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56 条记录 (耗时 0.033 秒)

    METHOD AND APPARATUS FOR SORTING PARTICLES
    31.
    发明申请
    METHOD AND APPARATUS FOR SORTING PARTICLES 审中-公开
    分离颗粒的方法和装置

    公开(公告)号：US20110005978A1

    公开(公告)日：2011-01-13

    申请号：US12821790

    申请日：2010-06-23

    申请人： Sebastian Böhm ,  John R. Gilbert ,  Manish Deshpande

    发明人： Sebastian Böhm ,  John R. Gilbert ,  Manish Deshpande

    IPC分类号： B03B5/00

    CPC分类号： G01N15/1459 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0487 ,  G01N2015/149

    摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

    摘要翻译： 用于分选移动通过毛细管尺寸的封闭通道系统的颗粒的方法和装置包括气泡阀，用于选择性地产生压力脉冲以将具有预定特征的颗粒与颗粒流分离。 颗粒分选系统还可以包括用于吸收压力脉冲的缓冲器。 颗粒分选系统可以包括多个紧密耦合的分类模块，其被组合以进一步提高排序率。 颗粒分选系统可以包括用于串行排列颗粒流的多级分选装置，以便降低误差率。

    Optical detector for a particle sorting system
    33.
    发明授权
    Optical detector for a particle sorting system 有权

    公开(公告)号：US07492522B2

    公开(公告)日：2009-02-17

    申请号：US11906621

    申请日：2007-10-03

    申请人： John R. Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    发明人： John R. Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    IPC分类号： G02B27/10 ,  C12M3/00 ,  G01N21/00

    CPC分类号： G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/6452 ,  G01N2015/1081

    摘要： An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

    Optical detector for a particle sorting system
    34.
    发明授权
    Optical detector for a particle sorting system 有权

    公开(公告)号：US07355699B2

    公开(公告)日：2008-04-08

    申请号：US11506522

    申请日：2006-08-18

    申请人： John R. Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    发明人： John R. Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    IPC分类号： G01N21/00

    CPC分类号： G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/6452 ,  G01N2015/1081

    摘要： An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

    Method and apparatus for sorting particles
    36.
    发明授权
    Method and apparatus for sorting particles 有权

    公开(公告)号：US09109993B2

    公开(公告)日：2015-08-18

    申请号：US12821790

    申请日：2010-06-23

    申请人： Sebastian Böhm ,  John R. Gilbert ,  Manish Deshpande

    发明人： Sebastian Böhm ,  John R. Gilbert ,  Manish Deshpande

    IPC分类号： B01L3/00 ,  G01N15/14

    摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

    Method and apparatus for sorting particles
    38.
    发明授权
    Method and apparatus for sorting particles 有权
    颗粒分选方法和装置

    公开(公告)号：US07584857B2

    公开(公告)日：2009-09-08

    申请号：US11499953

    申请日：2006-08-07

    申请人： Sebastian Böhm ,  John R. Gilbert ,  Manish Deshpande

    发明人： Sebastian Böhm ,  John R. Gilbert ,  Manish Deshpande

    IPC分类号： B03B5/00 ,  B07C5/00

    CPC分类号： B03B5/00 ,  B01L3/5027 ,  B07C5/34 ,  F15C5/00 ,  F16K99/0001 ,  F16K99/0028 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N15/14 ,  G01N2015/149 ,  Y10S209/906 ,  Y10S209/932

    摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

    摘要翻译： 用于分选移动通过毛细管尺寸的封闭通道系统的颗粒的方法和装置包括气泡阀，用于选择性地产生压力脉冲以将具有预定特征的颗粒与颗粒流分离。 颗粒分选系统还可以包括用于吸收压力脉冲的缓冲器。 颗粒分选系统可以包括多个紧密耦合的分类模块，其被组合以进一步提高排序率。 颗粒分选系统可以包括用于串行排列颗粒流的多级分选装置，以便降低误差率。

    Optical detector for a particle sorting system
    39.
    发明授权
    Optical detector for a particle sorting system 有权
    用于粒子分选系统的光学检测器

    公开(公告)号：US07576861B2

    公开(公告)日：2009-08-18

    申请号：US12079457

    申请日：2008-03-27

    申请人： John R. Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    发明人： John R. Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    IPC分类号： G01N21/00

    CPC分类号： G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/6452 ,  G01N2015/1081

    摘要： An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

    摘要翻译： 用于从空间通道阵列获取快速光谱的光学系统包括用于产生穿过微流体芯片或待监测通道的光束的光源，用于在相互作用之后捕获来自光源的光的一个或多个透镜或光纤 微流体通道中的颗粒或化学物质，以及一个或多个检测器。 可以包括光放大元件的检测器检测每个光信号并将光信号转换成电子信号。 每个表示光信号强度的电子信号从每个检测器传递到电子数据采集系统进行分析。 光放大元件可以包括耦合到光电二极管检测器阵列的光管阵列，多子光电管或基于多通道板的图像增强器。