-
公开(公告)号：US09724360B2
公开(公告)日：2017-08-08
申请号：US14926062
申请日：2015-10-29
Applicant: Gilead Sciences, Inc.
Inventor： Byoung Kwon Chun , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC: C07H15/18 , C07H7/06 , A61K31/685 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00
CPC classification number: A61K31/685 , A61K31/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/675 , A61K31/683 , A61K45/06 , C07D487/04 , C07D519/00 , C07F9/2429 , C07F9/65616 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K2300/00
Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
-
公开(公告)号：US09579332B2
公开(公告)日：2017-02-28
申请号：US13653982
申请日：2012-10-17
Applicant: Gilead Sciences, Inc.
Inventor： Constantine G. Boojamra , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Oleg V. Petrakovsky , Adrian S. Ray , Lijun Zhang
IPC: C07F9/02 , A61K31/675 , A61K31/662 , C07F9/6561 , C07H19/00 , A61K45/06 , C07H19/20
CPC classification number: C07H19/16 , A61K31/341 , A61K31/513 , A61K31/662 , A61K31/675 , A61K31/683 , A61K45/06 , C07F9/65616 , C07H19/00 , C07H19/20 , A61K2300/00
Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Abstract translation: 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
-
公开(公告)号：US09139604B2
公开(公告)日：2015-09-22
申请号：US14309790
申请日：2014-06-19
Applicant: Gilead Sciences, Inc.
Inventor： Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten A. Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie O'Shea , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
IPC: A61K31/44 , C07F9/6561 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/48 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/40 , C07F9/572 , C07F9/58 , C07F9/60 , C07F9/6503 , C07F9/6509 , C07F9/653 , C07F9/6539 , C07F9/655 , C07F9/6553 , C07H15/00 , C07H17/00 , C07H21/00 , C07H19/056 , C07H19/10 , C07H19/20
CPC classification number: C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Abstract translation: 本发明涉及具有抗病毒活性的磷取代的化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
-
公开(公告)号：US08697861B2
公开(公告)日：2014-04-15
申请号：US13626687
申请日：2012-09-25
Applicant: Gilead Sciences, Inc.
Inventor： Constantine G. Boojamra , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Oleg V. Petrakovsky , Adrian S. Ray , Lijun Zhang
CPC classification number: C07H19/16 , A61K31/341 , A61K31/513 , A61K31/662 , A61K31/675 , A61K31/683 , A61K45/06 , C07F9/65616 , C07H19/00 , C07H19/20 , A61K2300/00
Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Abstract translation: 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
-
公开(公告)号：US20130316969A1
公开(公告)日：2013-11-28
申请号：US13848593
申请日：2013-03-21
Applicant: Gilead Sciences, Inc.
Inventor： Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten A. Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie O'Shea , Sundaramoorthi Swaninathan , William J. Watkins , Jennifer Zhang
IPC: C07H19/20 , C07F9/6561 , C07H19/056 , C07H19/10
CPC classification number: C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
-
Patent Agency Ranking
公开(公告)号：US11420972B2
公开(公告)日：2022-08-23
申请号：US16879491
申请日：2020-05-20
Applicant: Gilead Sciences, Inc.
Inventor： Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dorothy Agnes Theodore
IPC: C07D487/04 , C07H19/04 , A61K9/00 , A61K31/706 , A61K45/06 , C07H7/06 , C07F9/6561
Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.
-
公开(公告)号：US11266666B2
公开(公告)日：2022-03-08
申请号：US16881419
申请日：2020-05-22
Applicant: GILEAD SCIENCES, INC.
Inventor： Byoung Kwon Chun , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC: A61K31/706 , A61K31/7056 , A61K31/685 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K31/6615 , A61K31/665 , A61K31/683 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00
Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
-
公开(公告)号：US20210308136A1
公开(公告)日：2021-10-07
申请号：US17204835
申请日：2021-03-17
Applicant: Gilead Sciences, Inc.
Inventor： Jamie Geier Bates , Adrian S. Ray
IPC: A61K31/519 , A61K31/216 , A61P1/16
Abstract: The present disclosure provides methods and compositions for treating, stabilizing or lessening the severity or progression of a non-alcoholic fatty liver disease.
-
公开(公告)号：US20210052613A1
公开(公告)日：2021-02-25
申请号：US16881419
申请日：2020-05-22
Applicant: GILEAD SCIENCES, INC.
Inventor： Byoung Kwon Chun , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC: A61K31/685 , A61K31/706 , A61K31/7056 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K31/6615 , A61K31/665 , A61K31/683 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00
Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
-
公开(公告)号：US10695361B2
公开(公告)日：2020-06-30
申请号：US16265016
申请日：2019-02-01
Applicant: GILEAD SCIENCES, INC.
Inventor： Michael O'Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC: A61K31/706 , A61K31/7056
Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
-
-
-
-
-
-
-
-
-
Search Results
46
records
(took 0.063 seconds)
