公开(公告)号：US20170215805A1

公开(公告)日：2017-08-03

申请号：US15488190

申请日：2017-04-14

Applicant: DexCom, Inc.

Inventor： Paul V. Goode ,  James H. Brauker ,  Arpurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

IPC: A61B5/00 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/145

CPC classification number: A61B5/7203 ,  A61B5/0004 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7225 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742 ,  A61B5/7475 ,  A61B2560/0223 ,  A61B2562/0247 ,  A61B2562/0271 ,  A61B2562/08

Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

公开(公告)号：US20170209101A1

公开(公告)日：2017-07-27

申请号：US15481347

申请日：2017-04-06

Applicant: DexCom, Inc.

Inventor： Paul V. Goode ,  James H. Brauker ,  Arpurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

IPC: A61B5/00 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/145

CPC classification number: A61B5/7203 ,  A61B5/0004 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7225 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742 ,  A61B5/7475 ,  A61B2560/0223 ,  A61B2562/0247 ,  A61B2562/0271 ,  A61B2562/08

Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

公开(公告)号：US09649069B2

公开(公告)日：2017-05-16

申请号：US15197349

申请日：2016-06-29

Applicant: DexCom, Inc.

Inventor： Paul V. Goode ,  James H. Brauker ,  Arpurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1473

CPC classification number: A61B5/7203 ,  A61B5/0004 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7225 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742 ,  A61B5/7475 ,  A61B2560/0223 ,  A61B2562/0247 ,  A61B2562/0271 ,  A61B2562/08

Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

公开(公告)号：US20160345879A1

公开(公告)日：2016-12-01

申请号：US15237536

申请日：2016-08-15

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Victoria E. Carr-Brendel ,  Paul V. Goode, JR. ,  Apurv Ullas Kamath ,  James Patrick Thrower ,  Ben Xavier

IPC: A61B5/145 ,  A61M5/172 ,  A61B5/1495 ,  A61B5/00 ,  A61B5/1468 ,  A61B5/1486

CPC classification number: A61B5/14532 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7264 ,  A61B5/7275 ,  A61B5/742 ,  A61B5/7455 ,  A61B5/746 ,  A61B5/7475 ,  A61M5/1723 ,  G06F19/00 ,  Y02A90/22 ,  Y02A90/26

Abstract: Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.

公开(公告)号：US09452259B2

公开(公告)日：2016-09-27

申请号：US14063941

申请日：2013-10-25

Applicant: DexCom, Inc.

Inventor： John Michael Dobbles ,  Apurv Ullas Kamath ,  Aarthi Mahalingam ,  James H. Brauker

IPC: A61M5/172 ,  A61B5/145 ,  A61M5/142 ,  G06F19/00 ,  A61B5/00 ,  A61M5/00 ,  A61M5/178 ,  A61M5/30 ,  A61M11/00 ,  A61M15/00

CPC classification number: A61M5/1723 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14546 ,  A61M5/003 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/178 ,  A61M5/20 ,  A61M5/30 ,  A61M11/00 ,  A61M15/00 ,  A61M15/0065 ,  A61M15/0068 ,  A61M15/008 ,  A61M15/0083 ,  A61M35/00 ,  A61M2005/14296 ,  A61M2205/3569 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/587 ,  A61M2205/8206 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H40/63

Abstract: Systems and methods for integrating a continuous glucose sensor 12, including a receiver 14, a medicament delivery device 16, a controller module, and optionally a single point glucose monitor 18 are provided. Integration may be manual, semi-automated and/or fully automated.

公开(公告)号：US20160235348A1

公开(公告)日：2016-08-18

申请号：US15136819

申请日：2016-04-22

Applicant: DexCom, Inc

Inventor： Apurv Ullas Kamath ,  Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode, JR.

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/742 ,  A61B2560/0223 ,  B33Y70/00 ,  B33Y80/00

Abstract: Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data.

Abstract translation: 本文公开了用于校准连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。 一个这样的系统利用一个或多个电极来测量另外的分析物。 这样的测量可以提供用于校准传感器的基线或灵敏度测量。 此外，可以使用基线和/或灵敏度测量来触发诸如数字数字滤波或暂停显示数据的事件。

公开(公告)号：US20160183856A1

公开(公告)日：2016-06-30

申请号：US15065623

申请日：2016-03-09

Applicant: DexCom, Inc.

Inventor： Jack Pryor ,  Apurv Ullas Kamath ,  Paul V. Goode, JR. ,  James H. Brauker

IPC: A61B5/1495 ,  A61B5/145

CPC classification number: A61B5/1495 ,  A61B5/0031 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/14735 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2560/0223

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

公开(公告)号：US20160178558A1

公开(公告)日：2016-06-23

申请号：US15059086

申请日：2016-03-02

Applicant: DexCom, Inc.

Inventor： Rathbun K. Rhodes ,  Mark A. Tapsak ,  James H. Brauker ,  Mark C. Shults

IPC: G01N27/327 ,  A61B5/145 ,  A61B5/1486 ,  G01N33/487

CPC classification number: G01N27/3272 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/002 ,  C12Q1/006 ,  G01N33/48707 ,  G01N33/48785

Abstract: The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.

公开(公告)号：US09328371B2

公开(公告)日：2016-05-03

申请号：US13943622

申请日：2013-07-16

Applicant: DexCom, Inc.

Inventor： Rathbun K. Rhodes ,  Mark A. Tapsak ,  James H. Brauker ,  Mark C. Shults

IPC: A61B5/05 ,  A61B5/00 ,  C12Q1/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: G01N27/3272 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/002 ,  C12Q1/006 ,  G01N33/48707 ,  G01N33/48785

Abstract: The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.

公开(公告)号：US20160095542A1

公开(公告)日：2016-04-07

申请号：US14968643

申请日：2015-12-14

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Sebastian Böhm ,  James H. Brauker ,  Paul V. Neale

IPC: A61B5/145 ,  A61B5/00

Abstract: A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.

Abstract translation: 提供了经配置以连续测量宿主中的分析物浓度的经皮传感器装置。 在一些实施例中，经皮传感器装置100包括构造成用于插入主体皮肤180下方的体内部分160，以及配置成在传感器插入入口之后保留在主体的皮肤180的表面上方的离体部分170 体内部分。 体内部分可以包括构造成用于刺穿主体的皮肤180的组织刺穿元件110和传感器主体120，传感器主体120包括提供足够的柱强度的材料或支撑构件130，以允许传感器主体可以在主机组织中推动而没有 实质屈曲。 离体部分170可以被配置为包括（或可操作地连接）传感器电子单元，并且可以包括安装单元150.这里还描述了传感器主体和组织刺穿元件的各种配置，其可以用于保护 传感器体的膜。