公开(公告)号：US09570761B2

公开(公告)日：2017-02-14

申请号：US14435762

申请日：2013-10-15

Applicant: Alexey Serov ,  Plamen B Atanassov ,  Barr Halevi ,  Paul Short

Inventor： Alexey Serov ,  Plamen B Atanassov ,  Barr Halevi ,  Paul Short

IPC: B01J23/745 ,  H01M4/90 ,  B01J31/18 ,  H01M4/86 ,  H01M4/88 ,  H01M8/10

CPC classification number: H01M4/9091 ,  B01J31/1805 ,  H01M4/8652 ,  H01M4/8814 ,  H01M4/8846 ,  H01M4/8885 ,  H01M4/9008 ,  H01M8/1011 ,  H01M2008/1095 ,  Y02E60/50 ,  Y02E60/523

Abstract: Novel catalytic materials and novel methods of preparing M-N—C catalytic materials utilizing a sacrificial support approach and using inexpensive active polymers as the carbon and nitrogen source and readily available metal precursors are described.

Abstract translation: 描述了新型催化材料和利用牺牲支撑方法制备M-N-C催化材料并使用廉价的活性聚合物作为碳源和氮源以及容易得到的金属前体的新方法。

公开(公告)号：US09555583B1

公开(公告)日：2017-01-31

申请号：US14085671

申请日：2013-11-20

Applicant: Sandia Corporation ,  STC.UNM ,  Board of Regents, The University of Texas System

Inventor： Shawn M. Dirk ,  Stephen Buerger ,  Kirsten Nicole Cicotte ,  Elizabeth L. Dirk ,  Greg Reece ,  Patrick Lin

IPC: B29C67/00 ,  A61N1/05 ,  B33Y10/00 ,  A61B17/11

CPC classification number: B29C67/0062 ,  A61B17/1128 ,  A61B2017/00526 ,  A61N1/0551 ,  B33Y10/00

Abstract: The present invention is related to methods of fabricating neural interfaces using 3D projection micro-stereolithography.

Abstract translation: 本发明涉及使用3D投影微立体光刻技术制造神经接口的方法。

公开(公告)号：US09533057B2

公开(公告)日：2017-01-03

申请号：US13577484

申请日：2011-02-08

Applicant: Bryce Chackerian ,  David S. Peabody

Inventor： Bryce Chackerian ,  David S. Peabody

IPC: C12N7/00 ,  A61K47/48 ,  A61K39/12 ,  A61K39/00

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/55566 ,  C12N7/00 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2795/18123

Abstract: The invention provides immunotherapeutic and prophylactic bacteriophage viral-like particle (VLPs) which are useful in the treatment and prevention of human papillomavirus (HPV) infections and related disorders, including cervical cancer and persistent infections associated with HPV. Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. VLPs and related compositions of the invention induce high titer antibody responses against HPV L2 and protect against HPV challenge in vivo. VLPs, VLP-containing compositions, and therapeutic methods of the invention induce an immunogenic response against HPV infection, confer immunity against HPV infection, protect against HPV infection, and reduce the likelihood of infection by HPV infection.

Abstract translation: 本发明提供免疫治疗和预防性噬菌体病毒样颗粒（VLP），其可用于治疗和预防人乳头状瘤病毒（HPV）感染和相关疾病，包括宫颈癌和与HPV相关的持续感染。 还提供了相关组合物（例如疫苗），核酸构建体和治疗方法。 本发明的VLP和相关组合物诱导针对HPV L2的高滴度抗体应答，并在体内保护免受HPV挑战。 VLP，含VLP的组合物和本发明的治疗方法诱导针对HPV感染的免疫原性应答，赋予HPV感染免疫，防止HPV感染，并降低HPV感染感染的可能性。

公开(公告)号：US09480653B2

公开(公告)日：2016-11-01

申请号：US14627739

申请日：2015-02-20

Applicant: STC.UNM ,  SANDIA CORPORATION

Inventor： C. Jeffrey Brinker ,  Carlee Erin Ashley ,  Xingmao Jiang ,  Juewen Liu ,  David S. Peabody ,  Walker Richard Wharton ,  Eric Carnes ,  Bryce Chackerian ,  Cheryl L. Willman

IPC: A61K9/56 ,  A61K9/127 ,  A61K9/51 ,  A61K49/00 ,  A61K31/575 ,  A61K31/513 ,  A61K33/24 ,  A61K31/704

CPC classification number: A61K9/127 ,  A61K9/1277 ,  A61K9/5115 ,  A61K9/5123 ,  A61K31/513 ,  A61K31/575 ,  A61K31/704 ,  A61K33/24 ,  A61K49/005

Abstract: Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.

公开(公告)号：US09453253B2

公开(公告)日：2016-09-27

申请号：US14404134

申请日：2013-03-07

Applicant: STC.UNM ,  THE JOHNS HOPKINS UNIVERSITY

Inventor： Graham Timmins ,  Seong Choi ,  Zachary Sharp ,  Viorel Atudorei ,  Mamoudou Maiga ,  William Bishai

IPC: G01N33/60 ,  C12Q1/04 ,  G01N33/569 ,  C12Q1/28

CPC classification number: C12Q1/04 ,  C12Q1/28 ,  C12Q2304/48 ,  G01N33/5695 ,  G01N33/60 ,  G01N2333/35

Abstract: The present invention is directed to methods of diagnosing the presence or absence of a bacterial infection in a patient, in particular, a tuberculosis infection, by measuring exhaled, isotopically labeled nitrogen gas after administration of isotopically labeled isoniazid.

Abstract translation: 本发明涉及通过在施用同位素标记的异烟肼之后测量呼出的，同位素标记的氮气来诊断患者中细菌感染的存在或不存在，特别是结核病感染的方法。

公开(公告)号：US09451161B2

公开(公告)日：2016-09-20

申请号：US14069153

申请日：2013-10-31

Applicant: Timothy William Perez ,  Marios Stephanou Pattichis ,  Yuebing Jiang

Inventor： Timothy William Perez ,  Marios Stephanou Pattichis ,  Yuebing Jiang

IPC: H04N5/00 ,  H04N5/232 ,  G06T3/40

CPC classification number: H04N5/23238 ,  G06T3/4007

Abstract: Certain embodiments of the present invention include a system and methods for providing a video image display technology with separate video perspective displays. Each perspective display may be tailored and adapted in real-time to the differing roles of each user, e.g., one or more medical professionals of a surgical team. As an example, one video perspective display may be a panoramic perspective display for a primary surgeon and a second video perspective may be a detailed perspective display for the surgical assistant.

Abstract translation: 本发明的某些实施例包括用于向视频图像显示技术提供分开的视频透视显示的系统和方法。 可以将每个透视显示器实时地定制并适应于每个用户（例如外科团队的一个或多个医疗专业人员）的不同角色。 作为示例，一个视频透视显示可以是用于主要外科医生的全景透视显示，并且第二视频透视图可以是用于外科助手的详细透视显示。

公开(公告)号：US09425464B2

公开(公告)日：2016-08-23

申请号：US14414132

申请日：2013-07-11

Applicant: Alexey Serov ,  Plamen B Atanassov

Inventor： Alexey Serov ,  Plamen B Atanassov

IPC: B01J23/745 ,  C07D235/30 ,  H01M4/90 ,  C07D235/32 ,  B01J37/08 ,  H01M8/10

CPC classification number: H01M4/9075 ,  B01J23/745 ,  B01J37/084 ,  C07D235/30 ,  C07D235/32 ,  H01M4/90 ,  H01M4/9041 ,  H01M2008/1095 ,  Y02E60/50

Abstract: A method of preparation of M-N—C catalytic material utilizing a sacrificial support approach and using inexpensive and readily available metal precursors and carbendazim (CBDZ) as the carbon source is described.

Abstract translation: 描述了使用牺牲支持方法并使用廉价且容易获得的金属前体和多菌灵（CBDZ）作为碳源制备M-N-C催化材料的方法。

公开(公告)号：US09393330B2

公开(公告)日：2016-07-19

申请号：US14067064

申请日：2013-10-30

Applicant: Yubin Miao ,  Haixun Guo

Inventor： Yubin Miao ,  Haixun Guo

IPC: A61K49/00 ,  A61K51/08 ,  C07K14/685 ,  G01N33/574 ,  G01N33/60

CPC classification number: A61K51/088 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K45/06 ,  C07K14/685 ,  G01N33/5743 ,  G01N33/60

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

Abstract translation: 本发明涉及包含环肽的新型非侵入性诊断工具/化合物，其中所述化合物结合MSH受体以在体内成像和治疗癌症，特别是黑素瘤，包括转移性黑素瘤。 本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。 新型成像探针能够检测癌细胞黑素瘤细胞，以及它们在组织中的转移扩散。 这代表了使用非侵入性分子成像技术在黑素瘤的诊断和治疗中包括转移性黑素瘤的量子进步。 本发明的新型探针也可用于启动黑素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

公开(公告)号：US09387348B2

公开(公告)日：2016-07-12

申请号：US14293621

申请日：2014-06-02

Applicant: Shuang Luan ,  Lijun Ma ,  Zhe Chen

Inventor： Shuang Luan ,  Lijun Ma ,  Zhe Chen

IPC: A61N5/00 ,  A61N5/10

CPC classification number: A61N5/1084 ,  A61B6/4085 ,  A61N5/10 ,  A61N5/1031 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1071 ,  A61N5/1081 ,  A61N2005/1074

Abstract: Photon-based radiosurgery is widely used for treating local and regional tumors. The key to improving the quality of radiosurgery is to increase the dose falloff rate from high dose regions inside the tumor to low dose regions of nearby healthy tissues and structures. Dynamic photon painting (DPP) further increases dose falloff rate by treating a target by moving a beam source along a dynamic trajectory, where the speed, direction and even dose rate of the beam source change constantly during irradiation. DPP creates dose gradient that rivals proton Bragg Peak and outperforms Gamma Knife® radiosurgery.

Abstract translation: 基于光子的放射外科手术广泛用于治疗局部和局部肿瘤。 提高放射外科手术质量的关键是提高肿瘤内部高剂量区域到附近健康组织和结构的低剂量区域的剂量衰减率。 动态光子绘画（DPP）通过沿着动态轨迹移动光束源来处理目标物体进一步增加剂量衰减速率，其中光束源的速度，方向和均匀剂量率在照射期间不断变化。 DPP产生与质子Bragg峰值相当的剂量梯度，并优于GammaKnife®放射外科手术。

公开(公告)号：US09365831B2

公开(公告)日：2016-06-14

申请号：US13520057

申请日：2010-12-31

Applicant: David S. Peabody ,  Bryce Chackerian

Inventor： David S. Peabody ,  Bryce Chackerian

IPC: C40B40/08 ,  C12N7/00 ,  A61K39/07 ,  A61K39/12 ,  C12N15/10 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K39/07 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N7/00 ,  C12N15/1037 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2795/16021 ,  C12N2795/16022 ,  C12N2795/16023 ,  C12N2795/16042 ,  C12N2795/18023 ,  C40B40/08

Abstract: The present invention relates to a system and method for controlling peptide display valency on virus-like particles (VLPs), especially including MS2 VLPs. In this method, large amounts of wild-type and low quantities of single-chain dimer coat proteins may be produced from a single RNA. Valency is controlled in immunogen (vaccine) production by providing a system that allows the production of large amounts of wild-type and low quantities of single-chain dimer coating proteins from a single RNA, allowing facile adjustment of display valency levels on VLPs, especially MS2 VLPS over a wide range, from few than one—on average—to as many as ninety per particle. This facilitates the production of immunogens and vaccines, including VLPs exhibiting low valency. Nucleic acid constructs useful in the expression of virus-like particles are disclosed, comprised of a coat polypeptide of MS2 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates MS2 niRNA. Nucleic acid constructs are also disclosed which are useful in the expression of virus-like particles comprised of a coat polypeptide of PP7 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates PP7 mRNA.

Abstract translation: 本发明涉及一种用于控制病毒样颗粒（VLPs），特别是包括MS2 VLP的肽显示效价的系统和方法。 在该方法中，可以从单个RNA产生大量野生型和低量的单链二聚体外壳蛋白。 通过提供允许从单个RNA产生大量野生型和少量单链二聚体包被蛋白质的系统，允许轻度调整VLP上的显示剂价位水平，特别是 MS2 VLPS在广泛的范围内，从一个平均至少一个到每个粒子多达九十个。 这有助于免疫原和疫苗的生产，包括显示低效价的VLP。 公开了可用于病毒样颗粒表达的核酸构建物，其由通过插入异源肽修饰的MS2的外壳多肽组成，其中异源肽显示在病毒样颗粒上并包裹MS2nRNA。 还公开了核酸构建体，其可用于由通过插入异源肽修饰的PP7的外壳多肽组成的病毒样颗粒的表达，其中异源肽显示在病毒样颗粒上并包裹PP7 mRNA。