间序列来计算解混合矩阵，并且还被配置为使用所述解混合矩阵对每个磁场矢量进行线性变换，以确定电流 的每个分支。

    In vitro assay for predicting renal proximal tubular cell toxicity
    316.
    发明授权
    In vitro assay for predicting renal proximal tubular cell toxicity 有权
    用于预测肾近端肾小管细胞毒性的体外测定

    公开(公告)号：US09568466B2

    公开(公告)日：2017-02-14

    申请号：US14416016

    申请日：2013-07-22

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Daniele Zink ,  Yao Li

    IPC: G01N33/50

    CPC classification number: G01N33/5014 ,  G01N33/5026 ,  G01N33/5044 ,  G01N2333/47 ,  G01N2333/4712 ,  G01N2458/00

    Abstract: There is provided an in vitro assay for screening a test compound for toxicity in renal proximal tubular cells. The method comprises contacting a test compound with a test population of renal proximal tubular cells; and examining one or more cell morphology features, examining one or more cytoskeleton features, and/or determining cell numbers of the renal proximal tubular cells in the test population and comparing such cell morphology, arrangement of cytoskeletal components and/or cell count with the respective features of a control population. A change in one or more cell morphology features, a change in arrangement of one or more cytoskeleton features or a decrease in cell numbers of the test population relative to the control population is indicative that the test compound is toxic for renal proximal tubular cells.

    Abstract translation: 提供了用于在肾近端肾小管细胞中筛选测试化合物毒性的体外测定。 该方法包括使测试化合物与肾近端肾小管细胞的测试群体接触; 并检查一个或多个细胞形态特征，检查一个或多个细胞骨架特征，和/或确定测试群体中肾近端肾小管细胞的细胞数，并将细胞骨架成分和/或细胞计数与相应的细胞形态 控制人口的特点。 一个或多个细胞形态特征的改变，一个或多个细胞骨架特征的排列变化或测试群体相对于对照群体的细胞数量的减少表明该测试化合物对肾近端肾小管细胞有毒性。

    Crosslinked peptide hydrogels
    317.
    发明授权
    Crosslinked peptide hydrogels 有权

    公开(公告)号：US09555163B2

    公开(公告)日：2017-01-31

    申请号：US14634559

    申请日：2015-02-27

    Applicant: Agency for Science, Technology and Research

    Inventor： Charlotte Hauser ,  Wei Yang Seow

    IPC: A61K38/00 ,  A61P43/00 ,  A01N25/00 ,  A61K47/00 ,  C12N5/00 ,  C12N5/02 ,  A61L27/52 ,  A61K47/42 ,  A61K38/02 ,  A61L27/22 ,  A61L27/38 ,  A61L27/50 ,  A61L26/00 ,  A61K9/06

    Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.

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