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公开(公告)号：US06653291B1
公开(公告)日：2003-11-25
申请号：US08390700
申请日：1995-02-17
IPC分类号： A01N4304
CPC分类号： A61K48/0025 , A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61K35/38 , A61K48/00 , A61L27/3629
摘要： A composition useful for the production of transformed eukaryotic cells is described. The composition comprises submucosal tissue and a nucleic acid sequence. The nucleic acid sequence is typically recombinant DNA including gene(s) encoding for one or more biofunctional proteins. Injection or implantation of the composition into a host induces the formation of transformed cells capable of expressing gene(s) encoded by the nucleic acid sequence.
摘要翻译： 描述了可用于生产转化真核细胞的组合物。 组合物包含粘膜下组织和核酸序列。 核酸序列通常是包含编码一种或多种生物功能蛋白质的基因的重组DNA。 将组合物注入或植入宿主中诱导能够表达由核酸序列编码的基因的转化细胞的形成。
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公开(公告)号：US06485723B1
公开(公告)日：2002-11-26
申请号：US09566497
申请日：2000-05-08
IPC分类号： A61K500
CPC分类号： A61L27/3808 , A61K35/38 , A61K35/44 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3683 , A61L27/3839 , C12N5/0068 , C12N5/0655 , C12N5/0676 , C12N5/0679 , C12N2500/32 , C12N2500/38 , C12N2533/92 , A61K2300/00
摘要： An improved tissue graft construct comprising submucosa of a warm-blooded vertebrate and a preselected group of eukaryotic cells are described. The improved tissue graft constructs can be used in accordance with the present invention to enhance the repair of damaged or diseased tissues in vivo.
摘要翻译： 描述了包括温血脊椎动物的粘膜下层和预选的真核细胞组的改进的组织移植物构建体。 可以根据本发明使用改进的组织移植物构建体，以增强体内受损或患病组织的修复。
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公开(公告)号：US06331319B1
公开(公告)日：2001-12-18
申请号：US09463937
申请日：2000-02-02
IPC分类号： A61K3538
CPC分类号： C12N5/0068 , A61K35/12 , A61K35/38 , A61L27/3629 , A61L27/3687 , A61L27/3695 , C12N2533/92
摘要： A tissue graft composition comprising submucosal tissue that has been enzymatically treated with galactosidase is described. The galactosidase modified submucosal tissue can be implanted to replace or support damaged or diseased tissues or utilized to form a cell culture growth substrate.
摘要翻译： 描述了包含用半乳糖苷酶酶处理的粘膜下组织的组织移植组合物。 可以植入半乳糖苷酶修饰的粘膜下组织来代替或支持受损或患病组织或用于形成细胞培养生长底物。
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公开(公告)号：US5968096A
公开(公告)日：1999-10-19
申请号：US908151
申请日：1997-08-06
申请人： Bryan Whitson , Boyle Cheng , Stephen F. Badylak
发明人： Bryan Whitson , Boyle Cheng , Stephen F. Badylak
CPC分类号： A61L27/3683 , A61F2/02 , A61L27/3629 , A61F2240/001
摘要： A perforated unitary multi-laminar tissue graft construct and method for preparing such construct is described. The method comprises overlapping strips of submucosa tissue with other strips of submucosal tissue, compressing at least the overlapped portions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets, and perforating the resulting unitary tissue graft construct. The perforated tissue graft compositions have enhanced mechanical and remodeling properties relative to non-perforated submucosal tissue grafts.
摘要翻译： 描述了一种穿孔单层多层组织移植物构建体及其制备方法。 该方法包括将粘膜下层组织与其它粘膜下组织条带重叠，在允许或促进压缩粘膜下层片脱水的条件下至少压缩两个表面的两个表面的重叠部分，并对所得的单一组织移植物构件进行穿孔。 穿孔组织移植组合物相对于非穿孔粘膜下组织移植物具有增强的机械和重塑性能。
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35.发明授权Tissue graft and method for urinary tract urothelium reconstruction and replacement 失效尿道尿道上皮重建和置换组织移植和方法
公开(公告)号：US5762966A
公开(公告)日：1998-06-09
申请号：US784117
申请日：1997-01-15
CPC分类号： A61L27/3629 , A61K35/38 , A61L27/3679 , A61L2430/22
摘要： A method for surgical repair of a diseased or damaged bladder is described. Diseased or damaged bladder tissue is surgically replaced with submucosal tissue of a warm blooded vertebrate to promote regrowth of endogenous urinary bladder tissue.
摘要翻译： 描述了患有或受损的膀胱的手术修复方法。 用温血脊椎动物的粘膜下组织手术替代疾病或损伤的膀胱组织，以促进内源性膀胱组织的再生长。
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公开(公告)号：US5711969A
公开(公告)日：1998-01-27
申请号：US418515
申请日：1995-04-07
申请人： Umesh H. Patel , Michael C. Hiles , Bryan Whitson , Boyle Cheng , Stephen F. Badylak , Klod Kokini
发明人： Umesh H. Patel , Michael C. Hiles , Bryan Whitson , Boyle Cheng , Stephen F. Badylak , Klod Kokini
CPC分类号： A61L27/3691 , A61F2/0063 , A61K35/38 , A61L27/3629
摘要： A unitary heterolaminar tissue graft construct is prepared by fusing partially overlapped strips or sheets of submucosa tissue. The submucosa components are fused by compressing at least the overlapped positions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets. Three dimensional graft constructs can be prepared by using complementary non-planar compressive surfaces.
摘要翻译： 通过融合部分重叠的粘膜下层组织片或片材来制备单一的异构层状组织移植物构建体。 通过在允许或促进压缩的粘膜下层片的脱水的条件下，通过在两个表面之间至少压缩所述条的重叠位置来熔化粘膜下层组分。 可以通过使用互补的非平面压缩表面来制备三维移植物构建体。
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公开(公告)号：US5695998A
公开(公告)日：1997-12-09
申请号：US386452
申请日：1995-02-10
申请人： Stephen F. Badylak , George Boder , Sherry Voytik , Robert J. Demeter , John Critser , Chi Liu
发明人： Stephen F. Badylak , George Boder , Sherry Voytik , Robert J. Demeter , John Critser , Chi Liu
CPC分类号： C12N5/0655 , C12M23/34 , C12M25/02 , C12N5/0068 , C12N5/0676 , C12N5/0679 , C12N2500/32 , C12N2500/38 , C12N2533/92 , Y10S623/915
摘要： A cell culture growth substrate comprising submucosal tissue of a warm-blooded vertebrate and a method for culturing eukaryotic cells are described. Submucosal tissue used in accordance with the present invention supports the proliferation and differentiation of eukaryotic cells when said cells are contacted with submucosal tissue under conditions conducive to cell proliferation.
摘要翻译： 描述了包含温血脊椎动物的粘膜下组织的细胞培养生长底物和培养真核细胞的方法。 根据本发明使用的粘膜下组织当所述细胞在有利于细胞增殖的条件下与粘膜下组织接触时，支持真核细胞的增殖和分化。
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公开(公告)号：US5573784A
公开(公告)日：1996-11-12
申请号：US423411
申请日：1995-04-18
申请人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
发明人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
CPC分类号： A61L27/3645 , A61B17/1146 , A61F2/02 , A61F2/08 , A61L27/3629 , A61L27/365 , A61L27/3662 , A61L27/3695 , Y10S623/915
摘要： Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.
摘要翻译： 可以使用由分层的肠组织段形成的组织移植来完成患病或损伤的内源性结缔组织的手术修复。 组织移植物包括从中膜肌层和至少中膜粘膜的腔部分离的肠粘膜粘膜下层。 移植物可通过拉伸进行调理，并形成为具有高拉伸强度的多层组合物，并且在其附着于现有生理结构的点处具有抗撕裂性。
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公开(公告)号：US09814744B2
公开(公告)日：2017-11-14
申请号：US13515661
申请日：2010-12-20
IPC分类号： A01N63/00 , A01N65/00 , A01N1/00 , A01N1/02 , A61K35/35 , A61L26/00 , A61L27/38 , A61L27/60 , C07K14/78 , C12N5/00 , C12N5/0775
CPC分类号： A61K35/35 , A61L26/0057 , A61L26/0076 , A61L27/3804 , A61L27/60 , C07K14/78 , C12N5/0068 , C12N5/0667 , C12N2533/90
摘要： Provided herein are methods of making a cell growth scaffold from adipose tissue, cell growth scaffolds having low lipid content and methods of using the cell growth scaffold.
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公开(公告)号：US09277999B2
公开(公告)日：2016-03-08
申请号：US12714195
申请日：2010-02-26
CPC分类号： A61F2/3099 , A61F2/30756 , A61F2/30942 , A61F2002/30062 , A61F2002/30069 , A61F2002/30113 , A61F2002/30125 , A61F2002/30574 , A61F2002/30576 , A61F2002/30581 , A61F2002/30588 , A61F2002/30754 , A61F2002/30766 , A61F2002/3092 , A61F2210/0004 , A61F2230/0006 , A61F2230/0008 , A61L27/14 , A61L27/3633 , A61L27/48 , A61L27/58 , A61L2430/06 , C08L89/00
摘要： Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can promote tissue regeneration of a temporal mandibular joint (TMJ) meniscus.
摘要翻译： 本文提供了组合物和医疗装置，特别是能够修复和替代软骨型半月板的可生物降解的支架。 本文还提供了使用支架治疗退行性组织病症的方法。 在某些实施方案中，这种支架可以促进颞下颌关节（TMJ）半月板的组织再生。
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