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公开(公告)号：US11827609B2
公开(公告)日：2023-11-28
申请号：US17399984
申请日：2021-08-11
IPC分类号： C07D239/95 , A61P31/18 , A61P35/00 , A61K31/517 , A61K31/519 , A61K45/06 , C07D471/04 , C07D487/04 , C07D495/04
CPC分类号： C07D239/95 , A61K31/517 , A61K31/519 , A61K45/06 , A61P31/18 , A61P35/00 , C07D471/04 , C07D487/04 , C07D495/04
摘要： This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them.
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公开(公告)号：US20230295172A1
公开(公告)日：2023-09-21
申请号：US18115955
申请日：2023-03-01
发明人： Mark J. Bartlett , Daniel H. Byun , Yifan Deng , Jennifer L. Cosman Ellis , Rao V. Kalla , Richard L. Mackman , Dustin S. Siegel , Xianhuang Zeng
IPC分类号： C07D487/04 , C07D519/00 , C07F9/6561 , A61P31/14
CPC分类号： C07D487/04 , C07D519/00 , C07F9/6561 , A61P31/14
摘要： Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
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公开(公告)号：US20230039553A1
公开(公告)日：2023-02-09
申请号：US17243911
申请日：2021-04-29
发明人： Mark J. Bartlett , Gregory F. Chin , Michael O. Clarke , Jennifer L. Cosman , Deeba Ensan , Bindu Goyal , Stephen Ho , Hon C. Hui , Richard L. Mackman , Michael R. Mish , Scott D. Schroeder , Nathan D. Shapiro , Dustin S. Siegel , Doris T. Tang , Hai Yang
IPC分类号： C07D487/04 , C07D519/00 , A61K45/06 , C07K16/28
摘要： The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.
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公开(公告)号：US11420972B2
公开(公告)日：2022-08-23
申请号：US16879491
申请日：2020-05-20
IPC分类号： C07D487/04 , C07H19/04 , A61K9/00 , A61K31/706 , A61K45/06 , C07H7/06 , C07F9/6561
摘要： Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.
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公开(公告)号：US11266666B2
公开(公告)日：2022-03-08
申请号：US16881419
申请日：2020-05-22
发明人： Byoung Kwon Chun , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/706 , A61K31/7056 , A61K31/685 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K31/6615 , A61K31/665 , A61K31/683 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00
摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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公开(公告)号：US20210292348A1
公开(公告)日：2021-09-23
申请号：US17178115
申请日：2021-02-17
发明人： Daniel H. Byun , Gregory F. Chin , Michael O. Clarke , Bindu Goyal , Petr Jansa , Richard L. Mackman , Michael R. Mish , Dustin S. Siegel
IPC分类号： C07F9/6561 , A61K45/06
摘要： The present disclosure describes 4′-fluoromethyl nucleosides for treating viral infections, including Dengue.
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公开(公告)号：US20210284670A1
公开(公告)日：2021-09-16
申请号：US17178463
申请日：2021-02-18
发明人： Gregory F. Chin , Byoung-Kwon Chun , Michael O. Clarke , Bindu Goyal , Hon C. Hui , Petr Jansa , Richard L. Mackman , Dustin S. Siegel , Hai Yang
IPC分类号： C07F9/6561 , A61P31/14
摘要： The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.
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公开(公告)号：US20210052613A1
公开(公告)日：2021-02-25
申请号：US16881419
申请日：2020-05-22
发明人： Byoung Kwon Chun , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/685 , A61K31/706 , A61K31/7056 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K31/6615 , A61K31/665 , A61K31/683 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00
摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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公开(公告)号：US10695361B2
公开(公告)日：2020-06-30
申请号：US16265016
申请日：2019-02-01
发明人： Michael O'Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/706 , A61K31/7056
摘要： Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
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公开(公告)号：US10548898B2
公开(公告)日：2020-02-04
申请号：US16239578
申请日：2019-01-04
发明人： Ondrej Baszczynski , Milan Dejmek , Yunfeng Eric Hu , Petr Jansa , Eric Lansdon , Richard L. Mackman , Petr Simon
IPC分类号： A61K31/517 , C07D401/12 , C07D239/94 , A61K45/06 , C07D239/84 , C07D239/95 , C07D403/12
摘要： Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.
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