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    TREATMENT OF INTERVERTEBRAL DISC DEGENERATION USING HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS
    33.
    发明申请
    TREATMENT OF INTERVERTEBRAL DISC DEGENERATION USING HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS 审中-公开
    使用人脐带组织细胞治疗椎间盘脱位

    公开(公告)号：US20090169597A1

    公开(公告)日：2009-07-02

    申请号：US12337439

    申请日：2008-12-17

    申请人： Laura J. Brown ,  Anna Gosiewska ,  Anthony J. Kihm ,  Brian C. Kramer

    发明人： Laura J. Brown ,  Anna Gosiewska ,  Anthony J. Kihm ,  Brian C. Kramer

    IPC分类号： A61K9/08 ,  A61K35/12 ,  A61F2/00

    CPC分类号： A61K35/50 ,  A61K35/12 ,  C12N5/0605

    摘要： Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.

    摘要翻译： 提供了治疗患有与IVD变性相关的疾病或病症的患者的方法。 所述方法包括施用从人脐带组织获得的细胞，或施用包含此类细胞的药物组合物或由此类细胞制备。 在一些实施方案中，施用细胞促进患者中退化的IVD组织的修复和再生。 还提供了用于本发明方法的药物组合物，以及用于实施该方法的试剂盒。

    hUTC as therapy for Alzheimer's disease
    34.
    发明授权
    hUTC as therapy for Alzheimer's disease 有权
    hUTC作为阿尔茨海默病的治疗

    公开(公告)号：US08722034B2

    公开(公告)日：2014-05-13

    申请号：US12748170

    申请日：2010-03-26

    申请人： Anthony J. Kihm ,  Anna Gosiewska

    发明人： Anthony J. Kihm ,  Anna Gosiewska

    IPC分类号： A61K48/00 ,  A61K35/50 ,  C12N5/00 ,  A61K35/48 ,  C12N5/073 ,  C12N5/10 ,  C12N15/63

    CPC分类号： A61K35/51 ,  A61K35/12 ,  A61K35/50 ,  C12N5/0605 ,  C12N5/10 ,  C12N15/63 ,  C12N2509/00 ,  C12N2510/00

    摘要： Methods for treating Alzheimer's disease, or the symptoms of Alzheimer's disease, are provided. Some embodiments are to methods for treatment comprising administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells, such as cell derivatives. Some embodiments are to methods for treatment comprising hUTC. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.

    摘要翻译： 提供了治疗阿尔茨海默病的方法或阿尔茨海默病的症状。 一些实施方案涉及治疗方法，包括施用从人脐带组织获得的细胞，或施用包含这种细胞的药物组合物或由这样的细胞制备，例如细胞衍生物。 一些实施方案涉及包含hUTC的治疗方法。 还提供了用于本发明方法的药物组合物，以及用于实施该方法的试剂盒。

    Peptide with osteogenic activity
    35.
    发明授权
    Peptide with osteogenic activity 有权
    具有成骨活性的肽

    公开(公告)号：US07163920B2

    公开(公告)日：2007-01-16

    申请号：US10674516

    申请日：2003-09-30

    申请人： Sridevi Dhanaraj ,  Anna Gosiewska ,  Ali Rezania ,  George A. Heavner ,  Xuanhan Lin ,  Chin-Feng Yi

    发明人： Sridevi Dhanaraj ,  Anna Gosiewska ,  Ali Rezania ,  George A. Heavner ,  Xuanhan Lin ,  Chin-Feng Yi

    IPC分类号： A61F2/28 ,  A61K38/08 ,  C07K7/06

    CPC分类号： A61K38/08 ,  A61K31/375 ,  A61K31/573 ,  A61K31/661 ,  A61K35/32 ,  A61K38/18 ,  A61K45/06 ,  A61L27/227 ,  A61K2300/00

    摘要： The present invention provides a composition including an isolated or recombinant peptide component that has osteogenic cell proliferative activity. The peptide, which promotes proliferation of osteoblasts, is useful for treatment of fractures, as a filler in deficient sites of bone, for inhibition of decrease in bone substance related to osteoporosis and periodontic diseases, and for prevention of fractures associated with osteoporosis and rheumatoid arthritis. The peptide, or cells that have been genetically engineered to produce the peptide, can be combined with a bone-compatible matrix to facilitate slow release of the peptide to a treatment site and/or provide a structure for developing bone.

    摘要翻译： 本发明提供了包含具有成骨细胞增殖活性的分离或重组的肽组分的组合物。 促进成骨细胞增殖的肽可用于治疗骨折，作为骨缺损部位的填充物，用于抑制与骨质疏松症和牙周病相关的骨质减少，以及用于预防与骨质疏松症和类风湿性关节炎相关的骨折 。 已经经遗传工程化以产生肽的肽或细胞可以与骨相容性基质组合以促进肽缓慢释放到治疗部位和/或提供用于发展骨的结构。

    Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering
    37.
    发明授权
    Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering 有权
    生物可吸收袋，含有组织工程不同生物吸收率的生物可吸收材料

    公开(公告)号：US06656488B2

    公开(公告)日：2003-12-02

    申请号：US09832700

    申请日：2001-04-11

    申请人： Chin-Feng Yi ,  Anna Gosiewska ,  Susan Roweton

    发明人： Chin-Feng Yi ,  Anna Gosiewska ,  Susan Roweton

    IPC分类号： A61F200

    CPC分类号： A61L27/52 ,  A61L27/58

    摘要： A device for tissue engineering is formed of a porous bioabsorbable bag containing at least two bioabsorbable materials having different rates of bioabsorption such as beads of different degrading rates and a bioabsorbable binding gel such as fibrin that binds the bioabsorbable materials in relation to each other. Slow degrading beads and the bag may be made of a copolymer of poly(L-lactide) and poly(glycolide), and fast degrading beads may be made of gelatin. The bag may contain cells and/or wound healing stimulants such as growth factors. Hydrolyzing enzymes may be used to enhance biodegradation of polymers. The device can be used to promote in-growth of host tissue into a void by inserting the bag with its contents into the void and conforming the bag to a desired shape. The binding gel may be injected into the bag after being placed in the void .

    摘要翻译： 用于组织工程的装置由含有至少两种具有不同生物吸收速率的生物可吸收材料（例如不同降解率的珠子）和生物可吸收结合凝胶（例如纤维蛋白）的多孔生物可吸收袋形成，其结合生物可吸收材料相互之间。 缓慢降解的珠和袋可以由聚（L-丙交酯）和聚（乙交酯）的共聚物制成，并且快速降解的珠可以由明胶制成。 袋子可以含有细胞和/或伤口愈合兴奋剂如生长因子。 水解酶可用于增强聚合物的生物降解。 该装置可用于通过将其内含物插入到空隙中并将袋符合到期望的形状来促进宿主组织的生长成为空隙。 结合凝胶在放入空隙后可以注入袋中。

    Tissue-engineering scaffolds containing self-assembled-peptide hydrogels
    39.
    发明授权
    Tissue-engineering scaffolds containing self-assembled-peptide hydrogels 有权
    含有自组装肽水凝胶的组织工程支架

    公开(公告)号：US08039258B2

    公开(公告)日：2011-10-18

    申请号：US10951357

    申请日：2004-09-28

    申请人： Ian Ross Harris ,  Alexander M. Harmon ,  Laura J. Brown ,  Anna Gosiewska

    发明人： Ian Ross Harris ,  Alexander M. Harmon ,  Laura J. Brown ,  Anna Gosiewska

    IPC分类号： C12N5/06

    CPC分类号： C12N5/06 ,  A61L27/227 ,  A61L27/52 ,  A61L27/56 ,  C12N2533/40 ,  C12N2533/50

    摘要： The present invention is directed to tissue-engineering scaffolds containing both a microporous scaffold made from a biocompatible material suitable for use in tissue-engineering scaffolds and a nanofiberous, nanoporous hydrogel formed from a self-assembling peptide, where at least a portion of the hydrogel is disposed within the pores of the microporous scaffold, thus providing tissue-engineering scaffolds having average pore diameters in the nanometer range and that provide both mechanical properties suitable for implantation into a body of a mammal and excellent tissue response once implanted in the body.

    摘要翻译： 本发明涉及包含由适合用于组织工程支架的生物相容性材料制成的微孔支架和由自组装肽形成的纳米纤维，纳米多孔水凝胶的组织工程支架，其中至少一部分水凝胶 设置在微孔支架的孔内，从而提供具有纳米范围内的平均孔径的组织工程支架，并且提供适合于植入哺乳动物身体的机械性能并且一旦植入体内就具有优异的组织反应。

    Repair and regeneration of renal tissue using human umbilical cord tissue-derived cells
    40.
    发明授权
    Repair and regeneration of renal tissue using human umbilical cord tissue-derived cells 有权
    使用人脐带组织来源的细胞修复和再生肾组织

    公开(公告)号：US08034329B2

    公开(公告)日：2011-10-11

    申请号：US12245571

    申请日：2008-10-03

    申请人： David C. Colter ,  Anna Gosiewska

    发明人： David C. Colter ,  Anna Gosiewska

    IPC分类号： A01N65/00

    CPC分类号： A61K35/44 ,  A61K35/12 ,  C12N5/0605

    摘要： Methods for treating a patient having a disease or damage to at least one kidney are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. When administered, the cells promote and support the repair and regeneration of the diseased or damaged kidney tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.

    摘要翻译： 提供了治疗患有至少一种肾脏疾病或损伤的患者的方法。 所述方法包括施用从人脐带组织获得的细胞，或施用包含此类细胞的药物组合物或由此类细胞制备。 当施用时，细胞促进并支持患者中患病或损坏的肾组织的修复和再生。 还提供了用于本发明方法的药物组合物，以及用于实施该方法的试剂盒。