Pegylated Single-Chain Insulin
    33.
    发明申请
    Pegylated Single-Chain Insulin 审中-公开
    聚乙二醇化单链胰岛素

    公开(公告)号:US20100216690A1

    公开(公告)日:2010-08-26

    申请号:US11908646

    申请日:2006-03-17

    IPC分类号: A61K38/28 C07K14/62 A61P3/10

    CPC分类号: C07K14/62 A61K38/00 A61K47/60

    摘要: The present invention is related to a single-chain insulin comprising the B- and the A-chain of human insulin or analogues thereof connected by a connecting peptide having from 3-35 amino acid residues, wherein the single-chain insulin comprises at least one PEG group attached to at least one lysine residue in the single-chain insulin molecule and/or to the B1 N terminal amino acid residue. The PEGylated single-chain insulins may comprise up to 4 PEG groups which may be the same or different.

    摘要翻译: 本发明涉及包含通过具有3-35个氨基酸残基的连接肽连接的人胰岛素的B链和A链的单链胰岛素或其类似物,其中所述单链胰岛素包含至少一个 PEG基团连接至单链胰岛素分子中至少一个赖氨酸残基和/或连接至B1N末端氨基酸残基。 PEG化的单链胰岛素可以包含最多4个可以相同或不同的PEG基团。

    Modular furniture system
    38.
    发明申请
    Modular furniture system 审中-公开
    模块化家具系统

    公开(公告)号:US20050162051A1

    公开(公告)日:2005-07-28

    申请号:US10512786

    申请日:2003-05-01

    摘要: A modular furniture system based on a fundamental building block is provided. The building block, or cell, includes first and second end plates and at least one horizontal support beam. A plurality of stacked and/or side-by-side cells provide a framework that can be arranged in an almost limitless number of ways. The cells serve as both storage space and division between neighboring work spaces, thus conserving raw materials and recovering floor space. The cells further provide raceways for concealing electrical wires and data cables, and are adapted for supporting work surfaces and connecting to vertical panels. The cells are adapted to receive various storage components, such as drawers, which may be inserted from both a front side and a back side of each cell. The cells are also adapted to receive tiles, which may cover open sides of each cell and/or cover the end plates of each cell. The tiles may provide any of a multitude of different aesthetic and functional surfaces. A single cell or stack of cells may include a foundation for increased rigidity and sturdiness.

    摘要翻译: 提供了基于基本构件的模块化家具系统。 构建块或电池包括第一和第二端板以及至少一个水平支撑梁。 多个堆叠和/或并排单元提供可以以几乎无限数量的方式布置的框架。 这些电池既用作相邻工作空间之间的存储空间,也可以分开,从而节省原材料并回收占地面积。 电池还提供用于隐藏电线和数据电缆的滚道,并且适于支撑工作表面并连接到垂直面板。 电池适于接收可从每个电池单元的前侧和后侧插入的各种存储部件,例如抽屉。 电池还适于接收瓷砖,其可以覆盖每个电池的开放侧面和/或覆盖每个电池的端板。 瓷砖可以提供任何多种不同的美学和功能表面。 单个电池或电池堆可能包括增加刚性和坚固性的基础。