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    RADIOLABELED ALPHA-MELANOCYTE STIMULATING HORMONE HYBRID PEPTIDE FOR MELANOMA TARGETING
    331.
    发明申请
    RADIOLABELED ALPHA-MELANOCYTE STIMULATING HORMONE HYBRID PEPTIDE FOR MELANOMA TARGETING 审中-公开

    公开(公告)号：US20170087259A1

    公开(公告)日：2017-03-30

    申请号：US15261890

    申请日：2016-09-10

    Applicant: STC.UNM

    Inventor： YUBIN MIAO

    IPC: A61K51/08 ,  A61K38/17

    CPC classification number: A61K51/086 ,  A61K38/00 ,  A61K38/17 ,  A61K51/082 ,  C07K7/56

    Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue, suggesting favorable selective activity of compounds according to the present invention, which can be used as effective therapeutic agents against melanoma, including metastatic melanoma. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are useful to initiate therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic and therapeutic tools for a number of conditions and diseases states, especially melanoma.

    Signal propagation biomolecules, devices and methods
    334.
    发明授权
    Signal propagation biomolecules, devices and methods 有权
    信号传播生物分子，装置和方法

    公开(公告)号：US09476090B2

    公开(公告)日：2016-10-25

    申请号：US14283993

    申请日：2014-05-21

    Applicant: STC.UNM

    Inventor： Carl Brown, III ,  Steven Wayde Graves ,  Darko Stefanovic ,  Matthew Richard Lakin

    IPC: C07H21/04 ,  C12Q1/68 ,  C07H21/02

    CPC classification number: C12Q1/6816 ,  C12Q2521/345 ,  C12Q2525/301 ,  C12Q2565/1015

    Abstract: This disclosure describes a structured polynucleotide, devices that include the structured polynucleotide, and methods involving the structured polynucleotide and/or devices. Generally, the structured polynucleotide includes five domains. A first domain acts as a toehold for an input DNA logic gate to initiate binding to an SCS biomolecule. A second domain acts as a substrate recognition sequence for an upstream DNA logic gate. A third domain acts as a toehold for a output DNA logic gate to initiate binding of the SCS biomolecule to the gate. A fourth domain acts as an effector sequence to alter the state of the output logic gate. A fifth domain acts as a cage sequence to lock the effector sequence in an inactive state until an input gate binds to the structured polynucleotide.

    Abstract translation: 本公开描述了结构化多核苷酸，包括结构化多核苷酸的装置和涉及结构化多核苷酸和/或装置的方法。 通常，结构化多核苷酸包括五个结构域。 第一个域用作输入DNA逻辑门的始发点，以启动与SCS生物分子的结合。 第二个域用作上游DNA逻辑门的底物识别序列。 第三个域用作输出DNA逻辑门的脚注，以启动SCS生物分子与门的结合。 第四个域用作效应序列来改变输出逻辑门的状态。 第五结构域充当笼状序列，以将效应序列锁定在无活性状态，直到输入门结合结构化多核苷酸。

    Core and Surface Modification of Mesoporous Silica Nanoparticles to Achieve Cell Specific Targeting In Vivo.
    337.
    发明申请
    Core and Surface Modification of Mesoporous Silica Nanoparticles to Achieve Cell Specific Targeting In Vivo. 审中-公开
    介孔二氧化硅纳米颗粒的核心和表面改性以实现细胞特异性靶向靶向。

    公开(公告)号：US20160287717A1

    公开(公告)日：2016-10-06

    申请号：US15023093

    申请日：2014-09-18

    Applicant: STC.UNM ,  SANDIA CORPORATION

    Inventor： Charles Jeffrey Brinker ,  Jason TOWNSON ,  Yu-Shen LIN ,  Paul N. DURFEE

    IPC: A61K47/48 ,  A61K9/51

    CPC classification number: A61K47/6929 ,  A61K9/0019 ,  A61K9/1271 ,  A61K9/5115 ,  A61K9/5146 ,  A61K47/02 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6923

    Abstract: In one aspect, the invention provides mesoporous silica nanoparticles (MSNPs), monodisperse populations of MSNPs and related protocells which exhibit single cell binding specificity to the substantial exclusion of non-targeted cells. For example, MSNPs and protocells of the invention may be used to target specific delivery of therapeutic agents to cancer cells or to specific blood vessel types (e.g. in the arterial, venous and/or capillary vessels or any combination of vessels). Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

    Abstract translation: 一方面，本发明提供介孔二氧化硅纳米颗粒（MSNP），MSNP的单分散群体和相关的原细胞，其显示出对非靶向细胞的实质排除的单细胞结合特异性。 例如，本发明的MSNPs和原细胞可用于靶向治疗剂到癌细胞或特定血管类型（例如在动脉，静脉和/或毛细血管或血管的任何组合中）的特异性递送。 还提供了相关的原细胞，药物组合物和治疗和诊断方法。

    METHODS TO INTRODUCE SUB-MICROMETER, SYMMETRY-BREAKING SURFACE CORRUGATION TO SILICON SUBSTRATES TO INCREASE LIGHT TRAPPING
    338.
    发明申请
    METHODS TO INTRODUCE SUB-MICROMETER, SYMMETRY-BREAKING SURFACE CORRUGATION TO SILICON SUBSTRATES TO INCREASE LIGHT TRAPPING 有权
    介绍低分子量薄膜的方法，将硅衬底的对称破裂表面校正增加到光线捕获

    公开(公告)号：US20160284886A1

    公开(公告)日：2016-09-29

    申请号：US15030039

    申请日：2014-10-17

    Applicant: STC.UNM

    Inventor： Sang Eon Han ,  Brittany R. Hoard ,  Sang M. Han ,  Swapnadip Ghosh

    IPC: H01L31/0236 ,  H01L31/20 ,  H01L31/0747

    CPC classification number: H01L31/02363 ,  G02B1/005 ,  H01L31/0747 ,  H01L31/1804 ,  H01L31/202 ,  H01L31/208 ,  H03H9/10 ,  H03H9/145 ,  H03H9/25 ,  Y02E10/547 ,  Y02P70/521

    Abstract: Provided is a method for fabricating a nanopatterned surface. The method includes forming a mask on a substrate, patterning the substrate to include a plurality of symmetry-breaking surface corrugations, and removing the mask. The mask includes a pattern defined by mask material portions that cover first surface portions of the substrate and a plurality of mask space portions that expose second surface portions of the substrate, wherein the plurality of mask space portions are arranged in a lattice arrangement having a row and column, and the row is not oriented parallel to a [110] direction of the substrate. The patterning the substrate includes anisotropically removing portions of the substrate exposed by the plurality of spaces.

    Abstract translation: 提供了一种制造纳米图案表面的方法。 该方法包括在衬底上形成掩模，图案化衬底以包括多个对称破裂表面波纹，以及去除掩模。 掩模包括由覆盖基板的第一表面部分的掩模材料部分限定的图案和暴露基板的第二表面部分的多个掩模空间部分，其中多个掩模空间部分布置成具有排的格子布置 和列，并且该行不平行于衬底的[110]方向取向。 图案化衬底包括由多个空间暴露的各向异性去除部分的衬底。

    MODULAR RNA REGULATORS AND METHODS
    339.
    发明申请
    MODULAR RNA REGULATORS AND METHODS 审中-公开
    模块RNA调节因子和方法

    公开(公告)号：US20160237439A1

    公开(公告)日：2016-08-18

    申请号：US15029307

    申请日：2014-10-10

    Applicant: STC.UNM

    Inventor： Fu-Sen LIANG

    IPC: C12N15/113

    CPC classification number: C12N15/1137 ,  C12N15/111 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/3181 ,  C12N2310/3231 ,  C12N2310/3233 ,  C12N2320/50 ,  C12Y301/00

    Abstract: This disclosure describes modular miRNA regulator molecules and methods of using modular miRNA regulator molecules. Generally, the modular miRNA regulator molecules include a recognition module and an inhibition module. Generally, the recognition module includes a polynucleotide in which at least a portion of the polynucleotide recognizes at least a portion of a preselected pre-miRNA. Generally, the inhibition module includes a moiety that inhibits nuclease processing of the preselected pre-RNA to a mature RNA.

    Abstract translation: 本公开描述了模块化miRNA调节剂分子和使用模块化miRNA调节剂分子的方法。 通常，模块化miRNA调节剂分子包括识别模块和抑制模块。 通常，识别模块包括多核苷酸，其中多核苷酸的至少一部分识别预选的前miRNA的至少一部分。 通常，抑制模块包括抑制核酸酶处理预选择的前RNA到成熟RNA的部分。

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