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    Methods and apparatus for testing disruption of a vagal nerve
    31.
    发明授权
    Methods and apparatus for testing disruption of a vagal nerve 失效
    用于测试迷走神经破裂的方法和装置

    公开(公告)号：US07991474B2

    公开(公告)日：2011-08-02

    申请号：US12054694

    申请日：2008-03-25

    申请人： William N. Aldrich ,  David Miller

    发明人： William N. Aldrich ,  David Miller

    IPC分类号： A61N1/36

    CPC分类号： A61B5/4233 ,  A61B5/04001 ,  A61B8/12 ,  A61B8/445 ,  A61B17/2202 ,  A61B18/1477 ,  A61B2018/00482 ,  A61N7/02 ,  A61N7/022

    摘要： Method and apparatus for disrupting a gastric vagal nerve in the gastroesophageal region and testing the function and disruption of the vagal nerve. In one example embodiment, a treatment device applies ultrasound at a high energy level, such as high intensity focused ultrasound, to a vagal nerve to disrupt it and then ultrasound at a lower energy level to another portion of the vagal nerve, preferably further from the stomach, so as to stimulate the vagal nerve. Alternative ways to test the function or disruption of the vagal nerve involve using PCP-GABA, a pancreatic polypeptide, pressure changes inside the stomach, the gastric mucusol pH, a dye agent in the stomach, and other tests.

    摘要翻译： 用于在胃食管区域中破坏胃迷走神经的方法和装置，并测试迷走神经的功能和破坏。 在一个示例性实施例中，治疗装置以高能量级（例如高强度聚焦超声）将超声波应用于迷走神经以将其破坏，然后以较低的能量级别向迷走神经的另一部分超声波，优选地进一步从 胃，以刺激迷走神经。 测试迷走神经功能或破坏的其他方法包括使用PCP-GABA，胰多肽，胃内压力变化，胃粘蛋白pH，胃中的染料剂等测试。

    Multi-layered, peelable hygienic cover for a stethoscope
    33.
    发明授权
    Multi-layered, peelable hygienic cover for a stethoscope 有权
    用于听诊器的多层，可剥离的卫生罩

    公开(公告)号：US07823690B2

    公开(公告)日：2010-11-02

    申请号：US12215197

    申请日：2008-06-25

    申请人： Bruce Hirsch ,  David Miller

    发明人： Bruce Hirsch ,  David Miller

    IPC分类号： A61B7/02

    CPC分类号： A61B7/02

    摘要： A disposable stethoscope cover that covers at least the surface of the diaphragm is disclosed. The cover contacts a patient during use and reduces transmittal of microorganisms. The cover is in the form of a flexible sheet having a top and a bottom surface. The sheet has an adhesive material on a portion of the surface thereof that secures the sheet to the surface of the diaphragm. The sheet further includes at least one wing extending from the sheet. The wing has an adhesive on at least one surface thereof for securing the wing to the sheet when the wing is folded over at least a portion of a tube section of the stethoscope.

    摘要翻译： 公开了至少覆盖隔膜表面的一次性听诊器盖。 使用时盖子与病人接触并减少微生物传播。 盖子是具有顶部和底部表面的柔性片材的形式。 片材在其表面的一部分上具有粘合材料，其将片材固定到膜片的表面。 片材还包括从片材延伸的至少一个翼片。 机翼在其至少一个表面上具有粘合剂，用于当机翼折叠在听诊器的管部分的至少一部分上时将翼固定到片材上。

    Systems and methods for needle access to an intervertebral disc
    35.
    发明授权
    Systems and methods for needle access to an intervertebral disc 有权
    用于针入椎间盘的系统和方法

    公开(公告)号：US07785314B2

    公开(公告)日：2010-08-31

    申请号：US11764067

    申请日：2007-06-15

    申请人： David Miller ,  Michael Smith ,  Steve Mouw ,  Erika Palmer

    发明人： David Miller ,  Michael Smith ,  Steve Mouw ,  Erika Palmer

    IPC分类号： A61M31/00

    CPC分类号： A61B17/7061 ,  A61B5/4824 ,  A61B17/3401 ,  A61B17/3415 ,  A61B17/3472 ,  A61B17/8827 ,  A61B90/39 ,  A61B90/92 ,  A61B90/94 ,  A61B2017/3486 ,  A61B2090/062 ,  A61M25/04 ,  A61M25/06 ,  A61M25/065 ,  A61M25/10 ,  A61M2025/0008

    摘要： A catheter with a balloon anchor may be sized to fit through an inner needle and introduced into the patient through the needle. The inner needle may comprise an atraumatic needle with a side port and/or a blunt tip. The catheter may include a radiopaque coil disposed over the distal portion of the catheter body to assist with catheter placement when viewed with fluoroscopy and/or x-ray. The distal portion of the catheter can be very flexible. A balloon inflation tube may terminate proximal to a proximal end of the expandable balloon anchor such that the distal portion of catheter can be flexible. This termination of the inflation tube may also position the inflation tube away from the annulus and nerve roots, so as to avoid irritation of the annulus and rubbing of the nerve roots that may potentially obscure FAD test results.

    摘要翻译： 具有气囊锚固件的导管的尺寸可以通过内针装配并通过针引入患者体内。 内针可以包括具有侧端口和/或钝头的无创伤针。 导管可以包括设置在导管主体的远端部分上方的不透射线的线圈，以在用荧光透视和/或x射线观察时辅助导管放置。 导管的远端部分可以非常灵活。 球囊充气管可以在可扩张气囊锚固件的近端附近终止，使得导管的远端部分可以是柔性的。 膨胀管的这种终止还可以使充气管远离环带和神经根，以避免刺激环带和摩擦神经根，这可能潜在地模糊FAD测试结果。

    Selective insect trapping system
    36.
    发明授权
    Selective insect trapping system 失效
    选择性昆虫捕获系统

    公开(公告)号：US07632167B1

    公开(公告)日：2009-12-15

    申请号：US11594011

    申请日：2006-11-07

    申请人： David Miller

    发明人： David Miller

    IPC分类号： A01K47/06 ,  A01M1/10

    CPC分类号： A01M1/106 ,  A01M1/103

    摘要： A selective insect trapping system including a trap entry portion having a groove formed therein, the groove sized for receiving a small hive beetle, the groove having angled side walls which broaden towards a base of the groove for hindering the small hive beetle from climbing out of the groove, the groove having a depth which prevents the small hive beetle from being able to fly out of the groove. The system further includes a receptacle configured for being connected to the trap entry portion, the receptacle being further configured for receiving and containing the small hive beetle. The trap entry portion has a passageway formed therein for allowing passage of the small hive beetle from the groove of the trap entry portion into the receptacle.

    摘要翻译： 一种选择性昆虫捕获系统，包括具有形成在其中的凹槽的捕获入口部分，所述凹槽的尺寸被设计成用于容纳小的蜂巢甲虫，所述凹槽具有成角度的侧壁，其朝向凹槽的基部变宽，以阻止小蜂巢甲虫爬出 所述凹槽具有防止所述小蜂巢甲虫能够从所述凹槽中飞出的深度。 所述系统还包括被配置为连接到所述捕获入口部分的插座，所述插座进一步构造成用于容纳和容纳所述小型蜂巢甲虫。 捕获器入口部分具有形成在其中的通道，用于允许小蜂巢甲虫从捕获器入口部分的槽通过到容器中。

    Hitching Mechanism
    37.
    发明申请
    Hitching Mechanism 审中-公开
    狩猎机制

    公开(公告)号：US20090230657A1

    公开(公告)日：2009-09-17

    申请号：US12046217

    申请日：2008-03-11

    申请人： David Miller

    发明人： David Miller

    IPC分类号： B60D1/36

    CPC分类号： B60D1/52 ,  B60D1/60

    摘要： An apparatus and a method providing for improved hitching of a towed implement to a tractor. The apparatus and method are of most use in small connections such as to a lawn tractor and provide for a handgrip to improve ease of moving the implement by hand and a hitching mechanism which serves to allow for the same hand to raise the hitch pin, engage the hitch, and then lower the hitch pin.

    摘要翻译： 一种设备和方法，用于改进牵引工具对拖拉机的连接。 该设备和方法在诸如草坪拖拉机的小连接中最常用，并且提供手柄以提高用手移动工具的便利性和用于允许相同的手抬起搭接销的接合机构，接合 搭接，然后降低搭扣针。

    Assay for toxin induced neuronal degeneration and viability in C. elegans
    38.
    发明授权
    Assay for toxin induced neuronal degeneration and viability in C. elegans 失效
    测定毒素诱导的神经元变性和秀丽隐杆线虫的活力

    公开(公告)号：US07531713B2

    公开(公告)日：2009-05-12

    申请号：US11029895

    申请日：2005-01-05

    申请人： Randy D. Blakely ,  Richard Nass ,  David Miller

    发明人： Randy D. Blakely ,  Richard Nass ,  David Miller

    IPC分类号： G01N33/00 ,  C12N15/00 ,  C12N15/09

    CPC分类号： G01N33/5014 ,  A01K67/0336 ,  A01K2217/05 ,  A01K2227/703 ,  A01K2267/035 ,  A01K2267/0393 ,  C12N2830/008 ,  G01N33/5008 ,  G01N33/5058 ,  G01N2500/00

    摘要： Provided are in vivo screening methods to detect and identify substances that affect neuronal viability, and/or prevent neurodegeneration, and/or confer neuroprotective effects The screening methods utilize recombinant C. elegans expressing a detectable marker in neuronal sub-groups and the use of neurotoxins specific to specific neuronal cells. Also provided are methods for identifying modulators of neurotransmitter transporters such as the dopamine transporter. Therefore, the invention provides methods for identifying substances that can be used in the prevention and therapy of neurodegenerative diseases.

    摘要翻译： 提供了用于检测和鉴定影响神经元存活力和/或预防神经变性和/或赋予神经保护作用的物质的体内筛选方法。筛选方法利用在神经元亚组中表达可检测标记的重组秀丽隐杆线虫和神经毒素的使用 特异性的特定神经细胞。 还提供了用于鉴定神经递质转运蛋白如多巴胺转运蛋白的调节剂的方法。 因此，本发明提供了用于鉴定可用于预防和治疗神经变性疾病的物质的方法。

    SYSTEM AND METHOD FOR INCREASING THE DEPTH FOCUS OF THE HUMAN EYE
    39.
    发明申请
    SYSTEM AND METHOD FOR INCREASING THE DEPTH FOCUS OF THE HUMAN EYE 审中-公开
    增加人眼深层聚焦的系统和方法

    公开(公告)号：US20090059168A1

    公开(公告)日：2009-03-05

    申请号：US12182038

    申请日：2008-07-29

    申请人： David Miller ,  Ernesto Blanco

    发明人： David Miller ,  Ernesto Blanco

    IPC分类号： G02C7/04

    CPC分类号： G02C7/16 ,  A61F2/145 ,  A61F2/15 ,  A61F2/1613 ,  A61F2/1659 ,  A61F2002/1699 ,  A61F2250/0098 ,  B01D69/141 ,  B01D2323/34 ,  G02C7/04 ,  G02C7/042 ,  G02C7/044 ,  G02C7/046 ,  G02C7/12 ,  G02C7/165 ,  G02C2202/20 ,  G02C2202/22

    摘要： A method and apparatus for increasing the depth of focus of the human eye is comprised of a lens body, an optic in the lens body configured to produce light interference, and a pinhole-like optical aperture substantially in the center of the optic. The optic may be configured to produce light scattering or composed of a light reflective material. Alternatively, the optic may increase the depth of focus via a combination of light interference, light scattering, light reflection and/or light absorption. The optic may also be configured as a series of concentric circles, a weave, a pattern of particles, or a pattern of curvatures. One method involves screening a patient for an ophthalmic lens using a pinhole screening device in the lens to increase the patient's depth of focus. Another method comprises surgically implanting a mask in the patient's eye to increase the depth of focus.

    摘要翻译： 用于增加人眼的深度的方法和装置包括透镜体，被配置为产生光干涉的透镜主体中的光学元件和基本上在光学元件中心的针孔状光学孔。 光学元件可以被配置为产生光散射或由光反射材料组成。 或者，光学元件可以通过光干涉，光散射，光反射和/或光吸收的组合来增加焦深。 光学元件还可以被配置为一系列同心圆，编织物，颗粒图案或曲率图案。 一种方法包括使用镜片中的针孔筛选装置筛选眼科镜片的患者，以增加患者的焦点深度。 另一种方法包括在患者眼睛中手术植入掩模以增加焦点深度。

    Methods and Apparatus for Testing Disruption of a Vagal Nerve
    40.
    发明申请
    Methods and Apparatus for Testing Disruption of a Vagal Nerve 失效
    用于测试迷走神经破坏的方法和装置

    公开(公告)号：US20090018473A1

    公开(公告)日：2009-01-15

    申请号：US12195197

    申请日：2008-08-20

    申请人： William N. Aldrich ,  David Miller

    发明人： William N. Aldrich ,  David Miller

    IPC分类号： A61N7/00

    CPC分类号： A61B5/4233 ,  A61B5/04001 ,  A61B8/12 ,  A61B8/445 ,  A61B17/2202 ,  A61B18/1477 ,  A61B2018/00482 ,  A61N7/02 ,  A61N7/022

    摘要： Method and apparatus for disrupting a gastric vagal nerve in the gastroesophageal region and testing the function and disruption of the vagal nerve. In one example embodiment, a treatment device applies ultrasound at a high energy level, such as high intensity focused ultrasound, to a vagal nerve to disrupt it and then ultrasound at a lower energy level to another portion of the vagal nerve, preferably further from the stomach, so as to stimulate the vagal nerve. Alternative ways to test the function or disruption of the vagal nerve involve using PCP-GABA, a pancreatic polypeptide, pressure changes inside the stomach, the gastric mucusol pH, a dye agent in the stomach, and other tests.

    摘要翻译： 用于在胃食管区域中破坏胃迷走神经的方法和装置，并测试迷走神经的功能和破坏。 在一个示例性实施例中，治疗装置以高能量级（例如高强度聚焦超声）将超声波应用于迷走神经以将其破坏，然后以较低的能量级别向迷走神经的另一部分超声波，优选地进一步从 胃，以刺激迷走神经。 测试迷走神经功能或破坏的其他方法包括使用PCP-GABA，胰多肽，胃内压力变化，胃粘蛋白pH，胃中的染料剂等测试。