公开(公告)号：US20180297939A1

公开(公告)日：2018-10-18

申请号：US15925559

申请日：2018-03-19

Applicant: FORMA Therapeutics, Inc.

Inventor： Kenneth W. Bair ,  Nicholas Barczak ,  Bingsong Han ,  David R. Lancia, JR. ,  Cuixian Liu ,  Matthew W. Martin ,  Pui Yee Ng ,  Aleksandra Rudnitskaya ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Xiaozhang Zheng

IPC: C07C259/06 ,  C07D471/04 ,  C07D417/04 ,  C07D241/08 ,  C07D213/56 ,  C07D233/68 ,  C07D235/14 ,  C07D487/10 ,  C07D471/10 ,  C07D295/155 ,  C07D209/44 ,  A61K31/5377 ,  A61K31/4439 ,  A61K31/495 ,  A61K31/44 ,  A61K31/417 ,  A61K31/4184 ,  A61K31/397 ,  C07D495/10 ,  A61K31/407 ,  A61K31/435 ,  A61K31/451 ,  A61K31/4035 ,  A61K31/277 ,  A61K31/438 ,  C07D221/20 ,  A61K31/185 ,  C07D307/68 ,  C07D213/65 ,  C07D295/192 ,  C07D211/58 ,  C07D211/16 ,  C07D513/10 ,  C07D209/46 ,  C07D209/42 ,  C07D277/56 ,  C07D209/08 ,  C07D498/04 ,  C07D207/267 ,  C07D493/08 ,  C07D207/10 ,  C07D491/10 ,  C07D487/08 ,  C07D487/04 ,  C07D261/18 ,  C07D257/04 ,  C07D249/18 ,  C07D417/12 ,  C07D241/12 ,  C07D409/12 ,  C07D409/04 ,  C07D405/12 ,  C07D239/22 ,  C07D239/20 ,  C07D235/30 ,  C07D401/12 ,  C07D401/04 ,  C07D333/70 ,  C07D233/38 ,  C07D233/36 ,  C07D231/18 ,  C07D231/14 ,  C07D317/68 ,  C07D215/12 ,  C07D213/81 ,  C07D213/75 ,  C07D401/14

CPC classification number: C07C259/06 ,  A61K31/185 ,  A61K31/277 ,  A61K31/397 ,  A61K31/4035 ,  A61K31/407 ,  A61K31/417 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/438 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/451 ,  A61K31/495 ,  A61K31/5377 ,  C07D207/10 ,  C07D207/267 ,  C07D209/08 ,  C07D209/42 ,  C07D209/44 ,  C07D209/46 ,  C07D211/16 ,  C07D211/58 ,  C07D213/56 ,  C07D213/65 ,  C07D213/75 ,  C07D213/81 ,  C07D215/12 ,  C07D221/20 ,  C07D231/14 ,  C07D231/18 ,  C07D233/36 ,  C07D233/38 ,  C07D233/68 ,  C07D235/14 ,  C07D235/30 ,  C07D239/20 ,  C07D239/22 ,  C07D241/08 ,  C07D241/12 ,  C07D249/18 ,  C07D257/04 ,  C07D261/18 ,  C07D277/56 ,  C07D295/155 ,  C07D295/192 ,  C07D307/68 ,  C07D317/68 ,  C07D333/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/10 ,  C07D493/08 ,  C07D495/10 ,  C07D498/04 ,  C07D513/10 ,  Y02A50/393 ,  Y02A50/411 ,  Y02A50/481

Abstract: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

公开(公告)号：US09630922B2

公开(公告)日：2017-04-25

申请号：US15130613

申请日：2016-04-15

Applicant: Forma Therapeutics, Inc.

Inventor： Pui Yee Ng ,  Heather Davis ,  Kenneth W. Bair ,  David S. Millan ,  Aleksandra Rudnitskaya ,  Xiaozhang Zheng ,  Bingsong Han ,  Nicholas Barczak ,  David R. Lancia, Jr.

IPC: C07D221/20 ,  C07D403/04 ,  C07D209/96 ,  C07D401/04 ,  C07D417/06 ,  C07D519/00 ,  C07D401/06 ,  C07D413/06 ,  C07D405/04 ,  C07D471/04 ,  C07D497/10 ,  C07D491/107 ,  C07D405/06 ,  C07D403/06 ,  C07D405/10

CPC classification number: C07D209/96 ,  C07D221/20 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/10 ,  C07D413/06 ,  C07D417/06 ,  C07D471/04 ,  C07D491/107 ,  C07D497/10 ,  C07D519/00

Abstract: The present invention is directed to inhibitors of histone deacetylases (HDACs) such as HDAC6, and their use in the treatment of diseases such as cell proliferative diseases (e.g., cancer), neurological (e.g., neurodegenerative disease or neurodevelopmental disease), inflammatory or autoimmune disease, infection, metabolic disease, hematologic disease, or cardiovascular disease.

公开(公告)号：US20170066729A1

公开(公告)日：2017-03-09

申请号：US15255817

申请日：2016-09-02

Applicant: Forma Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Bingsong Han ,  Nicholas Barczak ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, JR. ,  Kenneth W. Bair

IPC: C07D265/36 ,  C07D413/06 ,  C07D401/04 ,  C07D279/16 ,  C07D265/34 ,  C07D413/10 ,  C07D471/04 ,  C07D417/06 ,  C07D513/04 ,  C07D487/04 ,  C07D413/12 ,  C07D491/107

CPC classification number: C07D265/36 ,  C07D265/34 ,  C07D279/14 ,  C07D279/16 ,  C07D401/04 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D417/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D513/04

Abstract: The present invention is directed to compounds of Formula I: and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers or thereof, wherein R1, R2, R2′, L, X, W, Y1, Y2, Y3, and Y4 are described herein.

Abstract translation: 本发明涉及式I化合物及其药学上可接受的盐，前药，溶剂合物，水合物，互变异构体或异构体，其中R1，R2，R2'，L，X，W，Y1，Y2，Y3和 Y4。

公开(公告)号：US20160304462A1

公开(公告)日：2016-10-20

申请号：US15130613

申请日：2016-04-15

Applicant: Forma Therapeutics, Inc.

Inventor： Pui Yee Ng ,  Heather Davis ,  Kenneth W. Bair ,  David S. Millan ,  Aleksandra Rudnitskaya ,  Xiaozhang Zheng ,  Bingsong Han ,  Nicholas Barczak ,  David R. Lancia, JR.

IPC: C07D221/20 ,  C07D403/04 ,  C07D209/96 ,  C07D401/04 ,  C07D417/06 ,  C07D519/00 ,  C07D401/06 ,  C07D413/06 ,  C07D405/04 ,  C07D471/04 ,  C07D497/10 ,  C07D491/107 ,  C07D405/06 ,  C07D403/06

CPC classification number: C07D209/96 ,  C07D221/20 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/10 ,  C07D413/06 ,  C07D417/06 ,  C07D471/04 ,  C07D491/107 ,  C07D497/10 ,  C07D519/00

Abstract: The present invention is directed to inhibitors of histone deacetylases (HDACs) such as HDAC6, and their use in the treatment of diseases such as cell proliferative diseases (e.g., cancer), neurological (e.g., neurodegenerative disease or neurodevelopmental disease), inflammatory or autoimmune disease, infection, metabolic disease, hematologic disease, or cardiovascular disease.

Abstract translation: 本发明涉及组蛋白脱乙酰酶（HDAC）如HDAC6的抑制剂及其在治疗诸如细胞增殖性疾病（例如癌症），神经系统疾病（例如神经变性疾病或神经发育疾病），炎性或自身免疫性疾病 疾病，感染，代谢疾病，血液病或心血管疾病。

公开(公告)号：US11649242B2

公开(公告)日：2023-05-16

申请号：US17239364

申请日：2021-04-23

Applicant: FORMA Therapeutics, Inc.

Inventor： Anna Ericsson ,  Neal Green ,  Gary Gustafson ,  Bingsong Han ,  David R. Lancia, Jr. ,  Lorna Mitchell ,  David Richard ,  Tatiana Shelekhin ,  Chase C. Smith ,  Zhongguo Wang ,  Xiaozhang Zheng

IPC: C07D487/04 ,  C07D519/00 ,  A61P7/00 ,  A61K9/00 ,  A61K31/407

CPC classification number: C07D487/04 ,  A61K9/0053 ,  A61K31/407 ,  A61P7/00 ,  C07D519/00

Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

公开(公告)号：US20200055830A1

公开(公告)日：2020-02-20

申请号：US16662131

申请日：2019-10-24

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, JR. ,  David S. Millan ,  Matthew W. Martin ,  Kenneth W. Bair

IPC: C07D267/14 ,  C07D495/10 ,  C07D491/107 ,  C07D413/08 ,  C07D493/08 ,  C07D498/08 ,  C07D498/04 ,  C07D471/04 ,  C07D417/04 ,  C07D413/14 ,  C07D405/06 ,  C07D403/10 ,  C07D403/06 ,  C07D401/10 ,  C07D401/06 ,  C07D291/08 ,  C07D243/14 ,  C07D267/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/06

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US20200048211A1

公开(公告)日：2020-02-13

申请号：US16654704

申请日：2019-10-16

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  David S. Millan ,  Matthew W. Martin

IPC: C07D267/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/04 ,  C07D267/12 ,  C07D243/14 ,  C07D291/08 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D498/08 ,  C07D493/08 ,  C07D413/08 ,  C07D491/107 ,  C07D495/10

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US10508077B2

公开(公告)日：2019-12-17

申请号：US16387937

申请日：2019-04-18

Applicant: FORMA Therapeutics, Inc.

Inventor： Kenneth W. Bair ,  Nicholas Barczak ,  Bingsong Han ,  David R. Lancia, Jr. ,  Cuixian Liu ,  Matthew W. Martin ,  Pui Yee Ng ,  Aleksandra Rudnitskaya ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Xiaozhang Zheng

IPC: C07C259/06 ,  C07D471/04 ,  A61K31/5377 ,  A61K31/4439 ,  C07D417/04 ,  A61K31/495 ,  C07D241/08 ,  A61K31/44 ,  C07D213/56 ,  A61K31/417 ,  C07D233/68 ,  A61K31/4184 ,  C07D235/14 ,  A61K31/397 ,  A61K31/407 ,  C07D487/10 ,  A61K31/435 ,  C07D471/10 ,  A61K31/451 ,  C07D295/155 ,  A61K31/4035 ,  C07D209/44 ,  A61K31/277 ,  A61K31/438 ,  A61K31/185 ,  C07D495/10 ,  C07D221/20 ,  C07D307/68 ,  C07D213/65 ,  C07D295/192 ,  C07D211/58 ,  C07D211/16 ,  C07D513/10 ,  C07D209/46 ,  C07D209/42 ,  C07D277/56 ,  C07D209/08 ,  C07D498/04 ,  C07D207/267 ,  C07D493/08 ,  C07D207/10 ,  C07D491/10 ,  C07D487/08 ,  C07D487/04 ,  C07D261/18 ,  C07D257/04 ,  C07D249/18 ,  C07D417/12 ,  C07D241/12 ,  C07D409/12 ,  C07D409/04 ,  C07D405/12 ,  C07D239/22 ,  C07D239/20 ,  C07D235/30 ,  C07D401/12 ,  C07D401/04 ,  C07D333/70 ,  C07D233/38 ,  C07D233/36 ,  C07D231/18 ,  C07D231/14 ,  C07D317/68 ,  C07D215/12 ,  C07D213/81 ,  C07D213/75 ,  C07D401/14

Abstract: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

公开(公告)号：US10472337B2

公开(公告)日：2019-11-12

申请号：US16220046

申请日：2018-12-14

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  David S. Millan ,  Matthew W. Martin

IPC: A61K31/5513 ,  C07D243/14 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D413/06 ,  C07D417/06 ,  C07D267/14 ,  C07D413/12 ,  C07D413/04 ,  C07D291/08 ,  C07D405/06 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D498/08 ,  C07D493/08 ,  C07D413/08 ,  C07D491/107 ,  C07D495/10 ,  C07D267/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US10464909B2

公开(公告)日：2019-11-05

申请号：US16219381

申请日：2018-12-13

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Heather Davis ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  Kenneth W. Bair ,  David S. Millan ,  Matthew W. Martin

IPC: A61K31/553 ,  C07D498/04 ,  C07D267/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/04 ,  C07D243/14 ,  C07D291/08 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D498/08 ,  C07D493/08 ,  C07D413/08 ,  C07D491/107 ,  C07D495/10 ,  C07D267/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.