公开(公告)号：US07331931B2

公开(公告)日：2008-02-19

申请号：US10335218

申请日：2002-12-31

Applicant: Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B5/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing having a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A cartridge houses the penetrating member. The cartridge has first and second seals coupled to the penetrating member to maintain a sterile environment around a portion of the penetration member prior to penetrating member actuation. A user interface is configured to relay at least one of, penetrating member performance or a penetrating member setting.

Abstract translation: 本发明的这些和其它目的是在包括电动驱动力发生器的组织部位上使用的体液取样系统中实现的。 穿透构件可操作地联接到力发生器。 力产生器将构件沿着路径移动离开具有穿透构件出口的壳体，进入组织部位，在组织部位停止，并从组织部位抽出。 墨盒容纳穿透构件。 筒具有联接到穿透构件的第一和第二密封件，以在穿透构件致动之前保持穿透构件的一部分周围的无菌环境。 用户界面被配置为中继穿透构件性能或穿透构件设置中的至少一种。

公开(公告)号：US07297122B2

公开(公告)日：2007-11-20

申请号：US10335220

申请日：2002-12-31

Applicant: Dirk Boecker ,  Don Alden ,  Dominique M. Freeman

Inventor： Dirk Boecker ,  Don Alden ,  Dominique M. Freeman

IPC: A61B5/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a single drive force generator. A plurality of penetrating members are operatively coupled to the force generator. The force generator moves each of the members along a path out of a housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A flexible support member couples the penetrating members to define a linear array. The support member is movable and configured to move each of the penetrating members to a launch position associated with the force generator. A user interface is configured to relay at least one of, penetrating member performance or a penetrating member setting.

公开(公告)号：US20070219573A1

公开(公告)日：2007-09-20

申请号：US11737818

申请日：2007-04-20

Applicant: Dominique Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B17/34

CPC classification number: A61B5/15178 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/157

Abstract: A tissue penetrating system includes a plurality of penetrating members each having a tip. A penetrating member driver is coupled to the plurality of penetrating members. A support is provided with a plurality of openings. Each opening receives a penetrating member. Each tip of a penetrating member is uncovered during launch of a penetrating member by the penetrating driver member. A user interface is configured to relay at least one of, skin penetrating performance or a skin penetrating setting.

Abstract translation: 组织穿透系统包括各自具有尖端的多个穿透构件。 穿透构件驱动器联接到多个穿透构件。 支撑件设置有多个开口。 每个开口接收穿透构件。 穿透构件的每个尖端在通过穿透驱动构件发射穿透构件时未被覆盖。 用户界面被配置为中继皮肤穿透性能或皮肤穿透设置中的至少一种。

公开(公告)号：US07229458B2

公开(公告)日：2007-06-12

申请号：US10335211

申请日：2002-12-31

Applicant: Dirk Boecker ,  Don Alden ,  Dominique M. Freeman

Inventor： Dirk Boecker ,  Don Alden ,  Dominique M. Freeman

IPC: A61B17/32

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: A tissue penetrating system includes a plurality of cartridges each with a distal port and a proximal port. A plurality of penetrating members are provided, each coupled to a cartridge and having a sharpened distal tip and a shaft portion slidably disposed within the cartridge. A seal is formed by a fracturable material between the penetrating member and the cartridge. The seal is positioned at one or both of a distal port or a proximal port of the cartridge.

公开(公告)号：US20070073189A1

公开(公告)日：2007-03-29

申请号：US11536725

申请日：2006-09-29

Applicant: Dominique Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B5/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15176 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: A tissue penetrating system has a housing member. A plurality of penetrating members are positioned in the housing member. A tissue stabilizing member is coupled to the housing. A penetrating member sensor is coupled to the plurality of penetrating members. The penetrating member sensor is configured to provide information relative to a depth of penetration of a penetrating member through a skin surface.

Abstract translation: 组织穿透系统具有壳体构件。 多个穿透构件定位在壳体构件中。 组织稳定构件联接到壳体。 穿透构件传感器联接到多个穿透构件。 穿透构件传感器被配置为提供关于穿透构件穿过皮肤表面的穿透深度的信息。

公开(公告)号：US20070064516A1

公开(公告)日：2007-03-22

申请号：US11539945

申请日：2006-10-10

Applicant: Barry Briggs ,  Dominique Freeman ,  Don Alden ,  Jon Leonard ,  Dirk Boecker

Inventor： Barry Briggs ,  Dominique Freeman ,  Don Alden ,  Jon Leonard ,  Dirk Boecker

IPC: G11C8/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/15019 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150824 ,  A61B5/150832 ,  A61B5/15087 ,  A61B5/150916 ,  A61B5/150954 ,  A61B5/151 ,  A61B5/15111 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15174 ,  A61B5/15176 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/1519 ,  A61B5/15194 ,  A61B17/32093 ,  B01L3/5027 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver comprises of a drive force generator for advancing the lancet along a path into the tissue site, and a sensor configured to detect lancet position along said path during the lancing cycle.

公开(公告)号：US20060204399A1

公开(公告)日：2006-09-14

申请号：US10541124

申请日：2003-12-30

Applicant: Dominique Freeman ,  Dirk Boecker ,  Robert Jones ,  David Cullen ,  Malcolm McLeod ,  William Carlsen ,  Michael Owen ,  Christopher Dryer

Inventor： Dominique Freeman ,  Dirk Boecker ,  Robert Jones ,  David Cullen ,  Malcolm McLeod ,  William Carlsen ,  Michael Owen ,  Christopher Dryer

IPC: G01N21/64 ,  C12M1/34

CPC classification number: A61B5/14532 ,  A61B5/1411 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150274 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15176 ,  A61B5/157 ,  B01L3/5025 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2300/0803 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N21/6408

Abstract: A device is provided for use with a tissue penetrating system and/or a metering device for measuring analyte levels. The device comprises a cartridge and a plurality of analyte detecting members mounted on the cartridge. The cartridge may have a radial disc shape. The cartridge may also be sized to fit within the metering device. The analyte detecting members may be optical system using fluorescence lifetime to determine analyte levels. In one embodiment, the device may also include a fluid spreader positioned over at least a portion of the analyte detecting member to urge fluid toward one of the detecting members. A plurality of analyte detecting members may be used. Each analyte detecting member may be a low volume device.

公开(公告)号：US07025774B2

公开(公告)日：2006-04-11

申请号：US10127395

申请日：2002-04-19

Applicant: Dominique M. Freeman ,  Dirk Boecker ,  Don Alden ,  Barry Dean Briggs ,  Jon Hewitt Leonard ,  Ray Freeman ,  George Gogue

Inventor： Dominique M. Freeman ,  Dirk Boecker ,  Don Alden ,  Barry Dean Briggs ,  Jon Hewitt Leonard ,  Ray Freeman ,  George Gogue

IPC: A61B17/14

CPC classification number: A61M5/46 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150061 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/15019 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15176 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61B17/32093 ,  A61M5/158 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905 ,  G01N33/557 ,  G06F19/00

Abstract: A tissue penetration device and method of using same. The tissue penetration device may optionally include sampling and analyzing functions, which may be integrated. An embodiment provides control of a lancet used for sampling blood. Electric field coils or solenoids may drive the lancet using electromagnetic force. Advancement and retraction of a lancet may be controlled by a feedback loop monitoring the position and velocity of the lancet embodiments of the lancet driver can be configured to follow a predetermined tissue lancing profile. Embodiments of the invention include a lancet and method for using a lancet to maintain the patency of the wound tract once the lancet has cut into the skin.

公开(公告)号：US5676143A

公开(公告)日：1997-10-14

申请号：US677923

申请日：1996-07-10

Applicant: Jan Henning Simonsen ,  Dirk Boecker

Inventor： Jan Henning Simonsen ,  Dirk Boecker

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00 ,  G01N21/17 ,  G01N21/27 ,  G01N21/49 ,  G01N21/59 ,  G01N33/483

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/6826 ,  A61B5/6833 ,  A61B5/6838 ,  A61B2562/0233 ,  A61B2562/046

Abstract: An apparatus for determination of a glucose concentration in a biological matrix includes an irradiation device for irradiating light as primary light into a biological matrix, and a detection device for measuring intensity of light emerging as secondary light through the boundary surface of the biological matrix. The detection device detects light from the irradiation device after the light has propagated along a light path in the biological matrix. A data processing device processes measurement signals from the detection device. The irradiation device provides spatially limited illumination of an irradiation site, and the detection device is configured for spatially limited measurements of the secondary light emerging at the detection site. The detection site is located relative to the irradiation site such that the secondary light is multiply scattered at scattering centers in the biological matrix. The irradiation and detection devices are configured to provide at least two different light paths within the biological matrix during detection measurements, and to perform at least two detection measurements wherein the light paths are different. The detection device generates separate measurement signals for each of the at least two detection measurements. The data processing device converts the separate measurement signals into a signal which corresponds to a glucose concentration in the biological matrix.

Abstract translation: 用于测定生物体中葡萄糖浓度的装置包括将光作为一次光照射到生物体中的照射装置，以及检测装置，用于测量通过生物体的边界面产生的二次光的强度。 检测装置在光沿生物基质中的光路传播之后，检测来自照射装置的光。 一种数据处理装置从所述检测装置处理的测量信号。 照射装置提供照射部位的空间有限的照明，并且检测装置被配置用于在检测部位出现的二次光的空间有限的测量。 检测位置相对于照射部位定位，使得二次光在生物基质中的散射中心多次散射。 照射和检测装置被配置为在检测测量期间在生物矩阵内提供至少两个不同的光路，并且执行其中光路不同的至少两个检测测量。 的检测装置产生用于所述至少两个检测测量的单独的测量信号。 所述数据处理装置中的单独的测量信号转换成对应于在生物基质中的葡萄糖浓度的信号。

公开(公告)号：US08905945B2

公开(公告)日：2014-12-09

申请号：US13433402

申请日：2012-03-29

Applicant: Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B17/14 ,  A61B17/32 ,  A61B5/00 ,  A61B5/15 ,  A61B5/151 ,  A61B5/155

CPC classification number: A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150664 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/150916 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/15182 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  G01N27/28 ,  G06F19/00 ,  G06Q50/24

Abstract: A body fluid sampling system for use on a tissue site includes a single drive force generator. A plurality of penetrating members are operatively coupled to the force generator. The force generator moves each of the members along a path out of a housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A flexible support member couples the penetrating members to define a linear array. The support member is movable and configured to move each of the penetrating members to a launch position associated with the force generator.

Abstract translation: 用于组织部位的体液取样系统包括单个驱动力发生器。 多个穿透构件可操作地联接到力发生器。 力产生器沿着路径将每个构件沿穿过壳体的穿透构件出口移动到组织部位中，停止在组织部位中，并从组织部位中退出。 柔性支撑构件将穿透构件联接以限定线性阵列。 支撑构件是可移动的并且构造成将每个穿透构件移动到与力发生器相关联的发射位置。