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公开(公告)号：US20240178673A1
公开(公告)日：2024-05-30
申请号：US18551422
申请日：2022-03-30
Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , ALLIANCE FOR SUSTAINABLE ENERGY, LLC
Inventor： Bri-Mathias HODGE , Simon JULIEN , Amirhossein SAJADI
CPC classification number: H02J3/466 , H02J3/12 , H02J3/381 , H02J2300/26
Abstract: The present disclosure relates generally to systems, methods, and apparatus for hierarchical control of utility-scale, inverter-based generation for mitigation of generation variability and responsive provisions of ancillary services. Such systems may include one or more processors, computer-readable media, and executable instructions which, if executed at the processors, configure the system to determine, at a first control layer, an inverter maximum power potential for a set of inverters, to determine, at the second control layer, an initial combined power output associated with the set of inverters and to determine a power support level and to transmit, from the second control layer to a third control layer, an indication of the power support level. The executable instructions may also configure the system to determine a first net power request, and to transmit, from the third control layer to the second control layer, an indication of the first net power request.
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公开(公告)号：US20240158601A1
公开(公告)日：2024-05-16
申请号：US18530194
申请日：2023-12-05
Inventor： Andrew J. Hess , Ivan I. Smalyukh , Qingkun Liu , Joshua A. De La Cruz , Blaise Fleury , Eldho Abraham , Vladyslav Cherpak , Bohdan Senyuk
CPC classification number: C08J9/28 , C08J9/0061 , C12P19/04 , B32B23/048 , B32B2262/062 , B32B2266/126 , C08J2201/0504 , C08J2201/0546 , C08J2205/022 , C08J2205/026 , C08J2301/02 , C08J2383/04
Abstract: Disclosed are cellulose-based flexible gels containing cellulose nanorods, ribbons, fibers, and the like, and cellulose-enabled inorganic or polymeric composites, wherein the gels have tunable optical, heat transfer, and stiffness properties. The disclosed gels are in the form of hydrogels, organogels, liquid-crystal (LC) gels, and aerogels. Further disclosed are highly transparent and flexible cellulose nanofiber-polysiloxane composite aerogels featuring enhanced mechanical robustness, tunable optical anisotropy, and low thermal conductivity. Further disclosed are gels comprising cellulosic material derived from bacteria and processes for preparing bacterial cellulose gels and methods of use.
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公开(公告)号：US20240158443A1
公开(公告)日：2024-05-16
申请号：US18272674
申请日：2022-01-19
Inventor： Michael Stowell , William Old , Brady Worrell , John Mayer
Abstract: The invention described herein includes a novel platform for the development of novel shapeshifting drug-like compounds that overcome physical mass limitations as they possess the ability to interconvert internally and spontaneously, i.e., shapeshift, between multiple chemical structures with varying pharmacophore properties. In one preferred embodiment, the invention include systems, methods, and compositions for the synthesis of novel bullvalene amino acid (Bvas) compounds that may further be incorporated into Shape Shifting Cyclic Peptides (SSCP) with varying pharmacophore properties and their use as novel therapeutic compounds.
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公开(公告)号：US11976328B2
公开(公告)日：2024-05-07
申请号：US16928436
申请日：2020-07-14
Inventor： David A. Schwartz , Tasha E. Fingerlin , Weiming Zhang
IPC: C12Q1/686 , C12Q1/6883 , G01N33/68
CPC classification number: C12Q1/6883 , G01N33/6893 , C12Q2600/156 , C12Q2600/158 , G01N2800/12 , G01N2800/50 , G01N2800/52 , G01N2800/60
Abstract: Disclosed are biomarkers, methods and assay systems for the identification of poor prognosis of interstitial pneumonia (pulmonary fibrosis) in an individual diagnosed with suspected of having interstitial pneumonia.
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公开(公告)号：US11975314B2
公开(公告)日：2024-05-07
申请号：US17891898
申请日：2022-08-19
Inventor： Staci A. Moulton , Alan W. Weimer
IPC: B01J21/04 , B01J19/00 , B01J21/18 , B01J23/22 , B01J23/34 , B01J23/42 , B01J23/44 , B01J23/46 , B01J23/745 , B01J23/75 , B01J23/755 , B01J35/00 , B01J35/02 , B01J35/10 , B01J37/02 , B01J37/08 , B01J37/34 , C10G2/00
CPC classification number: B01J37/0221 , B01J19/0093 , B01J23/75 , B01J35/0013 , B01J35/006 , B01J35/023 , B01J35/1014 , B01J37/08 , B01J37/34 , C10G2/33 , B01J2219/00792 , B01J2219/00801 , B01J2219/00835
Abstract: Structures, catalysts, and reactors suitable for use for a variety of applications, including gas-to-liquid and coal-to-liquid processes and methods of forming the structures, catalysts, and reactors are disclosed. The catalyst material can be deposited onto an inner wall of a microtubular reactor and/or onto porous support structures using atomic layer deposition techniques.
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Patent Agency Ranking
公开(公告)号：US20240131113A1
公开(公告)日：2024-04-25
申请号：US18547382
申请日：2022-02-22
Applicant: The Regents of the University of Colorado, A Body Corporate , The University of North Texas Health Science Center at Fort Worth
Inventor： Ram H. NAGARAJ , Rooban B. NAHOMI , Dorota L. STANKOWSKA
CPC classification number: A61K38/1709 , A61K9/0019 , A61K9/0048 , A61K47/64 , A61P27/06 , C07K7/06 , C07K14/47
Abstract: Peptide-based therapies for a retinal disease, injury, or condition in a subject involve administering to the subject a pharmaceutical composition containing at least one peptide derived from a heat shock protein, including Hsp20 and αB-crystallin. The administered peptides may be acetylated and/or conjugated to a cell-penetrating peptide. Administration of the peptides may reduce or prevent the loss of at least one retinal cell type, including retinal ganglion cells and retinal endothelial cells. The loss of such cells causes retinal damage and loss of eyesight in patients afflicted with an ocular condition. The pharmaceutical compositions may be administered intravitreally using an administration device. A single injection may be therapeutically sufficient for treating various ocular conditions.
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公开(公告)号：US20240130973A1
公开(公告)日：2024-04-25
申请号：US18372556
申请日：2023-09-24
Inventor： Theodore Randolph , Robert Garcea
CPC classification number: A61K9/19 , A61K9/1623 , A61K9/1694 , A61K39/12 , A61K39/295 , A61K45/06 , C12N7/00 , A61K2039/5258
Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lyophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes. Yet other embodiments disclosed herein concern multi-targeted antigen complexes lyophilized in formulations of use to prolong stability and/or enhance immunogenicity. Other embodiments concern exposing lyophilized multi-targeted antigen complexes to elevated temperatures to enhance immunogenicity of the antigens of the complex to multiple pathogens.
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公开(公告)号：US11965831B2
公开(公告)日：2024-04-23
申请号：US16976946
申请日：2019-03-01
Inventor： Juliet T. Gopinath , Brendan M. Heffernan , Robert Niederriter , Stephanie A. Meyer , Diego Restrepo , Emily A. Gibson , Mark E. Siemens
CPC classification number: G01N21/6458 , G02B3/0087 , G02B21/0032 , G02B21/0068 , G02B21/0076 , G02B27/58 , G01N2021/6484
Abstract: Sub-diffraction limited fluorescent images using a fiber-based stimulated emission depletion (STED) microscope are reported. Both excitation and depletion beams are transported through polarization-maintaining fiber and a lateral resolution of 100 nm has been achieved.
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公开(公告)号：US11964985B2
公开(公告)日：2024-04-23
申请号：US15930188
申请日：2020-05-12
Inventor： Dan Theodorescu , Michael Fitzpatrick Wempe , David Ross , Samy Meroueh , Martin A. Schwartz , Phillip Reigan
IPC: C07D491/052 , A61K31/351 , A61K31/4162 , A61K31/437 , A61K31/505 , A61K31/5513 , A61K45/06
CPC classification number: C07D491/052 , A61K31/351 , A61K31/4162 , A61K31/437 , A61K31/505 , A61K31/5513 , A61K45/06
Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
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公开(公告)号：US20240124645A1
公开(公告)日：2024-04-18
申请号：US18267348
申请日：2021-12-17
Inventor： Christopher N. Bowman , Brady T. Worrell , Juan J. Hernandez , Matthew K. McBride , Sijia Huang , Maciej Podgorski
IPC: C08G63/688 , B33Y70/00 , C08G63/78 , C08J3/28
CPC classification number: C08G63/688 , B33Y70/00 , C08G63/78 , C08J3/28
Abstract: Described herein is a composition for producing a thiol-ene covalent adaptable network (CAN) polymer. The composition includes a first monomer including at least one thiol group; and a second monomer including at least one anhydride functional group and at least one alkene functional group. Also described herein are a polymer produced from the composition, a method of producing the polymer using the composition, a method of fabricating a polymer article using the composition, as well as a method of degrading the polymer.
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