公开(公告)号：US06579867B2

公开(公告)日：2003-06-17

申请号：US09915379

申请日：2001-07-27

Applicant: Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  Russell D. Stucky ,  Warren J. Porter

Inventor： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  Russell D. Stucky ,  Warren J. Porter

IPC: A61K3155

CPC classification number: C07D471/04 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/5513 ,  A61K38/05 ,  C07C237/22 ,  C07C2603/32 ,  C07D223/18 ,  C07D307/33 ,  C07D311/76 ,  C07D471/06 ,  C07D471/08

Abstract: Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US06313152B1

公开(公告)日：2001-11-06

申请号：US09390692

申请日：1999-09-07

Applicant: Jing Wu ,  Eugene D. Thorsett ,  Jeffrey S. Nissen ,  Thomas E. Mabry ,  Lee H. Latimer ,  Varghese John ,  Lawrence Y. Fang ,  James E. Audia

Inventor： Jing Wu ,  Eugene D. Thorsett ,  Jeffrey S. Nissen ,  Thomas E. Mabry ,  Lee H. Latimer ,  Varghese John ,  Lawrence Y. Fang ,  James E. Audia

IPC: A61K3144

CPC classification number: A61K31/198 ,  A61K31/223 ,  A61K31/277

Abstract: Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Abstract translation: 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。

公开(公告)号：US6117901A

公开(公告)日：2000-09-12

申请号：US976179

申请日：1997-11-21

Applicant: Jing Wu ,  Eugene D. Thorsett ,  Jeffrey S. Nissen ,  Thomas E. Mabry ,  Lee H. Latimer ,  Varghese John ,  Lawrence Y. Fang ,  James E. Audia

Inventor： Jing Wu ,  Eugene D. Thorsett ,  Jeffrey S. Nissen ,  Thomas E. Mabry ,  Lee H. Latimer ,  Varghese John ,  Lawrence Y. Fang ,  James E. Audia

IPC: A61K31/198 ,  A61K31/223 ,  A61K31/277 ,  A61K31/16

CPC classification number: A61K31/198 ,  A61K31/223 ,  A61K31/277

Abstract: Disclosed are compounds which inhibit .beta.-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits .beta.-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Abstract translation: 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默氏病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及预防和治疗这些药物组合物的阿尔茨海默氏病的治疗方法。

公开(公告)号：US5300436A

公开(公告)日：1994-04-05

申请号：US9075

申请日：1993-01-26

Applicant: Menek Goldstein ,  Jing Wu ,  David Filer ,  Arnold J. Friedhoff

Inventor： Menek Goldstein ,  Jing Wu ,  David Filer ,  Arnold J. Friedhoff

IPC: C12N9/02 ,  C12N15/00 ,  C12N9/04

CPC classification number: C12N9/0071 ,  C12Y114/16002

Abstract: Modification of the DNA encoding the enzyme tyrosine hydroxylase (TH) resulting in amino acid substitution in one of the first fifty five N-terminal residues, in particular replacing Ser-40 with Tyr or Leu, produced TH variants having substantially increased enzymatic activity upon transfection of suitable host cells. Cells transfected with the variant TH having enhanced enzymatic activity are useful for treating neurological or psychiatric disorders associated with deficient TH or dopamine, in particular Parkinson's disease, by grafting such cells into the brain.

Abstract translation: 编码酪氨酸羟化酶（TH）的DNA的修饰导致在前五十五个N-末端残基之一中氨基酸取代，特别是以Tyr或Leu替代Ser-40的氨基酸取代产生在转染时具有显着增加的酶活性的TH变体 的合适的宿主细胞。 用具有增强的酶活性的变体TH转染的细胞可用于通过将这种细胞移植到脑中来治疗与缺乏TH或多巴胺，特别是帕金森病相关的神经或精神疾病。

公开(公告)号：US11773383B2

公开(公告)日：2023-10-03

申请号：US17349933

申请日：2021-06-17

Applicant: Jing Wu ,  Lingqia Su ,  Yan Huang

Inventor： Jing Wu ,  Lingqia Su ,  Yan Huang

IPC: C12N9/92 ,  C12N9/18 ,  C12N9/10 ,  C12N15/75

CPC classification number: C12N9/18 ,  C12N9/1051 ,  C12N9/92 ,  C12N15/75 ,  C12Y204/01245 ,  C12Y301/01074 ,  C12Y503/01005

Abstract: Disclosed is a method for promoting extracellular expression of proteins in B. subtilis using cutinase, which belongs to the technical fields of genetic engineering, enzyme engineering and microbial engineering. It teaches co-expressing a cutinase mutant and a target protein in B. subtilis to promote extracellular expression of the target protein which is naturally located inside cells. The target protein includes xylose isomerase, 4,6-α-glucosyltransferase, 4-α-glucosyltransferase, trehalose synthase, branching enzyme and the like. The invention can achieve extracellular expression of intracellularly localized target protein, improve the production efficiency, reduce the production cost and simplify the subsequent extraction process.

公开(公告)号：US11349135B2

公开(公告)日：2022-05-31

申请号：US16984097

申请日：2020-08-03

Applicant: Tai-Nan Lin ,  Szu-Han Wu ,  Yi-Jing Wu ,  Min-Fang Han ,  Wei-Xin Kao ,  Hong-Yi Kuo ,  Chun-Yen Yeh ,  Yung-Neng Cheng ,  Ruey-Yi Lee

Inventor： Tai-Nan Lin ,  Szu-Han Wu ,  Yi-Jing Wu ,  Min-Fang Han ,  Wei-Xin Kao ,  Hong-Yi Kuo ,  Chun-Yen Yeh ,  Yung-Neng Cheng ,  Ruey-Yi Lee

IPC: H01M8/0286 ,  H01M8/0276 ,  H01M8/0282 ,  H01M8/2432 ,  H01M8/12

Abstract: A method of preparation and application for a glass ceramic sealing thin strip with high sealing performance, differing from using conventional glass ceramic packaging paste applied to the junction of the cell stack assembly and connecting plates. The glass ceramic sealing thin strip of present invention utilizes tape casting to produce a single layer or multi-layer stacking in accordance with the required thickness of the glass-ceramic sealing thin strip, and cutting the glass ceramic sealing thin strips from molds in accordance with the geometry of cell stacks with equal thickness of the glass ceramic sealing thin strip for SOFC cell stack assembly, aiming to overcome the setbacks of the conventional dispensing method with glass ceramic packaging paste that makes the thickness difficult to control, and to effectively improve sealing performance of the cell stack assembly and the power generation efficiency, and achieve commercial application with mass production.

公开(公告)号：US10988550B2

公开(公告)日：2021-04-27

申请号：US16196768

申请日：2018-11-20

Applicant: Jing Wu ,  Sheng Chen ,  Jun Liu

Inventor： Jing Wu ,  Sheng Chen ,  Jun Liu

IPC: C08B30/18 ,  A23L29/269 ,  C12P19/04 ,  C08L3/02 ,  C08B31/00

Abstract: Disclosed is a method for preparing a resistant dextrin product by using compound enzyme treatment. Starch is first subjected to high-temperature acidolysis to obtain pyrodextrin which is used as the substrate for the enzyme treatment. A compound enzyme reaction system including a starch branching enzyme and a CGTase is used for preparing the resistant dextrin product. The starch branching enzyme and the CGTase are added simultaneously or sequentially to treat the pyrodextrin to further increase the content of the resistant component in the product. The content of the resistant component of the enzyme treated product reaches up to 65.3%, a 21.3% increase from that of the pyrodextrin before the enzyme treatment.

公开(公告)号：US20190032062A1

公开(公告)日：2019-01-31

申请号：US15891564

申请日：2018-02-08

Applicant: Jing Wu ,  Quan Zhang ,  Liming Liu ,  Xiulai Chen ,  Jia Liu ,  Qiuling Luo

Inventor： Jing Wu ,  Quan Zhang ,  Liming Liu ,  Xiulai Chen ,  Jia Liu ,  Qiuling Luo

IPC: C12N15/70 ,  C12P19/26 ,  C12N9/90 ,  C12N9/10 ,  C12P19/24

CPC classification number: C12N15/70 ,  C12N9/1096 ,  C12N9/90 ,  C12P19/24 ,  C12P19/26 ,  C12Y504/0201

Abstract: The present invention relates to the field of biotechnology engineering. It provides a recombinant Escherichia coli that can produce fructosylated chondroitin with high yields and the method for constructing the recombinant strain. The present invention discloses a method for constructing an expression plasmid pETM6R1-RBS-glmM-GGGS-glmS that contains a glmM and a glmS gene under regulation of ribosome binding sites. The recombinant plasmid was transformed into E. coli K4 to obtain a recombinant E. coli strain ZQ33 that can produce fructosylated chondroitin up to 3.99 g·L−1 by fed-batch fermentation in a 5-L fermentor, which was increased by 108.90% compared to that of the wild type strain.

公开(公告)号：US20170364534A1

公开(公告)日：2017-12-21

申请号：US15624246

申请日：2017-06-15

Applicant: Chen ZHANG ,  Jing WU

Inventor： Chen ZHANG ,  Jing WU

IPC: G06F17/30 ,  G06N5/04 ,  G06N99/00

CPC classification number: G06F16/182 ,  G06F16/256 ,  G06F16/26 ,  G06F16/284 ,  G06F16/9024 ,  G06N5/04 ,  G06N20/00

Abstract: Systems for distributed graph data management that use graph structures to model data and respond to different types of queries. Systems that provide analytic tools and machine learning based on graph structures. Systems for distributed graph data management that provide packaged solutions for different application areas.

公开(公告)号：US20170117614A1

公开(公告)日：2017-04-27

申请号：US15283530

申请日：2016-10-03

Applicant: Jing Wu ,  Jianchun Mai ,  Chao Wang

Inventor： Jing Wu ,  Jianchun Mai ,  Chao Wang

IPC: H01Q1/24 ,  H01Q1/38 ,  H01Q1/48 ,  H01Q1/22 ,  H01Q1/36

CPC classification number: H01Q1/243 ,  H01Q1/2291 ,  H01Q5/328 ,  H01Q9/42 ,  H01Q21/28 ,  H01Q21/30

Abstract: An antenna system with a full metal back cover is provided in the present disclosure. The antenna system includes a metal back cover with a main body, a first sidewall and a second sidewall opposite to each other, a circuit board with a main ground point, a first antenna module and a second antenna module electrically connected to the circuit board. A first gap is formed between the first sidewall and the main body, and a second gap is formed between the second sidewall and the main body; the metal back cover is divided into a first metal portion including the first sidewall and a second metal portion including the second sidewall. The first metal portion includes a top slit penetrating through an edge of the first sidewall, and the second metal portion includes a bottom slit penetrating through an edge of the second sidewall.