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公开(公告)号：US20120101147A1
公开(公告)日：2012-04-26
申请号：US13132179
申请日：2009-12-02
申请人： Li-Huei Tsai , Andre Fischer , Stephen J. Haggarty , Weiping Tang , Stuart L. Schreiber , Edward Holson , Florence Wagner , Mikel P. Moyer
发明人： Li-Huei Tsai , Andre Fischer , Stephen J. Haggarty , Weiping Tang , Stuart L. Schreiber , Edward Holson , Florence Wagner , Mikel P. Moyer
IPC分类号： A61K31/7088 , A61K31/496 , A61K31/4436 , A61P25/28 , A61K31/381 , A61K31/18 , A61K31/16 , A61K31/165 , A61P25/00 , A61K31/44
CPC分类号： A61K31/00 , A61K9/0085 , A61K31/167 , A61K31/353 , A61K31/381 , A61K31/4418 , A61K31/4436 , A61K31/496 , A61K31/7068 , A61K31/7088 , A61K31/7105 , A61K45/06 , A61K2300/00
摘要： The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished by inhibiting HDAC2 and or selectively inhibiting HDAC1/2 or HDAC1/2/3.
摘要翻译： 本发明涉及用于增强和改善丢失记忆恢复的方法和产品。 特别地，所述方法通过抑制HDAC2和/或选择性抑制HDAC1 / 2或HDAC1 / 2/3来实现。
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32.发明申请公开(公告)号：US20120088300A1
公开(公告)日：2012-04-12
申请号：US12679406
申请日：2010-02-05
申请人： Douglas A. Melton , Malgorzata Borowiak , Rene Maehr , Shuibing Chen , Weiping Tang , Julia L. Fox , Stuart L. Schreiber
发明人： Douglas A. Melton , Malgorzata Borowiak , Rene Maehr , Shuibing Chen , Weiping Tang , Julia L. Fox , Stuart L. Schreiber
IPC分类号： C12N5/071 , C07C251/86 , C07C251/84
CPC分类号： C12N5/0678 , C12N5/0603 , C12N5/0606 , C12N2501/999 , C12N2506/02 , C12N2506/03
摘要： Certain embodiments disclosed herein are directed to a method of producing endoderm cells, such as definitive endoderm cells by exposing stem cells such as embryonic stem cells or induced pluripotent stem (iPS) cells to an effective amount of at least one compound described herein to differentiate the stem cells into the endoderm cells such as definitive endoderm cells. Differentated endoderm cells produced by the methods disclosed herein can be differentiated into pancreatic epithelium, and other endoderm derivatives such as thymus, liver, stomach, intestine and lung. Another aspect of the present invention relates to a method of producing pancreatic progenitor cells, such as Pdx1-positive pancreatic progenitor cells by exposing endoderm cells, such as definitive endoderm cells to an effective amount of at least one compound described herein to differentiate the definitive endoderm cells into Pdx1-positive pancreatic progenitor cells. Kits and compositions comprising Pdx1-positive pancreatic progenitor produced using the methods are also described.
摘要翻译： 本文公开的某些实施例涉及通过将干细胞如胚胎干细胞或诱导的多能干（iPS）细胞暴露于有效量的本文所述的至少一种化合物来分化本发明的内胚层细胞，例如定形内胚层细胞， 干细胞进入内胚层细胞，如定形内胚层细胞。 通过本文公开的方法产生的分化的内胚层细胞可以分化成胰腺上皮和其它内胚层衍生物如胸腺，肝，胃，肠和肺。 本发明的另一方面涉及通过将内胚层细胞如定形内胚层细胞暴露于有效量的至少一种本文所述的化合物来分化定形内胚层来产生胰腺祖细胞如Pdx1阳性胰腺祖细胞的方法 细胞进入Pdx1阳性胰腺祖细胞。 还描述了使用该方法制备的包含Pdx1阳性胰腺祖细胞的组合物和组合物。
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公开(公告)号：US20110313045A1
公开(公告)日：2011-12-22
申请号：US13221561
申请日：2011-08-30
IPC分类号： A61K31/16 , C07C259/06 , A61P35/00 , C12N5/071
CPC分类号： C12N9/80 , A01K2217/05 , A01K2217/075 , A61K31/00 , A61K31/165 , A61K31/407 , A61K38/00 , A61K48/00 , C07K5/126 , C07K14/4702 , C07K14/4703 , C07K2319/00 , C12N9/16
摘要： The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
摘要翻译： 本发明涉及由一系列基因（称为HDx相关基因）编码的蛋白质的发现，其涉及染色质结构的控制，因此涉及转录和翻译。 本发明提供可用于例如在体外和体内控制细胞增殖和分化的组合物和方法。
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公开(公告)号：US07932213B2
公开(公告)日：2011-04-26
申请号：US10370885
申请日：2003-02-20
IPC分类号： C40B40/04 , C40B30/04 , C40B50/08 , C40B60/04 , G01N33/566 , G01N33/543 , G01N33/53
CPC分类号： C40B60/14 , B01J19/0046 , B01J2219/00387 , B01J2219/00454 , B01J2219/00459 , B01J2219/005 , B01J2219/00533 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/0072 , C07B2200/11 , C07C311/49 , C40B30/04 , C40B40/04 , C40B50/14 , G01N33/54353 , Y10S436/809
摘要： The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. A composition is provided that comprises an array of chemical compounds attached to a solid support, wherein the density of the array of compounds is at least 1000 spots per cm2. The inventive arrays are generated by: providing a solid support functionalized with a selected chemical moiety capable of interacting with a chemical compound to form an attachment and delivering compounds to the solid support having a density of at least 1000 spots per cm2. The present invention also provides methods for utilizing these arrays to identify small molecule partners for biological macromolecules of interest.
摘要翻译： 本发明提供了有助于鉴定能够与感兴趣的生物大分子相互作用的化合物的组合物和方法。 提供了包含连接到固体支持物上的化学化合物阵列的组合物，其中化合物阵列的密度为每cm 2至少1000个点。 本发明的阵列通过以下方式产生：提供用选择的能够与化学化合物相互作用的选择的化学部分官能化的固体支持物，以形成连接并将化合物输送到具有至少1000个点/ cm 2的密度的固体支持物。 本发明还提供了利用这些阵列鉴定感兴趣的生物大分子的小分子配偶体的方法。
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35.发明申请METHOD OF HIGH-THROUGHPUT SCREENING OF MOLECULES AND COMPOUNDS FOR THEIR EFFECTS ON BIOLOGICAL AND CHEMICAL PROCESSES 审中-公开分子和化合物对生物和化学过程的影响的高通量筛选方法公开(公告)号：US20080311589A1
公开(公告)日：2008-12-18
申请号：US12107042
申请日：2008-04-21
申请人： Brent R. Stockwell , Stuart L. Schreiber , Timothy J. Mitchison , Tarun M. Kapoor , Thomas Mayer , Stephen J. Haggarty
发明人： Brent R. Stockwell , Stuart L. Schreiber , Timothy J. Mitchison , Tarun M. Kapoor , Thomas Mayer , Stephen J. Haggarty
IPC分类号： G01N33/53
CPC分类号： G01N33/6803
摘要： The present invention provides a system for high-throughput analysis of chemical compounds. Assays are performed in a high density platform, and compounds having pre-determined desirable effects are identified. Preferably, the compounds have biological effects, more preferably, the assays and detection are performed on whole cells.
摘要翻译： 本发明提供了化合物的高通量分析系统。 测定在高密度平台中进行，并且鉴定了具有预定的期望效果的化合物。 优选地，化合物具有生物学效应，更优选地，测定和检测在全细胞上进行。
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公开(公告)号：US06982082B1
公开(公告)日：2006-01-03
申请号：US08922240
申请日：1997-08-27
CPC分类号： A61K48/005 , A01K2217/05 , A01K2227/105 , A01K2267/0325 , A01K2267/035 , C07K7/645 , C12N9/90 , C12N15/8509 , C12N2830/008
摘要： This invention is directed to a modified cyclosporin A and to a modified, genetically engineered version of its receptor, cyclophilin. This invention is further directed to a method for treating host versus graft disease following blood marrow transplantation by transfecting stem cells so that after introduction into a patient the stem cells will express the modified cyclophilin, and, as necessary, administer the modified cyclosporin A to the patient.
摘要翻译： 本发明涉及改良的环孢菌素A及其受体，亲环蛋白的修饰的基因工程版本。 本发明还涉及一种通过转染干细胞来治疗血液骨髓移植后的宿主与移植物疾病的方法，使得在引入患者之后，干细胞将表达经修饰的亲环蛋白，并且根据需要将修饰的环孢菌素A施用于 患者。
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公开(公告)号：US06777217B1
公开(公告)日：2004-08-17
申请号：US08624735
申请日：1996-03-26
IPC分类号： C12N912
CPC分类号： C12N9/80 , A01K2217/05 , A01K2217/075 , A61K31/00 , A61K31/165 , A61K31/407 , A61K38/00 , A61K48/00 , C07K5/126 , C07K14/4702 , C07K14/4703 , C07K2319/00 , C12N9/16
摘要： The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
摘要翻译： 本发明涉及由一系列基因（称为HDx相关基因）编码的蛋白质的发现，其涉及染色质结构的控制，因此涉及转录和翻译。 本发明提供可用于例如在体外和体内控制细胞增殖和分化的组合物和方法。
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公开(公告)号：US06335358B1
公开(公告)日：2002-01-01
申请号：US08421583
申请日：1995-04-12
IPC分类号： A61K3136
CPC分类号： C07D487/04 , A61K31/4015 , A61K31/407 , C07D491/10 , C07D495/10 , C12N9/6421
摘要： Compounds related to lactacystin and lactacystin &bgr;-lactone, pharmaceutical compositions containing the compounds, and methods of use.
摘要翻译： 与乳胞素和乳胞蛋白β-内酯相关的化合物，含有这些化合物的药物组合物和使用方法。
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公开(公告)号：US5498597A
公开(公告)日：1996-03-12
申请号：US822966
申请日：1992-01-17
摘要： A purified preparation of FKBP-13, an FK506- and rapamycin-binding immunophilin; fragments and chimeras of FKBP-13 capable of binding FK506 and/or rapamycin; and DNA molecules encoding such polypeptides.
摘要翻译： FKBP-13，FK506-和雷帕霉素结合免疫亲和素的纯化制剂; 能够结合FK506和/或雷帕霉素的FKBP-13的片段和嵌合体; 和编码这种多肽的DNA分子。
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40.发明授权Compositions and methods for promoting the generation of PDX1+ pancreatic cells 有权促进PDX1 +胰腺细胞产生的组合物和方法公开(公告)号：US08728812B2
公开(公告)日：2014-05-20
申请号：US12989284
申请日：2009-04-22
申请人： Shuibing Chen , Douglas A. Melton , Malgorzata Borowiak , Julia Lamenzo , Stuart L. Schreiber , Lee F. Peng , Lance Davidow , Kelvin Lam , Lee L. Rubin
发明人： Shuibing Chen , Douglas A. Melton , Malgorzata Borowiak , Julia Lamenzo , Stuart L. Schreiber , Lee F. Peng , Lance Davidow , Kelvin Lam , Lee L. Rubin
CPC分类号： C12N5/0678 , C12N5/0606 , C12N5/0676 , C12N2501/115 , C12N2501/119 , C12N2501/16 , C12N2501/385 , C12N2501/415 , C12N2501/42 , C12N2501/727 , C12N2501/998 , C12N2501/999 , C12N2506/02
摘要： Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
摘要翻译： 本文公开的某些实施例涉及通过将人胚胎干细胞暴露于有效量的表I所列的至少一种化合物来产生胰腺细胞或胰腺细胞前体的方法，以将人胚胎干细胞分化成胰腺细胞或胰腺细胞 细胞前体。 还描述了使用这些方法生产的试剂盒和胰腺细胞系。
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