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    Method of inhibiting matrix metalloproteinases
    34.
    发明授权
    Method of inhibiting matrix metalloproteinases 失效
    抑制基质金属蛋白酶的方法

    公开(公告)号：US06620835B2

    公开(公告)日：2003-09-16

    申请号：US10162518

    申请日：2002-06-04

    Applicant: Patrick Michael O'Brien ,  Joseph Armand Picard ,  Drago Robert Sliskovic ,  Andrew David White

    Inventor： Patrick Michael O'Brien ,  Joseph Armand Picard ,  Drago Robert Sliskovic ,  Andrew David White

    IPC: A61K31381

    CPC classification number: C07D307/91 ,  A61K31/343 ,  A61K31/381 ,  C07C311/19 ,  C07C2603/18 ,  C07D333/76

    Abstract: The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I More particularly, the present invention relates to a method of treating diseases in which matrix metalloproteinases are involved such as multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurism, heart failure, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory diseases dependent upon tissue invasion by leukocytes.

    Abstract translation: 本发明涉及使用具有式IIIO的二苯并呋喃磺酰胺衍生物的化合物抑制基质金属蛋白酶的方法，本发明涉及治疗涉及基质金属蛋白酶的疾病的方法，例如多发性硬化，动脉粥样硬化斑块破裂，再狭窄 ，主动脉瘤，心力衰竭，牙周病，角膜溃疡，烧伤，褥疮性溃疡，慢性溃疡或创伤，癌症转移，肿瘤血管生成，关节炎或依赖于白细胞组织侵袭的其他自身免疫性或炎性疾病。

    Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases
    37.
    发明授权
    Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases 失效
    三环异构体及其衍生物作为基质金属蛋白酶抑制剂

    公开(公告)号：US06350885B1

    公开(公告)日：2002-02-26

    申请号：US09719026

    申请日：2001-02-20

    Applicant: Patrick Michael O'Brien ,  Joseph Armand Picard ,  Drago Robert Sliskovic

    Inventor： Patrick Michael O'Brien ,  Joseph Armand Picard ,  Drago Robert Sliskovic

    IPC: C07D30791

    CPC classification number: C07D209/80 ,  C07C59/86 ,  C07D209/86 ,  C07D209/94 ,  C07D233/78 ,  C07D307/91 ,  C07D333/76

    Abstract: Tricyclic heteroaromatic compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, heart failure, left ventricular dilation, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, osteoporosis, renal disease, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

    Abstract translation: 描述了三环杂芳族化合物和衍生物以及其制备方法及其药物组合物，其可用作基质金属蛋白酶抑制剂，特别是明胶酶A，胶原酶-3和溶基质蛋白酶-1以及治疗多发性硬化，动脉粥样硬化 斑块破裂，主动脉瘤，心力衰竭，左心室扩张，再狭窄，牙周病，角膜溃疡，烧伤治疗，褥疮溃疡，伤口愈合，癌症，炎症，疼痛，关节炎，骨质疏松症，肾脏疾病或其他自身免疫性或炎症性疾病 依赖于白细胞或其他活化的迁移细胞的组织侵袭，急性和慢性神经变性疾病，包括中风，头部创伤，脊髓损伤，阿尔茨海默病，肌萎缩性侧索硬化，脑淀粉样血管病，艾滋病，帕金森病，亨廷顿病，朊病毒疾病，肌无力 重症肌无力和Duchenne肌营养不良症。

    Collapsible spa unit
    38.
    发明授权
    Collapsible spa unit 失效
    可折叠水疗单位

    公开(公告)号：US6058521A

    公开(公告)日：2000-05-09

    申请号：US965444

    申请日：1997-11-06

    Applicant: Michael O'Brien

    Inventor： Michael O'Brien

    IPC: E04H4/00 ,  E04H4/04 ,  A47K3/06

    CPC classification number: E04H4/0043

    Abstract: A collapsible spa unit is disclosed including a base and a peripheral wall mounted to and extending above the base. The wall includes a plurality of discrete panels that are releasably interconnected to define an enclosed area. There is a liner that extends across an upper surface of the base and across an inside surface of each panel for holding water within the enclosed area. A conduit having jets is formed through the peripheral wall and the liner for conducting water into the enclosed area of the spa. A suction line is formed through the peripheral wall in the liner for discharging water out of the enclosed area. A pump located outside of the panels, and communicably interconnected with the conduit and suction line, draws water out of the enclosed area through the suction and reintroduces water into the enclosed area through the conduit.

    Abstract translation: 公开了一种可折叠的温泉单元，包括安装到基座上方并在基座上方延伸的基座和周壁。 壁包括多个离散面板，其可释放地互连以限定封闭区域。 有一个衬垫延伸穿过底座的上表面并穿过每个面板的内表面，用于将水保持在封闭区域内。 具有射流的导管通过周壁和衬套形成，用于将水导入温泉的封闭区域。 通过衬套中的周壁形成吸入管线，以将水从封闭区域排出。 位于面板外部并与导管和吸入管线可通信地相互连接的泵将水通过吸力从封闭区域吸出，并通过导管将水重新引入封闭区域。

    Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases
    39.
    发明授权
    Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases 失效
    氟化丁酸及其衍生物作为基质金属蛋白酶的抑制剂

    公开(公告)号：US06037361A

    公开(公告)日：2000-03-14

    申请号：US36751

    申请日：1998-03-09

    Applicant: Bruce David Roth ,  Patrick Michael O'Brien ,  Drago Robert Sliskovic

    Inventor： Bruce David Roth ,  Patrick Michael O'Brien ,  Drago Robert Sliskovic

    IPC: A61K31/192 ,  A61K31/343 ,  A61K31/381 ,  C07C59/88 ,  C07C251/48 ,  C07C259/06 ,  C07D209/86 ,  C07D307/91 ,  C07D333/76 ,  C07D405/06 ,  A01N43/38

    CPC classification number: C07D307/91 ,  A61K31/192 ,  A61K31/343 ,  A61K31/381 ,  C07C251/48 ,  C07C259/06 ,  C07C59/88 ,  C07D209/86 ,  C07D333/76 ,  C07D405/06 ,  C07C2103/18 ,  Y10S514/825 ,  Y10S514/885 ,  Y10S514/903

    Abstract: Fluorinated butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1, and also collagenase, matrilysin, and MMP-13, and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

    Abstract translation: 描述了氟化丁酸化合物和衍生物以及用于制备的酸法和其药物组合物，其可用作基质金属蛋白酶抑制剂，特别是明胶酶A（72kD明胶酶）和基质溶素-1，以及胶原酶，基质溶素， 和MMP-13，用于治疗多发性硬化，动脉粥样硬化斑块破裂，主动脉瘤，心力衰竭，再狭窄，牙周病，角膜溃疡，烧伤治疗，褥疮溃疡，伤口愈合，癌症，炎症，疼痛，关节炎或 依赖于白细胞或其他活化迁移细胞的组织侵袭的其它自身免疫性或炎性病症，急性和慢性神经变性疾病，包括中风，头部创伤，脊髓损伤，阿尔茨海默氏病，肌萎缩性侧索硬化，脑淀粉样血管病，艾滋病，帕金森病，亨廷顿舞蹈病 ，朊病毒疾病，重症肌无力和杜氏肌营养不良症。

    Head gasket with pre-embedded metal shim and method of using same
    40.
    发明授权
    Head gasket with pre-embedded metal shim and method of using same 失效
    带预嵌入金属垫片的头垫片及其使用方法

    公开(公告)号：US5586769A

    公开(公告)日：1996-12-24

    申请号：US432947

    申请日：1995-05-01

    Applicant: Martin Novil ,  Michael O'Brien

    Inventor： Martin Novil ,  Michael O'Brien

    IPC: F16J15/12 ,  F16J15/08

    CPC classification number: F16J15/123

    Abstract: A head gasket comprising a laminate, metallic core and fiber-elastomer facing layers on each major surface of the core and defining a plurality of combustion openings, oil and water holes and bolt holes. A thin shim is disposed on one of the facing layers. The shim has arcuate elements lying adjacent to each of a pair of adjacent combustion openings. U-shaped armors at each combustion opening have legs overlapping the edges of the facing layers and portions of the shim elements adjacent to the edges of the combustion openings, with the shim elements extending radially outwardly beyond the armor legs. When the armors, shim and facing layer are precompressed after assembly and during the manufacturing process, the facing layer is densified through a reduction in thickness under the armor, is greatly densified under the armor and shim through a reduction in thickness by approximately the thickness of the shim, and densified in proportion to the shim thickness where the shim elements extend radially outwardly beyond the legs. The gasket is substantially unreduced in thickness radially beyond the shim and armor.

    Abstract translation: 一种头垫片，其包括在芯的每个主表面上的层压体，金属芯和面向纤维的弹性体，并且限定多个燃烧开口，油和水孔以及螺栓孔。 薄垫片设置在一个面层上。 垫片具有与一对相邻的燃烧口中的每一个相邻的弧形元件。 在每个燃烧开口处的U形护甲具有与相对层的边缘和垫片元件的与燃烧开口的边缘相邻的部分重叠的腿，垫片元件径向向外延伸超过护甲腿。 当组装后和制造过程中装甲，垫片和面层均被预压缩时，面层通过装甲下方的厚度减小致密化，在装甲下大大地致密化，并通过厚度减小大约厚度 垫片，并且与垫片元件径向向外延伸超过腿部的垫片厚度成比例地致密化。 垫片在径向上基本上不被减薄，超过垫片和装甲。

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