公开(公告)号：US12234488B2

公开(公告)日：2025-02-25

申请号：US18068739

申请日：2022-12-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christian Helmut Bell ,  Harald Sobek ,  Heiko Walch ,  Kiyoshi Yasukawa ,  Misato Baba

IPC: C12P19/34 ,  C12N9/12 ,  C12Q1/68

Abstract: The present invention relates to a mutant reverse transcriptase (RT) with increased thermal stability relative to the wildtype, a nucleic acid encoding the mutant RT, a cell comprising the mutant RT or the nucleic acid, a kit comprising the mutant RT, the use of the mutant RT for cDNA synthesis, method for reverse transcription of RNA comprising synthesizing cDNA with the use of the mutant RT and a method for detecting an RNA marker in a sample with the use of the mutant RT.

公开(公告)号：US20250060381A1

公开(公告)日：2025-02-20

申请号：US18937855

申请日：2024-11-05

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Vladimirs Leontjevs ,  Philipp Riedel

IPC: G01N35/00

Abstract: A position tracking system for tracking a relative position between connected modules. A target is arrangeable on and/or within a first connected module, the connected modules mechanically interacting for transporting objects between modules; a position sensor is arrangeable on and/or within a second connected module and is configured for generating a sensor signal according to a relative position between the position sensor and target, a processing unit configured for tracking a relative position between the connected modules from the sensor signal; and a second sensor is configured for generating a second sensor signal according to at least a second parameter, wherein the second sensor is a temperature sensor and/or a humidity sensor, the processing unit being configured for considering the second sensor signal when determining the relative position between the connected modules. Further disclosed are related monitoring systems and methods for tracking and monitoring at least two connected modules.

公开(公告)号：US12194466B2

公开(公告)日：2025-01-14

申请号：US17229086

申请日：2021-04-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Thomas Fischer ,  Eloisa Lopez-Calle ,  Sascha Lutz ,  Josef Roedl ,  Juergen Spinke ,  Pamela Espindola ,  Thomas Manuel Keller ,  Thomas Dolbinow ,  Sabrina Adler ,  Erik Beiersdorf ,  Domenik Wensorra

IPC: B01L3/00 ,  G01N35/00 ,  G01N35/10

Abstract: A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.

公开(公告)号：US12163969B2

公开(公告)日：2024-12-10

申请号：US17327847

申请日：2021-05-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Daniel Arnold ,  Fabian Wenzler

IPC: G01N35/00 ,  B25J15/00 ,  B65G47/24 ,  B65G47/244 ,  G01N35/04 ,  B01L9/06 ,  B65G43/08 ,  G01N1/00 ,  G01N35/02 ,  G01N35/10 ,  G01N37/00

Abstract: A centering unit for diagnostics laboratory transporting compartment is presented. The centering unit for diagnostics laboratory transporting compartment comprises at least two arms with grippers for centering diagnostics laboratory transporting compartments of different diameters. For accurate and reliable centering of laboratory transporting compartments, the two arms are biased with a single elastic member. A laboratory system and a method for centering diagnostics laboratory transporting compartment and diagnostics laboratory transporting compartment holder are also disclosed.

公开(公告)号：US12159773B2

公开(公告)日：2024-12-03

申请号：US17809760

申请日：2022-06-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Nadja Arens ,  Daniel Intelmann

IPC: H01J49/00 ,  H01J49/42

Abstract: Systems for analyzing a biological sample include a separation unit configured to separate a component from the biological sample, an ionization unit configured to generate a plurality of ions from the component, an adjustable mass-selective filtering element, a detector configured to detect ions that pass through the mass-selective filtering element, and a controller connected to the mass-selective filtering element and to the detector, where the controller is configured so that during operation of the system, the controller adjusts the mass-selective filtering element and activates the detector to measure at least three different ion signals corresponding to the plurality of ions, and determines a mass axis shift of the system based on the at least three different ion signals.

公开(公告)号：US20240377388A1

公开(公告)日：2024-11-14

申请号：US18669957

申请日：2024-05-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael GERG ,  Dieter HEINDL ,  Lars HILLRINGHAUS ,  Klaus HIRZEL ,  Caroline Dorothea HOJER ,  Florian HUBER ,  Hans-Peter JOSEL ,  Thomas MEIER ,  Michael SCHRAEML ,  Edgar VOSS

IPC: G01N33/543 ,  C07K16/44

Abstract: The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.

公开(公告)号：US20240345120A1

公开(公告)日：2024-10-17

申请号：US18750107

申请日：2024-06-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Leon Felipe Apodaca Lujan ,  Timo Gutmann

IPC: G01N35/04

CPC classification number: G01N35/04 ,  G01N2035/0401 ,  G01N2035/0496

Abstract: A laboratory apparatus comprising a housing, wherein the housing comprises a through-opening, wherein the through-opening is adapted for passing through it a transport device for transporting laboratory sample containers in and/or out of the housing, and a cover, wherein the cover comprises at least two ring segments, wherein the ring segments are adjustable to each other between a distant adjustment with at least one distance in between ends of the ring segments for arranging them around the passed through transport device and a near adjustment with less or no distance in between the ends of the ring segments for surrounding the passed through transport device, and wherein the cover in the near adjustment is adapted to cover a part of the through-opening left free by the passed through transport device, wherein the laboratory apparatus is a pre-analytical, analytical, and/or post-analytical laboratory apparatus, in particular a sorting module.

公开(公告)号：US12119109B2

公开(公告)日：2024-10-15

申请号：US17207957

申请日：2021-03-22

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Urs Suter ,  Javier Jimenez Roda ,  Stefan Bucheli ,  Isabella Kanne Castejon ,  Dirk Abeln

IPC: G16H40/40 ,  G03H1/00 ,  G06F16/955 ,  G06T11/00 ,  G06V20/52 ,  H04L67/02 ,  H04L67/12

CPC classification number: G16H40/40 ,  G03H1/0005 ,  G06F16/955 ,  G06T11/00 ,  G06V20/52 ,  H04L67/02 ,  H04L67/12 ,  G03H2210/52 ,  G03H2210/53

Abstract: A computer-implemented method for tracking laboratory resources is disclosed. The laboratory resource comprises an identification feature. The method comprises an identification step comprising detecting the laboratory resource in the laboratory with an imaging sensor of an augmented reality device and identifying the laboratory resource with an identification unit of the augmented reality device by receiving identification information from the identification feature, a data retrieving step comprising retrieving information about the identified laboratory resource from a data server via a communication interface of the augmented reality device, and a tracking step comprising generating and displaying augmented reality information on a display device of the augmented reality device. The augmented reality information comprises a hologram comprising the retrieved information about the identified laboratory resource and/an instruction depending on the retrieved information about the identified laboratory resource.

公开(公告)号：US12117454B2

公开(公告)日：2024-10-15

申请号：US16868644

申请日：2020-05-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dirk Block ,  Hans-Peter Brunner ,  Ursula-Henrike Wienhues-Thelen ,  Christian Zaugg ,  Thomas Dieterle ,  Cheryl Mitchell ,  Johan Ubby ,  Sandra Sanders-van Wijk

IPC: G01N33/543 ,  G01N33/62 ,  G01N33/66 ,  G01N33/68 ,  G01N33/70 ,  G01N33/72 ,  G01N33/84

CPC classification number: G01N33/6893 ,  G01N33/62 ,  G01N33/66 ,  G01N33/6869 ,  G01N33/6887 ,  G01N33/70 ,  G01N33/723 ,  G01N33/84 ,  G01N2333/4737 ,  G01N2333/5412 ,  G01N2333/58 ,  G01N2333/78 ,  G01N2333/805 ,  G01N2800/325 ,  G01N2800/347 ,  G01N2800/52

Abstract: Methods for identifying a patient who is eligible for an intensification of heart failure therapy are disclosed. Furthermore, methods for optimizing B-type natriuretic peptide (BNP) and/or N-terminal pro B-type natriuretic peptide (NT-proBNP)-type peptide guided heart failure therapy are disclosed. The methods are based on the measurement of the level of at least one marker in a sample from a patient who has heart failure and who receives B-type natriuretic peptide (BNP) and/or N-terminal pro B-type natriuretic peptide (NT-proBNP)-type peptide guided heart failure therapy. Further described are kits and devices adapted to carry out the described methods.

公开(公告)号：US20240329071A1

公开(公告)日：2024-10-03

申请号：US18579561

申请日：2022-07-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Avinash Addihalli Narayana ,  Tobias Huber

IPC: G01N35/00 ,  B25J15/02

CPC classification number: G01N35/0099 ,  B25J15/0246

Abstract: A transfer device (110) for transferring sample containers in a sample handling system (112) is disclosed. The transfer device (110) comprises:



at least one transport device (114) comprising an array (116) of electromagnetic actuators (118), specifically electromagnetic actuators (118) comprising electromagnetic coils (120);
at least one moving unit (122) comprising at least one permanent magnet (124), wherein the moving unit (122) is movable in at least one movement plane (126), specifically in at least one movement plane (126) of the moving unit (122) defined by at least two moving directions (128), through the array (116) by magnetic interaction of the permanent magnet (124) with the electromagnetic actuators (118); and
at least one gripper unit (130) for positioning at least one of the sample containers, wherein the gripper unit (130) is movable in at least one gripping direction (132) essentially perpendicular to the movement plane (126), wherein the gripping unit (130) is attached to the moving unit (122).




Further disclosed is a sample handling system (112) for handling a plurality of sample containers and a method for transferring sample containers in a sample handling system (112).