公开(公告)号：US20060128742A1

公开(公告)日：2006-06-15

申请号：US11345132

申请日：2006-02-01

Applicant: David Edwards ,  Michael Berens ,  Christian Beaudry

Inventor： David Edwards ,  Michael Berens ,  Christian Beaudry

IPC: A61K31/4745

CPC classification number: G01N33/5011 ,  A61K31/00 ,  A61K31/192 ,  A61K31/215 ,  A61K31/381 ,  A61K31/4745 ,  A61K31/549 ,  A61K38/193 ,  A61K39/00 ,  A61K45/06 ,  G01N2500/10 ,  A61K2300/00

Abstract: Methods for treating an individual having cancer are provided. The method may include administering a cell migration inhibitor and a chemotherapeutic agent to the individual to inhibit migration of cancer cell. Inhibiting cell migration may increase cell division. In this manner, the cell migration inhibitor and the chemotherapeutic agent in combination may have increased efficacy compared to the chemotherapeutic agent alone due to the increased cell division. The cell migration inhibitor may include any of the inhibitors described herein. For example, the cell migration inhibitor may be an organic molecule having a molecular weight of less than about 700, a monoclonal antibody, or a natural product.

Abstract translation: 提供了治疗患有癌症的个体的方法。 该方法可以包括向个体施用细胞迁移抑制剂和化学治疗剂以抑制癌细胞的迁移。 抑制细胞迁移可能增加细胞分裂。 以这种方式，由于细胞分裂增加，细胞迁移抑制剂和化学治疗剂的组合可能与单独的化学治疗剂相比具有增加的功效。 细胞迁移抑制剂可以包括本文所述的任何抑制剂。 例如，细胞迁移抑制剂可以是分子量小于约700的有机分子，单克隆抗体或天然产物。

公开(公告)号：US20060017301A1

公开(公告)日：2006-01-26

申请号：US10894488

申请日：2004-07-20

Applicant: David Edwards

Inventor： David Edwards

IPC: B62D43/10

CPC classification number: B62D43/10

Abstract: A retention system for a vehicular spare tire includes a chamber having a bottom portion. A tray is configured for movement in a first direction relative to the bottom portion between an extended position and a stored position. At least one removable interconnecting member is configured to selectively interface with both the tray and the chamber for substantially preventing movement of the tray relative in the first direction. At least one guide member is configured to selectively interface with a back portion of the tray for substantially preventing movement of the back portion of the tray in a second direction relative to the bottom portion while the tray is in the stored position. The second direction is generally perpendicular to the first direction.

Abstract translation: 车辆备用轮胎的保持系统包括具有底部的腔室。 托盘构造成用于在延伸位置和存储位置之间相对于底部部分在第一方向上移动。 至少一个可移除互连构件被配置为选择性地与托盘和腔室相接合，用于基本上防止托盘相对于第一方向的移动。 至少一个引导构件构造成与托盘的后部选择性地接合，用于当托盘处于存储位置时基本上防止托盘的后部在相对于底部的第二方向上移动。 第二方向通常垂直于第一方向。

公开(公告)号：USD513215S1

公开(公告)日：2005-12-27

申请号：US29217025

申请日：2004-11-12

Applicant: Jarad W. Hall ,  Donald Lariviere ,  Thomas H. Kim ,  David Edwards

Designer： Jarad W. Hall ,  Donald Lariviere ,  Thomas H. Kim ,  David Edwards

公开(公告)号：US20050282355A1

公开(公告)日：2005-12-22

申请号：US10872235

申请日：2004-06-18

Applicant: David Edwards ,  Jason Munn ,  Kouroche Kian ,  Reza Mehrabi ,  Ian Forster ,  Thomas Weakley

Inventor： David Edwards ,  Jason Munn ,  Kouroche Kian ,  Reza Mehrabi ,  Ian Forster ,  Thomas Weakley

IPC: H01L21/30 ,  H01L21/44 ,  H01L21/46 ,  H01L21/48 ,  H01L21/50 ,  H01L21/60 ,  H01L21/603

CPC classification number: H01L24/75 ,  H01L24/81 ,  H01L2224/16 ,  H01L2224/75315 ,  H01L2224/81801 ,  H01L2924/01019 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/01075 ,  H01L2924/01078 ,  H01L2924/01082 ,  H01L2924/014 ,  H01L2924/07802 ,  H01L2924/10253 ,  H01L2924/14 ,  H01L2924/19041 ,  H01L2924/19042 ,  H01L2924/19043 ,  H01L2924/30105 ,  H01L2924/3011 ,  H01L2924/00

Abstract: A method of thermocompressive bonding of one or more electrical devices using individual heating elements and a resilient member to force the individual heating elements into compressive engagement with the electrical devices is provided. The individual heating elements may be Curie-point heating elements or conventional resistive heating elements. A method of thermocompressive bonding of one or more electrical devices using a transparent flexible platen and thermal radiation is also provided. In one embodiment, the thermal radiation is near infra-red thermal radiation and the transparent flexible platen is composed of silicone rubber. The bonding material may be an adhesive or a thermoplastic bonding material. A method of capacitively coupling a semiconductor chip to an electrical component with a pressure sensitive adhesive is also provided. The method includes compressing the chip by forcing a flexible platen of a bonding device into compressive engagement with the semiconductor chip.

Abstract translation: 提供了一种使用各个加热元件和一个弹性部件热压接合一个或多个电气装置以迫使各个加热元件与电气装置压缩接合的方法。 各个加热元件可以是居里点加热元件或常规电阻加热元件。 还提供了使用透明柔性压板和热辐射的一个或多个电气装置的热压接合方法。 在一个实施例中，热辐射接近红外热辐射，透明柔性压板由硅橡胶组成。 接合材料可以是粘合剂或热塑性粘合材料。 还提供了利用压敏粘合剂将半导体芯片电容耦合到电气部件的方法。 该方法包括通过迫使粘结装置的柔性压板与半导体芯片压缩接合来压缩芯片。

公开(公告)号：US20050232872A1

公开(公告)日：2005-10-20

申请号：US11154067

申请日：2005-06-14

Applicant: Daniel Deaver ,  David Edwards

Inventor： Daniel Deaver ,  David Edwards

IPC: A61K47/28 ,  A61K9/00 ,  A61K9/06 ,  A61K9/14 ,  A61K31/56 ,  A61K31/573 ,  A61K31/715 ,  A61K38/17 ,  A61K38/22 ,  A61K45/08 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K48/00 ,  A61L9/04

CPC classification number: A61K9/0046 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/006 ,  A61K9/0073 ,  A61K9/06 ,  A61K31/56 ,  A61K31/573 ,  A61K31/715 ,  A61K47/38 ,  A61K48/00 ,  A61K48/0008 ,  A61K48/0083 ,  Y10S977/906

Abstract: Compositions and methods for improving cellular internalization of one or more compounds are disclosed. The compositions include a compound to be delivered and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous sol. The composition also include, or are administered in conjunction with, an enhancer in an amount effective to maximize expression of or binding to receptors and enhance RME of the compound into the cells. This leads to high transport rates of compounds to be delivered across cell membranes, facilitating more efficient delivery of drugs and diagnostic agents. Compositions are applied topically orally, nasally, vaginally, rectally, and ocularly. The enhancer is administered with the composition or separately, either systemically or preferably locally. The compound to be delivered can also be the enhancer.

公开(公告)号：US20050115935A1

公开(公告)日：2005-06-02

申请号：US10502530

申请日：2003-01-24

Applicant: David Edwards ,  Brian Bryden

Inventor： David Edwards ,  Brian Bryden

IPC: B26F1/31 ,  B23K26/40 ,  B26F3/16 ,  B65B61/06 ,  B65D65/46 ,  C11D17/04 ,  B23K26/14

CPC classification number: B65B61/06 ,  B23K2103/42 ,  B23K2103/50 ,  C11D17/042

Abstract: A process for cutting or perforating a water-soluble or water-dispersible film or stack of films in the form of a web comprising a plurality of compartments by which each compartment is cut or perforated by applying a laser beam to the film or stack of films. The process for producing a water-soluble or water-dispersible container containing a composition comprises: a producing a base web water-soluble or water-dispersible film containing a plurality of pockets; b. filling each pocket with a composition; c. sealing the pockets with a top web water-soluble or water-dispersible film to produce closed containers; and d. separating at least one container from the plurality of containers by cutting or perforating the combined web with a laser beam.

Abstract translation: 一种用于切割或穿孔纤维网形式的水溶性或水分散性薄膜或一叠薄膜的方法，该薄膜或薄片包括多个隔室，每个隔间通过将激光束施加到薄膜或薄膜层而被切割或穿孔 。 制备含有组合物的水溶性或水分散性容器的方法包括：产生含有多个袋的基网水溶性或水分散性膜; b。 用一个组合填充每个口袋; C。 用顶部网状水溶性或水分散性膜密封袋，以产生密闭容器; 和d。 通过用激光束切割或穿孔组合的网来将至少一个容器与多个容器分离。

公开(公告)号：US20050056667A1

公开(公告)日：2005-03-17

申请号：US10663889

申请日：2003-09-16

Applicant: Kerry McClure ,  Brian Shanfeld ,  David Edwards

Inventor： Kerry McClure ,  Brian Shanfeld ,  David Edwards

IPC: B62D43/10 ,  B62D43/00

CPC classification number: B62D43/10

Abstract: The present invention relates to a support structure for a spare tire on a vehicle. A shell is attached to the vehicle and includes first and second end portions and a bottom portion extending at least partially between the first and second end portions. The shell at least partially defines a spare tire storage chamber and includes an opening providing access to the storage chamber, wherein the opening is adjacent to the first end portion. A support member is adapted to support a spare tire. The support member is slidably positioned above the bottom portion and is movable back and forth along a movement path from a first position in which the support member is substantially disposed within the shell and a second position in which the support member is at least partially disposed outside the shell. The support member includes a lower interface surface for directly contacting an upper interface surface of the bottom portion of the shell in sliding engagement as the support member is moved along the movement path. In certain embodiments, a retention member can be fixedly attached to the shell. In further embodiments, the support member and the shell have a cooperative locking configuration. A support structure adapted to support a spare tire for a vehicle is also disclosed.

Abstract translation: 本发明涉及一种用于车辆上备用轮胎的支撑结构。 壳体附接到车辆并且包括第一和第二端部以及至少部分地在第一和第二端部之间延伸的底部部分。 壳体至少部分地限定备用轮胎储存室，并且包括提供进入储存室的开口，其中开口邻近第一端部。 支撑构件适于支撑备用轮胎。 所述支撑构件可滑动地定位在所述底部的上方，并且可沿着运动路径从所述支撑构件基本上设置在所述壳体内的第一位置和所述支撑构件至少部分地设置在外部的第二位置来回移动; 贝壳。 支撑构件包括下接口表面，用于当支撑构件沿着移动路径移动时，滑动接合直接接触壳体底部的上部界面表面。 在某些实施例中，保持构件可以固定地附接到外壳。 在另外的实施例中，支撑构件和壳体具有协作锁定配置。 还公开了一种适于支撑用于车辆的备用轮胎的支撑结构。

公开(公告)号：US06766799B2

公开(公告)日：2004-07-27

申请号：US09835302

申请日：2001-04-16

Applicant: David Edwards ,  Mark Delong ,  Craig Dunbar ,  Ernest E. Penachio ,  Kevin Stapleton ,  Mark Wolff

Inventor： David Edwards ,  Mark Delong ,  Craig Dunbar ,  Ernest E. Penachio ,  Kevin Stapleton ,  Mark Wolff

IPC: A61M1500

CPC classification number: A61M15/0028 ,  A61M11/003 ,  A61M15/0033 ,  A61M15/0035 ,  A61M15/0041 ,  A61M2202/064

Abstract: Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures.

Abstract translation: 吸入装置和相关方法，用于便于患者容纳在容器中的粉末药物的吸入。 吸入装置具有容纳容器的腔室。 环周向耦合到腔室的内表面，以实现来自容器的较高可重复发射剂量的药物。 吸入装置还包括用于刺穿容器的改进的工具，需要更少的力并且经历更少的故障。

公开(公告)号：US6020312A

公开(公告)日：2000-02-01

申请号：US767903

申请日：1996-12-17

Applicant: David Edwards

Inventor： David Edwards

IPC: A01N63/00 ,  A01N63/04 ,  A01N65/00 ,  A61K38/00 ,  A61K38/04 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/16 ,  C07K1/04 ,  C07K5/00 ,  C07K5/08 ,  C07K5/083 ,  C07K5/087 ,  C07K5/097 ,  C07K5/10 ,  C07K5/107 ,  C07K5/117 ,  C07K7/00 ,  C07K7/06 ,  C07K16/00 ,  C07K17/00 ,  G01N33/50 ,  G01N33/569 ,  G01N33/53

CPC classification number: G01N33/56961 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  C07K1/047 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0821 ,  C07K5/1016 ,  C07K5/1024 ,  C07K7/06

Abstract: Compositions of the current invention are directed toward inhibiting the growth of microorganisms, particularly fungi. The compositions consist of chemically-synthesized antibiotics comprising certain amino acids. Methods of identifying particular antibiotic compositions from libraries of such compositions are disclosed. In addition, methods for preventing microbial growth in plants and animals are disclosed.

Abstract translation: 本发明的组合物旨在抑制微生物，特别是真菌的生长。 组合物由包含某些氨基酸的化学合成的抗生素组成。 公开了从这种组合物的文库鉴定特定抗生素组合物的方法。 另外，公开了防止植物和动物微生物生长的方法。

公开(公告)号：US5388862A

公开(公告)日：1995-02-14

申请号：US064045

申请日：1993-05-19

Applicant: David Edwards

Inventor： David Edwards

IPC: B32B7/02 ,  B32B15/12 ,  B42D15/00 ,  B42D15/10 ,  D21H11/00 ,  D21H19/02 ,  D21H21/40 ,  D21H21/42 ,  D21H21/48 ,  G02B5/28 ,  G07D7/00 ,  G07D7/12

CPC classification number: B42D25/30 ,  B42D25/23 ,  B42D25/29 ,  B42D25/355 ,  D21H21/42 ,  G07D7/12 ,  B42D2033/10 ,  B42D2035/36 ,  Y10S283/901

Abstract: A security article such as a banknote, credit card, identity card or travel document includes a security element which is visually detectable in transmitted light to display portions which transmit light and portions which are opaque, the security element including a plurality of layers that include a light-transmitting support layer and two or more series of opaque regions. The arrangement of the opaque regions is such that at certain parts of the security element the regions overlap to prevent light transmission and elsewhere along its length the opaque regions do not overlap or only partially overlap such that light transmission through the security element occurs.

Abstract translation: PCT No.PCT / GB91 / 02140 Sec。 371日期：1993年5月19日 102（e）日期1993年5月19日PCT提交1993年12月3日PCT公布。 出版物WO92 / 10608 日期：1992年6月25日。诸如纸币，信用卡，身份证或旅行证件的安全用品包括在透射光下可视地检测的安全元件，以显示透射光的部分和不透明的部分，安全元件包括 多个层，其包括透光支撑层和两个或更多个系列的不透明区域。 不透明区域的布置使得在安全元件的某些部分处，区域重叠以防止光透射并且沿其长度的其他位置，不透明区域不重叠或仅部分重叠，使得发生通过安全元件的光透射。