公开(公告)号：US20060186722A1

公开(公告)日：2006-08-24

申请号：US11404661

申请日：2006-04-14

Applicant: David Butler

Inventor： David Butler

IPC: A47C7/00

CPC classification number: B63B29/04 ,  Y10T403/1616 ,  Y10T403/1624 ,  Y10T403/73

Abstract: A seat assembly (10) for use in a watercraft (12) having a deck (14). The seat assembly (10) comprises a first portion (16) and a second portion (18) spaced from the first portion (16). First (52) and second (54) connector panels that are separable from and independent of the first (16) and second (18) portions interconnect the first (16) and second (18) portions. A plurality of locking tabs (56) extend from each of the connector panels (52,54) and are inserted into a plurality of slots (58) defined in the portions (16,18) to connect the connector panels (52,54) to the first (16) and second (18) portions. A mounting bracket (84) is attached to a base (82) of each of the connector panels (52,54) and perpendicularly extends from the connector panels (52,54) to mount the connector panels (52,54) to the deck (14) thereby securing the first (16) and second (18) portions to the deck (14).

Abstract translation: 一种用于具有甲板（14）的船舶（12）中的座椅组件（10）。 座椅组件（10）包括与第一部分（16）间隔开的第一部分（16）和第二部分（18）。 与第一（16）和第二（18）部分分离并独立于第一（16）和第二（18）部分的第一（52）和第二（54）连接器面板互连第一（16）和第二（18）部分。 多个锁定突片（56）从每个连接器面板（52,54）延伸并且被插入到限定在部分（16,18）中的多个狭槽（58）中，以将连接器面板（52,54） 到第一（16）和第二（18）部分。 安装支架（84）连接到每个连接器面板（52,54）的底座（82）上并且从连接器面板（52,54）垂直地延伸，以将连接器面板（52,54）安装到甲板 （14），从而将第一（16）和第二（18）部分固定到甲板（14）。

公开(公告)号：US09999673B2

公开(公告)日：2018-06-19

申请号：US13979336

申请日：2012-01-11

Applicant: Kallanthottathil G. Rajeev ,  Muthiah Manoharan ,  Muthusamy Jayaraman ,  Martin Maier ,  Jayaprakash K. Nair ,  David Butler

Inventor： Kallanthottathil G. Rajeev ,  Muthiah Manoharan ,  Muthusamy Jayaraman ,  Martin Maier ,  Jayaprakash K. Nair ,  David Butler

IPC: A61K47/18 ,  C07C235/06 ,  C07C271/16 ,  C07D207/12 ,  C07D307/20 ,  C07D207/14 ,  C07D307/12 ,  C08G65/329 ,  A61K47/48

CPC classification number: A61K47/18 ,  A61K47/6911 ,  C07C235/06 ,  C07C271/16 ,  C07D207/12 ,  C07D207/14 ,  C07D307/12 ,  C07D307/20 ,  C08G65/329 ,  C08L2203/02

Abstract: The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery.

公开(公告)号：US09454355B2

公开(公告)日：2016-09-27

申请号：US12836663

申请日：2010-07-15

Applicant: Ashley George ,  David Butler

Inventor： Ashley George ,  David Butler

IPC: G06F9/445

CPC classification number: G06F8/63 ,  G06F8/62 ,  G06F2212/205

Abstract: An information handling system is returned to its original manufacture state with a tool stored on a detachable memory device that retrieves image restore information from non-volatile memory of the information handling system, cleanses information stored on the non-volatile memory and then returns the image restore information to the non-volatile memory. By executing an image restore tool that applies the image restore information, the original manufacture image is re-built in the non-volatile memory after the cleansing so that any personal information stored on the non-volatile memory by a previous user is erased.

Abstract translation: 使用存储在可拆卸存储器装置上的工具将信息处理系统恢复到其原始制造状态，该装置从信息处理系统的非易失性存储器检索图像恢复信息，清理存储在非易失性存储器上的信息，然后返回图像 将信息恢复到非易失性存储器。 通过执行应用图像恢复信息的图像恢复工具，在清洁之后将原始制造图像重新构建在非易失性存储器中，从而擦除由先前用户存储在非易失性存储器上的任何个人信息。

公开(公告)号：US08999351B2

公开(公告)日：2015-04-07

申请号：US13128287

申请日：2009-11-10

Applicant: Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Muthusamy Jayaraman ,  David Butler ,  Jayaprakash K. Narayanannair ,  Martin Maier ,  Laxman Eltepu

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Muthusamy Jayaraman ,  David Butler ,  Jayaprakash K. Narayanannair ,  Martin Maier ,  Laxman Eltepu

IPC: A61K39/12 ,  A61K9/127 ,  A61K39/00 ,  C12N15/11

CPC classification number: A61K47/44 ,  A61K9/1272 ,  A61K31/7088 ,  A61K31/713 ,  A61K39/00 ,  A61K39/39 ,  A61K47/10 ,  A61K47/18 ,  A61K47/20 ,  A61K47/28 ,  A61K2039/55555 ,  A61K2039/55561 ,  C07C229/08 ,  C07C229/30 ,  C07C237/16 ,  C07C251/38 ,  C07C251/78 ,  C07C271/12 ,  C07C271/20 ,  C07C323/25 ,  C07D203/10 ,  C07D317/28 ,  C07D317/44 ,  C07D317/46 ,  C07D317/72 ,  C07D319/06 ,  C07D405/12 ,  C07D491/056 ,  C07D491/113 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/3515 ,  C12N2320/32 ,  Y02A50/464

Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure (I) wherein R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; E is O, S, N(Q), C(O), N(Q)C(O), C(O)N(Q), (Q)N(CO)O, O(CO)N(Q), S(O), NS(O)2N(Q), S(O)2, N(Q)S(O)2, SS, O═N, aryl, heteroaryl, cyclic or heterocycle; and, Q is H, alkyl, ω-aminoalkyl, ω-(substituted)aminoalky, ω-phosphoalkyl or ω-thiophosphoalkyl.

Abstract translation: 本发明提供有利地用于脂质颗粒以用于体内递送治疗剂至细胞的脂质。 特别地，本发明提供具有以下结构（I）的脂质，其中R1和R2各自独立地为任何取代的C 10 -C 30烷基，任选取代的C 10 -C 30烯基，任选取代的C 10 -C 30炔基，任选取代的C 10 -C 30 酰基或 - 连接子 - 配体; R 3为H，任选取代的C 1 -C 10烷基，任选取代的C 2 -C 10烯基，任选取代的C 2 -C 10炔基，烷基硫代烷基磷酸酯，烷基硫代磷酸酯，烷基二硫代磷酸酯，烷基膦酸酯，烷基胺，羟基烷基，ω-氨基烷基，ω-（取代的）氨基烷基， ω-磷酸烷基酯，ω-硫代磷酰基烷基酯，任选取代的聚乙二醇（PEG，mw 100-40K），任选取代的mPEG（mw 120-40K），杂芳基，杂环或连接基 - 配体; E是O，S，N（Q），C（O），N（Q）C（O），C（O）N（Q），（Q） ），S（O），NS（O）2N（Q），S（O）2，N（Q）S（O）2，SS，O = N，芳基，杂芳基，环状或杂环; Q为H，烷基，ω-氨基烷基，ω-（取代）氨基烷基，ω-磷酸烷基或ω-硫代磷酰基烷基。

公开(公告)号：US08774827B2

公开(公告)日：2014-07-08

申请号：US12534050

申请日：2009-07-31

Applicant: Joseph F. Scalisi ,  Desiree Mejia ,  David Butler ,  Roger B. Anderson

Inventor： Joseph F. Scalisi ,  Desiree Mejia ,  David Butler ,  Roger B. Anderson

IPC: H04W64/00 ,  H04W4/02

CPC classification number: G01S19/34 ,  G01S19/49

Abstract: A tracking device is disclosed for communication of location coordinate information. In one embodiment, the tracking device includes a signal transceiver device, a location coordinate acquisition device, and a computational processor activated and deactivated in accordance with a subscriber service usage profile. The location coordinate acquisition device generates a position fix of the tracking device and a signal transceiver device reports the position fix to a location tracking server. A flash memory device stores a zone management map. In accordance with a fix reporting period based at least in part on a subscriber service usage application including or accessing the subscriber service usage profile, an internal clock activates or deactivates the signal transceiver device, the computational processor, and/or the location coordinate acquisition device. In one example, the internal clock updates a fix reporting period based on current position fix relative to restricted and allowed areas on the zone management map.

Abstract translation: 公开了用于位置坐标信息的通信的跟踪装置。 在一个实施例中，跟踪设备包括信号收发器设备，位置坐标获取设备和根据订户服务使用简档激活和去激活的计算处理器。 位置坐标获取装置产生跟踪装置的位置锁定，并且信号收发器装置向位置跟踪服务器报告定位。 闪存设备存储区域管理映射。 根据至少部分地基于包括或访问订户服务使用简档的用户服务使用应用的固定报告周期，内部时钟激活或停用信号收发器设备，计算处理器和/或位置坐标获取设备 。 在一个示例中，内部时钟基于相对于区域管理映射上的受限制和允许区域的当前位置锁定更新修复报告周期。

公开(公告)号：US08702374B2

公开(公告)日：2014-04-22

申请号：US13015699

申请日：2011-01-28

Applicant: David Butler

Inventor： David Butler

IPC: F04D29/08

CPC classification number: F01D25/12 ,  F01D9/02 ,  F05D2240/57 ,  F05D2240/81 ,  F05D2260/201

Abstract: A gas turbine engine including a segment of an annular guide vane assembly is provided. When the engine is used, the segment directs hot combustion gases onto rotor blades of the engine. The segment includes a platform disposed at a side of the segment radially inward/outward with respect to the axis of rotation of the engine. The platform has a trailing edge portion downstream with respect to the flow of hot combustion gases through the segment, the trailing edge portion includes a rail that extends radially inwardly/outwardly from the trailing edge portion. The engine also includes a support and cooling arrangement for supporting the segment and directing a cooling fluid to cool the segment. The arrangement is located radially inward/outward of the platform, and includes a flange part that extends radially outwardly/inwardly from the arrangement. The arrangement further includes a leaf seal and a retaining pin.

Abstract translation: 提供一种包括环形导叶组件的一段的燃气涡轮发动机。 当使用发动机时，该段将热燃烧气体引导到发动机的转子叶片上。 该段包括相对于发动机的旋转轴线径向向内/向外设置在该段的一侧的平台。 平台相对于通过该段的热燃烧气体的流动下游具有后缘部分，后缘部分包括从后缘部分径向向内/向外延伸的轨道。 发动机还包括用于支撑该段并引导冷却流体冷却该段的支撑和冷却装置。 该装置位于平台的径向内部/外侧，并且包括从该装置径向向外/向内延伸的凸缘部分。 该装置还包括叶片密封件和固定销。

公开(公告)号：US08421619B2

公开(公告)日：2013-04-16

申请号：US13356643

申请日：2012-01-23

Applicant: Joseph F. Scalisi ,  David Butler ,  Roger B. Anderson ,  Desiree Mejia ,  Michael L. Beydler

Inventor： Joseph F. Scalisi ,  David Butler ,  Roger B. Anderson ,  Desiree Mejia ,  Michael L. Beydler

IPC: G08B1/08

CPC classification number: G08C17/02 ,  G01C21/165 ,  G01S19/19 ,  G01S19/34 ,  G01S19/49 ,  H04M1/72572 ,  H04M2250/10 ,  H04M2250/12

Abstract: A device and method to monitor location coordinates of an electronic tracking device are disclosed here. The device includes transceiver circuitry to receive at least one portion of a receive communication signal comprising location coordinates information; accelerometer circuitry to measure displacements of the portable electronic tracking device; a battery power monitor configured to activate and deactivate at least one portion of signaling circuitry; and processor circuitry configured to process the displacements. The method includes receiving at least one portion of a receive communication signal comprising location coordinates information; measuring displacements of a portable electronic tracking device; activating and deactivating at least one portion of signaling circuitry; and processing the at least one portion of the receive communication signal.

Abstract translation: 这里公开了一种用于监视电子跟踪装置的位置坐标的装置和方法。 所述设备包括收发器电路，用于接收包括位置坐标信息的接收通信信号的至少一部分; 加速度计电路，用于测量便携式电子跟踪装置的位移; 电池电力监视器，被配置为激活和停用信令电路的至少一部分; 以及配置成处理位移的处理器电路。 该方法包括接收包括位置坐标信息的接收通信信号的至少一部分; 测量便携式电子跟踪装置的位移; 激活和去激活信令电路的至少一部分; 以及处理所述接收通信信号的所述至少一部分。

公开(公告)号：US20120201667A1

公开(公告)日：2012-08-09

申请号：US13393304

申请日：2009-09-04

Applicant: David Butler

Inventor： David Butler

IPC: F03B11/02

CPC classification number: F01D5/186 ,  F01D9/041 ,  F05D2240/12 ,  F05D2240/126 ,  F05D2250/51

Abstract: A deflector for guiding a cooling fluid to a blade device of a turbine is provided. The deflector includes a first opening region with a first opening shape and a second opening region with a second opening shape. The deflector is connectable to a first blade device and to a second blade device in such a way that the cooling fluid is streamable through the first opening region into the first blade device and the cooling fluid is streamable through the second opening region into the second blade device. The first opening shape differs from the second opening shape for achieving a predetermined first mass flow of the cooling fluid into the first blade device and a predetermined second mass flow of the cooling fluid into the second blade device at predetermined installation locations of the first blade device and the second blade device.

Abstract translation: 提供了用于将冷却流体引导到涡轮机的叶片装置的偏转器。 偏转器包括具有第一开口形状的第一开口区域和具有第二开口形状的第二开口区域。 导流器可连接到第一叶片装置和第二叶片装置，使得冷却流体可流过第一开口区域进入第一叶片装置，并且冷却流体可流过第二开口区域进入第二叶片 设备。 第一开口形状与第二开口形状不同，用于在第一刀片装置的预定安装位置处实现冷却流体进入第一刀片装置的预定的第一质量流量和冷却流体进入第二刀片装置的预定的第二质量流量 和第二刀片装置。

公开(公告)号：US20120119905A1

公开(公告)日：2012-05-17

申请号：US13356599

申请日：2012-01-23

Applicant: Joseph F. Scalisi ,  David Butler ,  Roger B. Anderson ,  Desiree Mejia ,  Michael L. Beydler

Inventor： Joseph F. Scalisi ,  David Butler ,  Roger B. Anderson ,  Desiree Mejia ,  Michael L. Beydler

IPC: G08B1/08

CPC classification number: G08C17/02 ,  G01C21/165 ,  G01S19/19 ,  G01S19/34 ,  G01S19/49 ,  H04M1/72572 ,  H04M2250/10 ,  H04M2250/12

Abstract: A device and method to monitor location coordinates of an electronic tracking device are disclosed here. The device includes transceiver circuitry to receive at least one portion of a receive communication signal comprising location coordinates information; accelerometer circuitry to measure displacements of the portable electronic tracking device; a battery power monitor configured to selectively activate and deactivate at least one portion of the transceiver circuitry and location tracking circuitry; and processor circuitry configured to process the at least one portion of the receive communication signal. The method includes receiving at transceiver circuitry of a portable electronic tracking device at least one portion of a receive communication signal comprising location coordinates information; measuring displacements of the portable electronic tracking device; activating and deactivating at least one portion of the transceiver circuitry and location tracking circuitry; and processing the at least one portion of the receive communication signal using processor circuitry.

Abstract translation: 这里公开了一种用于监视电子跟踪装置的位置坐标的装置和方法。 所述设备包括收发器电路，用于接收包括位置坐标信息的接收通信信号的至少一部分; 加速度计电路，用于测量便携式电子跟踪装置的位移; 电池电力监视器，被配置为选择性地激活和去激活所述收发器电路和位置跟踪电路的至少一部分; 以及被配置为处理所述接收通信信号的所述至少一部分的处理器电路。 该方法包括在便携式电子跟踪装置的收发机电路处接收包括位置坐标信息的接收通信信号的至少一部分; 测量便携式电子跟踪装置的位移; 激活和去激活收发器电路和位置跟踪电路的至少一部分; 以及使用处理器电路处理所述接收通信信号的所述至少一部分。

公开(公告)号：US20120035115A1

公开(公告)日：2012-02-09

申请号：US13120389

申请日：2009-09-23

Applicant: Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Takeshi Yamada ,  David Butler ,  K. Narayanannair Jayaprakash ,  Muthusamy Jayraman ,  Shigeo Matsuda ,  Rajendra K. Pandey ,  Chang Geng Peng

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Takeshi Yamada ,  David Butler ,  K. Narayanannair Jayaprakash ,  Muthusamy Jayraman ,  Shigeo Matsuda ,  Rajendra K. Pandey ,  Chang Geng Peng

IPC: A61K38/14 ,  C07H19/10 ,  C07F9/6561 ,  C07H21/02 ,  A61K31/7072 ,  A61K31/675 ,  C07H1/00 ,  A61P31/12 ,  A61P31/04 ,  A61P33/00 ,  A61P35/00 ,  A61P37/08 ,  A61P37/06 ,  A61P37/04 ,  C07K9/00 ,  A61K31/7088

CPC classification number: C12N15/113 ,  A61K31/713 ,  A61K47/544 ,  A61K47/64 ,  C07H21/00 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/3513 ,  C12N2310/3515 ,  H04L65/602 ,  H04L67/36 ,  Y02A50/465

Abstract: The invention features compounds of formula I or II: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.

Abstract translation: 本发明的特征在于式I或II化合物：在一个实施方案中，本发明涉及将配体与寡核苷酸缀合的化合物和方法。 本发明还涉及治疗各种病症和疾病如病毒感染，细菌感染，寄生虫感染，癌症，过敏症，自身免疫疾病，免疫缺陷和免疫抑制的方法。