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公开(公告)号：US20210086101A1
公开(公告)日：2021-03-25
申请号：US17113311
申请日：2020-12-07
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer , Bjorn Markus Olovsson
Abstract: Disclosed is a device for chromatographic separations comprising: a manifold comprising a manifold body defining an elongate central duct, the central duct comprising a centrally-located closable duct valve providing selective fluid communication between a first portion of the central duct and an opposed second portion of the central duct, a first plurality of connectors, each connector of the first plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; a second plurality of connectors, each connector of the second plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; wherein said manifold body further defines: a first plurality of branch ducts, each branch duct of which extending from the first portion of the central duct to an individual one of the first plurality of connectors, each of the branch ducts of the first plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the first portion of the central duct, a second plurality of branch ducts, each branch duct of which extending from the second portion of the central duct to an individual one of the second plurality of connectors, each of the branch ducts of the second plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the second portion of the central duct; first and second ports in fluid communication with the centrally-located closable duct valve wherein said first port communicates with said first portion of the central duct and said second port communicates with said second portion of said central duct, wherein one of said first and second ports is further positioned to communicate with said central duct at a location between the centrally-located closable duct valve and the first and second plurality of branch ducts, respectively.
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公开(公告)号：US10888799B2
公开(公告)日：2021-01-12
申请号：US15534540
申请日：2015-12-23
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer , Bjorn Markus Olovsson
Abstract: Disclosed is a device for chromatographic separations comprising: a manifold comprising a manifold body defining an elongate central duct, the central duct comprising a centrally-located closable duct valve providing selective fluid communication between a first portion of the central duct and an opposed second portion of the central duct, a first plurality of connectors, each connector of the first plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; a second plurality of connectors, each connector of the second plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; wherein said manifold body further defines: a first plurality of branch ducts, each branch duct of which extending from the first portion of the central duct to an individual one of the first plurality of connectors, each of the branch ducts of the first plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the first portion of the central duct, a second plurality of branch ducts, each branch duct of which extending from the second portion of the central duct to an individual one of the second plurality of connectors, each of the branch ducts of the second plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the second portion of the central duct; first and second ports in fluid communication with the centrally-located closable duct valve wherein said first port communicates with said first portion of the central duct and said second port communicates with said second portion of said central duct, wherein one of said first and second ports is further positioned to communicate with said central duct at a location between the centrally-located closable duct valve and the first and second plurality of branch ducts, respectively.
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公开(公告)号：US12209235B2
公开(公告)日：2025-01-28
申请号：US16328431
申请日：2017-08-28
Applicant: CYTIVA SWEDEN AB
Inventor： Klaus Gebauer , Pierre Le Greves , Andrew David Pris , Jozsef Vasi , Sam Petrocelli , Hanno Ehring , Esmaeil Heidari , Ali Can
Abstract: A device and method for detecting the level of foam in a reactor vessel monitors the intensity of the light or the movement of the light detected by a camera which monitors at least one light source positioned inside the reactor vessel or viewable through the reactor vessel.
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公开(公告)号：US12152698B2
公开(公告)日：2024-11-26
申请号：US18462316
申请日：2023-09-06
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer
IPC: F16K7/04 , F16K7/12 , F16K31/12 , F16K31/122 , F16K31/126
Abstract: A valve configured to be in a first state, which is an open state when a flow through the tube should be allowed; a second state during some parts of a process run in the system, said second state is a closed state were a first closing force is provided; and a third state during some parts of a process run in the system, said third state is a closed state were a second closing force is provided which is a higher force than the first closing force.
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公开(公告)号：US12110481B2
公开(公告)日：2024-10-08
申请号：US16607516
申请日：2018-04-18
Applicant: Cytiva Sweden AB
Inventor： Victor Jose , Andreas Axen , Klaus Gebauer , Veena B N Rao , Patric Fricking , Hanish Lakhani
Abstract: A bio-processing system (100) is presented. The bio-processing system (100) includes one or more bio-processing units (110-114), one or more process supporting devices (116, 118), one or more sensors (120-132), and a bio-processing workflow controller (104) wirelessly coupled to at least one of the one or more bio-processing units (110-114), the one or more process supporting devices (116, 118), and the one or more sensors (120-132). The bio-processing workflow controller (104) includes a processor (202) configured to create a reconfigurable bio-processing workflow, and where the reconfigurable bio-processing workflow is representative of an arrangement of one or more of the one or more bio-processing units (110-114), the one or more process supporting devices (116, 118), and the one or more sensors (120-32) to perform at least one bio-processing operation.
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Patent Agency Ranking
公开(公告)号：US12084645B2
公开(公告)日：2024-09-10
申请号：US16301150
申请日：2017-05-11
Applicant: CYTIVA SWEDEN AB
Inventor： Klaus Gebauer , Thomas Erik Arctaedius , Patrick Jonsson , Andreas Marcstrom
Abstract: The invention discloses a hollow profile wall segment (1) for a bioreactor or mixer support vessel (2;2a;2b), comprising a base profile (3) with two parallel wide sides (4,5), two narrow sides (6,7) and at least one heat exchange channel (8) extending in a longitudinal direction of the base profile through an interior space (9) in the base profile, wherein the hollow profile wall segment is adapted to be joined with similar hollow profile wall segments to form a side wall (12) of a bioreactor or mixer support vessel (2) and wherein each narrow side comprises at least one coupling member (10,11;11a;150) capable of securing the hollow profile wall segment side by side with similar hollow profile wall segments.
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公开(公告)号：US20240150697A1
公开(公告)日：2024-05-09
申请号：US18550075
申请日：2022-04-25
Applicant: CYTIVA SWEDEN AB
Inventor： Klaus Gebauer , Tim Francois , Andreas Lundin , Bjorn Markus Olovsson , Kerstin Erickson , Tomas Dalmo
Abstract: The present invention relates to a reconfigurable bioprocessing system (80) operable to perform a predetermined set of bioprocessing operations therein. The reconfigurable bioprocessing system (80) comprises a base unit (60) comprising a plurality of valve actuators (102). At least one of the plurality of valve actuators (102) is operable to releasably engage with at least part of a pinch valve cassette (103, 203) to control fluid flow through the pinch valve cassette (103, 203). At least part of the pinch valve cassette (103, 203) is removably attachable to the base unit (60) and the pinch valve cassette (103, 203) is provided adjacent to said plurality of valve actuators (102). The reconfigurable bioprocessing system (80) also includes a control system operable to selectively actuate respective of said plurality of valve actuators (102) to provide a valve configuration within the pinch valve cassette (103, 203) to enable the base unit (60) and the pinch valve cassette (103, 203) together to perform one of the predetermined set of bioprocessing operations. A flow kit (107) for use in reconfigurable bioprocessing systems (80) and various methods (1000) for reconfiguring bioprocessing systems (80) (e.g. automatically) are also disclosed.
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公开(公告)号：US11969669B2
公开(公告)日：2024-04-30
申请号：US17690975
申请日：2022-03-09
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer
CPC classification number: B01D15/206 , B01D15/22 , C07K1/14 , C07K1/18 , C07K1/20 , C07K1/22 , G01N30/56 , G01N30/6017 , G01N30/6069 , G01N2030/562 , G01N30/6082 , G01N30/6086
Abstract: The invention relates to containers or bags for chromatographic media and methods of packing chromatography columns using such containers. The bags may be used for storing and/or transporting chromatographic media and can be inserted directly into the chamber of a chromatography column in readiness for use.
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公开(公告)号：US11549091B2
公开(公告)日：2023-01-10
申请号：US14910824
申请日：2013-08-27
Applicant: Cytiva Sweden AB
Inventor： Andreas Castan , Klaus Gebauer
IPC: C12M1/00 , C12M1/06 , C12M3/00 , C12M3/06 , C12N1/16 , C12N1/20 , C12N5/04 , C12N5/07 , C12N5/071
Abstract: The invention discloses a bioreactor with a vessel defining an inner volume, agitation means and at least one addition tube, wherein a delivery orifice in the addition tube is located within the inner volume and a check valve is arranged in proximity of the delivery orifice for allowing flow of a fluid in the direction from the addition tube into the inner volume of the vessel and blocking flow in the reverse direction.
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公开(公告)号：US11466241B2
公开(公告)日：2022-10-11
申请号：US15781217
申请日：2016-11-25
Applicant: CYTIVA SWEDEN AB
Inventor： Amit Kumar Singh , Klaus Gebauer , Supti Datta , Jakob Liderfelt , Nachiket Karmarkar , Ajit S. Vernekar , Mats Olsson , Rajan Thiyaga , Amit K. Sharma , Sasi Kumar Nutalapati , Fredrik Lundstrom , Jean Pierre Neff
Abstract: The invention discloses a first unit (1) for treatment of a bioprocess liquid comprising a first lateral face (2), a second lateral face (3) and a front face (4) which meets the two said lateral faces. The front face comprises: a plurality of valves (7) adapted to receive and act upon one or more legs (8) of a disposable flow path (6); optionally one or more pumps (10) adapted to receive and act upon one or more legs of the disposable flow path; optionally one or more sensors (11) adapted to receive and to measure one or more parameters in one or more legs of the disposable flow path; wherein the plurality of valves and optional pumps and sensors are vertically offset from each other to give one or more legs of a disposable flow path received by said valves and optional pumps and sensors a slope of at least 3.0 degrees from the horizontal plane (h).
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