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公开(公告)号：US20240139372A1
公开(公告)日：2024-05-02
申请号：US18450941
申请日：2023-08-16
Applicant: Abbott Cardiovascular Systems, Inc
Inventor： Ni Ding , Vincent James Gray
CPC classification number: A61L27/18 , A61L27/54 , A61L2420/06
Abstract: Systems, methods, and apparatuses for depositing polymer and/or other layers onto surfaces of, for example, implantable medical devices. In some embodiments, the polymer and/or other coating layers are deposited via plasma polymerization deposition. In some embodiments, primer layers are deposited via plasma polymerization deposition. A coating layer can be formed over a primer layer. The deposited layers can be bioresorbable and/or bioabsorbable.
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公开(公告)号：US10278844B2
公开(公告)日：2019-05-07
申请号：US15688486
申请日：2017-08-28
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Rommel Lumauig , Stephen D. Pacetti , Ni Ding , Joel Harrington , Xiao Ma , James P. Oberhauser , Jill McCoy , Chad J. Abunassar , Senthil Eswaran , Diem Ta
IPC: A61F2/915 , C08G63/08 , B29C71/02 , A61L31/06 , A61L31/14 , B29C71/00 , B29K67/00 , B29L31/00 , B29C35/04 , B29C35/08
Abstract: Methods are disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter.
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公开(公告)号：US10064982B2
公开(公告)日：2018-09-04
申请号：US14832889
申请日：2015-08-21
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Wouter E. Roorda , Ni Ding
IPC: A61F2/30 , A61L31/08 , B05D1/02 , A61L31/16 , A61K31/436 , A61L31/10 , A61F2/82 , A61K31/439
Abstract: An amorphous PDLLA stent coating for drug delivery is disclosed.
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公开(公告)号：US10010653B2
公开(公告)日：2018-07-03
申请号：US15016911
申请日：2016-02-05
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Erika Danielle Anderson-Bolden , Xinmin Xu , Ni Ding , Boyd V. Knott , Marc Culkin
CPC classification number: A61L31/10 , A61L31/16 , A61L2300/416 , B05D3/0209 , C08L67/04
Abstract: Methods of reducing crimping damage to polymer and drug coating on a scaffold are disclosed. The methods include physically aging a coating including a coating polymer and drug mixture on a scaffold in a manner that takes into account the differing kinetics of aging, that is, the different temperature dependence of the aging rate of the polymer and drug.
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公开(公告)号：US09901663B2
公开(公告)日：2018-02-27
申请号：US14267620
申请日：2014-05-01
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti , Ni Ding
CPC classification number: A61L31/16 , A61F2/82 , A61F2250/0067 , A61F2250/0068 , A61L27/50 , A61L27/505 , A61L27/54 , A61L31/022 , A61L31/143 , A61L2300/00 , A61L2300/416 , A61L2300/426 , A61L2300/604 , A61L2300/802 , B65B3/003 , Y10T29/49993
Abstract: A composition for loading into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may comprise a therapeutic agent, and a chelator, a precipitation agent, or a combination thereof. Medical devices, such as stents, with a structural element defined by a lumen and at least one opening to access the lumen, filled with the compositions are also described.
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Patent Agency Ranking
公开(公告)号：US20170224880A1
公开(公告)日：2017-08-10
申请号：US15016911
申请日：2016-02-05
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Erika Danielle Anderson-Bolden , Xinmin Xu , Ni Ding , Boyd V. Knott , Marc Culkin
CPC classification number: A61L31/10 , A61L31/16 , A61L2300/416 , B05D3/0209 , C08L67/04
Abstract: Methods of reducing crimping damage to polymer and drug coating on a scaffold are disclosed. The methods include physically aging a coating including a coating polymer and drug mixture on a scaffold in a manner that takes into account the differing kinetics of aging, that is, the different temperature dependence of the aging rate of the polymer and drug.
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公开(公告)号：US09669137B2
公开(公告)日：2017-06-06
申请号：US14613304
申请日：2015-02-03
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti , Fuh-Wei Tang , Xiao Ma , Ni Ding , Derek Mortisen
IPC: A61F2/82 , A61K47/48 , A61L31/06 , A61L31/10 , A61L31/14 , C08G63/91 , A61L2/08 , B29C71/04 , C08G63/08 , B29B13/08 , B29C35/08 , A61F2/91
CPC classification number: A61L31/06 , A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61K47/593 , A61L2/087 , A61L31/10 , A61L31/148 , A61L2300/606 , B29B13/08 , B29C71/04 , B29C2035/0827 , B29C2035/085 , B29C2035/0877 , C08G63/08 , C08G63/912
Abstract: It is provided herein modified polylactide (PLA) polymers comprising biocompatibile functional group(s) on the polymers and methods of making and using the modified PLA polymers.
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公开(公告)号：US09566723B2
公开(公告)日：2017-02-14
申请号：US14139740
申请日：2013-12-23
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma , Fuh-Wei Tang , Ni Ding
CPC classification number: B29C71/02 , A61F2/82 , A61F2/915 , A61F2002/91558 , A61F2002/91583 , A61F2210/0004 , A61F2240/001 , A61L2/007 , A61L2/08 , A61L2/087 , A61L31/06 , A61L31/148 , A61L2202/21 , A61L2202/24 , A61L2400/18 , B29C35/02 , B29C2035/0877 , B29C2071/022 , B29L2031/753 , C08J7/08 , C08J7/123 , C08J2367/04 , C08L67/04
Abstract: Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number-average molecular weight of the polymer of the polymeric stent, fall within a narrower range.
Abstract translation: 公开了用于在灭菌后和/或在卷曲之后和包装之前调节聚合物支架的方法，使得聚合物支架的性质落在较窄的值范围内。 在辐射灭菌后和/或在压接之后和灭菌之前将支架暴露于等于或高于环境的受控温度一段时间。 结果，聚合物支架的聚合物支架性质，特别是聚合物支架的聚合物的径向强度和数均分子量落在更窄的范围内。
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公开(公告)号：US20150359943A1
公开(公告)日：2015-12-17
申请号：US14832889
申请日：2015-08-21
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Wouter E. Roorda , Ni Ding
IPC: A61L31/08 , A61K31/439 , A61L31/16 , A61F2/82
CPC classification number: A61L31/08 , A61F2/82 , A61F2002/30062 , A61F2002/30064 , A61K31/436 , A61K31/439 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/606 , A61L2420/02 , A61L2420/06 , B05D1/02
Abstract: An amorphous PDLLA stent coating for drug delivery is disclosed.
Abstract translation: 公开了用于药物递送的无定形PDLLA支架涂层。
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40.发明授权Controlling moisture in and plasticization of bioresorbable polymer for melt processing 有权控制生物可吸收聚合物的水分和塑化，用于熔体加工公开(公告)号：US09168677B2
公开(公告)日：2015-10-27
申请号：US14311175
申请日：2014-06-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Bethany Steichen , Stephen Pacetti , Manish Gada , Thierry Glauser , Lothar Kleiner , Yunbing Wang , James Oberhauser , Ni Ding
CPC classification number: B29C47/0078 , B29B13/06 , B29B13/065 , B29C47/0014 , B29C47/0021 , B29C47/0023 , B29C47/1018 , B29C47/1072 , B29C47/76 , B29C47/92 , B29C2947/922 , B29C2947/92228 , B29C2947/92342 , B29C2947/92695 , B29C2947/92704 , B29C2947/92723 , B29K2995/006
Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.
Abstract translation: 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。 进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。
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